The role of the N-methyl-d-aspartate receptor in ketamine-induced apoptosis in rat forebrain culture

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

1999 • 2,023 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons

1989 • 1,456 citations

NMDA Antagonist Neurotoxicity: Mechanism and Prevention

1991 • 837 citations

Ethanol withdrawal seizures and the NMDA receptor complex

1990 • 444 citations

Mechanisms of excitotoxicity in neurologic diseases

1992 • 382 citations

Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions

1993 • 374 citations

Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis-necrosis continuum

1997 • 339 citations

Developmental Neurotoxicity of Ketamine: Morphometric Confirmation, Exposure Parameters, and Multiple Fluorescent Labeling of Apoptotic Neurons

2004 • 291 citations

Rapid Communication Chronic Ingestion of Ethanol Up‐Regulates NMDAR1 Receptor Subunit Immunoreactivity in Rat Hippocampus

1994 • 235 citations

1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo.

1985 • 224 citations

Micromolar l-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones

1998 • 173 citations

Chronic ethanol treatment upregulates the NMDA receptor function and binding in mammalian cortical neurons

1995 • 164 citations

Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons

1996 • 147 citations

Suppression of NMDA Receptor Function Using Antisense DNA Blocks Ocular Dominance Plasticity While Preserving Visual Responses

1998 • 140 citations

Glutamate-dopamine interactions in the basal ganglia: relationship to Parkinson's disease

1993 • 135 citations

NMDA and Kainate Induce Internucleosomal DNA Cleavage Associated With Both Apoptotic and Necrotic Cell Death in the Neonatal Rat Brain

1995 • 130 citations

Ethanol inhibits N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat cortical slices.

1990 • 113 citations

Blockade of Phencyclidine-Induced Cortical Apoptosis and Deficits in Prepulse Inhibition by M40403, a Superoxide Dismutase Mimetic

2003 • 98 citations

MK-801 pretreatment enhances N-methyl-d-aspartate-mediated brain injury and increases brain N-methyl-d-aspartate recognition site binding in rats

1990 • 93 citations

Chronic phencyclidine induces behavioral sensitization and apoptotic cell death in the olfactory and piriform cortex

1998 • 92 citations

Phencyclidine induction of the hsp70 stress gene in injured pyramidal neurons is mediated via multiple receptors and voltage gated calcium channels

1994 • 89 citations

Mechanisms of N-methyl-D-aspartate-induced apoptosis in phencyclidine-treated cultured forebrain neurons.

2000 • 85 citations

Up-regulation of N-methyl-D-aspartate receptors on cultured cortical neurons after exposure to antagonists.

1992 • 84 citations

Glutamate neurotoxicity in mouse cortical neurons: atypical necrosis with DNA ladders and chromatin condensation

1998 • 72 citations

Ethanol and Regulation of the NMDA Receptor Subunits in Fetal Cortical Neurons

1998 • 67 citations

Chronic phencyclidine increases NMDA receptor NR1 subunit mRNA in rat forebrain

1999 • 56 citations

Blockade of N-methyl-d-aspartate receptors by phencyclidine causes the loss of corticostriatal neurons

2004 • 51 citations

NMDA induces apoptosis and necrosis in neuronal cultures. Increased APP immunoreactivity is linked to apoptotic cells

1997 • 48 citations

Augmentation of locomotor activity by chronic phencyclidine is associated with an increase in striatal NMDA receptor function and an upregulation of the NR1 receptor subunit

1999 • 46 citations

Glycine site of the excitatory amino acid N-methyl-D-aspartate receptor in neonatal and adult brain.

1993 • 39 citations

N-methyl-D-aspartate receptors and Alzheimer's disease

1989 • 38 citations

Cloning and functional expression of a cDNA encoding the mouse β2 subunit of the kainate-selective glutamate receptor channel

1992 • 33 citations

Effects on ethanol withdrawal hyperexcitability of chronic treatment with a competitive N-methyl-D-aspartate receptor antagonist.

1995 • 27 citations