Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Differentiation and proliferation of hematopoietic stem cells

1993 • 1,417 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Expression of a Delta homologue in prospective neurons in the chick

1995 • 1,019 citations

A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS

1964 • 889 citations

The choice of cell fate in the epidermis of Drosophila

1991 • 736 citations

Notch Receptor Activation Inhibits Oligodendrocyte Differentiation

1998 • 675 citations

Jagged: A mammalian ligand that activates notch1

1995 • 617 citations

LIN-12/Notch signaling: lessons from worms and flies

1998 • 545 citations

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

1996 • 497 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD

1994 • 483 citations

Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta

1995 • 458 citations

Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian

1999 • 413 citations

Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

1997 • 399 citations

The Ins and Outs of Notch Signaling

1997 • 386 citations

Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo

1997 • 380 citations

Differentiation of human dendritic cells from monocytes in vitro

1997 • 356 citations

Alterations in Notch signaling in neoplastic lesions of the human cervix.

1995 • 355 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

Notch2: a second mammalian Notch gene

1992 • 346 citations

A homolog of Drosophila Notch expressed during mammalian development

1991 • 338 citations

The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells

1998 • 328 citations

A Chick Homologue ofSerrateand Its Relationship withNotchandDeltaHomologues during Central Neurogenesis

1996 • 323 citations

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium

1994 • 318 citations

The Human Homolog of Rat Jagged1Expressed by Marrow Stroma Inhibits Differentiation of 32D Cells through Interaction with Notch1

1998 • 282 citations

Colony-stimulating factor-induced monocyte survival and differentiation into macrophages in serum-free cultures.

1987 • 270 citations

Notch as a Mediator of Cell Fate Determination in Hematopoiesis: Evidence and Speculation

1999 • 265 citations

Jagged2: A Serrate-like Gene Expressed during Rat Embryogenesis

1996 • 243 citations

Differential Induction of Apoptosis by Fas–Fas Ligand Interactions in Human Monocytes and Macrophages

1997 • 243 citations

Cutting Edge: Protective Effects of Notch-1 on TCR-Induced Apoptosis

1999 • 223 citations

Dendritic Cell Development: Multiple Pathways to Nature's Adjuvants

1997 • 217 citations

Notch1 and Notch2 Inhibit Myeloid Differentiation in Response to Different Cytokines

1998 • 213 citations

Generation of CD1+RelB+ dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes

1996 • 212 citations

A stochastic model of self‐renewal and commitment to differentiation of the primitive hemopoietic stem cells in culture

1982 • 199 citations

Comparison of the effects of IL-3, granulocyte-macrophage colony-stimulating factor, and macrophage colony-stimulating factor in supporting monocyte differentiation in culture. Analysis of macrophage antibody-dependent cellular cytotoxicity.

1990 • 197 citations

Isolation and Functional Analysis of a cDNA for Human Jagged2, a Gene Encoding a Ligand for the Notch1 Receptor

1997 • 192 citations

The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos

1997 • 186 citations

Inhibition of granulocytic differentiation by mNotch1

1996 • 180 citations

A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors

1994 • 176 citations

Activation-induced apoptosis in human macrophages: developmental regulation of a novel cell death pathway by macrophage colony-stimulating factor and interferon gamma.

1995 • 174 citations

Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo

1995 • 159 citations

Stromal Expression of Jagged 1 Promotes Colony Formation by Fetal Hematopoietic Progenitor Cells

1998 • 150 citations

Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila

1997 • 147 citations

Macrophage Colony-Stimulating Factor Is Required for Human Monocyte Survival and Acts as a Cofactor for Their Terminal Differentiation to Macrophages In Vitro

1991 • 90 citations

Control of hematopoietic differentiation: Lack of specificity in signaling by cytokine receptors

1998 • 82 citations

Long term cultures of human monocytes in vitro impact of GM-CSF on survival and differentiation

1991 • 53 citations

Notch Activity Influences the ab versus gd T Cell Lineage Decision

1997 • 26 citations

Immunophenotypic characterisation of human peritoneal and alveolar macrophages and of human blood monocytes differentiated in the presence of either GM-CSF or M-CSF or a combination of GM-CSF/M-CSF.

1992 • 15 citations

Apoptosis in monocytes.

1998 • 7 citations