Anti-inflammatory activities of a new series of selective phosphodiesterase 4 inhibitors derived from 9-benzyladenine.

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1995 • 1,780 citations

Phosphodiesterase Isozymes

1998 • 655 citations

Phosphodiesterase inhibitors: new opportunities for the treatment of asthma.

1991 • 383 citations

Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta

1986 • 301 citations

Stereospecific binding of the antidepressant rolipram to brain protein structures

1986 • 235 citations

Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?

1997 • 232 citations

Neutrophil-mediated Pulmonary Vascular Injury: Synergistic Effect of Trace Amounts of Lipopolysaccharide and Neutrophil Stimuli on Vascular Permeability and Neutrophil Sequestration in the Lung

1987 • 228 citations

The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-α production by human mononuclear cells

1993 • 222 citations

Proposal for Pharmacologically Distinct Conformers of PDE4 Cyclic AMP Phosphodiesterases

1997 • 185 citations

The Association of Circulating Endotoxin with the Development of the Adult Respiratory Distress Syndrome

1989 • 182 citations

Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-alpha and IL-6 release by endotoxin-stimulated macrophages.

1995 • 159 citations

Biarylcarboxylic Acids and -amides: Inhibition of Phosphodiesterase Type IV versus [³H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret

1996 • 142 citations

Characterization of cAMP-dependent inhibition of LPS-induced TNFα production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor

1994 • 136 citations

SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions.

1998 • 135 citations

Stimulation of beta adrenoceptors in a human monocyte cell line (U937) up-regulates cyclic AMP-specific phosphodiesterase activity.

1992 • 124 citations

Mapping the functional domains of human recombinant phosphodiesterase 4A: structural requirements for catalytic activity and rolipram binding.

1996 • 114 citations

Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer

1996 • 113 citations

Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding

1996 • 104 citations

Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: correlation between function and interaction with a high-affinity rolipram binding site.

1995 • 102 citations

Cyclic nucleotide phosphodiesterase activities from pig coronary arteries. Lack of interconvertibility of major forms

1980 • 64 citations

Therapeutic intervention in a rat model of ARDS: IV. Phosphodiesterase IV inhibition.

1993 • 51 citations

Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl-2-imidazolidinones

1991 • 48 citations

PDE 4 inhibitors: the use of molecular cloning in the design and development of novel drugs

1997 • 48 citations

Detailed Characterization of a Purified Type 4 Phosphodiesterase, HSPDE4B2B: Differentiation of High- and Low-Affinity (R)-Rolipram Binding

1997 • 45 citations

9-Benzyladenines: Potent and Selective cAMP Phosphodiesterase Inhibitors

1997 • 42 citations

Analysis of PDE Isoenzyme Profiles in Cells and Tissues by Pharmacological Methods

1996 • 39 citations

Evidence that cyclic AMP phosphodiesterase inhibitors suppress interleukin‐2 release from murine splenocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer

1997 • 34 citations

Effects of interleukin‐10 and modulators of cyclic AMP formation on endotoxin‐induced inflammation in rat lung

1999 • 30 citations

Involvement of cyclic AMP in the effects of phosphodiesterase IV inhibitors on arachidonate release from mononuclear cells

1995 • 28 citations

Biochemical Characteristics and Cellular Regulation of Phosphodiesterase IV

1993 • 28 citations

Effect of the phosphodiesterase inhibitor 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 62711) on gastric secretion and gastric mucosal cyclic AMP

1978 • 26 citations

Anti-Inflammatory Effects of the Novel Phosphodiesterase IV Inhibitor RP 73401

1995 • 14 citations

An Isoform-selective Inhibitor of Cyclic AMP-Specific Phosphodiesterase (PDE4) with Anti-inflammatory Properties

1996 • 10 citations

Phosphodiesterase 4 inhibitors and db‐cAMP inhibit TNF‐α release from human mononuclear cells. Effects of cAMP and cGMP‐dependent protein kinase inhibitors

1996 • 9 citations

Dextran sulphate inhibits neutrophil emigration and neutrophil-dependent plasma leakage in rabbit skin

1993 • 6 citations