Epidermal Growth Factor and Insulin-Induced Deoxyribonucleic Acid Synthesis in Primary Rat Hepatocytes Is Phosphatidylinositol 3-Kinase Dependent and Dissociated from Protooncogene Induction1

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Liver Regeneration

1997 • 2,731 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Liver regeneration: molecular mechanisms of growth control

1990 • 922 citations

Insulin Action and the Insulin Signaling Network*

1995 • 823 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Control of p70 S6 kinase by kinase activity of FRAP in vivo

1995 • 717 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

Induction of DNA synthesis in BALB/c 3T3 cells by serum components: Reevaluation of the commitment process

1977 • 695 citations

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 • 673 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

IMMUNOPHARMACOLOGY OF RAPAMYCIN

1996 • 651 citations

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

1994 • 620 citations

Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration.

1995 • 613 citations

Protein Kinase C δ Activates the MEK-ERK Pathway in a Manner Independent of Ras and Dependent on Raf

1996 • 570 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1994 • 553 citations

Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism.

1989 • 528 citations

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

1995 • 520 citations

Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium.

1996 • 487 citations

Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation

1997 • 433 citations

Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.

1992 • 370 citations

Microinjected c- myc as a Competence Factor

1985 • 361 citations

Hormonal stimulation of DNA synthesis in primary cultures of adult rat hepatocytes.

1976 • 359 citations

p70s6k function is essential for G1 progression

1993 • 348 citations

DNA synthesis in primary cultures of adult rat hepatocytes in a defined medium: Effects of epidermal growth factor, insulin, glucagon, and cyclic‐AMP

1981 • 345 citations

Regulation of hepatic regeneration in rats by synergistic action of insulin and glucagon.

1975 • 329 citations

Signal transduction within the nucleus by mitogen-activated protein kinase.

1992 • 323 citations

Sequential protooncogene expression during rat liver regeneration.

1986 • 302 citations

The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.

1994 • 270 citations

Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis.

1995 • 269 citations

Mitogenic Signaling of Insulin-like Growth Factor I in MCF-7 Human Breast Cancer Cells Requires Phosphatidylinositol 3-Kinase and Is Independent of Mitogen-activated Protein Kinase

1997 • 262 citations

Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells.

1990 • 242 citations

Growth Factor Dependence of Progression through G1 and S Phases of Adult Rat Hepatocytes in Vitro

1996 • 225 citations

In vivo response of hepatocytes to growth factors requires an initial priming stimulus

1994 • 222 citations

Insulin action and the insulin signaling network

1995 • 216 citations

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.

1995 • 208 citations

Cell-extracellular matrix interactions can regulate the switch between growth and differentiation in rat hepatocytes: reciprocal expression of C/EBP alpha and immediate-early growth response transcription factors.

1994 • 199 citations

Liver regeneration versus direct hyperplasia

1996 • 187 citations

Signaling via Mitogen-Activated Protein Kinase Kinase (MEK1) Is Required for Golgi Fragmentation during Mitosis

1998 • 186 citations

Differential Effects of Constitutively Active Phosphatidylinositol 3-Kinase on Glucose Transport, Glycogen Synthase Activity, and DNA Synthesis in 3T3-L1 Adipocytes

1997 • 179 citations

Cloning and Characterization of a Wortmannin-sensitive Human Phosphatidylinositol 4-Kinase

1997 • 171 citations

Proto-oncogene expression in regenerating liver is simulated in cultures of primary adult rat hepatocytes.

1986 • 167 citations

Activation of pp70/85 S6 Kinases in Interleukin-2-Responsive Lymphoid Cells Is Mediated by Phosphatidylinositol 3-Kinase and Inhibited by Cyclic AMP

1995 • 164 citations

Tyrosine Phosphorylation Sites at Amino Acids 239 and 240 of Shc Are Involved in Epidermal Growth Factor-Induced Mitogenic Signaling That Is Distinct from Ras/Mitogen-Activated Protein Kinase Activation

1997 • 156 citations

Influence of epidermal growth factor on liver regeneration after partial hepatectomy in rats

1988 • 148 citations

Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription

1993 • 146 citations

Regulation of c-myc expression by Ras/Raf signalling

1998 • 134 citations

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.

1994 • 130 citations

Does Mitogen-Activated-Protein Kinase have a Role in Insulin Action?. The Cases for and Against

1995 • 125 citations

Internalization and Activation of the Rat Liver Insulin Receptor Kinase in vivo

1989 • 116 citations

Hormonal Factors Concerned with Liver Regeneration

1978 • 110 citations

Does Mitogen‐Activated‐Protein Kinase have a Role in Insulin Action?

1995 • 107 citations

Role of p70 S6 Protein Kinase in Angiotensin II-induced Protein Synthesis in Vascular Smooth Muscle Cells

1995 • 105 citations

Cell cycle reentry of mammalian fibroblasts is accompanied by the sustained activation of P44^mapk and P42^mapk isoforms in the G1 phase and their inactivation at the G1/s transition

1995 • 85 citations

Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase

1993 • 82 citations

Comparative effects of hepatocyte growth factor and epidermal growth factor on motility, morphology, mitogenesis, and signal transduction of primary rat hepatocytes

1994 • 79 citations

Insulin regulation of mitogen-activated protein kinase kinase (MEK), mitogen-activated protein kinase and casein kinase in the cell nucleus: a possible role in the regulation of gene expression

1997 • 75 citations

Specific Activation of p85-p110 Phosphatidylinositol 3′-Kinase Stimulates DNA Synthesis by ras- and p70 S6 Kinase-Dependent Pathways

1997 • 71 citations

Differential regulation and expression of jun, c-fos and c-myc proto-oncogenes during mouse liver regeneration and after inhibition of protein synthesis.

1990 • 71 citations

The effect of splanchnic viscera removal upon canine liver regeneration.

1978 • 69 citations

Insulin and insulin-like growth factor-I signal transduction requires p21ras.

1994 • 68 citations

Phosphatidylinositol 3′-Kinase and p70s6k Are Required for Insulin but Not Bisperoxovanadium 1,10-Phenanthroline (bpV(phen)) Inhibition of Insulin-like Growth Factor Binding Protein Gene Expression

1997 • 65 citations

Inhibition of MAP kinase blocks insulin‐mediated DNA synthesis and transcriptional activation of c‐fos by Elk‐1 in vascular smooth muscle cells

1997 • 58 citations

Differences in the steady-state levels of c- fos , c- jun and c- myc messenger RNA during mitogen-induced liver growth and compensatory regeneration

1993 • 57 citations

Density-dependent proliferation of adult rat hepatocytes in primary culture induced by epidermal growth factor is potentiated by cAMP-elevating agents

1997 • 41 citations

The SH2 domain of Shc suppresses EGF-induced mitogenesis in a dominant negative manner.

1995 • 40 citations

Expression of myc, fos and Ha‐ras associated with chemically induced cell proliferation in the rat liver

1994 • 39 citations

Increased expression of the N-myc gene during normal and neoplastic rat liver growth

1988 • 33 citations

Insulin and glucagon as modifiers of DNA synthesis in the regenerating rat liver

1976 • 32 citations

Proliferation of adult rat hepatocytes in primary culture induced by insulin is potentiated by cAMP-elevating agents

1997 • 30 citations

Inhibition of Raf-1 kinase expression abolishes insulin stimulation of DNA synthesis in H4IIE hepatoma cells.

1994 • 14 citations

Electroporation of Cultured adult rat hepatocytes with the c-myc gene potentiates DNA synthesis in response to epidermal growth factor

1988 • 13 citations

EGF-Induced Activation of 70-kDa S6 Kinase in CHO Cells Expressing Human EGF Receptors

1995 • 10 citations

Effects of epidermal growth factor, glucagon and insulin on the hepatocytes after experimental liver cell necrosis. In vivo studies with monoclonal anti-bromo-deoxyuridine staining.

1988 • 1 citations

Deleted Work

1955 • 0 citations