Inhibition of MAP kinase blocks insulin‐mediated DNA synthesis and transcriptional activation of c‐fos by Elk‐1 in vascular smooth muscle cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Experiments in molecular genetics

1972 • 28,260 citations

The MAPK signaling cascade

1995 • 3,300 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Hyperinsulinemia as an Independent Risk Factor for Ischemic Heart Disease

1996 • 1,727 citations

The smooth muscle cell in culture

1979 • 1,546 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.

1992 • 681 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

Role of basic fibroblast growth factor in vascular lesion formation.

1991 • 521 citations

Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia.

1996 • 486 citations

A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells

1986 • 408 citations

Journey to the surface of the cell: Fos regulation and the SRE.

1995 • 376 citations

Production of mRNA in chinese hamster cells: Relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences

1979 • 326 citations

Protein Kinase C-ζ Mediates Angiotensin II Activation of ERK1/2 in Vascular Smooth Muscle Cells

1997 • 220 citations

Mitogen-Activated Protein Kinase Activation Is Involved in Platelet-Derived Growth Factor-Directed Migration by Vascular Smooth Muscle Cells

1997 • 219 citations

Differential Signaling by Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in IRS-1-Deficient Cells

1997 • 212 citations

Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2.

1994 • 186 citations

Identification of c-fos sequences involved in induction by insulin and phorbol esters.

1988 • 184 citations

INSULIN AND ATHEROMA—AN UPDATE

1987 • 132 citations

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.

1994 • 130 citations

Binding and biological effects of insulin, insulin analogues and insulin-like growth factors in rat aortic smooth muscle cells. Comparison of maximal growth promoting activities

1991 • 116 citations

Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways.

1996 • 113 citations

Specific Activation of p85-p110 Phosphatidylinositol 3′-Kinase Stimulates DNA Synthesis by ras- and p70 S6 Kinase-Dependent Pathways

1997 • 71 citations

Troglitazone inhibits angiotensin II‐induced DNA synthesis and migration in vascular smooth muscle cells

1997 • 71 citations

Signal Transduction Pathways Leading to Insulin-Induced Early Gene Induction

1995 • 53 citations

Treatment of vascular smooth muscle cells with antisense phosphorothioate oligodeoxynucleotides directed against p42 and p44 mitogen-activated protein kinases abolishes DNA synthesis in response to platelet-derived growth factor

1996 • 32 citations

Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways

1996 • 28 citations

Insulin resistance and macrovascular disease

1996 • 16 citations