Cell cycle reentry of mammalian fibroblasts is accompanied by the sustained activation of P44^mapk and P42^mapk isoforms in the G1 phase and their inactivation at the G1/s transition

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

A Restriction Point for Control of Normal Animal Cell Proliferation

1974 • 1,389 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase

1991 • 491 citations

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1992 • 480 citations

Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin.

1991 • 468 citations

Mitogen-activated protein kinases: versatile transducers for cell signaling

1992 • 439 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase α

1981 • 389 citations

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

1993 • 333 citations

Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1

1994 • 331 citations

Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

1992 • 331 citations

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

1993 • 328 citations

Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes

1992 • 316 citations

The Role of p34 Kinases in the G1 to S-Phase Transition

1992 • 313 citations

The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts.

1993 • 305 citations

Cell cycle-specific effects of lovastatin.

1991 • 301 citations

Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1.

1992 • 292 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity.

1992 • 284 citations

A conserved kinase cascade for MAP kinase activation in yeast

1993 • 255 citations

Conjugation in Saccharomyces cerevisiae

1988 • 248 citations

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase

1992 • 239 citations

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

1992 • 235 citations

Signal Transduction During Pheromone Response in Yeast

1991 • 225 citations

A reversible arrest point in the late G1 phase of the mammalian cell cycle

1990 • 203 citations

The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase.

1993 • 203 citations

MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro

1993 • 190 citations

Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase

1993 • 170 citations

Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells

1992 • 163 citations

Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells.

1992 • 153 citations

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

1993 • 152 citations

Transmembrane Receptors and Intracellular Pathways that Control Cell Proliferation

1992 • 151 citations

Cyclin-dependent kinases: a new cell cycle motif?

1991 • 148 citations

The beta-PDGF receptor induces neuronal differentiation of PC12 cells.

1992 • 145 citations

MAP kinase and the activation of quiescent cells

1993 • 140 citations

Erks: their fifteen minutes has arrived.

1992 • 133 citations

[3] Determination of phosphoamino acid composition by acid hydrolysis of protein blotted to immobilon

1991 • 127 citations

Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity

1992 • 121 citations

A new class of reversible cell cycle inhibitors

1991 • 92 citations

Inhibition of c-Jun DNA binding by mitogen-activated protein kinase.

1992 • 78 citations

Growth factors and cell proliferation

1992 • 77 citations

A 40‐kDa myelin basic protein kinase, distinct from erk1 and erk2, is activated in mitotic HeLa cells

1994 • 42 citations

MAP kinases: activation, subcellular localization and role in the control of cell proliferation.

1993 • 40 citations