Back to search

Untargeted effects of ionizing radiation: Implications for radiation pathology

Data up to Jan 2025

Published2006
Citations119
References177

Total Citations Per Year

Abstract

References (177)

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

Oxidants, oxidative stress and the biology of ageing

2000 • 8,990 citations

Inflammation and cancer: back to Virchow?

2001 • 7,259 citations

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

NF-κB functions as a tumour promoter in inflammation-associated cancer

2004 • 2,370 citations

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

2004 • 2,361 citations

The relationship between the spleen colony-forming cell and the haemopoietic stem cell.

1978 • 2,290 citations

Defining the Epithelial Stem Cell Niche in Skin

2003 • 1,995 citations

ACTION OF X-RAYS ON MAMMALIAN CELLS

1956 • 1,660 citations

Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide

1998 • 1,566 citations

A blast from the past: clearance of apoptotic cells regulates immune responses

2002 • 1,558 citations

Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy

2001 • 1,556 citations

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

2000 • 1,306 citations

Reactive Oxygen Species as Intracellular Messengers During Cell Growth and Differentiation

2001 • 1,092 citations

Reactive Oxygen Species

2004 • 1,035 citations

Induction of sister chromatid exchanges by extremely low doses of alpha-particles.

1992 • 979 citations

Studies of the Mortality of Atomic Bomb Survivors. Report 12, Part I. Cancer: 1950-1990

1996 • 935 citations

Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence

2003 • 835 citations

Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis

1990 • 741 citations

Role of redox potential and reactive oxygen species in stress signaling

1999 • 695 citations

Origins of chromosome translocations in childhood leukaemia

2003 • 683 citations

Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: I. Radiation-Induced Genomic Instability and Bystander EffectsIn Vitro

2003 • 647 citations

Prenatal origin of acute lymphoblastic leukaemia in children

1999 • 640 citations

A Proinflammatory Cytokine Inhibits P53 Tumor Suppressor Activity

1999 • 635 citations

A niche for adult neural stem cells

2003 • 612 citations

Transmission of chromosomal instability after plutonium α-particle irradiation

1992 • 603 citations

Chromosome translocations and covert leukemic clones are generated during normal fetal development

2002 • 600 citations

Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells

2001 • 586 citations

Chronic Inflammation and Cancer

2013 • 585 citations

Backtracking leukemia to birth: Identification of clonotypic gene fusion sequences in neonatal blood spots

1997 • 558 citations

Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: II. Radiation-Induced Genomic Instability and Bystander EffectsIn Vivo,Clastogenic Factors and Transgenerational Effects

2003 • 535 citations

X-Ray Damage and Recovery in Mammalian Cells in Culture

1959 • 513 citations

Intercellular Communication Is Involved in the Bystander Regulation of Gene Expression in Human Cells Exposed to Very Low Fluences of Alpha Particles

1998 • 509 citations

The renal papilla is a niche for adult kidney stem cells

2004 • 502 citations

Radiation-Induced Bystander Effects: Past History and Future Directions

2001 • 496 citations

Induction of a bystander mutagenic effect of alpha particles in mammalian cells

2000 • 473 citations

Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells.

1997 • 445 citations

Phagocytes as Carcinogens: Malignant Transformation Produced by Human Neutrophils

1985 • 443 citations

Nitric oxide and oxygen radicals in infection, inflammation, and cancer.

1998 • 425 citations

Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?

2001 • 371 citations

The stem-cell niche theory: lessons from flies

2002 • 354 citations

Factors underlying the cell growth-related bystander responses to alpha particles.

2000 • 346 citations

LEUKÆMIC TRANSFORMATION OF ENGRAFTED HUMAN MARROW CELLS IN VIVO

1971 • 324 citations

Reactive oxygen species, chromosome mutation, and cancer: possible role of clastogenic factors in carcinogenesis

1994 • 321 citations

Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect

2003 • 315 citations

The Bystander Effect in Radiation Oncogenesis: I. Transformation in C3H 10T½ CellsIn Vitrocan be Initiated in the Unirradiated Neighbors of Irradiated Cells

2001 • 308 citations

Chromosomal instability in the descendants of unirradiated surviving cells after α-particle irradiation

1998 • 303 citations

Alpha-Particle-Induced Sister Chromatid Exchange in Normal Human Lung Fibroblasts: Evidence for an Extranuclear Target

1996 • 286 citations

High Yields of Lethal Mutations in Somatic Mammalian Cells that Survive Ionizing Radiation

1986 • 285 citations

The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting

2003 • 280 citations

Delayed Chromosomal Instability Induced by DNA Damage

1993 • 276 citations

Phagocytosis Triggers Macrophage Release of Fas Ligand and Induces Apoptosis of Bystander Leukocytes

1999 • 274 citations

Phenotypic Reversion or Death of Cancer Cells by Altering Signaling Pathways in Three-Dimensional Contexts

2002 • 268 citations

Unexpected Sensitivity to the Induction of Mutations by Very Low Doses of Alpha-Particle Radiation: Evidence for a Bystander Effect

1999 • 265 citations

Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells.

1997 • 264 citations

Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures

1996 • 263 citations

Extracellular Signaling through the Microenvironment: A Hypothesis Relating Carcinogenesis, Bystander Effects, and Genomic Instability

2001 • 252 citations

Activated neutrophils induce prolonged DNA damage in neighboring cells

1988 • 243 citations

X-Ray-Induced Heritable Damage (Small-Colony Formation) in Cultured Mammalian Cells

1964 • 242 citations

Homing and mobilization in the stem cell niche

1999 • 240 citations

Science, medicine, and the future: Childhood leukaemia

2002 • 239 citations

Inflammation, chromosomal instability, and cancer: the schistosomiasis model.

1994 • 229 citations

Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation

2003 • 229 citations

Studies of the Mortality of Atomic Bomb Survivors. Report 12, Part II. Noncancer Mortality: 1950-1990

1999 • 229 citations

Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts

2001 • 222 citations

Mitogen-activated protein kinase pathways in redox signaling

2003 • 219 citations

Radiation risk to low fluences of α particles may be greater than we thought

2001 • 218 citations

The Bystander Effect in Radiation Oncogenesis: II. A Quantitative Model

2001 • 216 citations

Stromal Matrix Metalloproteinase-9 Regulates the Vascular Architecture in Neuroblastoma by Promoting Pericyte Recruitment

2004 • 214 citations

Chromosomal instability in unirradiated cells induced in vivo by a bystander effect of ionizing radiation.

2000 • 211 citations

Genomic instability and bystander effects: a historical perspective

2003 • 210 citations

Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation?

2003 • 209 citations

Delayed chromosomal instability induced by DNA damage.

1993 • 208 citations

The nature of mutants induced by ionising radiation in cultured hamster cells III. Molecular characterization of HPRT-deficient mutants induced by γ-rays or α-particles showing that the majority have deletions of all or part of the hprt gene

1986 • 207 citations

Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review

2003 • 203 citations

Influence of oxygen radical injury on DNA methylation

1997 • 202 citations

α-particle-induced chromosomal instability in human bone marrow cells

1994 • 200 citations

Radiation-Induced Genomic Instability: Delayed Mutagenic and Cytogenetic Effects of X Rays and Alpha Particles

1997 • 199 citations

Radiation-Induced Chromosomal Instability in BALB/c and C57BL/6 Mice: The Difference Is as Clear as Black and White

1997 • 193 citations

Non-targeted and delayed effects of exposure to ionizing radiation

2007 • 192 citations

Alpha Particles Induce the Production of Interleukin-8 by Human Cells

1999 • 188 citations

Proliferation Kinetics of X-irradiated Mouse L Cells Studied with Time-lapse Photography. II

1969 • 182 citations

Low dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells

2002 • 182 citations

Radiation-induced Genomic Instability: Delayed Cytogenetic Aberrations and Apoptosis in Primary Human Bone Marrow Cells

1995 • 181 citations

Delayed Reproductive Death in X-irradiated Chinese Hamster Ovary Cells

1991 • 171 citations

Somatic cell mutation detection and quantification of X-ray-induced mutation in cultured, diploid human fibroblasts

1973 • 169 citations

Radiation-induced genomic instability

1998 • 169 citations

Increased Chromosome Aberration Levels in Cells from Mouse Fetuses after Zygote X-irradiation

1989 • 162 citations

Alpha-particle-induced p53 protein expression in a rat lung epithelial cell strain.

1994 • 161 citations

Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotype

1992 • 161 citations

Apoptosis, reproductive failure, and oxidative stress in Chinese hamster ovary cells with compromised genomic integrity.

1998 • 160 citations

Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors

2003 • 158 citations

Leukemia relapse after allogeneic bone marrow transplantation: a review

1994 • 156 citations

Complex chromosome aberrations in peripheral blood lymphocytes as a potential biomarker of exposure to high-LET alpha-particles

2000 • 151 citations

Control of cell proliferation by reactive oxygen species

1996 • 150 citations

Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53

1998 • 142 citations

Damage to the bases in DNA induced by stimulated human neutrophils.

1989 • 139 citations

Clonal chromosome aberrations and genomic instability in X-irradiated human T-lymphocyte cultures

1993 • 138 citations

HPRTMutants Induced in Bystander Cells by Very Low Fluences of Alpha Particles Result Primarily from Point Mutations

2001 • 133 citations

Alpha-Particle-Induced Increases in the Radioresistance of Normal Human Bystander Cells

2002 • 132 citations

Negative Regulators of Hemopoiesis and Stroma Function in Patients with Myelodysplastic Syndrome

2000 • 129 citations

Genetic factors influencing alpha-particle-induced chromosomal instability

1997 • 128 citations

Radiation-induced genomic instability: a paradigm-breaking phenomenon and its relevance to environmentally induced cancer

2000 • 126 citations

Bystander-induced Apoptosis and Premature Differentiation in Primary Urothelial Explants after Charged Particle Microbeam Irradiation

2002 • 125 citations

Characterization of a novel epigenetic effect of ionizing radiation: the death-inducing effect.

2003 • 119 citations

Clonal Analysis of Delayed Karyotypic Abnormalities and Gene Mutations in Radiation-Induced Genetic Instability

1996 • 114 citations

Radiation-induced bystander effects, carcinogenesis and models

2003 • 113 citations

Stromal abnormalities in neoplastic bone marrow diseases

1996 • 112 citations

Clastogenic Factors in the Plasma of Chernobyl Accident Recovery Workers: Anticlastogenic Effect of Ginkgo biloba Extract

1995 • 111 citations

Damaging and protective cell signalling in the untargeted effects of ionizing radiation

2004 • 110 citations

Inflammation and Coronary Heart Disease: An Overview

2001 • 106 citations

Specific chromosome instability induced by heavy ions: a step towards transformation of human fibroblasts?

1993 • 105 citations

Production of Delayed Death and Neoplastic Transformation in CGL1 Cells by Radiation-Induced Bystander Effects

2001 • 103 citations

Persistent subclinical inflammation among A-bomb survivors

2001 • 103 citations

A stem cell niche theory of intestinal crypt maintenance based on a study of somatic mutation in colonic mucosa.

1992 • 101 citations

Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells

1990 • 101 citations

Bystander effects in radiation-induced genomic instability

2002 • 94 citations

In vivo chromosomal instability and transmissible aberrations in the progeny of haemopoietic stem cells induced by high- and low-LET radiations

2001 • 93 citations

Attenuation of radiation-induced genomic instability by free radical scavengers and cellular proliferation

2001 • 93 citations

Donor cell leukemia: Report of a case occurring 11 years after allogeneic bone marrow transplantation and review of the literature

2000 • 89 citations

Delayed lethality, apoptosis and micronucleus formation in human fibroblasts irradiated with X-rays or alpha-particles

1999 • 88 citations

Chromosome aberrations in normal leukocytes induced by the plasma of exposed individuals.

1977 • 88 citations

Activation of the Nitric Oxide Synthase 2 Pathway in the Response of Bone Marrow Stromal Cells to High Doses of Ionizing Radiation

2000 • 77 citations

The Role of the Macrophage in Apoptosis: Hunter, Gatherer, and Regulator

2002 • 71 citations

Oxidative stress-related clastogenic factors in plasma from Chernobyl liquidators: protective effects of antioxidant plant phenols, vitamins and oligoelements

1997 • 71 citations

Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review

2003 • 70 citations

Dose– and time–response relationships for lethal mutations and chromosomal instability induced by ionizing radiation in an immortalized human keratinocyte cell line

2000 • 69 citations

A Long-Term Cohort Study of the Atomic-Bomb Survivors

1996 • 68 citations

Identification and characterization of three subtypes of radiation response in normal human urothelial cultures exposed to ionizing radiation

1999 • 67 citations

Induction of Chromosomal Instability in Human Mammary Cells by Neutrons and Gamma Rays

1997 • 64 citations

Delayed Chromosomal Instability in Human T-lymphocyte Clones Exposed to Ionizing Radiation

1995 • 63 citations

Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis.

1994 • 61 citations

Transient infiltration of neutrophils into the thymus in association with apoptosis induced by whole-body X-irradiation

2000 • 55 citations

Human Fetuses do not Register Chromosome Damage Inflicted by Radiation Exposure in Lymphoid Precursor Cells except for a Small but Significant Effect at Low Doses

2004 • 55 citations

LEUKÆMIC TRANSFORMATION OF ENGRAFTED HUMAN CELLS IN VIVO

1971 • 53 citations

Delayed appearance of radiation-induced mutations at the Hprt locus in murine hemopoietic cells.

1997 • 53 citations

Bystander effect on cell growth stimulation in neoplastic HSGc cells induced by heavy-ion irradiation

2003 • 52 citations

Latent expression of p53 mutations and radiation-induced mammary cancer.

1995 • 50 citations

[58] Clastogenic factors: Detection and assay

1990 • 50 citations

Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors

2003 • 49 citations

Radiation-Induced Bystander Effects

2003 • 48 citations

The Bystander Effect in C3H 10T Cells and Radon-Induced Lung Cancer

2001 • 48 citations

No Evidence for Chromosomal Instability in Radiation Workers withIn VivoExposure to Plutonium

2001 • 48 citations

Are Chromosomal Instabilities Induced by Exposure of Cultured Normal Human Cells to Low- or High-LET Radiation?

2003 • 47 citations

Plating Efficiency as a Function of Time Postirradiation: Evidence for the Delayed Expression of Lethal Mutations

1989 • 47 citations

Functional disturbance of marrow stromal microenvironment in the myelodysplastic syndromes

2002 • 46 citations

Intraclonal Recovery of Division Probability in Pedigrees of Single X-irradiated Mammalian Cells

1970 • 45 citations

The nature of mutants induced by ionizing radiation in cultured hamster cells

1986 • 44 citations

Lack of Detectable Transmissible Chromosomal Instability afterIn VivoorIn VitroExposure of Mouse Bone Marrow Cells to224Ra Alpha Particles

2001 • 40 citations

Manifestations and mechanisms of radiation-induced genomic instability in V-79 Chinese hamster cells

1998 • 38 citations

Inducible genomic instability: Inducible genomic instability: New insights into the biological effects of ionizing radiation

2000 • 38 citations

Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

2002 • 38 citations

Delayed Cell Death, Giant Cell Formation and Chromosome Instability Induced by X-irradiation in Human Embryo Cells

1999 • 38 citations

Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene

1992 • 38 citations

Radiation-induced chromosomal instability in human mammary epithelial cells

1996 • 37 citations

Effects of irradiation of CBA/CA mice on hematopoietic stem cells and stromal cells in long-term bone marrow cultures.

1996 • 37 citations

Role of Bone Marrow Stromal Cells in Irradiation Leukemogenesis

1996 • 37 citations

A comparative investigation of DNA strand breaks, sister chromatid exchanges and K-ras gene mutations induced by cadmium salts in cultured human cells

2004 • 36 citations

A model system for leukemic transformation of immortalized hemopoietic cells in irradiated recipient mice.

1988 • 36 citations

Chromosomal instability in human lymphocytes after low dose rate gamma -irradiation and delayed mitogen stimulation

1998 • 34 citations

Influence of microbial environment on development of myeloid leukemia in X‐irradiated rfm mice

1968 • 33 citations

Exacerbating factors of radiation-induced myeloid leukemogenesis

1993 • 31 citations

Effects of irradiation of recipient mice on the behavior and leukemogenic potential of factor-dependent hematopoietic cell lines

1990 • 30 citations

Lethality and Mutagenesis of B Lymphocyte Progenitor Cells Following Exposure to α-particles and X-rays

1994 • 28 citations

Stromal cell involvement in leukemogenesis and carcinogenesis.

1996 • 27 citations

Origin of stroma cells in long-term bone marrow cultures from patients with acute myeloid leukemia

1999 • 26 citations

Alteration in hematopoietic stem cell seeding and proliferation by both high and low dose rate irradiation of bone marrow stromal cells in vitro

1988 • 25 citations

Involvement of the bone marrow stroma in the residual hematopoietic damage induced by irradiation of adult and young mice.

1994 • 25 citations

Recurrence of Philadelphia Chromosome-Positive Leukemia in Donor Cells after Bone Marrow Transplantation for Chronic Granulocytic Leukemia

1993 • 24 citations

Elevated Frequency of Microsatellite Mutations in TK6 Human Lymphoblast Clones Selected for Mutations at the Thymidine Kinase Locus

1994 • 24 citations

Perturbation in the ability of bone marrow stroma from patients with acute myeloid leukemia but not chronic myeloid leukemia to support normal early hematopoietic progenitor cells

1997 • 22 citations

In Situ Detection of Chromosome Bridge Formation and Delayed Reproductive Death in Normal Human Embryonic Cells Surviving X Irradiation

1998 • 22 citations

Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus.

1994 • 13 citations

Hematopoietic stem cell- and marrow stromal cell-specific requirements for gamma irradiation leukemogenesis in vitro.

1990 • 12 citations

X-ray induction of microsatellite instability at autosomal loci in human lymphoblastoid WTK1 cells

2001 • 12 citations

Dangerous liaisons

2004 • 7 citations

Cited By (0)

Loading...
Untargeted effects of ionizing radiation: Implications for radiation pathology (2006) – Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | Metascience Observatory Explorer