Untargeted effects of ionizing radiation: Implications for radiation pathology
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References (177)
Atherosclerosis — An Inflammatory Disease
1999 • 21,494 citations
Oxidants, oxidative stress and the biology of ageing
2000 • 8,990 citations
Inflammation and cancer: back to Virchow?
2001 • 7,259 citations
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.
1998 • 3,085 citations
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
2000 • 2,700 citations
NF-κB functions as a tumour promoter in inflammation-associated cancer
2004 • 2,370 citations
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
2004 • 2,361 citations
The relationship between the spleen colony-forming cell and the haemopoietic stem cell.
1978 • 2,290 citations
Defining the Epithelial Stem Cell Niche in Skin
2003 • 1,995 citations
ACTION OF X-RAYS ON MAMMALIAN CELLS
1956 • 1,660 citations
Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide
1998 • 1,566 citations
A blast from the past: clearance of apoptotic cells regulates immune responses
2002 • 1,558 citations
Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy
2001 • 1,556 citations
MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis
2000 • 1,306 citations
Reactive Oxygen Species as Intracellular Messengers During Cell Growth and Differentiation
2001 • 1,092 citations
Reactive Oxygen Species
2004 • 1,035 citations
Induction of sister chromatid exchanges by extremely low doses of alpha-particles.
1992 • 979 citations
Studies of the Mortality of Atomic Bomb Survivors. Report 12, Part I. Cancer: 1950-1990
1996 • 935 citations
Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence
2003 • 835 citations
Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis
1990 • 741 citations
Role of redox potential and reactive oxygen species in stress signaling
1999 • 695 citations
Origins of chromosome translocations in childhood leukaemia
2003 • 683 citations
Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: I. Radiation-Induced Genomic Instability and Bystander EffectsIn Vitro
2003 • 647 citations
Prenatal origin of acute lymphoblastic leukaemia in children
1999 • 640 citations
A Proinflammatory Cytokine Inhibits P53 Tumor Suppressor Activity
1999 • 635 citations
A niche for adult neural stem cells
2003 • 612 citations
Transmission of chromosomal instability after plutonium α-particle irradiation
1992 • 603 citations
Chromosome translocations and covert leukemic clones are generated during normal fetal development
2002 • 600 citations
Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells
2001 • 586 citations
Chronic Inflammation and Cancer
2013 • 585 citations
Backtracking leukemia to birth: Identification of clonotypic gene fusion sequences in neonatal blood spots
1997 • 558 citations
Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: II. Radiation-Induced Genomic Instability and Bystander EffectsIn Vivo,Clastogenic Factors and Transgenerational Effects
2003 • 535 citations
X-Ray Damage and Recovery in Mammalian Cells in Culture
1959 • 513 citations
Intercellular Communication Is Involved in the Bystander Regulation of Gene Expression in Human Cells Exposed to Very Low Fluences of Alpha Particles
1998 • 509 citations
The renal papilla is a niche for adult kidney stem cells
2004 • 502 citations
Radiation-Induced Bystander Effects: Past History and Future Directions
2001 • 496 citations
Induction of a bystander mutagenic effect of alpha particles in mammalian cells
2000 • 473 citations
Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells.
1997 • 445 citations
Phagocytes as Carcinogens: Malignant Transformation Produced by Human Neutrophils
1985 • 443 citations
Nitric oxide and oxygen radicals in infection, inflammation, and cancer.
1998 • 425 citations
Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?
2001 • 371 citations
The stem-cell niche theory: lessons from flies
2002 • 354 citations
Factors underlying the cell growth-related bystander responses to alpha particles.
2000 • 346 citations
LEUKÆMIC TRANSFORMATION OF ENGRAFTED HUMAN MARROW CELLS IN VIVO
1971 • 324 citations
Reactive oxygen species, chromosome mutation, and cancer: possible role of clastogenic factors in carcinogenesis
1994 • 321 citations
Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect
2003 • 315 citations
The Bystander Effect in Radiation Oncogenesis: I. Transformation in C3H 10T½ CellsIn Vitrocan be Initiated in the Unirradiated Neighbors of Irradiated Cells
2001 • 308 citations
Chromosomal instability in the descendants of unirradiated surviving cells after α-particle irradiation
1998 • 303 citations
Alpha-Particle-Induced Sister Chromatid Exchange in Normal Human Lung Fibroblasts: Evidence for an Extranuclear Target
1996 • 286 citations
High Yields of Lethal Mutations in Somatic Mammalian Cells that Survive Ionizing Radiation
1986 • 285 citations
The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting
2003 • 280 citations
Delayed Chromosomal Instability Induced by DNA Damage
1993 • 276 citations
Phagocytosis Triggers Macrophage Release of Fas Ligand and Induces Apoptosis of Bystander Leukocytes
1999 • 274 citations
Phenotypic Reversion or Death of Cancer Cells by Altering Signaling Pathways in Three-Dimensional Contexts
2002 • 268 citations
Unexpected Sensitivity to the Induction of Mutations by Very Low Doses of Alpha-Particle Radiation: Evidence for a Bystander Effect
1999 • 265 citations
Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells.
1997 • 264 citations
Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures
1996 • 263 citations
Extracellular Signaling through the Microenvironment: A Hypothesis Relating Carcinogenesis, Bystander Effects, and Genomic Instability
2001 • 252 citations
Activated neutrophils induce prolonged DNA damage in neighboring cells
1988 • 243 citations
X-Ray-Induced Heritable Damage (Small-Colony Formation) in Cultured Mammalian Cells
1964 • 242 citations
Homing and mobilization in the stem cell niche
1999 • 240 citations
Science, medicine, and the future: Childhood leukaemia
2002 • 239 citations
Inflammation, chromosomal instability, and cancer: the schistosomiasis model.
1994 • 229 citations
Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation
2003 • 229 citations
Studies of the Mortality of Atomic Bomb Survivors. Report 12, Part II. Noncancer Mortality: 1950-1990
1999 • 229 citations
Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts
2001 • 222 citations
Mitogen-activated protein kinase pathways in redox signaling
2003 • 219 citations
Radiation risk to low fluences of α particles may be greater than we thought
2001 • 218 citations
The Bystander Effect in Radiation Oncogenesis: II. A Quantitative Model
2001 • 216 citations
Stromal Matrix Metalloproteinase-9 Regulates the Vascular Architecture in Neuroblastoma by Promoting Pericyte Recruitment
2004 • 214 citations
Chromosomal instability in unirradiated cells induced in vivo by a bystander effect of ionizing radiation.
2000 • 211 citations
Genomic instability and bystander effects: a historical perspective
2003 • 210 citations
Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation?
2003 • 209 citations
Delayed chromosomal instability induced by DNA damage.
1993 • 208 citations
The nature of mutants induced by ionising radiation in cultured hamster cells III. Molecular characterization of HPRT-deficient mutants induced by γ-rays or α-particles showing that the majority have deletions of all or part of the hprt gene
1986 • 207 citations
Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review
2003 • 203 citations
Influence of oxygen radical injury on DNA methylation
1997 • 202 citations
α-particle-induced chromosomal instability in human bone marrow cells
1994 • 200 citations
Radiation-Induced Genomic Instability: Delayed Mutagenic and Cytogenetic Effects of X Rays and Alpha Particles
1997 • 199 citations
Radiation-Induced Chromosomal Instability in BALB/c and C57BL/6 Mice: The Difference Is as Clear as Black and White
1997 • 193 citations
Non-targeted and delayed effects of exposure to ionizing radiation
2007 • 192 citations
Alpha Particles Induce the Production of Interleukin-8 by Human Cells
1999 • 188 citations
Proliferation Kinetics of X-irradiated Mouse L Cells Studied with Time-lapse Photography. II
1969 • 182 citations
Low dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells
2002 • 182 citations
Radiation-induced Genomic Instability: Delayed Cytogenetic Aberrations and Apoptosis in Primary Human Bone Marrow Cells
1995 • 181 citations
Delayed Reproductive Death in X-irradiated Chinese Hamster Ovary Cells
1991 • 171 citations
Somatic cell mutation detection and quantification of X-ray-induced mutation in cultured, diploid human fibroblasts
1973 • 169 citations
Radiation-induced genomic instability
1998 • 169 citations
Increased Chromosome Aberration Levels in Cells from Mouse Fetuses after Zygote X-irradiation
1989 • 162 citations
Alpha-particle-induced p53 protein expression in a rat lung epithelial cell strain.
1994 • 161 citations
Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotype
1992 • 161 citations
Apoptosis, reproductive failure, and oxidative stress in Chinese hamster ovary cells with compromised genomic integrity.
1998 • 160 citations
Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors
2003 • 158 citations
Leukemia relapse after allogeneic bone marrow transplantation: a review
1994 • 156 citations
Complex chromosome aberrations in peripheral blood lymphocytes as a potential biomarker of exposure to high-LET alpha-particles
2000 • 151 citations
Control of cell proliferation by reactive oxygen species
1996 • 150 citations
Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53
1998 • 142 citations
Damage to the bases in DNA induced by stimulated human neutrophils.
1989 • 139 citations
Clonal chromosome aberrations and genomic instability in X-irradiated human T-lymphocyte cultures
1993 • 138 citations
HPRTMutants Induced in Bystander Cells by Very Low Fluences of Alpha Particles Result Primarily from Point Mutations
2001 • 133 citations
Alpha-Particle-Induced Increases in the Radioresistance of Normal Human Bystander Cells
2002 • 132 citations
Negative Regulators of Hemopoiesis and Stroma Function in Patients with Myelodysplastic Syndrome
2000 • 129 citations
Genetic factors influencing alpha-particle-induced chromosomal instability
1997 • 128 citations
Radiation-induced genomic instability: a paradigm-breaking phenomenon and its relevance to environmentally induced cancer
2000 • 126 citations
Bystander-induced Apoptosis and Premature Differentiation in Primary Urothelial Explants after Charged Particle Microbeam Irradiation
2002 • 125 citations
Characterization of a novel epigenetic effect of ionizing radiation: the death-inducing effect.
2003 • 119 citations
Clonal Analysis of Delayed Karyotypic Abnormalities and Gene Mutations in Radiation-Induced Genetic Instability
1996 • 114 citations
Radiation-induced bystander effects, carcinogenesis and models
2003 • 113 citations
Stromal abnormalities in neoplastic bone marrow diseases
1996 • 112 citations
Clastogenic Factors in the Plasma of Chernobyl Accident Recovery Workers: Anticlastogenic Effect of Ginkgo biloba Extract
1995 • 111 citations
Damaging and protective cell signalling in the untargeted effects of ionizing radiation
2004 • 110 citations
Inflammation and Coronary Heart Disease: An Overview
2001 • 106 citations
Specific chromosome instability induced by heavy ions: a step towards transformation of human fibroblasts?
1993 • 105 citations
Production of Delayed Death and Neoplastic Transformation in CGL1 Cells by Radiation-Induced Bystander Effects
2001 • 103 citations
Persistent subclinical inflammation among A-bomb survivors
2001 • 103 citations
A stem cell niche theory of intestinal crypt maintenance based on a study of somatic mutation in colonic mucosa.
1992 • 101 citations
Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells
1990 • 101 citations
Bystander effects in radiation-induced genomic instability
2002 • 94 citations
In vivo chromosomal instability and transmissible aberrations in the progeny of haemopoietic stem cells induced by high- and low-LET radiations
2001 • 93 citations
Attenuation of radiation-induced genomic instability by free radical scavengers and cellular proliferation
2001 • 93 citations
Donor cell leukemia: Report of a case occurring 11 years after allogeneic bone marrow transplantation and review of the literature
2000 • 89 citations
Delayed lethality, apoptosis and micronucleus formation in human fibroblasts irradiated with X-rays or alpha-particles
1999 • 88 citations
Chromosome aberrations in normal leukocytes induced by the plasma of exposed individuals.
1977 • 88 citations
Activation of the Nitric Oxide Synthase 2 Pathway in the Response of Bone Marrow Stromal Cells to High Doses of Ionizing Radiation
2000 • 77 citations
The Role of the Macrophage in Apoptosis: Hunter, Gatherer, and Regulator
2002 • 71 citations
Oxidative stress-related clastogenic factors in plasma from Chernobyl liquidators: protective effects of antioxidant plant phenols, vitamins and oligoelements
1997 • 71 citations
Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review
2003 • 70 citations
Dose– and time–response relationships for lethal mutations and chromosomal instability induced by ionizing radiation in an immortalized human keratinocyte cell line
2000 • 69 citations
A Long-Term Cohort Study of the Atomic-Bomb Survivors
1996 • 68 citations
Identification and characterization of three subtypes of radiation response in normal human urothelial cultures exposed to ionizing radiation
1999 • 67 citations
Induction of Chromosomal Instability in Human Mammary Cells by Neutrons and Gamma Rays
1997 • 64 citations
Delayed Chromosomal Instability in Human T-lymphocyte Clones Exposed to Ionizing Radiation
1995 • 63 citations
Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis.
1994 • 61 citations
Transient infiltration of neutrophils into the thymus in association with apoptosis induced by whole-body X-irradiation
2000 • 55 citations
Human Fetuses do not Register Chromosome Damage Inflicted by Radiation Exposure in Lymphoid Precursor Cells except for a Small but Significant Effect at Low Doses
2004 • 55 citations
LEUKÆMIC TRANSFORMATION OF ENGRAFTED HUMAN CELLS IN VIVO
1971 • 53 citations
Delayed appearance of radiation-induced mutations at the Hprt locus in murine hemopoietic cells.
1997 • 53 citations
Bystander effect on cell growth stimulation in neoplastic HSGc cells induced by heavy-ion irradiation
2003 • 52 citations
Latent expression of p53 mutations and radiation-induced mammary cancer.
1995 • 50 citations
[58] Clastogenic factors: Detection and assay
1990 • 50 citations
Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors
2003 • 49 citations
Radiation-Induced Bystander Effects
2003 • 48 citations
The Bystander Effect in C3H 10T Cells and Radon-Induced Lung Cancer
2001 • 48 citations
No Evidence for Chromosomal Instability in Radiation Workers withIn VivoExposure to Plutonium
2001 • 48 citations
Are Chromosomal Instabilities Induced by Exposure of Cultured Normal Human Cells to Low- or High-LET Radiation?
2003 • 47 citations
Plating Efficiency as a Function of Time Postirradiation: Evidence for the Delayed Expression of Lethal Mutations
1989 • 47 citations
Functional disturbance of marrow stromal microenvironment in the myelodysplastic syndromes
2002 • 46 citations
Intraclonal Recovery of Division Probability in Pedigrees of Single X-irradiated Mammalian Cells
1970 • 45 citations
The nature of mutants induced by ionizing radiation in cultured hamster cells
1986 • 44 citations
Lack of Detectable Transmissible Chromosomal Instability afterIn VivoorIn VitroExposure of Mouse Bone Marrow Cells to224Ra Alpha Particles
2001 • 40 citations
Manifestations and mechanisms of radiation-induced genomic instability in V-79 Chinese hamster cells
1998 • 38 citations
Inducible genomic instability: Inducible genomic instability: New insights into the biological effects of ionizing radiation
2000 • 38 citations
Leukemia in donor cells after allogeneic hematopoietic stem cell transplant
2002 • 38 citations
Delayed Cell Death, Giant Cell Formation and Chromosome Instability Induced by X-irradiation in Human Embryo Cells
1999 • 38 citations
Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene
1992 • 38 citations
Radiation-induced chromosomal instability in human mammary epithelial cells
1996 • 37 citations
Effects of irradiation of CBA/CA mice on hematopoietic stem cells and stromal cells in long-term bone marrow cultures.
1996 • 37 citations
Role of Bone Marrow Stromal Cells in Irradiation Leukemogenesis
1996 • 37 citations
A comparative investigation of DNA strand breaks, sister chromatid exchanges and K-ras gene mutations induced by cadmium salts in cultured human cells
2004 • 36 citations
A model system for leukemic transformation of immortalized hemopoietic cells in irradiated recipient mice.
1988 • 36 citations
Chromosomal instability in human lymphocytes after low dose rate gamma -irradiation and delayed mitogen stimulation
1998 • 34 citations
Influence of microbial environment on development of myeloid leukemia in X‐irradiated rfm mice
1968 • 33 citations
Exacerbating factors of radiation-induced myeloid leukemogenesis
1993 • 31 citations
Effects of irradiation of recipient mice on the behavior and leukemogenic potential of factor-dependent hematopoietic cell lines
1990 • 30 citations
Lethality and Mutagenesis of B Lymphocyte Progenitor Cells Following Exposure to α-particles and X-rays
1994 • 28 citations
Stromal cell involvement in leukemogenesis and carcinogenesis.
1996 • 27 citations
Origin of stroma cells in long-term bone marrow cultures from patients with acute myeloid leukemia
1999 • 26 citations
Alteration in hematopoietic stem cell seeding and proliferation by both high and low dose rate irradiation of bone marrow stromal cells in vitro
1988 • 25 citations
Involvement of the bone marrow stroma in the residual hematopoietic damage induced by irradiation of adult and young mice.
1994 • 25 citations
Recurrence of Philadelphia Chromosome-Positive Leukemia in Donor Cells after Bone Marrow Transplantation for Chronic Granulocytic Leukemia
1993 • 24 citations
Elevated Frequency of Microsatellite Mutations in TK6 Human Lymphoblast Clones Selected for Mutations at the Thymidine Kinase Locus
1994 • 24 citations
Perturbation in the ability of bone marrow stroma from patients with acute myeloid leukemia but not chronic myeloid leukemia to support normal early hematopoietic progenitor cells
1997 • 22 citations
In Situ Detection of Chromosome Bridge Formation and Delayed Reproductive Death in Normal Human Embryonic Cells Surviving X Irradiation
1998 • 22 citations
Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus.
1994 • 13 citations
Hematopoietic stem cell- and marrow stromal cell-specific requirements for gamma irradiation leukemogenesis in vitro.
1990 • 12 citations
X-ray induction of microsatellite instability at autosomal loci in human lymphoblastoid WTK1 cells
2001 • 12 citations
Dangerous liaisons
2004 • 7 citations