A comparative investigation of DNA strand breaks, sister chromatid exchanges and K-ras gene mutations induced by cadmium salts in cultured human cells

A simple technique for quantitation of low levels of DNA damage in individual cells

1988 • 10,537 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

New Giemsa method for the differential staining of sister chromatids

1974 • 3,198 citations

Toxic Metals and Oxidative Stress Part I: Mechanisms Involved in Me-tal induced Oxidative Damage

2001 • 1,856 citations

Molecular and cellular mechanisms of cadmium carcinogenesis

2003 • 1,447 citations

Cadmium carcinogenesis in review

2000 • 906 citations

Blocking Oncogenic Ras Signaling for Cancer Therapy

2001 • 837 citations

K-rasOncogene Activation as a Prognostic Marker in Adenocarcinoma of the Lung

1990 • 811 citations

Oxidative Mechanisms in the Toxicity of Chromium and Cadmium Ions

2001 • 783 citations

Cadmium, Gene Regulation, and Cellular Signalling in Mammalian Cells

1997 • 530 citations

How sensitive is PCR-SSCP?

1993 • 468 citations

Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique.

1991 • 336 citations

Carcinogenicity of metal compounds: possible role of DNA repair inhibition

1998 • 281 citations

Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications

2002 • 265 citations

Possible Role of Oxidative Damage in Metal-Induced Carcinogenesis

1995 • 261 citations

Induction and repair inhibition of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells

1997 • 260 citations

Zinc Finger Proteins as Potential Targets for Toxic Metal Ions: Differential Effects on Structure and Function

2001 • 256 citations

The concepts of tail moment and tail inertia in the single cell gel electrophoresis assay

1995 • 193 citations

K‐ ras oncogene activation in lung adenocarcinomas from former smokers evidence that K‐ ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung

1993 • 187 citations

Environmental mutagenesis

1996 • 186 citations

Is the capacity of lead acetate and cadmium chloride to induce genotoxic damage due to direct DNA-metal interaction?

2001 • 174 citations

K-ras oncogene activation in lung adenocarcinomas from former smokers evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung

1993 • 169 citations

ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis.

1992 • 168 citations

Statistics of the Comet assay: a key to discriminate between genotoxic effects

2003 • 159 citations

Effects of carcinogenic metals on gene expression

2002 • 148 citations

Comparative investigations of the genotoxic effects of metals in the single cell gel (SCG) assay and the sister chromatid exchange (SCE) test

1994 • 143 citations

Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability

2002 • 138 citations

The Comet Moment as a Measure of DNA Damage in the Comet Assay

1995 • 130 citations

Genotoxic ability of cadmium, chromium and nickel salts studied by kinetochore staining in the cytokinesis-blocked micronucleus assay

2001 • 114 citations

Evaluation of the direct genotoxic potential of cadmium in four different rodent cell lines

1998 • 111 citations

Mutagenicity of metal salts in the L5178Y mouse lymphoma assay

1982 • 110 citations

CHRONIC TOXIC AND CARCINOGENIC EFFECTS OF ORAL CADMIUM IN THE NOBLE (NBL/Cr) RAT: INDUCTION OF NEOPLASTIC AND PROLIFERATIVE LESIONS OF THE ADRENAL, KIDNEY, PROSTATE, AND TESTES

1999 • 106 citations

Disturbance of DNA damage recognition after UV-irradiation by nickel(II) and cadmium(II) in mammalian cells

1998 • 105 citations

Cadmium Induces c-myc, p53, and c-jun Expression in Normal Human Prostate Epithelial Cells as a Prelude to Apoptosis

2000 • 105 citations

Effect of arsenic and cadmium on the persistence of mutagen-induced DNA lesions in human cells

1996 • 97 citations

Carcinogenic effects of cadmium in the noble (NBL/Cr) rat: induction of pituitary, testicular, and injection site tumors and intraepithelial proliferative lesions of the dorsolateral prostate

1999 • 89 citations

Possible Role of Caspase-3 Inhibition in Cadmium-Induced Blockage of Apoptosis

2000 • 86 citations

DNA damage by cadmium and arsenic salts assessed by the single cell gel electrophoresis assay

2001 • 84 citations

Restriction Endonuclease-Mediated Selective Polymerase Chain Reaction

1998 • 76 citations

Activated protooncogenes in human lung tumors from smokers.

1991 • 73 citations

Cadmium-induced apoptosis of primary epithelial lung cells: involvement of Bax and p53, but not of oxidative stress.

2002 • 73 citations

Induction of Apoptosis in Cells by Cadmium: Quantitative Negative Correlation between Basal or Induced Metallothionein Concentration and Apoptotic Rate

2001 • 68 citations

Inducibility of sister-chromatid exchanges by heavy-metal ions

1982 • 64 citations

K-Ras oncogene activation as a prognostic marker in adenocarcinoma of the lung

1991 • 63 citations

Correlation between K-ras gene mutation and prognosis of patients with nonsmall cell lung carcinoma

1997 • 57 citations

Distribution of p53 and K-ras mutations in human lung cancer tissues

1997 • 57 citations

Technical Report Image analysis of comet assay measurements

1997 • 53 citations

Alterations of K-ras, p53, and erbB-2/neu in human lung adenocarcinomas

1994 • 53 citations

K-ras point mutation occurs in the early stage of carcinogenesis in lung cancer

1998 • 47 citations

Induction of genotoxicity by cadmium chloride inhalation in several organs of CD-1 mice

2000 • 44 citations

Inhibition by germanium oxide of the mutagenicity of cadmium chloride in various genotoxicity assays

1992 • 43 citations

A modified mutagenic PCR-RFLP method for K-ras codon 12 and 13 mutations detection in NSCLC patients

2001 • 41 citations

Molecular abnormalities in lung carcinogenesis and their potential clinical implications

2001 • 39 citations

Aneugenic effects of some metal compounds assessed by chromosome counting in MRC-5 human cells

2000 • 38 citations

Sister chromatid exchanges in human lymphocytes treated in vitro with cadmium in Go and S phase of their cell cycles

1998 • 36 citations

Analysis of metal-induced mutations altering the expression or structure of a retrovial gene in a mammalian cell line

1988 • 32 citations

Genotoxicity of cadmium chloride in human lymphocytes evaluated by the comet assay and cytogenetic tests

2002 • 29 citations

Differential susceptibility to carcinogen‐induced amplification of sv40 and dhfr sequences in sv40‐transformed human keratinocytes

1992 • 24 citations

Differences in K-ras Codon 12 Mutation Frequency between “High-Risk” and “Low-Risk” HPV-Infected Samples

1999 • 13 citations

Use of the anaphase-telophase test to detect aneugenic compounds: Effects of propionaldehyde and cadmium chloride

1994 • 12 citations

Contribution to the validation of the anaphase-telophase test: aneugenic and clastogenic effects of cadmium sulfate, potassium dichromate and nickel chloride in Chinese hamster ovary cells

1999 • 12 citations

A rapid PCR ELISA for the detection of activated K-ras in colorectal cancer

1995 • 10 citations

Genotoxic effects of cadmium chloride on human amniotic fluid cells cultured in vitro.

2001 • 3 citations