Reactive Oxygen Species

Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress

2000 • 3,760 citations

Endothelial Dysfunction

2003 • 2,137 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

Toxicity of iron and hydrogen peroxide: the Fenton reaction

1995 • 1,232 citations

Prognostic Value of Myeloperoxidase in Patients with Chest Pain

2003 • 1,049 citations

Vascular NAD(P)H oxidases: specific features, expression, and regulation

2003 • 1,029 citations

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E

2002 • 989 citations

Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide

1999 • 769 citations

In Vivo Formation of 8-Iso-Prostaglandin F _2α and Platelet Activation in Diabetes Mellitus

1999 • 753 citations

Nitric Oxide Insufficiency, Platelet Activation, and Arterial Thrombosis

2001 • 580 citations

Platelets in Inflammation and Thrombosis

2003 • 556 citations

COX-2 and beyond: approaches to prostaglandin inhibition in human disease

2003 • 511 citations

Interactions of Oxidants With Vascular Signaling Systems

2000 • 469 citations

Oxidized Lipoproteins Degrade the Endothelial Surface Layer

2000 • 378 citations

Paradoxical fate and biological action of peroxynitrite on human platelets.

1994 • 364 citations

Hydrogen Peroxide Is Involved in Collagen-Induced Platelet Activation

1998 • 310 citations

Hydrogen peroxide elicits pulmonary arterial relaxation and guanylate cyclase activation

1987 • 265 citations

The Reaction of Superoxide with Reduced Glutathione

1994 • 264 citations

Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells.

1988 • 263 citations

NAD(P)H oxidase–dependent platelet superoxide anion release increases platelet recruitment

2002 • 261 citations

Dynamic state of glutathione in blood plasma.

1980 • 249 citations

Oxygen Free Radicals and Platelet Activation

1997 • 236 citations

Role of Platelets in the Development of Atherosclerosis

2004 • 233 citations

Outside-in Integrin Signal Transduction

1996 • 214 citations

Mechanism of covalent modification of glyceraldehyde‐3‐phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents

1994 • 212 citations

Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270

2003 • 210 citations

Vitamin E. An inhibitor of the platelet release reaction.

1976 • 209 citations

Increased Oxidative Stress and Platelet Activation in Patients With Hypertension and Renovascular Disease

2002 • 207 citations

Cyclooxygenase-1 Participates in Selected Vasodilator Responses of the Cerebral Circulation

2001 • 205 citations

Involvement of NADH/NADPH Oxidase in Human Platelet ROS Production

2001 • 198 citations

Generation of reactive oxygen species in blood platelets

2002 • 197 citations

N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin.

1985 • 188 citations

Enhancement of platelet function by superoxide anion.

1977 • 186 citations

Sustained integrin ligation involves extracellular free sulfhydryls and enzymatically catalyzed disulfide exchange

2002 • 184 citations

Decreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis.

1996 • 164 citations

Superoxide production and reducing activity in human platelets.

1977 • 162 citations

Enzymatically catalyzed disulfide exchange is required for platelet adhesion to collagen via integrin α2β1

2003 • 156 citations

Platelet-released phospholipids link haemostasis and angiogenesis

2001 • 153 citations

gp91phox-Dependent Expression of Platelet CD40 Ligand

2004 • 151 citations

Platelet chemokines and their receptors: what is their relevance to platelet storage and transfusion practice?

2001 • 151 citations

Platelet Activation by Superoxide Anion and Hydroxyl Radicals Intrinsically Generated by Platelets That Had Undergone Anoxia and Then Reoxygenated

1997 • 149 citations

Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols.

1995 • 148 citations

Differential role of platelet granular mediators in angiogenesis

2004 • 143 citations

Vitamin E and vascular homeostasis: implications for atherosclerosis

1999 • 141 citations

Superoxide anions enhance platelet adhesion and aggregation

1989 • 141 citations

Resveratrol and vitamin C as antioxidants in blood platelets

2002 • 141 citations

Distribution of blood platelets flowing in arterioles

1985 • 137 citations

Membrane Potential-Dependent Inhibition of Platelet Adhesion to Endothelial Cells by Epoxyeicosatrienoic Acids

2004 • 131 citations

Iron-Dependent Human Platelet Activation and Hydroxyl Radical Formation

1999 • 123 citations

Superoxide in the Vascular System

2002 • 123 citations

Oxidative stress promotes blood cell-endothelial cell interactions in the microcirculation

2002 • 122 citations

The Small G-protein Rac Mediates Depolarization-induced Superoxide Formation in Human Endothelial Cells

2000 • 118 citations

Oral Vitamin C Reduces Arterial Stiffness and Platelet Aggregation in Humans

1999 • 115 citations

The functional role of blood platelet components in angiogenesis

2004 • 112 citations

Antioxidant vitamins and risk of cardiovascular disease. Review of large-scale randomised trials.

2002 • 110 citations

The Platelet Integrin αIIbβ3 Has an Endogenous Thiol Isomerase Activity

2000 • 108 citations

Redox Control of Platelet Aggregation

2002 • 106 citations

Vitamins in human arteriosclerosis with emphasis on vitamin C and vitamin E

2003 • 105 citations

Cerebral Microvascular Responses to Hypercholesterolemia

2003 • 104 citations

Superoxide Anion and Hydroxyl Radical Release by Collagen-induced Platelet Aggregation - Role of Arachidonic Acid Metabolism

2000 • 98 citations

Augmented oxidative stress of platelets in chronic smokers

2001 • 96 citations

Carnitine inhibits arachidonic acid turnover, platelet function, and oxidative stress

2003 • 90 citations

Nitrate Resistance In Platelets From Patients With Stable Angina Pectoris

1999 • 89 citations

Changes in antioxidant enzymes activities, aggregability and malonyldialdehyde concentration in blood platelets from patients with coronary heart disease

1993 • 88 citations

Alterations in platelet Ca 2+ signalling in diabetic patients is due to increased formation of superoxide anions and reduced nitric oxide production

1999 • 86 citations

Determinants of Platelet Activation in Human Essential Hypertension

2003 • 85 citations

Oxidant stress: a key determinant of atherothrombosis

2003 • 82 citations

Enhanced protein glutathiolation and oxidative stress in cigarette smokers

2003 • 82 citations

Superoxide mediates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules

2003 • 80 citations

Nitric oxide-dependent and independent effects on human platelets treated with peroxynitrite

1998 • 80 citations

Oxygen Radical Generation in Human Platelets: Dependence on 12-Lipoxygenase Activity and on the Glutathione Cycle

1990 • 79 citations

Antioxidant Vitamins and Lipid Therapy

2002 • 78 citations

Hydrogen peroxide release from human blood platelets

1982 • 69 citations

Modulation of platelet function by reactive oxygen metabolites

1994 • 66 citations

Active oxygen species play a role in mediating platelet aggregation and cyclic flow variations in severely stenosed and endothelium-injured coronary arteries.

1993 • 65 citations

Free oxygen radicals contribute to platelet aggregation and cyclic flow variations in stenosed and endothelium-injured canine coronary arteries

1994 • 63 citations

α‐Tocopherol and protein kinase C inhibition enhance platelet‐derived nitric oxide release

2000 • 63 citations

The potent platelet inhibitory effects of S-nitrosated albumin coating of artificial surfaces

1999 • 60 citations

Alterations in human vascular endothelial cell function by oxygen free radicals. Platelet adherence and prostacyclin release.

1991 • 59 citations

Regulation of Endogenous Reactive Oxygen Species in Platelets Can Reverse Aggregation

2003 • 55 citations

Platelet Glutathione and Thromboxane Synthesis in Diabetes

1985 • 53 citations

Anti-platelet effects of different phenolic compounds from Yucca schidigera Roezl. Bark

2002 • 51 citations

Acute Effects of Vitamin C on Platelet Responsiveness to Nitric Oxide Donors and Endothelial Function in Patients with Chronic Heart Failure

2001 • 50 citations

Hydrogen peroxide, an inhibitor of platelet function: Effect on adenine nucleotide metabolism, and the release reaction

1977 • 49 citations

Diphenylene iodonium, an inhibitor of free radical formation, inhibits platelet aggregation

1991 • 49 citations

Platelet Nitric Oxide and Superoxide Release During the Development of Nitrate Tolerance

2002 • 47 citations

Platelet Adhesion and Aggregation without Endothelial Denudation or Exposure of Basal Lamina and/or Collagen

1997 • 46 citations

Polymorphonuclear leukocyte-derived O2-reactive species activate primed platelets in human whole blood

1993 • 45 citations

Enzymatic oxidant and antioxidants of human blood platelets in unstable angina and myocardial infarction

2000 • 43 citations

Priming of Platelet α _IIb β ₃ by Oxidants Is Associated With Tyrosine Phosphorylation of β ₃

1998 • 42 citations

Platelet surface glutathione reductase-like activity

2004 • 42 citations

Redox Modulation of Integrin α_IIbβ₃ Involves a Novel Allosteric Regulation of Its Thiol Isomerase Activity

2003 • 39 citations

Depolarization of Endothelial Cells Enhances Platelet Aggregation Through Oxidative Inactivation of Endothelial NTPDase

2002 • 37 citations

Hydrogen Peroxide as Trigger of Platelet Aggregation

1991 • 35 citations

Antithrombotic effects of peroxynitrite: Inhibition and reversal of aggregation in human platelets

1995 • 35 citations

H2O2 activity on platelet adhesion to fibrinogen and protein tyrosine phosphorylation

2000 • 34 citations

Purification and characterization of glutathione peroxidase from human blood platelets. Age-related changes in the enzyme

1994 • 33 citations

Evidence for the generation of hydroxyl radical during arachidonic acid metabolism by human platelets

1981 • 33 citations

Glycoprotein IIb/IIIa inhibition enhances platelet nitric oxide release

2004 • 31 citations

Redox Modulation of Integrin α_IIbβ₃ Involves a Novel Allosteric Regulation of Its Thiol Isomerase Activity,

2004 • 30 citations

Oxygen-radical-mediated lipid peroxidation and inhibition of ADP-induced platelet aggregation

1991 • 28 citations

Dipyridamole inhibits platelet aggregation induced by oxygen-derived free radicals

1992 • 28 citations

Long-Term Smoking Causes Nitroglycerin Resistance in Platelets by Depletion of Intraplatelet Glutathione

2001 • 27 citations

The Generation of Superoxide Anion in Blood Platelets in Response to Different Forms of Proteus mirabilis Lipopolysaccharide: Effects of Staurosporin, Wortmannin, and Indomethacin

2001 • 25 citations

Intraplatelet Tetrahydrobiopterin Plays an Important Role in Regulating Canine Coronary Arterial Thrombosis by Modulating Intraplatelet Nitric Oxide and Superoxide Generation

2001 • 25 citations

Role of Reduced Glutathione on Platelet Functions

1979 • 25 citations

Xanthine oxidase mediates cyclic flow variations in a canine model of coronary arterial thrombosis

1996 • 24 citations

Effect of membrane-permeable sulfhydryl reagents and depletion of glutathione on calcium mobilisation in human platelets

1997 • 22 citations

Lung Ischemia: Endothelial Cell Signaling by Reactive Oxygen Species

2003 • 21 citations

5 Platelet-vessel wall interaction: Role of nitric oxide, prostaglandins and endothelins

1993 • 21 citations

Role of Platelets and Leukocytes in Modulation of Vascular Tone^a

1994 • 21 citations

OXYGEN-FREE RADICALS AND NITRIC OXIDE ARE INVOLVED IN THE THROMBUS GROWTH PRODUCED BY IONTOPHORESIS OF ADP

1998 • 21 citations

Tetrahydrobiopterin impairs the action of endothelial nitric oxide via superoxide derived from platelets

2000 • 19 citations

Highly Effective Non-Viral Gene Transfer into Vascular Smooth Muscle Cells of Cultured Resistance Arteries Demonstrated by Genetic Inhibition of Sphingosine-1-Phosphate-Induced Vasoconstriction

2003 • 19 citations

Synergism between Nitric Oxide and Hydrogen Peroxide in the Inhibition of Platelet Function: The Roles of Soluble Guanylyl Cyclase and Vasodilator-Stimulated Phosphoprotein

2001 • 17 citations

Production of 8-epi prostaglandin F2α in human platelets during administration of organic nitrates

2002 • 16 citations

Relationship between Platelets and Neutrophil Adhesion and Neointimal Growth after Repeated Arterial Wall Injury Induced by Angioplasty in Pigs

2001 • 15 citations

A Novel Platelet-Derived Renal Vasoconstrictor Agent in Normotensives and Essential Hypertensives

1992 • 15 citations

In vitro effect of reduced glutathione on platelet function.

1996 • 14 citations

Lipid peroxidation in human blood platelets during unstable angina and myocardial infarction.

2001 • 4 citations

11,12-EETs hyperpolarize human platelets

2001 • 3 citations