Antiviral drug resistance

MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE

1943 • 3,852 citations

HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time

1996 • 3,496 citations

Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy

1997 • 2,989 citations

A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or Less

1997 • 2,670 citations

Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia

1997 • 2,154 citations

Treatment with Indinavir, Zidovudine, and Lamivudine in Adults with Human Immunodeficiency Virus Infection and Prior Antiretroviral Therapy

1997 • 1,912 citations

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 • 1,574 citations

Avian Influenza A (H5N1) Infection in Humans

2005 • 1,274 citations

Influenza virus M2 protein has ion channel activity

1992 • 1,205 citations

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

1989 • 1,199 citations

Antiretroviral-Drug Resistance among Patients Recently Infected with HIV

2002 • 1,150 citations

Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase

1995 • 1,139 citations

Mutation rates among RNA viruses

1999 • 1,122 citations

The molecular basis of the specific anti-influenza action of amantadine.

1985 • 800 citations

Antiretroviral Drug Resistance Testing in Adult HIV-1 Infection

2000 • 793 citations

Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern

2005 • 707 citations

Virologic and Immunologic Consequences of Discontinuing Combination Antiretroviral-Drug Therapy in HIV-Infected Patients with Detectable Viremia

2001 • 657 citations

Antiretroviral Drug Resistance Testing in Adults With HIV Infection

1998 • 582 citations

Rapid Changes in Human Immunodeficiency Virus Type 1 RNA Load and Appearance of Drug-Resistant Virus Populations in Persons Treated with Lamivudine (3TC)

1995 • 524 citations

Antiretroviral Drug Resistance Testing in Adults Infected with Human Immunodeficiency Virus Type 1: 2003 Recommendations of an International AIDS Society–USA Panel

2003 • 524 citations

The prevalence of antiretroviral drug resistance in the United States

2004 • 415 citations

Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy

1999 • 372 citations

Reduced Antiretroviral Drug Susceptibility Among Patients With Primary HIV Infection

1999 • 348 citations

Phenotypic Mechanism of HIV-1 Resistance to 3‘-Azido-3‘-deoxythymidine (AZT): Increased Polymerization Processivity and Enhanced Sensitivity to Pyrophosphate of the Mutant Viral Reverse Transcriptase

1998 • 342 citations

Influenza virus M2 integral membrane protein is a homotetramer stabilized by formation of disulfide bonds

1991 • 337 citations

Estimated Global Distribution and Regional Spread of HIV-1 Genetic Subtypes in the Year 2000

2002 • 320 citations

Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms

2002 • 312 citations

Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

1998 • 294 citations

In vivo compartmentalization of human immunodeficiency virus: evidence from the examination of pol sequences from autopsy tissues

1997 • 283 citations

Resistance-Associated Loss of Viral Fitness in Human Immunodeficiency Virus Type 1: Phenotypic Analysis of Protease and gag Coevolution in Protease Inhibitor-Treated Patients

1998 • 270 citations

Structured Treatment Interruption in Patients with Multidrug-Resistant Human Immunodeficiency Virus

2003 • 266 citations

Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: Intrinsic stability predicts lifelong persistence

2003 • 246 citations

Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure

1997 • 241 citations

Management of Antiviral Resistance in Patients with Chronic Hepatitis B

2004 • 240 citations

The transmembrane domain of influenza A M2 protein forms amantadine-sensitive proton channels in planar lipid bilayers

1992 • 235 citations

Broad Nucleoside Reverse‐Transcriptase Inhibitor Cross‐Resistance in Human Immunodeficiency Virus Type 1 Clinical Isolates

2003 • 218 citations

Antiretroviral Drug Resistance Testing in Adult HIV-1 Infection

2000 • 212 citations

Effect of stage of disease and drug dose on zidovudine susceptibilities of isolates of human immunodeficiency virus.

1990 • 204 citations

Children With Influenza A Infection: Treatment With Rimantadine

1987 • 198 citations

Nevirapine-resistant human immunodeficiency virus: kinetics of replication and estimated prevalence in untreated patients

1996 • 194 citations

Transmission Fitness of Drug‐Resistant Human Immunodeficiency Virus and the Prevalence of Resistance in the Antiretroviral‐Treated Population

2003 • 168 citations

A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate.

1986 • 154 citations

Genetic Composition of Human Immunodeficiency Virus Type 1 in Cerebrospinal Fluid and Blood without Treatment and during Failing Antiretroviral Therapy

2005 • 144 citations

Pharmacokinetic, Safety, and Antiviral Profiles of Oral Ganciclovir in Persons Infected with Human Immunodeficiency Virus: A Phase I/II Study

1995 • 107 citations

Semen-Specific Genetic Characteristics of Human Immunodeficiency Virus Type 1 env

2005 • 103 citations

Drug resistance in non-subtype B HIV-1

2003 • 94 citations

Natural Occurrence of Drug Resistance Mutations in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Isolates

1994 • 87 citations

Improvement of retroviral retargeting by using amino acid spacers between an additional binding domain and the N terminus of Moloney murine leukemia virus SU

1996 • 82 citations

In vivo Selection of an Influenza A2 Strain resistant to Amantadine

1970 • 79 citations

Antiviral drug resistance

1998 • 75 citations

Early brain injury in the SIV–macaque model of AIDS

2000 • 70 citations

Neuraminidase Inhibitor Susceptibility Network Position Statement: Antiviral Resistance in Influenza A/H5N1 Viruses

2005 • 66 citations

Chemotherapy and vaccination: a possible strategy for the control of highly virulent influenza virus

1985 • 64 citations

COMBINED DRUG TREATMENT OF TUBERCULOSIS. I. PREVENTION OF EMERGENCE OF MUTANT POPULATIONS OF TUBERCLE BACILLI RESISTANT TO BOTH STREPTOMYCIN AND ISONIAZID IN VITRO

1959 • 57 citations

A WORKING HYPOTHESIS—VIRUS RESISTANCE DEVELOPMENT AS AN INDICATOR OF SPECIFIC ANTIVIRAL ACTIVITY

1977 • 50 citations

A novel TaqMan real-time PCR assay to estimate ex vivo human immunodeficiency virus type 1 fitness in the era of multi-target (pol and env) antiretroviral therapy

2003 • 41 citations

Antiviral Drug Resistance in Herpes Simplex Virus

1996 • 33 citations

The Clinical Significance of the Emergence of Drug-Resistant Organisms during the Therapy of Chronic Pulmonary Tuberculosis with Hydrazides of Isonicotinic Acid

1953 • 19 citations