T Cell Signaling Mechanisms that Regulate HIV-1 Infection

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time

1996 • 3,496 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells

2000 • 2,384 citations

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

1997 • 2,011 citations

HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy

1995 • 1,997 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses

2000 • 1,665 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

Origin, maturation and antigen presenting function of dendritic cells

1997 • 1,375 citations

Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and Recipients

1995 • 1,158 citations

The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

1997 • 1,124 citations

Integration of murine leukemia virus DNA depends on mitosis.

1993 • 931 citations

Host factors and the pathogenesis of HIV-induced disease

1996 • 857 citations

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

1994 • 845 citations

HIV-1 Genome Nuclear Import Is Mediated by a Central DNA Flap

2000 • 831 citations

A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells

1993 • 810 citations

HIV-1 replication is controlled at the level of T cell activation and proviral integration.

1990 • 800 citations

Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus

1994 • 798 citations

In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency

1995 • 755 citations

CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro

1997 • 722 citations

Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques.

1996 • 705 citations

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.

1992 • 604 citations

Quiescent T Lymphocytes as an Inducible Virus Reservoir in HIV-1 Infection

1991 • 584 citations

Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages

1999 • 577 citations

Antigen-independent activation of naive and memory resting T cells by a cytokine combination.

1994 • 541 citations

Viral Load and Disease Progression in Infants Infected with Human Immunodeficiency Virus Type 1

1997 • 540 citations

Human immunodeficiency virus infection of cells arrested in the cell cycle.

1992 • 523 citations

Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1

1994 • 505 citations

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

1997 • 483 citations

Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals.

1990 • 443 citations

Cytokine Signals Are Sufficient for HIV-1 Infection of Resting Human T Lymphocytes

1999 • 428 citations

Lymphocyte life-span and memory

1994 • 405 citations

Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle

1992 • 399 citations

HIV-1 Regulatory/Accessory Genes: Keys to Unraveling Viral and Host Cell Biology

1998 • 392 citations

Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells

1999 • 367 citations

HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase

1995 • 360 citations

Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes.

1991 • 358 citations

HIV-1 Auxiliary Proteins: Making Connections in a Dying Cell

1998 • 328 citations

HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator

1995 • 309 citations

Homing of naive, memory and effector lymphocytes

1993 • 295 citations

The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes.

1994 • 287 citations

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene.

1993 • 282 citations

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

2000 • 269 citations

In vivoHIV-1 infection of CD45RA⁺CD4⁺T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4⁺T cell decline

2000 • 259 citations

Coreceptors--Implications for HIV Pathogenesis and Therapy

1997 • 258 citations

Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import

1996 • 253 citations

Host Control of HIV-1 Parasitism in T Cells by the Nuclear Factor of Activated T Cells

1998 • 221 citations

Human immunodeficiency virus type 1 replication is blocked prior to reverse transcription and integration in freshly isolated peripheral blood monocytes

1996 • 221 citations

The Primate Lentiviral Receptor Bonzo/STRL33 Is Coordinately Regulated with CCR5 and Its Expression Pattern Is Conserved Between Human and Mouse

2000 • 219 citations

Both Memory and CD45RA⁺/CD62L⁺Naive CD4⁺T Cells Are Infected in Human Immunodeficiency Virus Type 1-Infected Individuals

1999 • 217 citations

Host factors in the pathogenesis of HIV disease

1997 • 200 citations

Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro

1995 • 199 citations

Mother-to-Child Transmission of the Human Immunodeficiency Virus

1995 • 198 citations

Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro.

1997 • 187 citations

HIV-1 Nef increases T cell activation in a stimulus-dependent manner

1999 • 180 citations

DC-SIGN

2000 • 179 citations

A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation

1997 • 178 citations

Dendritic Cells Express Multiple Chemokine Receptors Used as Coreceptors for HIV Entry

1998 • 167 citations

Interactions of HIV-1 NEF with cellular signal transducing proteins

2000 • 156 citations

Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase

1998 • 156 citations

Novel immunoregulatory functions of phenotypically distinct subpopulations of CD4+ cells in the human neonate.

1990 • 142 citations

Absconding with the Chaperone: Essential Cyclophilin–Gag Interaction in HIV-1 Virions

1996 • 135 citations

The role of CD40 and CD80 accessory cell molecules in dendritic cell-dependent HIV-1 infection

1994 • 128 citations

Dendritic cells and the replication of HIV-1

1996 • 122 citations

Both a precursor and a mature population of dendritic cells can bind HIV. However, only the mature population that expresses CD80 can pass infection to unstimulated CD4+ T cells.

1995 • 117 citations

CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus

1997 • 116 citations

Ontogeny of expression of UCHL1 antigen on TcR‐1⁺ (CD4/8) and TcRδ⁺ T cells

1989 • 112 citations

Migration pathways and immunologic memory among T lymphocytes.

1992 • 97 citations

Expression Patterns of the HIV Type 1 Coreceptors CCR5 and CXCR4 on CD4⁺T Cells and Monocytes from Cord and Adult Blood

1998 • 93 citations

Quantitative Alterations of the Functionally Distinct Subsets of CD4 and CD8 T Lymphocytes in Asymptomatic HIV Infection

1997 • 89 citations

Functional analysis of human T cell subsets defined by CD45 isoform expression.

1992 • 89 citations

Immunological and virological markers in individuals progressing from seroconversion to AIDS

1991 • 86 citations

Highly purified CD25⁻resting T cells cannot be infectedde novowith HIV-1

1997 • 79 citations

G protein-coupled receptors in HIV and SIV entry: New perspectives on lentivirus–host interactions and on the utility of animal models

1998 • 74 citations

Nef Enhances Human Immunodeficiency Virus Replication and Responsiveness to Interleukin-2 in Human Lymphoid Tissue Ex Vivo

1999 • 72 citations

Differential tropism of HIV-1 isolates for distinct thymocyte subsets in vitro

1996 • 61 citations

Human naive T cells activated by cytokines differentiate into a split phenotype with functional features intermediate between naive and memory T cells

1995 • 61 citations

Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis

1997 • 59 citations

Role of the Thymus in Pediatric HIV-1 Infection

1998 • 54 citations

Immunological memory in T cells

1991 • 53 citations

Mechanism of human immunodeficiency virus type 1 localization in CD4-negative thymocytes: differentiation from a CD4-positive precursor allows productive infection

1997 • 52 citations

Pathogenesis of Pediatric Human Immunodeficiency Virus Type 1 Infection

1994 • 52 citations

Increased losses of CD4+CD45RA+ cells in late stages of HIV infection is related to increased risk of death

1997 • 52 citations

Activation and differentiation antigens on T cells of healthy, at-risk, and HIV-infected children.

1993 • 49 citations

HIV infection of CD45RA+ and CD45RO+ CD4+ T cells

1997 • 46 citations

The Role of the Cell Cycle in HIV-1 Infection

1995 • 44 citations

Interleukin-2 and human immunodeficiency virus infection: Pathogenic mechanisms and potential for immunologic enhancement

1996 • 42 citations

Differential requirements for HIV-1 replication in naive and memory CD4 T cells from asymptomatic HIV-1 seropositive carriers and AIDS patients

1993 • 23 citations

Dendritic Cell-T Cell Conjugates that Migrate from Normal Human Skin are an Explosive Site of Infection for HIV-1

1995 • 16 citations

Cell-Cell Interactions Regulate Dendritic Cell-Dependent HIV-1 Production in CD4+ T Lymphocytes

1995 • 4 citations