Mechanism of human immunodeficiency virus type 1 localization in CD4-negative thymocytes: differentiation from a CD4-positive precursor allows productive infection

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1986 • 2,918 citations

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

The SCID-hu Mouse: Murine Model for the Analysis of Human Hematolymphoid Differentiation and Function

1988 • 1,394 citations

Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy

1995 • 1,066 citations

Pathogenesis of human immunodeficiency virus infection

1993 • 835 citations

Dual Infection of the Central Nervous System by AIDS Viruses with Distinct Cellular Tropisms

1987 • 831 citations

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1991 • 760 citations

Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4

1992 • 553 citations

The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle

1995 • 518 citations

Dead cell discrimination with 7‐amino‐actinomcin D in combination with dual color immunofluorescence in single laser flow cytometry

1992 • 443 citations

The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function

1988 • 389 citations

HIV induces thymus depletion in vivo

1993 • 384 citations

Long-term human hematopoiesis in the SCID-hu mouse.

1990 • 353 citations

Switch of CD8 T Cells to Noncytolytic CD8 ^- CD4 ^- Cells that Make T _H 2 Cytokines and Help B Cells

1993 • 343 citations

The SCID-hu mouse as a model for HIV-1 infection

1993 • 288 citations

Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse.

1993 • 265 citations

CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor

1990 • 228 citations

CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef

1996 • 227 citations

Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow

1992 • 224 citations

HIV-1-induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo

1995 • 214 citations

Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity

1994 • 195 citations

Infection of natural killer cells by human herpesvirus 6

1993 • 192 citations

Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4

1994 • 179 citations

Intracellular interaction of human immunodeficiency virus type 1 (ARV-2) envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane

1990 • 131 citations

Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene

1987 • 127 citations

Thymic Abnormalities in Fetuses Aborted From Human Immunodeficiency Virus Type 1 Seropositive Women

1992 • 124 citations

Frequent infection of peripheral blood CD8-positive T-lymphocytes with HIV-1

1996 • 124 citations

The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4

1993 • 114 citations

Excess Intrauterine Fetal Demise Associated with Maternal Human Immunodeficiency Virus Infection

1995 • 111 citations

Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice

1996 • 108 citations

CD2-CD4-CD8- lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2+CD4+CD8+ thymic precursor.

1993 • 82 citations

Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes

1995 • 80 citations

CD8+ T lymphocytes in the lung of acquired immunodeficiency syndrome patients harbor human immunodeficiency virus type 1

1995 • 77 citations

Differential tropism of HIV-1 isolates for distinct thymocyte subsets in vitro

1996 • 61 citations

Two subpopulations of human triple-negative thymic cells are susceptible to infection by human immunodeficiency virus type 1 in vitro

1994 • 55 citations

A new reporter system for detection of retroviral infection.

1995 • 54 citations

Infection of CD8+ T lymphocytes with HIV. Requirement for interaction with infected CD4+ cells and induction of infectious virus from chronically infected CD8+ cells.

1991 • 53 citations

In vivo pathogenic properties of two clonal human immunodeficiency virus type 1 isolates

1995 • 52 citations

In vitro studies of HIV-1 expression in thymocytes from infants and children

1992 • 46 citations

The origin of CD4−CD8−TCRαβ+ thymocytes: a model based on T-cell receptor avidity

1995 • 44 citations

CD4⁻CD8⁻ thymocytes that express the T cell receptor may have previously expressed CD8

1990 • 41 citations

Effects of cytokines on HIV-1 production by thymocytes.

1994 • 29 citations

CD4/CD8-negative T cells with αβ antigen receptors

1994 • 27 citations

Detection of unintegrated human immunodeficiency virus type 1 DNA in persistently infected CD8+ cells

1993 • 27 citations

Interleukin-4 induces expression of the CD45RA antigen on human thymocyte subpopulations

1990 • 26 citations

Double-negative (CD4- CD8-) T cells with an alpha/beta T cell receptor. Non-MHC-restricted cytolytic activity and lymphokine production.

1990 • 24 citations

Persistent productive HIV-1 infection of a CD4- human fetal thymocyte line.

1992 • 22 citations

Selective stimulation of human thymocyte subpopulations by recombinant IL-4 and IL-3

1989 • 17 citations

Human thymocytes do not respond to interleukin-2 after removal of mature “bright” CD5 positive cells

1989 • 16 citations