Selective immunomodulation by the autoimmunity-inducing xenobiotics streptozotocin and HgCl2

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

F4/80, a monoclonal antibody directed specifically against the mouse macrophage

1981 • 1,582 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.

1995 • 554 citations

TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity

1991 • 365 citations

Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases

1984 • 354 citations

Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

1995 • 343 citations

The basis of autoimmunity: part II genetic predisposition

1995 • 205 citations

Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: Influence of inbred background, sex, and thymus

1982 • 177 citations

T cell immune responses to haptens. Structural models for allergic and autoimmune reactions

1996 • 175 citations

IL-4 is required for the IgE and IgG1 increase and IgG1 autoantibody formation in mice treated with mercuric chloride.

1991 • 156 citations

Genetic Influence of the Streptozotocin-induced Insulitis and Hyperglycemia

1977 • 153 citations

Murine susceptibility to mercury

1992 • 140 citations

Autoreactive T cells in mercury-induced autoimmunity. Ability to induce the autoimmune disease.

1988 • 139 citations

Mercuric chloride‐induced anti‐glomerular basement membrane antibodies in the rat Genetic control

1977 • 136 citations

Nitric oxide generation from streptozotocin ¹

1994 • 119 citations

Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin.

1996 • 100 citations

Murine Susceptibility to Mercury

1993 • 90 citations

Predictive Immunotoxicological Test Systems: Suitability of the Popliteal Lymph Node Assay in Mice and Rats

1995 • 84 citations

Alteration of a model antigen by Au(III) leads to T cell sensitization to cryptic peptides

1996 • 79 citations

Mercuric chloride, a chemical responsible for T helper cell (Th)2-mediated autoimmunity in brown Norway rats, directly triggers T cells to produce interleukin-4.

1995 • 77 citations

Compounds that induce autoimmunity in the Brown Norway rat sensitize mast cells for mediator release and interleukin-4 expression

1995 • 73 citations

The induction of immune complex deposits in mice by peroral and parenteral administration of mercuric chloride: strain dependent susceptibility.

1987 • 73 citations

Multiple low dose streptozotocin induces systemic MHC expression in mice by triggering T cells to release IFN-gamma.

1989 • 71 citations

Immunopathological signs in mice treated with mercury compounds — I. Identification by the popliteal lymph node assay of responder and nonreponder strains

1988 • 71 citations

The Use of Reporter Antigens in the Popliteal Lymph Node Assay to Assess Immunomodulation by Chemicals

1997 • 63 citations

Treatment With Anti-T-Lymphocyte Antibodies Prevents Induction of Insulitis in Mice Given Multiple Doses of Streptozocin

1987 • 62 citations

Interleukin‐4 Gene Expression in Mercury‐Induced Autoimmunity

1995 • 61 citations

Specific Immunity to Streptozocin: Cellular Requirements for Induction of Lymphoproliferation

1988 • 53 citations

Discordance for autoimmunity in monozygotic twins. are “identical” twins really identical?

1993 • 53 citations

Induction of tolerance to autoimmune diabetes with islet antigens.

1992 • 48 citations

Autoimmunity and Toxicology: Immune Disregulation Induced by Drugs and Chemicals

1989 • 45 citations

IFN-gamma receptor-Ig fusion proteins. Half-life, immunogenicity, and in vivo activity.

1992 • 38 citations

Quantification of natural antibody producing B cells in rats by an improved ELISPOT technique using the polyvinylidene difluoride membrane as the solid support

1995 • 34 citations

The Influence of Genetic Background on the Susceptibility of Inbred Mice to Streptozotocin-induced Diabetes

1984 • 34 citations

Activation of CD4+ and CD8+ lymphocyte subsets by streptozotocin in murine popliteal lymph node (PLN) test

1992 • 34 citations

Successful Induction of Allergic Contact Dermatitis to Mercury and Chromium in Mice

1991 • 29 citations

-Cell Function in Mice Injected with Mononuclear Splenocytes from Multiple-Dose Streptozotocin Diabetic Mice

1994 • 20 citations

The autoimmunogenic chemicals HgCl₂ and diphenylhydantoin stimulate IgG production to TNP–Ficoll and TNP–OVA, supporting and extending the graft‐versus‐host hypothesis for chemical induction of autoimmunity

1996 • 19 citations

T Cell-Dependent Class II Major Histocompatibility Complex Antigen Expression in vivo Induced by the Diabotegen Streptozotocin

1989 • 7 citations