Possible mechanisms involved in the release and modulation of release of neuroactive agents

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Enzymatic Basis for Active Transport of Na⁺ and K⁺ Across Cell Membrane

1965 • 2,008 citations

Ionic Blockage of Sodium Channels in Nerve

1973 • 1,590 citations

Regulation of noradrenaline release by presynaptic receptor systems

1977 • 1,482 citations

The separation of synaptic vesicles from nerve-ending particles (‘synaptosomes’)

1964 • 1,213 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

Phospholipid Methylation and Biological Signal Transmission

1980 • 1,101 citations

The sodium-potassium adenosine triphosphatase: pharmacological, physiological and biochemical aspects.

1975 • 868 citations

TURNOVER OF TRANSMITTER AND SYNAPTIC VESICLES AT THE FROG NEUROMUSCULAR JUNCTION

1973 • 835 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Two molecular forms of (Na+ + K+)-stimulated ATPase in brain. Separation, and difference in affinity for strophanthidin.

1979 • 598 citations

The timing of calcium action during neuromuscular transmission

1967 • 564 citations

Transmitter leakage from motor nerve endings

1977 • 443 citations

Transmitter release induced by injection of calcium ions into nerve terminals

1973 • 443 citations

Protein phosphorylation in the brain

1983 • 428 citations

The (Na+ + K+)-activated ATPase Enzymatic and transport properties

1979 • 401 citations

Dopamine can be released by two mechanisms differentially affected by the dopamine transport inhibitor nomifensine.

1979 • 382 citations

Presynaptic modulation of neurochemical transmission

1979 • 379 citations

A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.

1983 • 368 citations

Vesicle hypothesis of the release of quanta of acetylcholine.

1980 • 364 citations

Actomyosin-Like Protein in Brain

1973 • 364 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA

1969 • 355 citations

Synthesis, storage and release of [¹⁴C]acetylcholine in isolated rat diaphragm muscles

1970 • 353 citations

Stimulation of Ca ²⁺ -dependent neurotransmitter release and presynaptic nerve terminal protein phosphorylation by calmodulin and a calmodulin-like protein isolated from synaptic vesicles

1979 • 346 citations

Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture

1980 • 306 citations

Corticotropin-(1–24)-tetracosapeptide affects protein phosphorylation and polyphosphoinositide metabolism in rat brain

1981 • 287 citations

Locations of amino acids in brain slices from the rat. Tetrodotoxin-sensitive release of amino acids

1972 • 260 citations

The mechanism of acetylcholine release from parasympathetic nerves

1971 • 251 citations

Intracellular studies showing modulation of facial motoneurone excitability by serotonin

1980 • 239 citations

Biochemistry of Neurotransmitter Release

1979 • 237 citations

PHOSPHOLIPIDS IN SYNAPTIC FUNCTION

1979 • 235 citations

A new activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+-, calmodulin-dependent protein kinase. Purification and characterization.

1981 • 234 citations

Identification and Properties of Methyltransferases That Synthesize Phosphatidylcholine in Rat Brain Synaptosomes

1980 • 212 citations

Antagonism of the paralysis produced by botulinum toxin in the rat

1977 • 202 citations

Effects of ethanol on neurotransmitter release by rat brain cortical.

1975 • 199 citations

Stimulation, by inhibition of (Na⁺‐K⁺‐Mg²⁺)‐activated, ATP‐ase, of acetylcholine release in cortical slices from rat brain

1972 • 196 citations

Changes in total and quantal release of acetylcholine in the mouse diaphragm during activation and inhibition of membrane ATPase.

1979 • 191 citations

Na+-K+-activated adenosinetriphosphatase as a trigger in transmitter release

1978 • 191 citations

The present status of the vesicular hypothesis

1979 • 181 citations

Strontium and quantal release of transmitter at the neuromuscular junction

1969 • 179 citations

The origin and fate of secretory packages, especially synaptic vesicles

1977 • 178 citations

Studies on membrane fusion. I. Interactions of pure phospholipid membranes and the effect of myristic acid, lysolecithin, proteins and dimethylsulfoxide.

1976 • 170 citations

Non vesicular release of neurotransmitter.

1982 • 170 citations

Release of norepinephrine and dopamine-beta-hydroxylase by nerve stimulation. I. Role of neuronal and extraneuronal uptake and of alpha presynaptic receptors.

1974 • 165 citations

Synaptic Phosphoproteins: Specific Changes After Repetitive Stimulation of the Hippocampal Slice

1979 • 162 citations

The role of thiamine in nervous tissue

1979 • 160 citations

Pituitary Gland: Enzymic Formation of Methanol from S -Adenosylmethionine

1965 • 159 citations

Muscle-Like Contractile Proteins and Tubulin in Synaptosomes

1974 • 158 citations

Recent hypotheses regarding the phosphatidylinositol effect

1981 • 156 citations

LES COMPARTIMENTS D'ACETYLCHOLINE DE L'ORGANE ELECTRIQUE DE LA TORPILLE ET LEURS MODIFICATIONS PAR LA STIMULATION

1972 • 156 citations

Structure and ultrastructure of the frog motor endplate

1974 • 156 citations

Synaptic transmission in squid giant synapse after potassium conductance blockage with external 3- and 4-aminopyridine

1976 • 155 citations

REGIONAL AND SUBCELLULAR DISTRIBUTION OF PROTEIN CARBOXYMETHYLASE IN BRAIN AND OTHER TISSUES

1976 • 149 citations

AMINO ACIDS IN SYNAPTIC VESICLES FROM MAMMALIAN CEREBRAL CORTEX: A REAPPRAISAL

1973 • 142 citations

Correlations Between Na⁺‐K⁺ ATPase Activity and Acetylcholine Release in Rat Cortical Synaptosomes

1981 • 136 citations

Non-quantal release of transmitter at mouse neuromuscular junction and its dependence on the activity of Na+−K+ ATP-ase

1977 • 128 citations

Ca2+- and calmodulin-stimulated endogenous phosphorylation of neurotubulin.

1981 • 126 citations

Requirement for calcium ions in acetylcholine-stimulated phosphodiesteratic cleavage of phosphatidyl-myo-inositol 4,5-bisphosphate in rabbit iris smooth muscle

1980 • 122 citations

The relationship of transmitter release and storage to fine structure in a sympathetic ganglion

1974 • 122 citations

Is phosphatidylinositol really out of the calcium gate?

1982 • 121 citations

Tuberoinfundibular dopamine neurons and the regulation of prolactin secretion

1981 • 119 citations

Kinetics of a Ca2+-triggered membrane aggregation reaction of phospholipid membranes

1975 • 111 citations

ON THE SITE OF ORIGIN OF TRANSMITTER AMINO ACIDS RELEASED BY DEPOLARIZATION OF NERVE TERMINALS IN VITRO

1977 • 111 citations

Morphological and biochemical heterogeneity of cholinergic synaptic vesicles

1977 • 110 citations

The effects of sympathetic nerve stimulation and guanethidine on parasympathetic neuroeffector transmission; the inhibition of acetylcholine release

1971 • 108 citations

A rapid method for the purification of S-adenosylmethionine: Protein-carboxyl O-methyltransferase by affinity chromatography

1978 • 105 citations

Intracellular signals in the brain.

1979 • 103 citations

Subcellualr distribution of protein carboxymethylase and its endogenous substrates in the adrenal medulla: possible role in excitation-secretion coupling.

1976 • 103 citations

Depolarization-release coupling systems in neurons.

1977 • 102 citations

Modification of calmodulin function by enzymatic carboxyl methylation

1981 • 101 citations

Transmission abolished on a cholinergic synapse after injection of acetylcholin-esterase into the presynaptic neurone

1974 • 100 citations

Presynaptic inhibition leading to disinhibition of acetylcholine release from interneurons of the caudate nucleus: Effects of dopamine, β-endorphin and d-Ala2-Pro5-enkephalinamide

1977 • 98 citations

Ca²⁺ and Calmodulin‐Dependent Phosphorylation of Endogenous Synaptic Vesicle Tubulin by a Vesicle‐Bound Calmodulin Kinase System

1982 • 98 citations

Phosphatidate as a Molecular Link Between Depolarization and Neurotransmitter Release in the Brain

1981 • 95 citations

Simultaneous Release of Acetylcholine and ATP from Stimulated Cholinergic Synaptosomes

1981 • 95 citations

Is phosphatidylinositol now out of the calcium gate?

1982 • 95 citations

The effects of prolonged repetitive stimulation in hemicholinium on the frog neuromuscular junction.

1975 • 94 citations

Nerve terminal ATPase as possible trigger for neurotransmitter release

1975 • 93 citations

Structure and function in smooth tonic muscles of lamellibranch molluscs

1964 • 89 citations

Serotonin stimulates phosphorylation of Protein I in the facial motor nucleus of rat brain

1981 • 80 citations

Release of acetylcholine from rat brain synaptosomes by various agents in the absence of external calcium ions.

1984 • 79 citations

Protein carboxymethylation: Role in the regulation of cell functions

1981 • 78 citations

Origin of transmitters released by electrical stimulation from a small, metabolically very active vesicular pool of cholinergic synapses in guinea-pig cerebral cortex

1979 • 77 citations

The release of acetylcholine from post‐ganglionic cell bodies in response to depolarization.

1980 • 74 citations

The effect of catecholamines on transport (Na,K) adenosine triphosphatase

1977 • 74 citations

Transfer of synaptic vesicle antigens to the presynaptic plasma membrane during exocytosis.

1981 • 72 citations

Soluble and particulate forms of phosphoinositide phosphodiesterase in ox brain

1972 • 71 citations

Termination of transmitter release by stimulation of sodium‐potassium activated ATPase.

1977 • 70 citations

Kinetics of catecholamine sensitive Na+K+ ATPase activity in mouse brain synaptosomes

1977 • 70 citations

Bridging of IgE receptors activates phospholipid methylation and adenylate cyclase in mast cell plasma membranes.

1981 • 69 citations

Distribution and properties of adrenergic storage vesicles in nerve terminals.

1976 • 66 citations

THE EFFECTS OF OUABAIN AND THE ACTIVATION OF NEURAL MEMBRANE ATPase BY BIOGENIC AMINES

1976 • 65 citations

A New Activator Protein That Activates Tryptophan 5-Monooxygenase and Tyrosine 3-Monooxygenase in the Presence of Ca2+-, Calmodulin- dependent Protein Kinase

1981 • 65 citations

Fusion of dipalmitoylphosphatidylcholine vesicle membranes induced by concanavalin A.

1975 • 63 citations

Are vesicles necessary for release of acetylcholine at cholinergic synapses?

1979 • 63 citations

The action of acetylcholine and other drugs on the efflux of potassium and rubidium from smooth muscle of the guinea‐pig intestine

1997 • 61 citations

Evidence for a role in stimulus--secretion coupling of prostaglandins derived from release of arachidonoyl residues as a result of phosphatidylinositol breakdown.

1980 • 59 citations

ISOLATION OF [³H]ACETYLCHOLINE POOLS BY SUBCELLULAR FRACTIONATION OF CEREBRAL CORTEX SLICES INCUBATED WITH [³H]CHOLINE

1971 • 58 citations

Regulation of phosphorylation of proteins I, IIIa, and IIIb in rat neurohypophysis in vitro by electrical stimulation and by neuroactive agents.

1982 • 58 citations

Evidence for the role of non‐quantal acetylcholine in the maintenance of the membrane potential of rat skeletal muscle

1982 • 55 citations

Facilitation of transmitter release at squid synapses.

1978 • 54 citations

Effect of metabolic inhibitors and ouabain on amphetamine- and potassium-induced release of biogenic amines from isolated brain tissue

1978 • 50 citations

Specific stimulated uptake of acetylcholine by Torpedo electric organ synaptic vesicles.

1980 • 50 citations

Exocytosis modelling: An electrostatic function for calcium in stimulus-secretion coupling

1975 • 49 citations

Erythrosin B is a specific inhibitor of high affinity 3H-ouabain binding and ion transport in rat brain

1981 • 48 citations

Evidence that transmitter can be released from regions of the nerve cell other than presynaptic axon terminal: Axonal release of acetylcholine without modulation

1983 • 47 citations

Proteins of the synaptic membrane

1977 • 47 citations

Thiamine and Cholinergic Transmission in the Electric Organ of Torpedo

1980 • 47 citations

The possible role of fixed membrane surface charges in acetylcholine release at the frog neuromuscular junction

1973 • 44 citations

Na+ regulates release of Ca++ sequestered in synaptosomal mitochondria

1977 • 43 citations

Na-K activated ATPase and the release of acetylcholine and noradrenaline.

1982 • 41 citations

Characterization of receptor-mediated catecholamine activation of rat brain corticl Na+-K+-ATPase

1980 • 38 citations

Effect of biogenic amines and gaba on ATPase activities in mouse tissue

1976 • 37 citations

Inhibition of neuronal sodium and potassium ion activated adenosinetriphosphatase by pyrithiamin

1983 • 37 citations

Effects of metabolic inhibitors on norepinephrine release from the perfused spleen of the cat.

1970 • 35 citations

Movement of strontium ions into mast cells and its relationship to the secretory response

1977 • 35 citations

Release of norepinephrine from isolated rat iris by field stimulation.

1970 • 35 citations

Acetylcholine changes underlying transmission of a single nerve impulse in the presence of 4‐aminopyridine in Torpedo

1982 • 35 citations

Dopamine agonists stimulate protein carboxylmethylation in striatal synaptosomes.

1982 • 35 citations

Effect of reserpine on release of [3H]noradrenaline, [3H]dopamine and [3H]metaraminol from field stimulated rat iris

1971 • 34 citations

The interaction of calcium and strontium with phosphatidyl serine in the anaphylactic secretion of histamine

1973 • 34 citations

Absence of adenine nucleotide release from autonomic ganglion

1974 • 33 citations

Protein phosphorylation during afterdischarge in peptidergic neurons of Aplysia

1982 • 33 citations

High affinity choline uptake and calcium-dependent acetylcholine release in proteoliposomes derived from rat cortical synaptosomes

1983 • 32 citations

Adrenergic False Transmitters

1972 • 31 citations

Metabolism of Phosphoinositides

1983 • 29 citations

Corticotropin-releasing factor stimulates phospholipid methylation and corticotropin secretion in mouse pituitary tumor cells.

1982 • 27 citations

Thiamine and Cholinergic Transmission in the Electric Organ of Torpedo

1980 • 26 citations

Regulation of nerve terminal calcium channel selectivity by a weak acid site

1979 • 25 citations

Calcium metabolism and acetylcholine release at the nerve-electroplaque junction.

1980 • 24 citations

MECHANISM OF NEUROTOXICITY OF CARDIOTONIC GLYCOSIDES

1977 • 24 citations

Kinetics of cation-induced aggregation of Torpedo electric organ synaptic vesicles

1979 • 22 citations

Phospholipid Methylation and Noradrenaline Exchanges in a Synaptosomal Preparation from the Rat Brain

1982 • 22 citations

Release of norepinephrine and dopamine-beta-hydroxylase by nerve stimulation. V. Enhanced release associated with a granular effect of a benzoquinolizine derivative with reserpine-like properties.

1975 • 21 citations

Acetylcholine release from proteoliposomes equipped with synaptosomal membrane constituents

1983 • 19 citations

Dual action of ouabain on transmitter release at neuromuscular junctions of the frog.

1979 • 18 citations

Effect of adrenergic factors on peristalsis and acetylcholine release

1971 • 17 citations

Vesicular Heterogeneity and Turnover of Acetylcholine and ATP in Cholinergic Synaptic Vesicles

1979 • 14 citations

Enhanced exocytotic release of norepinephrine consequent to nerve stimulation by low concentrations of cyclic nucleotides in the presence of phenoxy-benzamine.

1978 • 13 citations

Quantal size is not altered by abrupt changes in nerve terminal volume

1978 • 10 citations

The effect of α-, β adrenergic receptor agonists and antagonists on the efflux of 22Na and uptake of 42K by rat brain cortical slices

1982 • 10 citations

THE ROLE OF VESICLES IN CHOLINERGIC SYSTEMS

1980 • 10 citations

Role of storage vesicles in synaptic transmission.

1979 • 9 citations

Universities accused of inefficient book-keeping

1979 • 2 citations