Protein phosphorylation in the brain

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

Molecular Biology of Learning: Modulation of Transmitter Release

1982 • 1,534 citations

Calcium channel modulation by neurotransmitters, enzymes and drugs

1983 • 1,267 citations

Psychopharmacology : a generation of progress

1978 • 1,168 citations

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.

1983 • 1,162 citations

The role of protein phosphorylation in neural and hormonal control of cellular activity

1982 • 1,116 citations

Psychopharmacology: A Generation of Progress

1979 • 1,101 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.

1982 • 1,008 citations

Phosphorylated Proteins as Physiological Effectors

1978 • 975 citations

Control of acetylcholine receptors in skeletal muscle

1979 • 770 citations

Dendritic release of dopamine in the substantia nigra

1981 • 732 citations

Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones

1982 • 658 citations

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. I. Its general distribution in synapses of the central and peripheral nervous system demonstrated by immunofluorescence in frozen and plastic sections.

1983 • 555 citations

Cyclic AMP-dependent endogenous phosphorylation of a microtubule-associated protein.

1975 • 551 citations

Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes.

1983 • 535 citations

The Nicotinic Cholinergic Receptor: Correlation of Molecular Structure with Functional Properties

1982 • 456 citations

Light-dependent phosphorylation of rhodopsin: number of phosphorylation sites

1982 • 441 citations

Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current

1982 • 421 citations

Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. I. Solubilization, purification, and some properties of an endogenous phosphoprotein.

1977 • 411 citations

Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes.

1977 • 393 citations

Multiple phosphorylation sites in mammalian neurofilament polypeptides.

1982 • 381 citations

Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia.

1980 • 380 citations

The Cell surface and neuronal function

1980 • 379 citations

A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions

1983 • 342 citations

Molecular characterization of the cAMP-dependent protein kinase bound to microtubule-associated protein 2.

1982 • 334 citations

Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture

1980 • 306 citations

Transneuronal regulation of tyrosine hydroxylase expression in olfactory bulb of mouse and rat

1983 • 300 citations

Two calcium/calmodulin-dependent protein kinases, which are highly concentrated in brain, phosphorylate protein I at distinct sites.

1981 • 296 citations

Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.

1978 • 291 citations

Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation.

1978 • 286 citations

Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium.

1979 • 284 citations

A calcium/calmodulin-dependent protein kinase from mammalian brain that phosphorylates Synapsin I: partial purification and characterization

1983 • 265 citations

Calcium/phospholipid regulates phosphorylation of a Mr "87k" substrate protein in brain synaptosomes.

1982 • 257 citations

ATP mediates rapid reversal of cyclic GMP phosphodiesterase activation in visual receptor membranes

1980 • 251 citations

Purification and Characterization of a Ca²⁺‐ and Calmodulin‐Dependent Protein Kinase from Rat Brain

1982 • 235 citations

Differential phosphorylation of multiple sites in purified protein I by cyclic AMP-dependent and calcium-dependent protein kinases.

1981 • 233 citations

Dopamine selectively increases 3H-GABA release from slices of rat substantia nigra in vitro

1977 • 218 citations

Inhibitor of adenosine 3':5'-monophosphate-dependent protein kinase blocks presynaptic facilitation in Aplysia

1982 • 207 citations

Subcellular distribution in cerebral cortex of two proteins phosphorylated by a cAMP-dependent protein kinase.

1979 • 200 citations

Regional distribution of calcium- and cyclic adenosine 3':5'-monophosphate-regulated protein phosphorylation systems in mammalian brain. II. Soluble systems.

1983 • 198 citations

Tyrosine hydroxylase: a substrate of cyclic AMP-dependent protein kinase.

1980 • 189 citations

cAMP-dependent protein kinase phosphorylates the nicotinic acetylcholine receptor

1983 • 187 citations

ATP, cyclic AMP, and magnesium increase the affinity of rat striatal tyrosine hydroxylase for its cofactor.

1975 • 184 citations

Evidence for involvement of protein kinase in the activation by adenosine 3':5'-monophosphate of brain tyrosine 3-monooxygenase.

1975 • 179 citations

Depolarizing agents and cyclic nucleotides regulate the phosphorylation of specific neuronal proteins in rat cerebral cortex slices.

1978 • 178 citations

Phosphorylation and activation of tyrosine hydroxylase mediate the cAMP-induced increase in catecholamine biosynthesis in adrenal chromaffin cells.

1982 • 177 citations

Adenosine 3′,5-Monophosphatedependent Phosphorylation of a Specific Protein in Synaptic Membrane Fractions from Rat Cerebrum

1972 • 177 citations

Post‐tetanic potentiation at the neuromuscular junction of the frog

1969 • 176 citations

Selective phosphorylation of the alpha subunit of the sodium channel by cAMP-dependent protein kinase.

1982 • 168 citations

Modification of microtubule steady-state dynamics by phosphorylation of the microtubule-associated proteins.

1981 • 160 citations

Ca2+ -activated K+ conductance in internally perfused snail neurons is enhanced by protein phosphorylation.

1982 • 158 citations

In Vitro and in Vivo Phosphorylation of Myelin Basic Protein by Exogenous and Endogenous Adenosine 3′ : 5′-Monophosphate-dependent Protein Kinases in Brain

1974 • 145 citations

Mechanism of ATP quench of phosphodiesterase activation in rod disc membranes.

1983 • 144 citations

Regional distribution of calcium- and cyclic adenosine 3':5'- monophosphate-regulated protein phosphorylation systems in mammalian brain. I. Particulate systems

1983 • 143 citations

An endogenous substrate for cGMP-dependent protein kinase in mammalian cerebellum

1978 • 140 citations

Tyrosine hydroxylase activation in depolarized dopaminergic terminals—involvement of Ca2+ -dependent phosphorylation

1983 • 140 citations

Interaction of calmodulin with myosin light chain kinase and cAMP-dependent protein kinase in bovine brain.

1981 • 137 citations

Regional distribution of calcium- and cyclic adenosine 3':5'- monophosphate-regulated protein phosphorylation systems in mammalian brain. II. Soluble systems

1983 • 136 citations

Immunocytochemical localization, in synapses, of protein I, an endogenous substrate for protein kinases in mammalian brain.

1979 • 135 citations

Basic Protein in Brain Myelin Is Phosphorylated by Endogenous Phospholipid-Sensitive Ca²⁺-Dependent Protein Kinase

1982 • 116 citations

Phosphorylation of selected serine and threonine residues in myelin basic protein by endogenous and exogenous protein kinases

1974 • 115 citations

Stimulation of tyrosine hydroxylase activity by cyclic amp in synaptosomes and in soluble striatal enzyme preparations

1976 • 110 citations

Widespread distribution of protein I in the central and peripheral nervous systems.

1979 • 108 citations

Phosphorylation and activation of tyrosine hydroxylase mediate the acetylcholine-induced increase in catecholamine biosynthesis in adrenal chromaffin cells.

1982 • 106 citations

In vitro phosphorylation of bovine adrenal tyrosine hydroxylase by adenosine 3‘:5‘-monophosphate-dependent protein kinase.

1979 • 104 citations

Phosphorylation of microtubule-associated protein 2 by calmodulin-dependent protein kinase (Kinase II) which occurs only in the brain tissues

1982 • 103 citations

Multiple site phosphorylation of tyrosine hydroxylase. Differential regulation in situ by a 8-bromo-cAMP and acetylcholine.

1982 • 100 citations

A Cyclic Adenosine Monophosphate Link in the Catecholamine Enhancement of Transmitter Release at the Neuromuscular Junction

1974 • 100 citations

Phosphorylation of Myelin Basic Protein

1974 • 97 citations

Evidence for the lack of direct phosphorylation of bovine caudate tyrosine hydroxylase following activation by exposure to enzymatic phosphorylating conditions

1975 • 93 citations

Intracellular injection of protein kinase inhibitor blocks the serotonin-induced increase in K+ conductance in Aplysia neuron R15.

1982 • 93 citations

Facilitation, augmentation, and potentiation of synaptic transmission at the superior cervical ganglion of the rabbit.

1980 • 91 citations

Protein Kinase Injection Reduces Voltage-Dependent Potassium Currents

1983 • 90 citations

Sustained potentiation of transmitter release by adrenaline and dibutyryl cyclic AMP in sympathetic ganglia

1981 • 90 citations

A specific substrate from rabbit cerebellum for guanosine-3‘:5‘-monophosphate-dependent protein kinase. III. Amino acid sequences at the two phosphorylation sites.

1981 • 88 citations

Neurofilament protein is phosphorylated in the squid giant axon.

1978 • 87 citations

A specific substrate from rabbit cerebellum for guanosine 3‘:5‘-monophosphate-dependent protein kinase. I. Purification and characterization.

1981 • 85 citations

Nerve impulses increase the phosphorylation state of protein I in rabbit superior cervical ganglion

1982 • 85 citations

Dopamine and depolarizing agents regulate the state of phosphorylation of protein I in the mammalian superior cervical sympathetic ganglion.

1980 • 84 citations

Serotonin stimulates phosphorylation of Protein I in the facial motor nucleus of rat brain

1981 • 80 citations

Preferential phosphorylation of the 150,000 molecular weight component of neurofilaments by a cyclic AMP-dependent, microtubule-associated protein kinase.

1981 • 76 citations

Corticosterone Increases the Amount of Protein 1, A Neuron-Specific Phosphoprotein, in Rat Hippocampus

1981 • 74 citations

Disassembly of microtubules by the action of calmodulin-dependent protein kinase (kinase II) which occurs only in the brain tissues

1983 • 72 citations

Characteristics of the protein kinase activity associated with rat neurofilament preparations

1983 • 69 citations

A MAP-2-stimulated protein kinase activity associated with neurofilaments

1981 • 68 citations

Neurofilament protein phosphorylation. Species generality and reaction characteristics.

1982 • 67 citations

Phosphorylation of Microtubule‐Associated Proteins

1976 • 67 citations

Purification and characterization of protein IIIb, a mammalian brain phosphoprotein.

1982 • 64 citations

A Comparison of In Vitro‐ and In Vivo Phosphorylated Neurofilament Polypeptides

1981 • 63 citations

Serum antibodies that distinguish between the phospho- and dephospho-forms of a phosphoprotein

1982 • 62 citations

Tyrosine hydroxylase: studies on the phosphorylation of a purified preparation of the brain enzyme by the cyclic AMP-dependent protein kinase.

1981 • 61 citations

Translation of tyrosine hydroxylase from poly(A)-mRNA in pheochromocytoma cells is enhanced by dexamethasone.

1981 • 60 citations

A specific substrate from rabbit cerebellum for guanosine 3':5'-monophosphate-dependent protein kinase. II. Kinetic studies on its phosphorylation by guanosine 3':5'-monophosphate-dependent and adenosine 3':5'-monophosphate-dependent protein kinases.

1981 • 60 citations

Regulation of phosphorylation of proteins I, IIIa, and IIIb in rat neurohypophysis in vitro by electrical stimulation and by neuroactive agents.

1982 • 58 citations

Distribution of protein I and regulation of its state of phosphorylation in the rabbit superior cervical ganglion

1982 • 57 citations

Calcium ion stimulated endogenous protein kinase catalyzed phosphorylation of basic proteins in myelin subfractions and myelin-like membrane fraction from rat brain

1980 • 55 citations

Ca2+-Calmodulin dependent phosphorylation of myelin isolated from rabbit brain

1980 • 55 citations

Influence of Nerve Activity on the Macromolecular Content of Neurons and their Effector Organs

1981 • 54 citations

PROTEIN KINASES IN MYELIN OF RAT BRAIN: SOLUBILIZATION AND CHARACTERIZATION

1975 • 49 citations

On a soluble system for studying light activation of rod outer segment cyclic GMP phosphodiesterase

1977 • 46 citations

Protein kinases of retinal rod outer segments: identification and partial characterization of cyclic nucleotide dependent protein kinase and rhodopsin kinase

1981 • 45 citations

Calmodulin and Intracellular Ca++ Receptors

1982 • 44 citations

Regulation of the state of phosphorylation of specific neuronal proteins in mouse brain by in vivo administration of anesthetic and convulsant agents.

1979 • 43 citations

Isolation, characterization, and purification to homogeneity of a rat brain protein (GABA-modulin).

1982 • 42 citations

Activation of rhodopsin phosphorylation is triggered by the lumirhodopsin–metarhodopsin I transition

1983 • 41 citations

Cellular and subcellular localization of protein I in the peripheral nervous system.

1982 • 41 citations

Topography of the rhodopsin molecule. Identification of the domain phosphorylated

1978 • 37 citations

Neurotransmitter- and neuromodulator-dependent alterations in phosphorylation of protein I in slices of rat facial nucleus.

1981 • 36 citations

Neurotransmitter- and neuromodulator-dependent alterations in phosphorylation of protein I in slices of rat facial nucleus

1981 • 36 citations

The emerging molecular view of the sodium channel

1982 • 35 citations

Phosphorylation induces a decrease in the biological activity of the protein inhibitor (GABA-modulin) of gamma-aminobutyric acid binding sites.

1983 • 35 citations

The Role of Cyclic Nucleotides in the Nervous System

1982 • 31 citations

A Diurnal Rhythm in Pineal Protein 1 Content Mediated by β-Adrenergic Neurotransmission

1982 • 15 citations

In vivo phosphorylation of neurofilament proteins in the central nervous system of immature rat and rabbit

1982 • 13 citations

In Vivo Incorporation of [³²P]Orthophosphate into Myelin Basic Protein of Developing Rabbit Brain: Its Location in Components 3 and 5 and in a New Protein Tentatively Identified as Basic Protein Component 7

1982 • 10 citations

A Highly Active Calcium Ion Stimulated Endogenous Protein Kinase in Myelin: Kinetic and Other Characteristics, Calmodulin Dependence and Comparison with Other Brain Kinase(S)

1982 • 6 citations

Phosphorylation of myelin basic protein by vaccinia virus

1980 • 5 citations

Calmdoulin Dependent Protein Kinases from Rat Brain

1982 • 2 citations