Presynaptic modulation of neurochemical transmission

Stereotaxic Mapping of the Monoamine Pathways in the Rat Brain*

1971 • 3,816 citations

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

Adenosine 3‘,5‘-Phosphate in Biological Materials

1962 • 2,102 citations

Evidence for the existence of monoamine neurons in the central nervous system

1965 • 1,538 citations

Regulation of noradrenaline release by presynaptic receptor systems

1977 • 1,482 citations

The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart1

1929 • 1,470 citations

Biogenic Amines and the States of Sleep

1969 • 1,274 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

Muscarinic Cholinergic Binding in Rat Brain

1974 • 1,214 citations

Presynaptic regulation of catecholamine release

1974 • 1,145 citations

Cellular localization of brain monoamines.

1962 • 1,141 citations

Tetrodotoxin Blockage of Sodium Conductance Increase in Lobster Giant Axons

1964 • 1,065 citations

Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine

1975 • 1,010 citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

1975 • 981 citations

Opiate analgesics inhibit substance P release from rat trigeminal nucleus

1977 • 968 citations

Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.

1977 • 887 citations

Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

1975 • 874 citations

From neuron to brain

1976 • 867 citations

Autoradiographic localization of opiate receptors in rat brain. I. Spinal cord and lower medulla

1977 • 863 citations

Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-hydroxydopamine

1968 • 862 citations

TWO KINDS OF TRYPTAMINE RECEPTOR

1957 • 838 citations

Activation by Adenosine Triphosphate in the Phosphorylation Kinetics of Sodium and Potassium Ion Transport Adenosine Triphosphatase

1972 • 826 citations

Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena.

1966 • 809 citations

Immunohistochemical studies using antibodies to leucine-enkephalin: Initial observations on the nervous system of the rat

1976 • 767 citations

The after‐effects of impulses in the giant nerve fibres of Loligo

1956 • 748 citations

Catecholamine receptors on locus coeruleus neurons: Pharmacological characterization

1977 • 712 citations

The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea‐pig ileum longitudinal muscle strip

1969 • 698 citations

Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters†

1976 • 694 citations

Neurons containing beta-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies.

1978 • 656 citations

Effects of substance P on functionally identified units in cat spinal cord

1976 • 655 citations

Local regulation of adrenergic neurotransmission.

1977 • 645 citations

A CONCEPT FOR A ROLE OF SEROTONIN AND NOREPINEPHRINE AS CHEMICAL MEDIATORS IN THE BRAIN

1957 • 637 citations

THE ACTION OF MORPHINE AND RELATED SUBSTANCES ON CONTRACTION AND ON ACETYLCHOLINE OUTPUT OF COAXIALLY STIMULATED GUINEA‐PIG ILEUM

1997 • 632 citations

Opioid peptide enkephalin: immunohistochemical mapping in rat central nervous system.

1977 • 617 citations

PRESYNAPTIC RECEPTORS AND THEIR ROLE IN THE REGULATION OF TRANSMITTER RELEASE.

1977 • 616 citations

The origin of acetylcholine released from guinea‐pig intestine and longitudinal muscle strips

1968 • 610 citations

ACETYLCHOLINE METABOLISM OF A SYMPATHETIC GANGLION

1961 • 552 citations

Evidence for a central noradrenaline receptor stimulation by clonidine

1970 • 550 citations

Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non‐adrenergic inhibitory nerves in the gut

1997 • 548 citations

Dopamine ?Autoreceptors?: Pharmacological characterization by microiontophoretic single cell recording studies

1977 • 544 citations

Prostaglandins released by the Spleen

1968 • 542 citations

New concepts on the mechanism of action of benzodiazepines

1975 • 539 citations

Serotonin Content of Some Mammalian Tissues and Urine and a Method for Its Determination

1953 • 504 citations

Serotonin nerve terminals in adult rat neocortex

1975 • 504 citations

Mesencephalic dopamine neurons projecting to neocortex

1974 • 503 citations

A radioautographic study of the efferent pathways of the nucleus locus coeruleus

1974 • 500 citations

Studies on the Mechanism of the Dopamine-Mediated Inhibition of Prolactin Secretion¹

1974 • 499 citations

On the projections from the locus coeruleus noradrenaline neurons: The cerebellar innervation

1971 • 477 citations

Antischizophrenic Drugs and Brain Cholinergic Receptors

1974 • 474 citations

Presynaptic inhibition in the vertebrate central nervous system

2006 • 474 citations

Über humorale Übertragbarkeit der Herznervenwirkung

1924 • 473 citations

[D-Ala ² ]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic

1976 • 466 citations

Preferential blockade of presynaptic α-adrenoceptors by yohimbine

1975 • 466 citations

Presynaptic inhibition at the crayfish neuromuscular junction

1961 • 463 citations

THE AXON HILLOCK AND THE INITIAL SEGMENT

1968 • 458 citations

Relative pre- and postsynaptic potencies of ?-adrenoceptor agonists in the rabbit pulmonary artery

1975 • 455 citations

Drug‐Induced Changes in the Release of ³H‐Monoamines from Field Stimulated Rat Brain Slices

1971 • 453 citations

On the specific vaso‐dilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin)

1936 • 452 citations

Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones

1973 • 436 citations

Intracellular recording from the myenteric plexus of the guinea‐pig ileum

1973 • 435 citations

Origin and blockade of the synaptic responses of curarized sympathetic ganglia

1961 • 427 citations

Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity

1972 • 421 citations

Dopamine-Sensitive Adenyl Cyclase: Possible Role in Synaptic Transmission

1971 • 415 citations

Evidence for two separate opiate peptide neuronal systems

1978 • 413 citations

The output of sympathetic transmitter from the spleen of the cat

1957 • 405 citations

Central inhibitory action attributable to presynaptic depolarization produced by muscle afferent volleys

1961 • 405 citations

Heterogeneity of striatal and limbic dopamine innervation: Highly fluorescent islands in developing and adult rats

1972 • 404 citations

Anesthesia and the responsiveness of individual neurons of the caudate nucleus of the cat to acetylcholine, norepinephrine and dopamine administered by microelectrophoresis.

1965 • 395 citations

The spontaneous and evoked release of acetylcholine from the cerebral cortex

1963 • 386 citations

Cellular localization of monoamines in the median eminence and the infundibular stem of some mammals

1963 • 383 citations

Anti-muscarinic properties of neuroleptics and drug-induced Parkinsonism

1974 • 382 citations

Serotonin content of the brain stem nuclei in the rat

1974 • 380 citations

The action of norepinephrine in the rat hippocampus. I. Iontophoretic studies

1974 • 380 citations

Activation of the pathway from locus coeruleus to rat cerebellar Purkinje neurons: pharmacological evidence of noradrenergic central inhibition.

1973 • 370 citations

The effect of adenosine on the release of the transmitter from the phrenic nerve of the rat

1972 • 366 citations

Effect of drugs on the uptake and metabolism of H3-norepinephrine.

1961 • 364 citations

The effects of adrenaline, noradrenaline and isoprenaline on inhibitory α‐ and β‐adrenoceptors in the longitudinal muscle of the guinea‐pig ileum

1970 • 360 citations

Synaptic vesicles in sympathetic neurons.

1971 • 357 citations

The Myocardium in Hyperfunction, Hypertrophy and Heart Failure.

1969 • 357 citations

THE ASSAY AND DISTRIBUTION OF COENZYME A

1948 • 354 citations

Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. II. Sensitivity of Purkinje cells to norepinephrine and related substances administered by microiontophoresis

1971 • 354 citations

Synthesis, storage and release of [¹⁴C]acetylcholine in isolated rat diaphragm muscles

1970 • 353 citations

THE DISTRIBUTION OF SEROTONIN, 5‐HYDROXYTRYPTOPHAN DECARBOXYLASE, AND MONOAMINE OXIDASE IN BRAIN*

1957 • 350 citations

Antipsychotic drug actions: a clue to the neuropathology of schizophrenia?

1973 • 336 citations

Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. I. Localization of the fibers and their synapses

1971 • 334 citations

POSSIBLE ROLE OF A β‐ADRENOCEPTOR IN THE REGULATION OF NORADRENALINE RELEASE BY NERVE STIMULATION THROUGH A POSITIVE FEED‐BACK MECHANISM

1975 • 334 citations

On the association between transmitter secretion and the release of adenine nucleotides from mammalian motor nerve terminals.

1975 • 333 citations

Brain amines and models of experimental hypertension.

1975 • 329 citations

Presynaptic receptor systems on the noradrenergic neurones of rat brain

1977 • 325 citations

The mechanism of inhibition of neuronal activity by opiates in the spinal cord of cat

1976 • 321 citations

Micro‐electrophoretic studies of neurones in the cat hippocampus

1966 • 320 citations

Comparison of the effects of clonidine on pre-and postsynaptic adrenoceptors in the rabbit pulmonary artery

1974 • 316 citations

Enkephalin receptors on dopaminergic neurones in rat striatum

1977 • 312 citations

Electronmicroscopic localization of 5-hydroxydopamine (3,4,5-trihydroxy-phenyl-ethylamine), a New ‘false’ sympathetic transmitter

1967 • 311 citations

Adrenergic innervation of the intestinal wall studied by fluorescence microscopy

1964 • 310 citations

Regional distribution of leu and met enkephalin in rat brain

1977 • 307 citations

The generation of impulses in motoneurones

1957 • 306 citations

The action of norepinephrine in the rat hippocampus. II. Activation of the input pathway

1974 • 302 citations

Evidence for a long Leu-enkephalin striopallidal pathway in rat brain

1978 • 300 citations

Effect of clozapine on the turnover of dopamine in the corpus striatum and in the limbic system

1973 • 296 citations

Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart

1972 • 293 citations

Effects of α-adrenoceptor agonists and antagonists on pre- and postsynaptically located α-adrenoceptors

1976 • 292 citations

In Vitro Models in the Study of Structure-Activity Relationships of Narcotic Analgesics

1975 • 289 citations

Effects of adenosine on adrenergic neurotransmission; Prejunctional inhibition and postjunctional enhancement

1976 • 288 citations

Adenosine triphosphate. A constituent of cholinergic synaptic vesicles

1974 • 288 citations

Determination of methionine enkephalin in discrete regions of rat brain

1977 • 280 citations

ACTIONS OF CERTAIN AMINES ON CEREBRAL CORTICAL NEURONES

1963 • 280 citations

Sympathetic Postganglionic Mechanism

1959 • 280 citations

β-Endorphin as a potent analgesic by intravenous injection

1976 • 279 citations

Generation of slow inhibitory and excitatory postsynaptic potentials.

1970 • 277 citations

Metabolically linked vasoactive chemicals in local regulation of blood flow.

1968 • 275 citations

Utilization of sodium-dependent high affinity choline uptake as a measure of the activity of cholinergic neurons

1975 • 269 citations

Evidence for an α-sympathomimetic component in the effects of catapresan on vasomotor centres: Antagonism by piperoxane

1971 • 268 citations

The regional distribution of a morphine-like factor enkephalin in monkey brain

1976 • 266 citations

Evidence against adrenergic motor transmission in the guinea‐pig vas deferens

1971 • 264 citations

Enhanced striatal acetylcholine release by chlorpromazine and its reversal by apomorphine

1973 • 263 citations

Naloxone-induced reversal of schizophrenic hallucinations

1977 • 262 citations

β-Endorphin-Induced Changes in Schizophrenic and Depressed Patients

1977 • 253 citations

The inhibitory effect of adenosine and related nucleotides on the release of acetylcholine

1976 • 252 citations

β-Endorphin in vitro inhibition of striatal dopamine release

1976 • 252 citations

The mechanism of acetylcholine release from parasympathetic nerves

1971 • 251 citations

Further observations on the physiology and pharmacology of a sympathetic ganglion

1934 • 246 citations

Histochemical studies of the autonomic innervation of the gut.

1965 • 246 citations

Substance P and Excitatory Transmitter of Primary Sensory Neurons

1976 • 244 citations

Sympathetic inhibition of the urinary bladder and of pelvic ganglionic transmission in the cat

1972 • 244 citations

Adenosine 3′,5′-Monophosphate: Electrophysiological Evidence for a Role in Synaptic Transmission

1972 • 243 citations

Regional 5-hydroxytryptamine following selective midbrain raphe lesions in the rat

1974 • 242 citations

Regulation of monoamine metabolism in the central nervous system.

1972 • 241 citations

The Action of Neuroleptic Drugs on Dopamine-Stimulated Adenosine Cyclic 3',5'-Monophosphate Production in Rat Neostriatum and Limbic Forebrain

1974 • 240 citations

Presynaptic receptor systems in catecholaminergic transmission

1977 • 239 citations

Effects of dopaminergic receptor agonists and antagonists on the activity of the neo-striatal cholinergic system

1975 • 236 citations

Dopamine turnover in the corpus striatum and the limbic system after treatment with neuroleptic and anti-acetylcholine drugs

1972 • 235 citations

Modification of Morphine Withdrawal by Drugs interacting with Humoral Mechanisms: Some Contradictions and their Interpretation

1972 • 233 citations

The quantal components of the mammalian end‐plate potential

1956 • 232 citations

Regulation of Norepinephrine Biosynthesis

1970 • 231 citations

Some evidence for the existence of dopaminergic neurons in the rat cortex

1973 • 230 citations

CENTRAL DOPAMINERGIC NEURONS: NEUROPHYSIOLOGICAL IDENTIFICATION AND RESPONSES TO DRUGS**This research was supported by NIMH Grant MH-17871, USPHS Research Scientist Development Award MH-14459 (to G. K. A.), and the State of Connecticut.

1973 • 230 citations

Recent studies on functions and control of prolactin secretion in rats.

1972 • 229 citations

Anion permeability of the inhibitory post‐synaptic membrane of the crayfish neuromuscular junction

1967 • 227 citations

Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor.

1976 • 226 citations

Effect of drugs used in psychoses on cerebral dopamine metabolism

1970 • 226 citations

Inhibition of adrenergic neurotransmission by clonidine: An action on prejunctional α-receptors

1973 • 225 citations

Release of noradrenaline by splenic nerve stimulation and its dependence on calcium

1967 • 222 citations

Synaptic mechanisms in the substantia nigra

1976 • 217 citations

Evidence that Acetylcholine Released by Gastrin and Related Polypeptides Contributes to their Effect on Gastrointestinal Motility

1973 • 217 citations

Role of the α‐adrenoceptor in regulating noradrenaline overflow by nerve stimulation

1972 • 216 citations

Effect of nicotine and other drugs on the release of 3H-norepinephrine and 3H-dopamine from rat brain slices

1974 • 214 citations

Role of cyclic AMP in synaptic transmission in the mammalian peripheral nervous system.

1974 • 212 citations

Dopamine‐Containing Cells in Sympathetic Ganglia

1970 • 212 citations

Physiological and pharmacological evidence for a serotonergic projection to the hippocampus

1975 • 210 citations

Inhibition of acetylcholine release from cholinergic nerves by adenosine, adenine nucleotides and morphine: antagonism by theophylline.

1976 • 209 citations

Dopaminergic neurons: drug-induced antagonism of the increase in tyrosine hydroxylase activity produced by cessation of impulse flow.

1974 • 208 citations

Interaction between cholinergic and catecholaminergic neurones in rat brain

1972 • 208 citations

Central actions of ibotenic acid and muscimol

1968 • 208 citations

RELEASE OF γ‐AMINOBUTYRIC ACID INTO THE FOURTH VENTRICLE INDUCED BY STIMULATION OF THE CAT'S CEREBELLUM

1969 • 207 citations

Inhibition of noradrenaline uptake2 in the isolated rat heart by steroids, clonidine and methoxylated phenylethylamines

1972 • 207 citations

INHIBITION BY MORPHINE OF THE RELEASE OF ACETYLCHOLINE FROM THE INTESTINE OF THE GUINEA‐PIG

1957 • 206 citations

The after effects of a tetanus on mammalian muscle

1938 • 205 citations

Studies on the effect of prostaglandins E1 and E2 on the sympathetic neuromuscular transmission in some animal tissues.

1970 • 204 citations

Central Synaptic Transmission-Microelectrophoretic Studies

1969 • 203 citations

GAMMA-AMINOBUTYRIC ACID AND OTHER BLOCKING COMPOUNDS IN CRUSTACEA: III. THEIR RELATIVE CONCENTRATIONS IN SEPARATED MOTOR AND INHIBITORY AXONS

1963 • 203 citations

5‐Hydroxytryptamine participation in the vagal inhibitory innervation of the stomach

1967 • 203 citations

Substance P and analgesia

1976 • 202 citations

[Noradrenalin loss from the isolated rabbit heart following sympathetic nerve irritation and its pharmacological alteration].

1962 • 202 citations

Morphine and β-endorphin inhibit release of noradrenaline from cerebral cortex but not of dopamine from rat striatum

1978 • 201 citations

STUDIES ON ADRENERGIC NERVES. THE USE OF RAT AND MOUSE IRIS FOR DIRECT OBSERVATIONS ON THEIR PHYSIOLOGY AND PHARMACOLOGY AT CELLULAR AND SUBCELLULAR LEVELS.

1965 • 200 citations

MODIFICATION BY DRUGS OF THE METABOLISM OF 3,4‐DIHYDROXYPHENYLETHYLAMINE, NORADRENALINE AND 5‐HYDROXYTRYPTAMINE IN THE BRAIN

1965 • 200 citations

Negative feedback regulation of noradrenaline release by nerve stimulation in the perfused cat's spleen: differences in potency of phenoxybenzamine in blocking the pre‐ and post‐synaptic adrenergic receptors

1974 • 198 citations

A muscarinic inhibition of the noradrenaline release evoked by postganglionic sympathetic nerve stimulation

1969 • 197 citations

THE ESTIMATION OF SMALL QUANTITIES OF 3,4‐DIHYDROXYPHENYLETHYLAMINE IN TISSUES

1965 • 197 citations

Stimulation, by inhibition of (Na⁺‐K⁺‐Mg²⁺)‐activated, ATP‐ase, of acetylcholine release in cortical slices from rat brain

1972 • 196 citations

EFFECT OF ELECTRICAL STIMULATION ON THE YIELD AND COMPOSITION OF SYNAPTIC VESICLES FROM THE CHOLINERGIC SYNAPSES OF THE ELECTRIC ORGAN OF TORPEDO: A COMBINED BIOCHEMICAL, ELECTROPHYSIOLOGICAL AND MORPHOLOGICAL STUDY

1974 • 195 citations

Evidence that angiotensin enhances transmitter release during sympathetic nerve stimulation

1971 • 194 citations

Metabolism of [14C]adenine and derivatives by cerebral tissues, superfused and electrically stimulated

1972 • 193 citations

Fundamental Mechanisms in the Release of Catecholamines

1972 • 192 citations

Depression of Acetylcholine Release from Cerebral Cortical Slices by Cholinesterase Inhibition and by Oxotremorine

1973 • 191 citations

THE EFFECTS OF ADENOSINE TRIPHOSPHATE AND ADENOSINE DIPHOSPHATE ON TRANSMISSION AT THE RAT AND FROG NEUROMUSCULAR JUNCTIONS

1975 • 191 citations

Na+-K+-activated adenosinetriphosphatase as a trigger in transmitter release

1978 • 191 citations

The effect of cholinergic drugs on [3H]acetylcholine release from slices of rat hippocampus, striatum and cortex

1977 • 191 citations

Calcium-Dependent Norepinephrine Release from Presynaptic Nerve Endings In Vitro

1972 • 187 citations

Drug‐induced changes in the release of [³H]‐noradrenaline from field stimulated rat iris

1971 • 186 citations

Dual Adrenoceptor‐mediated Control of Noradrenaline Secretion from Human Vasoconstrictor Nerves: Facilitation by β‐receptors and Inhibition by α‐receptors

1975 • 185 citations

A new example of a morphine‐sensitive neuro‐effector junction: Adrenergic transmission in the mouse vas deferens

1997 • 184 citations

Control of insulin secretion by catecholamines, stress, and the sympathetic nervous system.

1973 • 183 citations

The metabolism of [³H]noradrenaline released by electrical stimulation from the isolated nictitating membrane of the cat and from the vas deferens of the rat

1970 • 182 citations

Microphysiology of vertebrate neuromuscular transmission.

1973 • 180 citations

Nicotinic effect of acetylcholine on the release of newly synthesized [3H]dopamine in rat striatal slices and cat caudate nucleus

1976 • 180 citations

Postsynaptic localization of muscarinic cholinergic receptor binding in rat hippocampus

1974 • 179 citations

Differential effect of neuroleptic drugs on dopamine turnover in the extrapyramidal and limbic system

1976 • 176 citations

Inhibition of sympathetic neurotransmission in canine blood vessels by adenosine and adenine nucleotides.

1977 • 175 citations

After‐effects of nerve impulses on signalling in the central nervous system of the leech

1969 • 174 citations

RELEASE OF ATP FROM A SYNAPTOSOMAL PREPARATION BY ELEVATED EXTRACELLULAR K⁺ AND BY VERATRIDINE

1978 • 173 citations

The rate of norepinephrine synthesis measured in vivo during short intervals; influence of adrenergic nerve impulse activity.

1968 • 172 citations

Influence of extracellular noradrenaline on the stimulation-evoked secretion of noradrenaline from sympathetic nerves: Evidence for an ?-receptor-mediated feed-back inhibition of noradrenaline release

1972 • 172 citations

Effect of vagal stimulation on the overflow of norepinephrine into the coronary sinus during cardiac sympathetic nerve stimulation in the dog.

1976 • 172 citations

Increase of membrane conductance by adrenaline in the smooth muscle of guinea-pig taenia coli

1969 • 171 citations

Intravenous Naloxone Administration in Schizophrenia and Affective Illness

1977 • 170 citations

Prostaglandins as modulators of the autonomic nervous system.

1974 • 169 citations

Noradrenaline inhibition of acetylcholine release from guinea-pig brain

1978 • 168 citations

A TECHNIQUE FOR THE STUDY OF ACETYLCHOLINE TURNOVER IN MOUSE BRAIN IN VIVO

1969 • 168 citations

The role of presynaptic receptors in the release and synthesis of 3H-dopamine by slices of rat striatum

1976 • 166 citations

Release of norepinephrine and dopamine-beta-hydroxylase by nerve stimulation. I. Role of neuronal and extraneuronal uptake and of alpha presynaptic receptors.

1974 • 165 citations

Presynaptic receptor systems on the noradrenergic neurones of the rabbit pulmonary artery

1977 • 165 citations

Pharmacological classification of adrenergic α receptors in the guinea pig

1978 • 164 citations

The regulation of norepinephrine synthesis in sympathetic nerves: effect of nerve stimulation, cocaine, and catecholamine-releasing agents.

1966 • 164 citations

The Role of Cyclic Nucleotides in the CNS

1977 • 163 citations

Reflex activation of sympathetic pathways to vesical smooth muscle and parasympathetic ganglia by electrical stimulation of vesical afferents.

1976 • 162 citations

In vivo identification of muscarinic cholinergic receptor binding in rat brain

1974 • 160 citations

Comparison of the effects of neuroleptic drugs on pre- and postsynaptic dopaminergic mechanisms in the rat striatum.

1976 • 160 citations

Amino Acids Released from the Cerebral Cortex in Relation to Its State of Activation

1965 • 158 citations

Adenosine as a putative transmitter in the cerebral cortex. Studies with potentiators and antagonists

1975 • 158 citations

In vitro release of Leu- and Met-enkephalin from the corpus striatum

1978 • 158 citations

β₂‐Adrenoceptors Facilitating Noradrenaline Secretion from Human Vasoconstrictor Nerves

1976 • 158 citations

An estimate of adenosine triphosphate release into the venous effluent from exercising human forearm muscle

1972 • 157 citations

A superactive antinociceptive pentapeptide, (D‐Met²,Pro⁵)‐enkephalinamide

1977 • 157 citations

Depression of spinal motoneurones by noradrenaline, 5-hydroxytryptamine and histamine

1968 • 157 citations

Depression by morphine and chloralose of acetylcholine release from the cat's brain

1965 • 156 citations

Morphine‐tolerant longitudinal muscle strip from guinea‐pig ileum

1973 • 155 citations

Changes of of extracellular potassium concentration induced by neuronal activity in the spinal cord of the cat

1974 • 155 citations

Effect of prostaglandin E2 on central and peripheral catecholamine neurons

1973 • 153 citations

SELECTIVE LOCALIZATION OF A HIGH AFFINITY CHOLINE UPTAKE SYSTEM AND ITS ROLE IN ACh FORMATTON IN CHOLINERGIC NERVE TERMINALS

1976 • 153 citations

d -Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback Pathway

1976 • 153 citations

EVIDENCE FOR A ROLE OF CYCLIC AMP IN NEUROMUSCULAR TRANSMISSION

1969 • 153 citations

The action of adrenaline on transmission in the superior cervical ganglion

1944 • 153 citations

UPTAKE AND RELEASE OF [¹⁴C]ADENINE DERIVATIVES AT BEDS OF MAMMALIAN CORTICAL SYNAPTOSOMES IN A SUPERFUSION SYSTEM

1974 • 153 citations

Isolation and structure identification of a morphine-like peptide “enkephalin” in bovine brain

1976 • 152 citations

A potent depressant action of adenine derivatives on cerebral cortical neurones

1975 • 152 citations

MECHANISM OF THE INDIRECT SYMPATHOMIMETIC EFFECT OF 5‐HYDROXYTRYPTAMINE ON THE ISOLATED HEART OF THE RABBIT

1976 • 151 citations

Influence of morphine and naloxone on the release of noradrenaline from rat brain cortex slices

1974 • 149 citations

Actions of angiotensin on adrenergic nerve endings.

1978 • 149 citations

Outflux of various phosphates during membrane depolarization of excitable tissues

1962 • 147 citations

Depression of Corticospinal Cells by Various Purines and Pyrimidines

1974 • 146 citations

Serotonin receptors in the brain.

1977 • 146 citations

Glial contamination of synaptosomal fractions

1976 • 146 citations

Importance of nervous impulse flow for the neuroleptic induced increase in amine turnover in central dopamine neurons

1971 • 145 citations

Presynaptic inhibitory actions of adenine nucleotides and adenosine on neurotransmission in the rat vas deferens

1977 • 145 citations

A MUSCARINIC MECHANISM INHIBITING THE RELEASE OF NORADRENALINE FROM PERIPHERAL ADRENERGIC NERVE FIBRES BY NICOTINIC AGENTS

1968 • 144 citations

Is GABA release modulated by presynaptic receptors?

1978 • 144 citations

Blockade of central 5-hydroxytryptamine receptors by methiothepin

1972 • 143 citations

Effects of Neuroleptics on Striatal Tyrosine Hydroxylase: Changes in Affinity for the Pteridine Cofactor

1974 • 141 citations

Effects of dopamine on the superior cervical ganglion of the rabbit

1974 • 140 citations

Cellular Localization of Monoamines in the Median Eminence and in the Infundibular Stem of Some Mammals

1963 • 140 citations

New possibilities for adrenergic modulation of ganglionic transmission.

1966 • 136 citations

The pharmacology of 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine (clozapine).

1971 • 136 citations

Release and metabolism of substance P in rat hypothalamus

1976 • 135 citations

Effect of flow‐stop on noradrenaline release from normal spleens and spleens treated with cocaine, phentolamine or phenoxybenzamine

1971 • 135 citations

Effects of microiontophoretically applied methionine-enkephalin on single neurones in rat brainstem

1976 • 135 citations

Enkephalin: A potential modulator of noradrenaline release in rat brain

1976 • 135 citations

Activation of a noradrenergic pathway from the brain stem to rat cerebral cortex

1977 • 134 citations

THE EFFECT OF TERTIARY AND QUATERNARY ATROPINE ON CORTICAL ACETYLCHOLINE OUTPUT AND ON THE ELECTROENCEPHALOGRAM IN CATS

1964 • 133 citations

Release of enkephalin from rat globus pallidus in vitro

1978 • 132 citations

SYMPATHETIC POSTGANGLIONIC CHOLINERGIC FIBRES

1960 • 132 citations

Metabolic response of synaptosomes to electrical stimulation: Release of amino acids

1970 • 131 citations

Possible axo-axonal synapses between peripheral adrenergic and cholinergic nerve terminals

1970 • 131 citations

Localization of opiate receptor binding in synaptic membranes of rat brain

1974 • 131 citations

THE OCCURRENCE OF PROSTAGLANDIN E₂ IN SPLENIC VENOUS BLOOD OF THE DOG FOLLOWING SPLENIC NERVE STIMULATION

1968 • 130 citations

Control by prostaglandin E2 of sympathetic neurotransmission in the spleen

1970 • 129 citations

Evaluation of mechanisms controlling the release and inactivation of the adrenergic transmitter in the rabbit portal vein and vas deferens

1972 • 128 citations

Inhibition by prostaglandin E1 of noradrenaline release and of effector response to nerve stimulation in the cat spleen

1969 • 126 citations

Renal Pressor System and Neurogenic Control of Arterial Pressure

1963 • 126 citations

Some effects produced by adrenaline upon neuromuscular propagation in rats

1958 • 126 citations

Effects of narcotic analgesics and antagonists on the in vivo release of acetylcholine from the cerebral cortex of the cat

1971 • 126 citations

The cholinergic pharmacology of hippocampal pyramidal cells: A microiontophoretic study

1976 • 126 citations

Naloxone in Chronic Schizophrenia

1977 • 126 citations

The effect of drugs on the release of norepinephrine-H from central nervous system tissued by electrical stimulation in vitro.

1967 • 126 citations

Dual localization of histamine in an ascending neuronal pathway and in non-neuronal cells evidenced by lesions in the lateral hypothalamic area

1976 • 125 citations

Cholinergic mechanisms in the caudate nucleus

1966 • 124 citations

Inhibition by dopamine of 3H-noradrenaline release elicited by nerve stimulation in the isolated cat's nictitating membrane

1975 • 124 citations

The subcellular localization of 5-hydroxytryptamine in guinea pig brain

1963 • 123 citations

Increased Nerve Stimulation Induced Release of Noradrenaline from the Rabbit Heart after Inhibition of Prostaglandin Synthesis

1971 • 122 citations

Effects of changes in ionic environment on the action of acetylcholine and adrenaline on the smooth muscle cells of guinea‐pig taenia coli

1963 • 121 citations

³H‐Noradrenaline Release and Mechanical Response in the Field Stimulated Mouse Vas Deferens

1971 • 121 citations

THE EFFECT OF ANALGESIC DRUGS ON THE RELEASE OF ACETYLCHOLINE FROM ELECTRICALLY STIMULATED GUINEA‐PIG ILEUM

1966 • 120 citations

Release of noradrenaline from the cat spleen by potassium

1968 • 119 citations

Accumulation and disappearance of catecholamines formed from tyrosine-14C in mouse brain; effect of some psychotropic drugs

1968 • 117 citations

Release of [3H]acetylcholine from rat hippocampal slices: Effect of septal lesion and of graded concentrations of muscarinic agonists and antagonists

1977 • 116 citations

Clozapine--a new antipsychotic agent.

1974 • 116 citations

PATTERNS OF AMINO ACID RELEASE FROM NERVE-ENDINGS ISOLATED FROM SPINAL CORD AND MEDULLA

1973 • 114 citations

Presynaptic inhibition at mammalian peripheral synapse?

1974 • 114 citations

A comparison of the effects of adenosine triphosphate with noradrenaline and with the inhibitory potential of the guinea‐pig taenia coli

1973 • 114 citations

AN ANALYSIS OF THE RESPONSES OF THE ISOLATED PORTAL VEIN OF THE RABBIT TO ELECTRICAL STIMULATION AND TO DRUGS

1967 • 113 citations

Direct detection of depolarisation-induced release of ATP from a synaptosomal preparation

1977 • 113 citations

Regulation of striatal acetylcholine concentration by dopamine receptors

1974 • 112 citations

In-vivo measurements of tryptophan and tyrosine hydroxylase activities in mouse brain

1973 • 111 citations

Enhanced release of dopamine -hydroxylase and norepinephrine from sympathetic nerves by dibutyryl cyclic adenosine 3', 5'-monophosphate and theophylline.

1973 • 111 citations

Site of adrenaline blockade in the superior cervical ganglion of the rabbit

1971 • 111 citations

Postsynaptic receptors are not essential for dopaminergic feedback regulation

1977 • 110 citations

Catecholamines released from cerebral cortex in the cat; decrease during sensory stimulation

1976 • 110 citations

Possible involvement of a transmitter different from norepinephrine in the residual responses to nerve stimulation of the cat nictitating membrane after pretreatment with reserpine.

1976 • 110 citations

Influence of drugs on the firing of serotonin-containing neurons in brain.

1972 • 110 citations

Involvement of brain cholinergic mechanisms in the action of chlorpromazine

1974 • 110 citations

Inhibition by Acetylcholine of Adrenergic Neurotransmission in Vascular Smooth Muscle

1974 • 110 citations

AGONIST AND ANTAGONIST ACTIONS OF MORPHINELIKE DRUGS ON THE GUINEA‐PIG ISOLATED ILEUM

1966 • 109 citations

SYNTHESIS AND STORAGE OF ACETYLCHOLINE IN NERVOUS TISSUE

1963 • 109 citations

Neurogenic release of purine compounds in blood vessels.

1975 • 108 citations

Concomitant Adrenergic and Parasympathetic Fibres in the Rat Iris

1966 • 108 citations

The effects of sympathetic nerve stimulation and guanethidine on parasympathetic neuroeffector transmission; the inhibition of acetylcholine release

1971 • 108 citations

Blockade of the nicotine-induced norepinephrine release by cocaine, phenoxybenzamine and desipramine.

1970 • 108 citations

On the relation between ATP splitting and secretion in the adrenal chromaffin cell: extrusion of ATP (unhydrolysed) during release of catecholamines

1966 • 107 citations

The dopamine-releasing actions of neuroleptics and ethanol.

1974 • 107 citations

Effect of synaptic transmission blockade on morphine action in the guinea-pig myenteric plexus.

1976 • 105 citations

Antagonistic effects of apomorphine and haloperidol on rat striatal synaptosomal tyrosine hydroxylase

1974 • 105 citations

Cardiovascular regulation by central adrenergic mechanisms and its alteration by hypotensive drugs.

1975 • 105 citations

Isoenzymes of soluble and membrane-bound acetylcholinesterase in bovine splanchnic nerve and adrenal medulla

1975 • 105 citations

Possible feed-back inhibition of noradrenaline release by purine compounds

1977 • 104 citations

Influence of ?-receptor stimulants on noradrenaline release

1971 • 104 citations

The release of acetylcholine from perfused sympathetic ganglia and skeletal muscles

1956 • 104 citations

Effect of psychoactive drugs on the output of acetylcholine from the cerebral cortex of the cat

1968 • 103 citations

The actions of the catecholamines on transmission in the superior cervical ganglion of the cat.

1966 • 103 citations

On the mechanism of release of norepinephrine from sympathetic nerves induced by depolarizing agents and sympathomimetic drugs.

1975 • 103 citations

Electrical events in cardiac adrenergic nerves and noradrenaline release from the heart induced by acetylcholine and KCl

1968 • 102 citations

Theophylline, epinephrine, and neostigmine facilitation of neuromuscular transmission.

1967 • 102 citations

Modulating Effect of Prostaglandin E₂ on Noradrenaline Release from the Isolated Cat Spleen

1969 • 102 citations

Studies on the Ganglionic Site of Action of Sympathetic Outflow to the Stomach

1966 • 101 citations

Stereospecific increase by narcotic antagonists of evoked acetylcholine output in guinea-pig ileum

1975 • 101 citations

A Cyclic Adenosine Monophosphate Link in the Catecholamine Enhancement of Transmitter Release at the Neuromuscular Junction

1974 • 100 citations

HISTAMINE AND SOME ANTIHISTAMINES: THEIR ACTIONS ON CEREBRAL CORTICAL NEURONES

1968 • 100 citations

The effect of prolactin on dopamine release from rat striatum and medial basal hypothalamus

1978 • 100 citations

Inhibition of adrenergic neurotransmission in canine vascular smooth muscle by histamine: mediation by H2-receptors.

1976 • 99 citations

The inhibition of noradrenaline uptake by drugs.

1965 • 99 citations

Effect of duration and frequency of stimulation on the presynaptic inhibition by ?-adrenoceptor stimulation of the adrenergic transmission

1973 • 99 citations

Inhibitory Synapses on Somas of Purkinje Cells in the Cerebellum

1963 • 98 citations

Presynaptic inhibition leading to disinhibition of acetylcholine release from interneurons of the caudate nucleus: Effects of dopamine, β-endorphin and d-Ala2-Pro5-enkephalinamide

1977 • 98 citations

Stimulation by atropine of acetylcholine release and synthesis in cortical slices from rat brain

1970 • 98 citations

Inhibition by parasympathetic nerve stimulation of the release of the adrenergic transmitter

1970 • 98 citations

Clozapine--a potential antipsychotic agent without extrapyramidal manifestations.

1974 • 98 citations

ANGIOTENSIN AND PERIPHERAL SYMPATHETIC NERVE ACTIVITY

1964 • 97 citations

THE REGULATION OF TRANSMITTER RELEASE ELICITED BY NERVE STIMULATION THROUGH A PRESYNAPTIC FEED-BACK MECHANISM

1973 • 97 citations

Adrenaline and Transmission in the Sympathetic Ganglion of the Cat

1952 • 97 citations

THE INFLUENCE OF CENTRALLY ACTING CHOLINOLYTIC DRUGS ON BRAIN ACETYLCHOLINE LEVELS

1964 • 96 citations

The use of the push-pull cannula to estimate the dynamics of acetylcholine and catecholamines within various brain areas

1976 • 95 citations

Influence of enkephalin on K+-evoked efflux of putative neurotransmitters in rat brain

1977 • 95 citations

The sympathomimetic effect of acetylcholine on the spleen of the cat

1963 • 95 citations

Prostaglandin-induced neurotransmission failure in the field-stimulated, isolated vas deferens

1972 • 94 citations

Prostaglandins reverse Inhibition of Electrically-induced Contractions of Guinea Pig Ileum by Morphine, Indomethacin and Acetylsalicylic Acid

1973 • 94 citations

The cerebral acetylcholine release in conscious rabbits with semi-permanently implanted epidural cups

1968 • 94 citations

Effects of methionine-enkephalin and leucine-enkephalin compared with those of morphine on brainstem neurones in cat

1976 • 94 citations

Inhibition of the sympathetic nervous system by 5,6-dihydroxy-2-dimethylamino tetralin (M-7), apomorphine and dopamine.

1975 • 94 citations

Changes in neostriatal da metabolism after carbachol or atropine microinjections into the substantia nigra

1974 • 93 citations

Nerve terminal ATPase as possible trigger for neurotransmitter release

1975 • 93 citations

The inhibition of catecholamine biosynthesis by apomorphine

1970 • 93 citations

On the locaticn of methicnine enkephalin neurons in rat striatum

1977 • 93 citations

The Pharmacology of the Synaptic and Acetylcholine‐Induced Excitation of Ventrobasal Thalamic Neurones

1964 • 93 citations

Physiological significance of α-adrenoceptor-mediated negative feedback mechanism regulating noradrenaline release during nerve stimulation

1977 • 92 citations

The influence of atropine on the release and uptake of acetylcholine by the isolated cerebral cortex of the rat

1966 • 92 citations

Post-stimulation changes of extracellular potassium concentration in the spinal cord of the rat

1972 • 92 citations

The effect of catecholamines and sympathetic stimulation on the release of acetylcholine from the guinea‐pig colon

1969 • 92 citations

Inhibition of post‐ganglionic motor transmission in vas deferens by indirectly acting sympathomimetic drugs

1972 • 91 citations

The effect of topically applied atropine on resting and evoked cortical acetylcholine release

1969 • 90 citations

The responsiveness of individual hypothalamic neurons to microelectrophoretically administered endogenous amines

1963 • 90 citations

Relationship between acetylcholine content and release in the cat's cerebral cortex

1970 • 89 citations

Piribedil and apomorphine: pre- and postsynaptic effects on dopamine synthesis and neuronal activity.

1975 • 89 citations

Effects of adenosine analogs on rat cerebral cortical neurons

1976 • 89 citations

The effect of intracerebroventricularly administered GABA on brain monoamine metabolism

1977 • 89 citations

DEMONSTRATION OF ACETYLCHOLINE RELEASE BY MEASURING EFFLUX OF LABELLED CHOLINE FROM CEREBRAL CORTICAL SLICES

1972 • 89 citations

Modification of the evoked release of noradrenaline from the perfused cat spleen by various ions and agents

1972 • 89 citations

Effects of LSD on synthesis and release of 5-HT in rat brain slices

1974 • 89 citations

Autonomic Neuroreceptor Mechanisms in Brain Vessels

1974 • 88 citations

A pharmacologic comparison of histamine receptors in isolated extracranial and intracranial arteries in vitro

1975 • 88 citations

The release of 3H-adenosine and its derivatives from cat sensorimotor cortex

1975 • 88 citations

Effect of frequency of stimulation on the inhibition by noradrenaline of the acetylcholine output from parasympathetic nerve terminals

1971 • 87 citations

Activation of Na-K Activated ATPase in Rat Brain by Catecholamine

1973 • 87 citations

Inhibition of gastrointestinal movement by sympathetic nerve stimulation: the site of action

1967 • 87 citations

Pre- and postsynaptic components in effect of drugs with α adrenoceptor affinity

1975 • 86 citations

Potentiation of phenothiazines by?-methyltyrosine in treatment of chronic schizophrenia

1972 • 86 citations

Postsynaptic release of adenosine triphosphate induced by single impulse transmitter action

1976 • 86 citations

Cholinergic link hypothesis in adrenergic neuroeffector transmission.

1966 • 85 citations

ELECTRICAL STUDIES ON THE PHARMACOLOGY OF AUTONOMIC SYNAPSES II. THE ACTION OF A SYMPATHOMIMETIC DRUG (EPINEPHRINE) ON SYMPATHETIC GANGLIA

1939 • 84 citations

Cyclic amp and α-receptor-mediated modulation of noradrenaline release from rat brain slices

1976 • 84 citations

Modulation by histamine of the efflux of radiolabeled catecholamines from rat brain slices

1977 • 84 citations

Electrically stimulated release of opiate-like material from the myenteric plexus of the guinea pig ileum

1977 • 84 citations

THE OUTPUT PER STIMULUS OF ACETYLCHOLINE FROM CEREBRAL CORTICAL SLICES IN THE PRESENCE OR ABSENCE OF CHOLINESTERASE INHIBITION

1974 • 84 citations

Effect of muscarinic agonists on the release of 3H-norepinephrine and 3H-doapmine by potassium and electrical stimulation from rat brain slices

1974 • 84 citations

Release of norepinephrine and dopamine-beta-hydroxylase by nerve stimulation. IV. An evaluation of a role for cyclic adenosine monophosphate.

1975 • 84 citations

Oxotremorine and central monoamine neurons

1967 • 83 citations

β Endorphin inhibits ACh turnover in nuclei of rat brain

1977 • 83 citations

In vivo actions of clozapine and haloperidol on the turnover rate of acetylcholine in rat striatum.

1976 • 82 citations

Action of various adenine derivatives on cerebellar Purkinje cells

1975 • 82 citations

Inhibition of adrenergic neurotransmission by parasympathomimetics in the rabbit ear artery.

1973 • 82 citations

THE EFFECT OF INDOMETHACIN ON THE RELEASE OF PROSTAGLANDIN E₂ AND ACETYLCHOLINE FROM GUINEA‐PIG ISOLATED ILEUM AT REST AND DURING FIELD STIMULATION

1974 • 81 citations

The effect of trivastal, haloperidol and dibutyryl cyclic AMP on [14C]dopamine synthesis in rat striatum

1973 • 81 citations

Dopamine neurons: role of impulse flow and presynaptic receptors in the regulation of tyrosine hydroxylase.

1975 • 81 citations

Synthesis and uptake of 5-hydroxytryptamine by the myenteric plexus of the guinea-pig ileum. A histochemical study.

1971 • 80 citations

Synaptic Transmission in the Central Nervous System and Its Relevance for Drug Action

1969 • 80 citations

Effects of phenoxybenzamine on the uptake and metabolism of noradrenaline in the rat heart and vas deferens

1969 • 80 citations

Release of ATP from stimulated nerve electroplaque junctions

1975 • 78 citations

The action of EGTA on the catecholamines stimulation of rat brain Na-K-ATPase

1974 • 78 citations

Histamine H1 and H2-Receptors at a Ganglionic Synapse

1973 • 78 citations

K+-dependent phosphatase activity observed in the presence of both adenosine triphosphate and Na+

1969 • 78 citations

Stimulating action of atropine on the release of acetylcholine by rat cerebral cortex in vitro

1971 • 77 citations

Neuronal peptide (enkephalin) receptors in the ear artery of the rabbit

1976 • 77 citations

Ascorbic acid-like effect of the soluble fraction of rat brain on adenosine triphosphatases and its relation to catecholamines and chelating agents

1974 • 77 citations

EFFECT OF COCAINE, PHENOXYBENZAMINE AND PHENTOLAMINE ON THE CATECHOLAMINE OUTPUT FROM SPLEEN AND ADRENAL MEDULLA.

1963 • 77 citations

A quantitative electron microscopic study of the purkinje cell axon initial segment

1976 • 77 citations

Secretion, Fates and Actions of Insulin and Related Products

1966 • 77 citations

Subcellular localization of 5-hydroxytryptamine in rat brain

1963 • 77 citations

The site and receptors responsible for the inhibition by sympathetic nerves of intestinal smooth muscle and its parasympathetic motor nerves

1977 • 76 citations

α-Bungarotoxin enhances transmitter ‘released’ at the neuromuscular junction

1978 • 76 citations

Influence of cocaine and phenoxybenzamine on noradrenaline uptake and release

1971 • 76 citations

Regulatory significance of the release and action of adenine derivatives in cerebral systems

1972 • 76 citations

THE EFFECTS OF MORPHINE ON THE RELEASE OF NORADRENALINE FROM THE CAT ISOLATED NICTITATING MEMBRANE AND THE GUINEA‐PIG ILEUM MYENTERIC PLEXUS‐LONGITUDINAL MUSCLE PREPARATION

1975 • 75 citations

A MODULATING ROLE OF PROSTAGLANDINS IN CONTRACTIONS OF THE GUINEA‐PIG ILEUM

1974 • 75 citations

Potentiation of postjunctional cholinergic sensitivity of rat diaphragm muscle by high-energy-phosphate adenine nucleotides

1976 • 75 citations

Acetylcholine release from guinea‐pig ileum by parasympathetic ganglion stimulants and gastrin‐like polypeptides

1973 • 75 citations

Effects of several muscarinic agonists on cardiac performance and the release of noradrenaline from sympathetic nerves of the perfused rabbit heart

1972 • 74 citations

The inactivation of infused noradrenaline by the cat spleen

1965 • 74 citations

The effect of catecholamines on transport (Na,K) adenosine triphosphatase

1977 • 74 citations

Failure of hypophysectomy to alter brain content of opioid peptides (endorphins)

1976 • 74 citations

Acetylcholine-releasing effect of gastrin and related polypeptides

1972 • 73 citations

The stimulus‐induced release of acetylcholine from synaptosome beds and its calcium dependence

1972 • 73 citations

CHOLINERGIC TRANSMISSION AND ACETYLCHOLINE OUTPUT

1963 • 73 citations

The effects of a soluble factor and of catecholamines on the activity of adenosine triphosphatase in subcellular fractions of rat brain

1972 • 73 citations

Effects of morphine on kinetics of 14C-dopamine in rat striatal slices

1974 • 72 citations

THE EFFECTS OF MORPHINE ON THE RELEASE OF NORADRENALINE FROM THE MOUSE VAS DEFERENS

1976 • 72 citations

Pharmacology of pyramidal tract cells in the cerebral cortex

1973 • 72 citations

The effect of lithium on acetylcholine release and synthesis

1972 • 72 citations

Opioid peptides and opiates differ in receptor selectivity

1977 • 71 citations

Pharmacological experiments on the release of the sympathetic transmitter

1963 • 71 citations

Influence of drugs with affinity for α-adrenoceptors on noradrenaline release by potassium, tyramine and dimethylphenylpiperazinium

1974 • 71 citations

Involvement of adrenergic receptors in central vagus activity

1971 • 71 citations

Termination of transmitter release by stimulation of sodium‐potassium activated ATPase.

1977 • 70 citations

Actions and interactions of narcotic agonists and antagonists on brain stem neurones

1974 • 70 citations

Mode of Action of Morphine-like Drugs on Autonomic Neuro-effectors

1968 • 70 citations

RELEASE OF ³H‐PURINES FROM [³H]‐ADENINE LABELLED RABBIT KIDNEY FOLLOWING SYMPATHETIC NERVE STIMULATION, AND ITS INHIBITION BY α‐ADRENOCEPTOR BLOCKADE

1978 • 69 citations

Effect of angiotensin and phenoxybenzamine on release of norepinephrine in vessels during sympathetic nerve stimulation

1967 • 69 citations

LIBERATION OF ACETYLCHOLINE AND ADRENALINE BY STIMULATING ISOLATED NERVES

1939 • 69 citations

Unterschiede zwischen Tyramin und Dimethylphenylpiperazin in der Ca++-Abhängigkeit und im zeitlichen Verlauf der Noradrenalin-Freisetzung am isolierten Kaninchenherzen

1967 • 69 citations

EVIDENCE FOR PROSTAGLANDIN MEDIATED PREJUNCTIONAL CONTROL OF RENAL SYMPATHETIC TRANSMITTER RELEASE AND VASCULAR TONE

1975 • 68 citations

The effects of dibutyryl cyclic adenosine 3',5'-monophosphate, theophylline and aminophylline on neuromuscular transmission in the rat.

1974 • 68 citations

THE DISTRIBUTION OF MUSCARINIC RECEPTOR SITES IN THE NERVOUS SYSTEM OF THE DOG

1974 • 68 citations

Adrenergic innervation of the ileum of the cat

1971 • 68 citations

Basic Mechanisms and Local Feedback Control of Secretion of Adrenergic and Cholinergic Neurotransmitters

1975 • 68 citations

Characterization of an endogenous morphine-like factor(enkephalin) in mammalian brain.

1976 • 67 citations

FORMATION, STORAGE, AND RELEASE OF ACETYLCHOLINE AT NERVE ENDINGS

1959 • 67 citations

Effects of desipramine, phentolamine and phenoxybenzamine on the release of noradrenaline from isolated tissues

1970 • 67 citations

CHOLINE UPTAKE BY CHOLINERGIC NEURON CELL SOMAS

1976 • 66 citations

SIZES OF END PLATE COMPARTMENTS, DENSITIES OF ACETYLCHOLINE RECEPTOR AND OTHER QUANTITATIVE ASPECTS OF NEUROMUSCULAR TRANSMISSION

1973 • 65 citations

THE EFFECTS OF OUABAIN AND THE ACTIVATION OF NEURAL MEMBRANE ATPase BY BIOGENIC AMINES

1976 • 65 citations

Extracellular potassium and trasmitter release at the giant synapse of squid.

1977 • 64 citations

Antagonism by Calcium of the Inhibitory Action of Prostaglandin E₂ on Sympathetic Neuro‐transmission in the Cat Spleen

1970 • 64 citations

Evidence for drug actions on both pre- and postsynaptic catecholamine receptors in the CNS.

1975 • 64 citations

Effect of amantadine on cerebral acetyl-choline release and content in the guinea pig

1973 • 64 citations

Relation between the rate of stimulation and the quantity of noradrenaline liberated from sympathetic nerve endings in the isolated perfused spleen of the cat.

1965 • 64 citations

The role of calcium in the central effects of biogenic amines

1974 • 63 citations

Liquid Chromatographic Analysis of Endogenous Catecholamine Release from Brain Slices

1977 • 63 citations

Role of chemical factors in regulation of flow through kidney, hindlimb, and heart

1965 • 63 citations

Regional accumulation of catecholamines formed from tyrosine-14C in rat brain: Effect of chlorpromazine

1969 • 62 citations

Effect of oxotremorine on homovanillic acid concentration in the striatum of the rat

1974 • 62 citations

The turnover rate of acetylcholine in brain nuclei of rats injected intraventricularly and intraseptally with alpha and beta-endorphin

1978 • 62 citations

Regulation of [3H]5-hydroxytryptamine release from rat brain slices

1974 • 61 citations

Presynaptic α‐ and β‐adrenoceptor Mediated Control of Noradrenaline Release in Human Oviduct

1975 • 61 citations

Modulation by prostaglandins of contractions in guinea-pig ileum

1975 • 61 citations

Substanz P, ein Polypeptid aus Darm und Gehirn mit depressiven, hyperalgetischen und Morphin-antagonistischen Wirkungen auf das Zentralnervensystem

1956 • 61 citations

Prostaglandin-induced inhibition of vascular tone and reactivity in the cat's hindleg in vivo

1972 • 60 citations

The nerve impulse-blocking actions of tranquilizers and the binding of neuroleptics to synaptosome membranes.

1974 • 60 citations

Release of endogenous noradrenaline from an isolated muscular artery

1971 • 60 citations

Differential behaviour of LPH‐(61–91)‐peptide in different model systems: Comparison of the opioid activities of LPH‐(61–91)‐peptide and its fragments

1977 • 60 citations

Inhibition of firing is the primary effect of microelectrophoresis phoresis of cortisol to units in th rat tuberal hypothalamus

1974 • 60 citations

Hallucinogenic phenylethylamines: Interactions with serotonin turnover and receptors

1974 • 60 citations

The inhibitory action of noradrenaline and adrenaline on release of acetylcholine from guinea-pig ileum longitudinal strips

1968 • 60 citations

Direct localisation of β-adrenoceptor sites in rat cerebellum by a new fluorescent analogue of propranolol

1976 • 59 citations

Direct evidence of acetylcholine releasing effect of serotonin in the Auerbach plexus

1978 • 59 citations

Inhibition of acetylcholine turnover in rat hippocampus by intraseptal injections of ?-endorphin and morphine

1977 • 59 citations

Nerve stimulation-meditated overflow of norepinephrine and dopamine-beta-hydroxylase. III. Effects of norepinephrine depletion on the alpha presynaptic regulation of release.

1975 • 59 citations

Inhibition by sympathomimetic amines of the release of norepinephrine evoked by nerve stimulation in the cat spleen.

1973 • 59 citations

A quantitative study of alpha adrenergic receptors in the spleen and aorta of the rabbit.

1972 • 59 citations

Tremorine and atropine effects on brain acetylcholine

1963 • 59 citations

Effects of Acetylcholine and Some Other Smooth Muscle Stimulants on the Electrical and Mechanical Responses of the Guinea‐Pig Vas Deferens to Nerve Stimulation

1973 • 58 citations

STIMULATION OF PRESYNAPTIC β‐ADRENOCEPTORS ENHANCES [³H]‐N0RADRENALINE RELEASE DURING NERVE STIMULATION IN THE PERFUSED CAT SPLEEN

1978 • 57 citations

The effect of central stimulant drugs on acetylcholine release from rat cerebral cortex

1968 • 57 citations

The estrous cycle: its influence on single unit activity in the forebrain

1971 • 57 citations

The turnover rate of gamma-aminobutyric acid in the nuclei of telencephalon: implications in the pharmacology of antipsychotics and of a minor tranquilizer.

1977 • 57 citations

An electrophysiological analysis of the storage and release of noradrenaline at sympathetic nerve terminals

1973 • 57 citations

Effects of pilocarpine or arecoline administration on acetylcholine levels and serotonin turnover in rat brain.

1972 • 57 citations

The possibility that ATP is a transmitter at sensory nerve endings.

1953 • 57 citations

Atropine-induced changes of cerebral dopamine turnover

1971 • 57 citations

Effect of ergot drugs on central 5-hydroxytryptamine neurons: Evidence for 5-hydroxytryptamine release or 5-hydroxytryptamine receptor stimulation

1975 • 56 citations

RELATED CHANGES IN AMOUNTS OF ACh AND ATP IN RESTING AND ACTIVE TORPEDO NERVE ELECTROPLAQUE SYNAPSES

1977 • 56 citations

Adenosine inhibition of isolated rabbit ileum and antagonism by theophylline.

1976 • 56 citations

Acetylcholine release from the rabbit isolated superior cervical ganglion preparation

1973 • 55 citations

Release of 3H-γ-Aminobutyric Acid from the Brain during Synaptic Inhibition

1969 • 55 citations

The storage and release of acetylcholine by cholinergic nerve terminals: recent results with non-mammalian preparations.

1972 • 55 citations

Evidence that most noradrenaline is stored without ATP in sympathetic large dense core nerve vesicles

1974 • 55 citations

MODIFICATION OF BRAIN ACETYLCHOLINE RELEASE BY MORPHINE AND ITS ANTAGONISTS IN NORMAL AND MORPHINE‐DEPENDENT RATS

1974 • 54 citations

Depression of rat cerebral cortical neurones by H1 and H2 histamine receptor agonists

1976 • 54 citations

Inhibition by prostaglandin E1 of parasympathetic neuro-transmission in the rabbit heart

1971 • 53 citations

PULSE-TO-PULSE MODULATION OF NORADRENALINE RELEASE THROUGH A PREJUNCTIONAL α-RECEPTOR AUTO-INHIBITORY MECHANISM

1973 • 53 citations

The influence of drugs on the uptake of acetylcholine by slices of rat cerebral cortex

1969 • 52 citations

Facilitation of the release of noradrenaline and dopamine- -hydroxylase at low stimulation frequencies by -blocking agents.

1971 • 52 citations

Modulation of Synaptic Transmitter Release by Repetitive Postsynaptic Action Potentials

1976 • 52 citations

Acetylcholine Release at Parasympathetic Synapses

1950 • 52 citations

Effects of narcotic opiates and serotonin on the electrical behavior of neurons in the guinea pig myenteric plexus

1974 • 52 citations

Dual site of action of phenoxybenzamine in the cat's spleen: Blockade of α-adrenergic receptors and inhibition of re-uptake of neurally released norepinephrine

1964 • 52 citations

Alpha-adrenoceptor Mediated Feed-back Control of Sympathetic Neurotransmitter Secretion in Guinea-pig Vas Deferens

1973 • 52 citations

Constant rate infusion of deuterated phosphorylcholine to measure the effects of morphine on acetylcholine turnover rate in specific nuclei of rat brain

1977 • 52 citations

The effect of intraperitoneally administered GABA on brain monoamine metabolism

1977 • 51 citations

Inhibitory effect of prostaglandin E2 on noradrenaline secretion from sympathetic nerves as a function of external calcium

1973 • 51 citations

Extracellular recording from the guinea-pig myenteric plexus and the action of morphine

1977 • 51 citations

THE EFFECT OF BICUCULLINE, METRAZOL, PICROTOXIN AND STRYCHNINE ON THE RELEASE OF [³H]GABA FROM RAT BRAIN SLICES

1971 • 51 citations

PROSTAGLANDINS AT ADRENERGIC NERVE-ENDINGS

1973 • 51 citations

The effects of cholinomimetic drugs on responses to sympathetic nerve stimulation and noradrenaline in the rabbit ear artery

1970 • 51 citations

On the Release of Prostaglandin E₂from the Rabbit Heart Following Infusion of Noradrenaline

1973 • 50 citations

Some Further Aspects on the Release of the Adrenergic Transmitter

1970 • 50 citations

Cation dependence of the noradrenaline-releasing action of tyramine

1969 • 50 citations

Cholinomimetic Drugs and Release of the Adrenergic Transmitter

1970 • 50 citations

The influence of raphe lesions on the effect of morphine on nociception and cortical ACh output

1975 • 50 citations

ATP; related nucleotides and adenosine on neurotransmission

1978 • 49 citations

AN EXAMINATION OF ADRENERGIC AXONS AROUND PANCREATIC ARTERIOLES OF THE CAT FOR THE PRESENCE OF ACETYLCHOLINESTERASE BY HIGH RESOLUTION AUTORADIOGRAPHIC AND HISTOCHEMICAL METHODS

1968 • 49 citations

Effect of hyoscine on the output of acetylcholine into perfused cerebral ventricles of cats.

1965 • 49 citations

Synaptic organization of the glomerular complexes in the lateral geniculate nucleus of Cebus monkey

1968 • 49 citations

Effects of morphine, nalorphine and naloxone on neocortical release of acetylcholine in the rat

1973 • 49 citations

Modulation by prostaglandins of the release of acetylcholine and noradrenaline in guinea pig isolated ileum

1979 • 49 citations

PROCEEDINGS OF THE BRITISH PHARMACOLOGICAL SOCIETY

1973 • 48 citations

Affinity of Noradrenaline and Dopamine for Neural α‐Receptors Mediating Negative Feedback Control of Noradrenaline Secretion in Human Vasoconstrictor Nerves

1975 • 48 citations

Effects of neuroleptics on release of 3H-dopamine from slices of rat corpus striatum

1977 • 48 citations

Evidence for an α‐ and β₂‐Receptor Mediated Inhibition of the Twitch Response in the Guinea Pig Vas Deferens by Noradrenaline

1975 • 48 citations

Correlation between analgesia and the decrease of acetylcholine turnover rate in cortex and hippocampus elicited by morphine, meperidine, viminol R2 and azidomorphine.

1976 • 47 citations

The relationship between tremor and change in brain acetylcholine concentration produced by injection of tremorine or oxotremorine in the rat

1969 • 47 citations

Gas chromatographic evaluation of the influence of oxotremorine upon the regional distribution of acetylcholine in rat brain¹

1970 • 47 citations

Synaptic architecture in the medial geniculate body (ventral division)

1968 • 47 citations

Effect of calcium on the relationship between frequency of stimulation and release of noradrenaline from the perfused spleen of the cat

1975 • 46 citations

Interactions of angiotensin, phenoxybenzamine and propranolol on noradrenaline release during sympathetic nerve stimulation

1972 • 46 citations

Do presynaptic auto-receptors control dopamine release?

1978 • 46 citations

Evidence against cyclic adenosine 3′,5′-monophosphate (AMP) mediation of noradrenaline depression of cerebral cortical neurones

1973 • 45 citations

Acute changes in central serotonin metabolism induced by the blockade or stimulation of serotoninergic receptors during ontogenesis in the rat.

1977 • 45 citations

Prostaglandin-Dependent and-independent feedback control of noradrenaline secretion in vasoconstrictor nerves of normotensive human subjects

1973 • 45 citations

TREMORGENIC AGENTS AND BRAIN ACETYLCHOLINE

1966 • 45 citations

Influence of reserpine‐induced depletion of noradrenaline on the negative feed‐back mechanism for transmitter release during nerve stimulation

1973 • 45 citations

Frequency dependence of dual negative feedback control of secretion of sympathetic neurotransmitter in guinea‐pig vas deferens

1973 • 44 citations

The in vivo release of acetylcholine from cat caudate nucleus after pharmacological and surgical manipulations of dopaminergic nigrostriatal neurons

1973 • 44 citations

Evidence against a physiological role of prostaglandins in the regulation of noradrenaline release in the cat spleen.

1975 • 43 citations

AN ELECTROPHYSIOLOGICAL ANALYSIS OF THE EFFECTS OF AMINE‐UPTAKE BLOCKERS AND α‐ADRENOCEPTOR BLOCKERS ON ADRENERGIC NEUROMUSCULAR TRANSMISSION

1975 • 43 citations

Effect of nigral lesion on chlorpromazine-induced acceleration of dopamine synthesis from [14C]tyrosine

1971 • 42 citations

THE ORIGIN OF THE ACETYLCHOLINE RELEASED SPONTANEOUSLY FROM THE GUINEA‐PIG ISOLATED ILEUM

1963 • 42 citations

Interactions of morphine, adenosine, adenosine triphosphate and phosphodiesterase inhibitors on the field-stimulated guinea-pig ileum.

1975 • 42 citations

THE CARDIOVASCULAR EFFECTS OF BROMOCRIPTINE IN PARKINSONISM

1976 • 42 citations

Prostaglandin E Restricting Noradrenaline Secretion—Neural in Origin?

1972 • 42 citations

AN ELECTROPHYSIOLOGICAL ANALYSIS OF THE EFFECT OF Ca IONS ON NEUROMUSCULAR TRANSMISSION IN THE MOUSE VAS DEFERENS

1975 • 42 citations

Action of catecholamines on release of acetylcholine from human taenia coli

1970 • 41 citations

Specificity of blockade of the nicotine-induced release of 3H-norepinephrine from adrenergic neurons of the guinea-pig heart by various pharmacological agents.

1974 • 41 citations

Vascular and Metabolic Effects of Theophylline, Dibuturyl Cyclic AMP and Dibuturyl Cyclic GMP in Canine Subcutaneous Adipose Tissue in situ¹

1974 • 41 citations

Oxotremorine- and atropine-induced changes of dopamine metabolism in the rat striatum

1975 • 41 citations

Kinetics of Secretion of Sympathetic Neurotransmitter as a Function of External Calcium: Mechanism of Inhibitory Effect of Prostaglandin E

1973 • 40 citations

Detection of two endorphin-like peptides in nucleus caudatus

1978 • 40 citations

A role of cyclic nucleotides in neuromuscular transmission.

1976 • 40 citations

Venous Relaxation Caused by Acetylcholine Acting on the Sympathetic Nerves

1973 • 40 citations

The role of acetylcholine in synaptic transmission at parasympathetic ganglia

1953 • 40 citations

Effects of dopaminergic drugs and acute medial forebrain bundle lesions on striatal acetylcholine levels

1975 • 40 citations

THE EFFECT OF AMITRIPTYLINE ON PRESYNAPTIC MECHANISMS IN NORADRENERGIC NERVES

1978 • 39 citations

Modification of precipitated morphine withdrawal syndrome by drugs affecting cholinergic mechanisms

1973 • 39 citations

MORPHINE–NALOXONE INTERACTION IN THE CENTRAL CHOLINERGIC SYSTEM: THE INFLUENCE OF SUBCORTICAL LESIONING AND ELECTRICAL STIMULATION

1976 • 39 citations

Noradrenaline Storage in Skeletal Muscle¹

1964 • 39 citations

THE EFFECTS OF CYCLIC N‐2‐O‐DIBUTYRYL‐ADENOSINE 3′, 5′‐MONOPHOSPHATE, ADRENALINE AND AMINOPHYLLINE ON THE ISOMETRIC CONTRACTILITY OF THE ISOLATED HEMIDIAPHRAGM OF THE RAT

1975 • 38 citations

Effects of some catecholamines on noradrenergic transmission in the rabbit ear artery.

1976 • 38 citations

Modification of Precipitated Morphine and Methadone Abstinence in Mice by Acetylcholine Antagonists

1973 • 38 citations

Evidence for the presynaptic location of adenylate cyclase and the cyclic AMP-stimulated protein kinase which is bound to synaptic membranes

1977 • 38 citations

Effect of biogenic amines and gaba on ATPase activities in mouse tissue

1976 • 37 citations

Action of adenosine triphosphate on endplate potentials recorded from muscle fibres of the rat‐diaphragm and frog sartorius

1973 • 37 citations

Release of norepinephrine and dopamine-beta-hydroxylase by nerve stimulation. II. Effects of papaverine.

1974 • 37 citations

Acetylcholine synthesis in rat brain: Dissimilar effects of clozapine and chlorpromazine

1975 • 37 citations

Prostaglandin as a tool for local control of transmitter release from sympathetic nerves

1973 • 37 citations

PROTECTION BY PHENTOLAMINE AGAINST THE EFFECTS OF PHENOXYBENZAMINE ON TRANSMITTER RELEASE ELICITED BY NERVE STIMULATION IN THE PERFUSED CAT HEART

1974 • 37 citations

Action of morphine on guinea-pig myenteric plexus and mouse vas deferens studied by intracellular recording

1975 • 37 citations

An electrophysiological analysis of the uptake of noradrenaline at sympathetic nerve terminals

1973 • 36 citations

Effects of caffeine on neuromuscular transmission in the rat

1973 • 36 citations

The effect of cyclic nucleotides on the release of 3H-dopamine from rat striatal slices.

1976 • 36 citations

Effects of methylxanthines and imidazole on hte contractions of guinea-pig ileum induced by transmural stimulation

1976 • 36 citations

Effects of colchicine and cytochalasin B on the release of 3H-norepinephrine from guinea-pig atria evoked by high potassium, nicotine and tyramine

1973 • 36 citations

Muscarinic modulation of acetylcholine release evoked by dimethylphenylpiperazinium and high potassium from guinea-pig myenteric plexus

1978 • 35 citations

Interrelationships between Adrenergic and Cholinergic Mechanisms

1972 • 35 citations

Effect of presynaptic α-adrenoceptor blockade on responses to cardiac nerve stimulation in anesthetized dogs

1976 • 34 citations

Proceedings: Interaction between adrenergic and cholinergic systems: presynaptic inhibitory effect of noradrenaline on acetylcholine release.

1974 • 34 citations

Presynaptic inhibition of acetylcholine release by endogenous and exogenous noradrenaline at high rate of stimulation.

1970 • 34 citations

Blockade by morphine of acetylcholine release from the caudate nucleus in the mid-pontine pretrigeminal cat

1975 • 34 citations

ENHANCEMENT BY OXOTREMORINE OF ACETYLCHOLINE RELEASE FROM THE RAT PHRENIC NERVE

1978 • 34 citations

Slow potentials induced by changes of extracellular potassium in the spinal cord of the cat

1975 • 33 citations

EFFECTS OF IPRINDOLE ON RESPONSES OF SINGLE CORTICAL AND CAUDATE NEURONES TO MONOAMINES AND ACETYLCHOLINE

1975 • 33 citations

Negative naloxone effects in schizophrenic patients

1977 • 33 citations

Inhibition of the effect of repetitive stimulation on spinal motoneurones of the cat by morphine and pethidine

1966 • 33 citations

Absence of adenine nucleotide release from autonomic ganglion

1974 • 33 citations

The effect of epinephrine, levarterenol, and dl-isoproterenol on transmission in the superior cervical ganglion of the cat.

1956 • 33 citations

AN INHIBITORY ROLE FOR NORADRENALINE IN THE MOUSE VAS DEFERENS

1977 • 32 citations

Adrenergic False Transmitters

1972 • 31 citations

Facilitation of noradrenaline release from rat brain synaptosomes by prostaglandin E2

1976 • 31 citations

Prostaglandin Release and Mechanical Performance in the Isolated Rabbit Heart during Induced Changes in the Internal Environment

1975 • 31 citations

Comparison of effect of morphine‐like analgesics on transmurally stimulated guinea‐pig ileum

1969 • 31 citations

Structure activity relations for inhibition of neurotransmission in rat vas deferens by adenosine

1978 • 30 citations

Influence of prostaglandins on autonomic responses

1971 • 30 citations

Analysis of the mechanism of action of some ganglion‐blocking drugs in the rabbit superior cervical ganglion

1972 • 30 citations

Catecholamine release and receptors in brain slices

1973 • 30 citations

Comparison of secretion of sympathetic neurotransmitter induced by nerve stimulation with that evoked by high potassium, as triggers of dual alpha-adrenoceptor mediated negative feed-back control of noradrenaline secretion

1973 • 30 citations

Effect of the norepinephrine receptor stimulating agent ?clonidine? on the turnover of 5-hydroxytryptamine in some areas of the rat brain

1975 • 30 citations

Biochemical evidence of adrenergic interaction with cholinergic function in the central nervous system of the rat

1971 • 29 citations

A new view on an old drug: Pilocarpine

1960 • 29 citations

THE ACTION OF CATECHOLAMINES IN SYMPATHETIC GANGLIA

1963 • 28 citations

?-Sympathicomimetische Eigenschaften als Ursache der blutdrucksteigernden und blutdrucksenkenden Wirkung von BAY 1470 (2-(2,6-Xylidino)-5,6-dihydro-4H-1,3-thiazinhydrochlorid)

1971 • 28 citations

Adenosine 3′:5′-cyclic monophosphate as a mediator in the action of neurohumoral agents

1972 • 28 citations

On the mechanism of release of norepinephrine from cat spleen slices by sodium deprivation and calcium pretreatment.

1975 • 27 citations

Caffeine effects on transmitter depletion and mobilization at motor nerve terminals

1969 • 27 citations

Tolerance to and physical dependence on morphine: relation to neocortical acetylcholine release in the cat.

1974 • 27 citations

Lack of effect of morphine in reducing the release of labelled acetylcholine from brain slices stimulated electrically

1974 • 27 citations

Nicotinic drugs and postganglionic sympathetic transmission

1970 • 27 citations

Mechanism of morphine block of electrical activity in ganglia of Auerbach's plexus

1976 • 27 citations

Cholinergic and adrenergic inhibition in the rat cerebral cortex

1967 • 26 citations

Sympathomimetic inhibition of noradrenaline release: Mediated by prostaglandins?

1973 • 26 citations

Clozapine, a novel major tranquilizer. Clinical experiences and pharmacotherapeutic hypotheses.

1972 • 25 citations

Ganglionic blocking properties of epinephrine and related amines

1966 • 24 citations

Effect of acetylcholine on the response of the isolated rabbit ear artery to stimulation of the perivascular sympathetic nerves

1972 • 24 citations

Morphine-like analgesic effect of a pituitary hormone, β-lipotropin

1976 • 24 citations

The effect of number of stimuli and rate of stimulation on the inhibition by PGE1 of adrenergic transmission

1973 • 23 citations

Der Einflu� von Atropin auf die Noradrenalin-Freisetzung durch Acetylcholin

1967 • 23 citations

Effect of clonidine on responses to cardiac nerve stimulation as a function of impulse frequency and stimulus duration in vagotomized dogs

1974 • 23 citations

Effect of clozapine and some other antipsychotic agents on synthesis and turnover of dopamine formed from 14C-tyrosine in mouse brain.

1973 • 23 citations

Cholinergic, adrenergic, and purinergic neuromuscular transmission.

1977 • 23 citations

SYNTHESIS AND RELEASE OF PROSTAGLANDINS BY RAT BRAIN SYNAPTOSOMAL FRACTIONS¹

1976 • 23 citations

HIGH AFFINITY CHOLINE TRANSPORT IN GUINEA PIG BRAIN AND THE EFFECT OF NOREPINEPHRINE

1975 • 23 citations

The variation of noradrenaline output with frequency of nerve stimulation and the effect of morphine on the cat nictitating membrane and on the guinea-pig myenteric plexus.

1972 • 23 citations

MODULATION BY ACETYLCHOLINE OF ADRENERGIC TRANSMISSION IN THE RABBIT EAR ARTERY

1975 • 23 citations

The effects of hexamethonium, morphine and adrenaline on the output of acetylcholine from the myenteric plexus-longitudinal muscle preparation of the ileum.

1970 • 22 citations

EFFECTS OF ACETYLCHOLINE RELEASING DRUGS ON ELECTRICAL ACTIVITIES OBTAINED FROM AUERBACH'S PLEXUS IN THE GUINEA PIG ILEUM

1974 • 22 citations

The effect of ergotamine and methysergide on serotonin metabolism in the rat brain.

1975 • 22 citations

Inhibitory effect of dopamine on acetylcholine release from caudate nucleus.

1977 • 22 citations

5-HT hyperpolarization of bullforg sympathetic ganglion cell membrane

1973 • 22 citations

Regulation of catecholamine release. The muscarinic inhibitory mechanism

1973 • 21 citations

AN ELECTROPHYSIOLOGICAL ANALYSIS OF THE EFFECTS OF RESERPINE ON ADRENERGIC NEUROMUSCULAR TRANSMISSION

1975 • 21 citations

On the Mechanism of the Enhancement by Smooth Muscle Stimulants of the Motor Responses of the Guinea‐pig Vas Deferens to Nerve Stimulation

1974 • 21 citations

Role of the α‐Receptor in the Control of Noradrenaline Release from Sympathetic Nerves

1974 • 21 citations

The effect of 1,1-dimethyl-4-phenyl-piperazinium on the response of mesenteric arteries to sympathetic nerve stimulation

1969 • 21 citations

Catecholamine-stimulated prostaglandin synthesis in rat brain synaptosomes

1976 • 21 citations

Inhibition of adrenergic neurotransmission by prostaglandin E1 (PGE1) in the rabbit ear artery

1976 • 21 citations

Effect of Atropine on Vascular Adrenergic Neuroeffector Transmission

1977 • 21 citations

Dependence liability of enkephalin in the myenteric plexus of the guinea pig

1976 • 21 citations

A Prolonged After-Effect of Intense Synaptic Activity on Acetylcholine in a Sympathetic Ganglion

1975 • 20 citations

The effects of PGE1 on responses to cardiac vagus nerve stimulation and acetylcholine release

1973 • 20 citations

Isolation of a COOH-terminal beta-lipotropin fragment (residues 61--91) with morphine-like analgesic activity from porcine pituitary glands.

1976 • 20 citations

Proceedings: Modulation of frequency-dependent noradrenaline release by calcium, angiotensin and morphine.

1974 • 19 citations

Stereoselectivity of Presynaptic a‐Adrenoceptors Involved in Feedback Control of Sympathetic Neurotransmitter Secretion

1974 • 19 citations

Receptor Feedback and Dopamine Turnover in CNS

1975 • 19 citations

Subsensitivity of the presynaptic alpha adrenoceptors after short-term surgical denervation of the cat nictitating membrane.

1977 • 19 citations

Effect of oxotremorine on endogenous acetylcholine and on uptake and biotransformation of radioactive choline in discrete regions of mouse brain in vivo

1976 • 19 citations

Investigation of the mechanism of action of oxotremorine on the guinea‐pig isolated ileum preparation

1971 • 19 citations

Modification by prostaglandin E₂ (PGE₂) of the response of guinea‐pig isolated vasa deferentia and atria to adrenergic stimuli

1972 • 18 citations

Effect of hemicholinium-3 on the release and net synthesis of acetylcholine in Auerbach's plexus of guinea pig ileum

1977 • 18 citations

5-HT and the electrogenic sodium pump

1974 • 18 citations

Coenzyme A is a purine nucleotide modulator of acetylcholine output

1978 • 18 citations

Effect of normorphine and enkephalin on spontaneous potentials in the vas deferens

1976 • 18 citations

PROLACTIN STIMULATION TEST WITH PERPHENAZINE: AN EVALUATION OF PLASMA PROLACTIN LEVELS AND PITUITARY SECRETORY ACTIVITY IN THE RAT

1976 • 18 citations

Functional significance of α-stimulation and α-blockade on responses to cardiac nerve stimulation in anesthetized dogs

1974 • 17 citations

Adrenergic mechanisms in the relaxation of guinea-pig taenia coli in vitro.

1971 • 17 citations

Prostaglandin Induced Inhibition of Neurotransmission in the Isolated Guinea Pig Seminal Vesicle

1972 • 17 citations

Effect of adrenergic factors on peristalsis and acetylcholine release

1971 • 17 citations

Output of Sympathin from the Spleen

1956 • 17 citations

Perfusion of the spleen with blood containing prostaglandin E ₁ : transmitter liberation and uptake

1969 • 17 citations

Modulation of adrenergic transmission by acetylcholine.

1975 • 17 citations

Effects of cyclic nucleotides on mammalian motor nerve terminals.

1976 • 16 citations

RELEASE OF NORADRENALINE FROM CAT SPLEEN SLICES BY POTASSIUM

1978 • 16 citations

ASPECTS ON PROSTAGLANDIN AND α-RECEPTOR MEDIATED CONTROL OF TRANSMITTER RELEASE FROM ADRENERGIC NERVES

1973 • 16 citations

The effect of cyclic N-2-O-dibutyryl-adenosine-3′, 5′-monophosphate on neuromuscular transmission and concentration of glycogen in the isolated phrenic nerve-diaphragm preparation of the rat

1972 • 16 citations

Two kinds of opiate receptor.

1977 • 16 citations

Inhibition of the sympathetic nervous system by dopamine.

1975 • 16 citations

THE EFFECT OF MORPHINE ON THE ADRENERGIC NERVES OF THE ISOLATED GUINEA‐PIG JEJUNUM

1961 • 15 citations

The effect of oxotremorine on the acetylcholine content of different parts of cat brain

1970 • 15 citations

Inhibition of sodium-potassium activated brain adenosine triphosphatase (Na+ - K+-ATPase) by adrenergic blocking alkylating agents

1969 • 15 citations

Presynaptic action of epineprhine on sympathetic ganglia

1969 • 15 citations

Some physiological and pharmacological characteristics of the stimulus induced release of norepinephrine from the rabbit superior cervical ganglion

1975 • 14 citations

Effects of lysergic acid diethylamide on autonomic post‐ganglionic transmission.

1975 • 14 citations

Differentiation between opioid peptides by naltrexone

1977 • 14 citations

The effect of electrical stimulation and drugs on the release of acetylcholine from the frog spinal cord

1976 • 14 citations

Effects of sympathetic nerve stimulation on electrical activity of Auerbach's plexus and intestinal smooth muscle tone

1977 • 14 citations

Effect of β‐haloalkylamines and ephedrine on noradrenaline release from the intact spleen of the cat

1970 • 14 citations

Stimulation by morphine of acetylcholine output from the cerebral cortex of septal rats

1975 • 13 citations

Presynaptic Modulation by Norepinephrine and Dopamine of Acetylcholine Release in the Peripheral and Central Nervous System

1978 • 13 citations

Presence of muscarinic inhibitory and absence of nicotinic excitatory receptors at the terminal sympathetic nerves of chicken hearts

1976 • 13 citations

PROCEEDINGS OF THE BRITISH PHARMACOLOGICAL SOCIETY

1975 • 12 citations

Restriction of transmitter release from adrenergic nerves mediated by prostaglandins and alpha-adrenoreceptors.

1974 • 12 citations

Effect of atropine on acetylcholine release from cerebral cortical slices stimulated at different frequencies.

1971 • 12 citations

The Isolated Nictitating Membrane of the Cat

1978 • 12 citations

Differential blockage and potentiation of transmission in a sympathetic ganglion.

1970 • 12 citations

Evidence against prostaglandin E having a physiological role in acetylcholine liberation from Auerbach's plexus of guinea-pig ileum

1975 • 11 citations

Influence of adenosine, cAMP and db-cAMP on responses of the isolated terminal guinea-pig ileum to electrical stimulation.

1976 • 11 citations

The action of enkephalins and enkephalin analogues on neurotransmission in the isolated nictitating membrane of the cat

1978 • 11 citations

The effect of methacholine on noradrenaline release from the rabbit heart perfused with indometacin

1974 • 11 citations

Effect of prostaglandin E1 and indomethacin on responses of longitudinal muscle of guinea-pig ileum to cholecystokinin

1979 • 11 citations

Release of Sympathetic Transmitter by Nerve Stimulation

2008 • 11 citations

Proceedings: Changes in acetylcholinesterase concentration in rabbit cerebrospinal fluid following central electrical stimulation.

1976 • 10 citations

Effect of arecoline on synaptosomal K+-phosphatase and (Na+ + K+)-ATPase.

1976 • 10 citations

Adrenergic neuroeffector junctions sensitive and insensitive to the effect of PGE.

1974 • 10 citations

Increase by enkephalin of acetylcholine release from striatal slices of the rat.

1978 • 10 citations

36 Competition between β-haloalkylamines and norepinephrine for sites in cardiac muscle

1961 • 9 citations

[The action of isoprenaline on intestinal muscle].

1952 • 9 citations

Effect of atropine and oxotremorine on the release of acetylcholine from the frog spinal cord

1976 • 8 citations

Effect of Scopolamine on the Cerebral Accumulation of <sup>14</sup>C-Catecholamines from <sup>14</sup>C-Tyrosine

1972 • 8 citations

Presynaptic inhibition of acetylcholine release from cholinergic neurones in the myenteric plexus of the guinea-pig ileum [proceedings].

1978 • 7 citations

Prostaglandin E₂ Inhibits Nerve Stimulation‐Induced Smooth Muscle Contraction in Isolated Human Omental Vein by Depressing Secretion of Noradrenaline

1976 • 7 citations

Effects of naturally occurring catecholamines on adrenergic neuro-effector interaction in isolated cutaneous veins.

1976 • 6 citations

Effects of acetylcholine on vasoconstriction and release of 3 H-noradrenaline in response to sympathetic nerve stimulation in the isolated artery of the rabbit ear.

1972 • 6 citations

Do potassium ions released from nerve modulate the sensitivity to transmitter in ‘close’ neuro-effector junctions of the vas deferens?

1977 • 6 citations

The effect of oxotremorine on the acetylcholine output from the CSF containing spaces

1975 • 6 citations

The Twitch Contraction in Guinea‐pig Isolated Vas Def erens–Result of Cooperative Interaction of Potassium and Noradrenaline Released from Adrenergic Nerves in Close Junctions?

1976 • 6 citations

A simple, rapid method for detecting the efflux of small quantities of adenosine triphosphate from biological tissues

1974 • 4 citations

Comparison of the effects of dopamine and noradrenaline on single cortical neurones [proceedings].

1977 • 4 citations

Coenzyme A or adenosine inhibiting acetylcholine release? (reply)

1978 • 3 citations

Selective inhibition of noradrenergic transmission in vascular smooth muscle.

1978 • 3 citations

Applicability of the isolated perfused rat brain for studying central cholinergic mechanisms

1974 • 3 citations

Inhibition of norepinephrine release in vascular smooth muscle by acetycholine. Due to hyperpolarization of adrenergic nerve endings?

1975 • 3 citations

Effects of chlorpromazine on acetylcholine turnover in vivo.

1974 • 2 citations

SYNTHESIS OF 5-HYDROXYTRYPTAMINE BY INTRINSIC NEURONS OF THE MAMMALIAN MYENTERIC PLEXUS

1977 • 2 citations

BLOCKING EFFECT OF ATROPINE ON VASCULAR ADRENERGIC NEUROEFFECTOR TRANSMISSION

1977 • 1 citations

Chemistry of the lipotropins

1976 • 1 citations

Deleted Work

1955 • 0 citations