The present status of the vesicular hypothesis

Quantal components of the end‐plate potential

1954 • 2,182 citations

EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTION

1973 • 2,122 citations

Spontaneous subthreshold activity at motor nerve endings

1952 • 1,820 citations

Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.

1979 • 1,408 citations

Stimulus‐secretion coupling: the concept and clues from chromaffin and other cells

1968 • 1,393 citations

The separation of synaptic vesicles from nerve-ending particles (‘synaptosomes’)

1964 • 1,213 citations

The release of neural transmitter substances

1969 • 1,134 citations

Handbook of Psychopharmacology

1978 • 1,034 citations

TURNOVER OF TRANSMITTER AND SYNAPTIC VESICLES AT THE FROG NEUROMUSCULAR JUNCTION

1973 • 835 citations

The release of neural transmitter substances

1970 • 685 citations

Tetrodotoxin‐resistant electric activity in presynaptic terminals

1969 • 613 citations

Cholinergic Mechanisms

1981 • 609 citations

SOME FEATURES OF THE SUBMICROSCOPIC MORPHOLOGY OF SYNAPSES IN FROG AND EARTHWORM

1955 • 576 citations

The isolation and characterization of acetylcholine-containing particles from brain

1959 • 570 citations

ACETYLCHOLINE METABOLISM OF A SYMPATHETIC GANGLION

1961 • 552 citations

Functional changes in frog neuromuscular junctions studied with freeze-fracture

1974 • 516 citations

Distribution of lipids in subcellular particles of guinea-pig brain

1964 • 476 citations

Structure and Function of Synapses.

1972 • 472 citations

THE "VESICLE IN A BASKET"

1969 • 445 citations

Transmitter leakage from motor nerve endings

1977 • 443 citations

ISOLATION OF SYNAPTIC VESICLES AND STRUCTURAL ORGANIZATION OF THE ACETYLCHOLINE SYSTEM WITHIN BRAIN NERVE ENDINGS*

1963 • 435 citations

Cholinesterases and Anticholinesterase Agents

1963 • 409 citations

The fine structure of the neuromuscular junction of the frog

1960 • 396 citations

Actomyosin-Like Protein in Brain

1973 • 364 citations

Synthesis, storage and release of [¹⁴C]acetylcholine in isolated rat diaphragm muscles

1970 • 353 citations

THE FORMATION OF ACETYLCHOLINE. A NEW ENZYME: "CHOLINE ACETYLASE"

1943 • 326 citations

The number of transmitter molecules in a quantum: an estimate from iontophoretic application of acetylcholine at the neuromuscular synapse.

1975 • 325 citations

Electron microscopy of presynaptic organelles of the spinal cord.

1963 • 307 citations

Metabolic Compartmentation and Neurotransmission

1975 • 301 citations

DEPLETION OF VESICLES FROM FROG NEUROMUSCULAR JUNCTIONS BY PROLONGED TETANIC STIMULATION

1972 • 296 citations

The smooth endoplasmic reticulum: structure and role in the renewal of axonal membrane and synaptic vesicles by fast axonal tranport

1975 • 294 citations

Correlation between nerve terminal size and transmitter release at the neuromuscular junction of the frog

1971 • 292 citations

Adenosine triphosphate. A constituent of cholinergic synaptic vesicles

1974 • 288 citations

THE ULTRASTRUCTURE OF A REPTILIAN MYONEURAL JUNCTION

1956 • 262 citations

Studies of excitable membranes. II. A comparison of specializations at neuromuscular junctions and nonjunctional sarcolemmas of mammalian fast and slow twitch muscle fibers.

1976 • 262 citations

Effect of lanthanum ions on function and structure of frog neuromuscular junctions

1971 • 259 citations

Lipid composition of synaptic plasma membranes isolated from rat brain by zonal centrifugation

1969 • 248 citations

Calcium buffering in presynaptic nerve terminals. I. Evidence for involvement of a nonmitochondrial ATP-dependent sequestration mechanism.

1978 • 240 citations

Ultrastructure of the ‘active zone’ in the frog neuromuscular junction

1973 • 221 citations

The preparation and characterization of synaptic vesicles of high purity

1976 • 221 citations

Histophysiology of Synapses and Neurosecretion

1964 • 216 citations

Presynaptic action of hemicholinium at the neuromuscular junction

1965 • 215 citations

Multimodal Distribution of Frog Miniature Endplate Potentials in Adult, Denervated, and Tadpole Leg Muscle

1974 • 210 citations

CHANGES IN THE FINE STRUCTURE OF THE NEUROMUSCULAR JUNCTION OF THE FROG CAUSED BY BLACK WIDOW SPIDER VENOM

1972 • 207 citations

The biogenesis of adrenal chromaffin granules

1977 • 203 citations

Stimulation-Dependent Alterations in Peroxidase Uptake at Lobster Neuromuscular Junctions

1971 • 202 citations

Biological Sciences: Release of ATP from Rat Motor Nerve Terminals

1973 • 201 citations

The effect of type D botulinum toxin on frog neuromuscular junctions

1971 • 200 citations

Stimulation, by inhibition of (Na⁺‐K⁺‐Mg²⁺)‐activated, ATP‐ase, of acetylcholine release in cortical slices from rat brain

1972 • 196 citations

EFFECT OF ELECTRICAL STIMULATION ON THE YIELD AND COMPOSITION OF SYNAPTIC VESICLES FROM THE CHOLINERGIC SYNAPSES OF THE ELECTRIC ORGAN OF TORPEDO: A COMBINED BIOCHEMICAL, ELECTROPHYSIOLOGICAL AND MORPHOLOGICAL STUDY

1974 • 195 citations

Changes in total and quantal release of acetylcholine in the mouse diaphragm during activation and inhibition of membrane ATPase.

1979 • 191 citations

The isolation of pure cholinergic synaptic vesicles from the electric organs of elasmobranch fish of the family Torpedinidae

1972 • 189 citations

The ‘compartmentation’ of choline acetyltransferase within the synaptosome

1967 • 182 citations

Microphysiology of vertebrate neuromuscular transmission.

1973 • 180 citations

Evidence that coated vesicles isolated from brain are calcium-sequestering organelles resembling sarcoplasmic reticulum.

1977 • 180 citations

Isolation of pure cholinergic nerve endings from Torpedo electric organ. Evaluation of their metabolic properties.

1977 • 177 citations

RELEASE OF ATP FROM A SYNAPTOSOMAL PREPARATION BY ELEVATED EXTRACELLULAR K⁺ AND BY VERATRIDINE

1978 • 173 citations

Calcium Transient in Presynaptic Terminal of Squid Giant Synapse: Detection with Aequorin

1972 • 171 citations

ON THE ISOLATION OF NERVE ENDINGS AND SYNAPTIC VESICLES

1961 • 168 citations

Isolation of pure cholinergic nerve endings from the electric organ of Torpedo marmorata

1976 • 163 citations

LES COMPARTIMENTS D'ACETYLCHOLINE DE L'ORGANE ELECTRIQUE DE LA TORPILLE ET LEURS MODIFICATIONS PAR LA STIMULATION

1972 • 156 citations

The preferential release of newly synthesized transmitter by a sympathetic ganglion

1969 • 156 citations

Calcium buffering in presynaptic nerve terminals. II. Kinetic properties of the nonmitochondrial Ca sequestration mechanism.

1978 • 154 citations

The effects of nerve stimulation and hemicholinium on synaptic vesicles at the mammalian neuromuscular junction

1970 • 153 citations

Chemical and physical characterization of cholinergic synaptic vesicles

1978 • 153 citations

Contributions of New Impregnation Methods and Freeze Etching to the Problems of Synaptic Fine Structure

1969 • 148 citations

THE ORGANIZATION OF SYNAPTIC AXOPLASM IN THE LAMPREY (PETROMYZON MARINUS) CENTRAL NERVOUS SYSTEM

1970 • 148 citations

Spontaneous subminature end‐plate potentials in mouse diaphragm muscle: evidence for synchronous release.

1976 • 148 citations

Evidence for the vesicle hypothesis

1968 • 145 citations

Purification of synaptic vesicles from elasmobranch electric organ and the use of biophysical criteria to demonstrate purity

1978 • 143 citations

An analysis of the action of a false transmitter at the neuromuscular junction.

1977 • 142 citations

Recycling of synaptic vesicles in the cholinergic synapses of the torpedo electric organ during induced transmitter release

1977 • 138 citations

Quantum aspects of central and ganglionic synaptic transmission in vertebrates

1971 • 137 citations

Presynaptic microtubules and their association with synaptic vesicles

1975 • 136 citations

Effects of Black Widow Spider Venom on the Frog Neuromuscular Junction: Effects on the Fine Structure of the Frog Neuromuscular Junction

1970 • 136 citations

Acetylcholine release in the cat's superior cervical ganglion

1953 • 134 citations

SYNAPTIC VESICLE DEPLETION AND RECOVERY IN CAT SYMPATHETIC GANGLIA ELECTRICALLY STIMULATED IN VIVO

1974 • 130 citations

Acetylcholine and choline acetyltransferase in the diaphragm of the rat

1964 • 129 citations

Non-quantal release of transmitter at mouse neuromuscular junction and its dependence on the activity of Na+−K+ ATP-ase

1977 • 128 citations

UPTAKE OF EXOGENOUS HORSERADISH PEROXIDASE BY COATED VESICLES IN MOUSE NEUROMUSCULAR JUNCTIONS

1969 • 123 citations

ASPECTS OF ACETYLCHOLINE METABOLISM IN THE ELECTRIC ORGAN OF TORPEDO MARMORATA

1971 • 122 citations

The relationship of transmitter release and storage to fine structure in a sympathetic ganglion

1974 • 122 citations

The action of sodium pump inhibitors on neuromuscular transmission

1968 • 122 citations

Transmitter release by mammalian motor nerve terminals in response to focal polarization

1973 • 120 citations

The chemical structure of synaptic membranes

1973 • 117 citations

Calcium dependence of spontaneous acetylcholine release at mammalian motor nerve terminals.

1965 • 117 citations

FRACTIONNEMENT DE L'ORGANE ELECTRIQUE DE LA TORPILLE: LOCALISATION SUBCELLULAIRE DE L'ACETYLCHOLINE SUBCELLULAR FRACTIONATION OF THE ELECTRIC ORGAN OF TORPEDO MARMORATA

1970 • 117 citations

Isolation of Synaptic Vesicles from Nerve Endings of the Rat Brain

1962 • 114 citations

The Dependence of Acetylcholinesterase Aggregation at Low Ionic Strength upon a Polyanionic Component

1978 • 114 citations

ACETYLCHOLINESTERASE OF RAT SYMPATHETIC GANGLION: MOLECULAR FORMS, LOCALIZATION AND EFFECTS OF DENERVATION

1978 • 111 citations

The effect of curare on the release of acetylcholine from mammalian motor nerve terminals and an estimate of quantum content.

1975 • 111 citations

Submicroscopic Changes of the Nerve Endings in the Adrenal Medulla after Stimulation of the Splanchnic Nerve

1957 • 105 citations

Adenosine Triphosphatase Activity Associated with Purified Cholinergic Synaptic Vesicles of Torpedo marmorata

1977 • 105 citations

Topography of the synaptosomal membrane.

1976 • 105 citations

VESICULAR STORAGE AND RELEASE OF ACETYLCHOLINE IN TORPEDO ELECTROPLAQUE SYNAPSES

1978 • 103 citations

THE CALCIUM BINDING SITES OF SYNAPTIC VESICLES OF THE FROG SARTORIUS NEUROMUSCULAR JUNCTION

1974 • 102 citations

Neurochemistry of Cholinergic Terminals

1976 • 101 citations

Retrieval and recycling of synaptic vesicle membrane in pinched-off nerve terminals (synaptosomes).

1978 • 101 citations

The release of adenosine triphosphate from frog skeletal muscle in vitro

1968 • 101 citations

Transmission abolished on a cholinergic synapse after injection of acetylcholin-esterase into the presynaptic neurone

1974 • 100 citations

Ultrastructure of normal and stimulated motor endplates

1972 • 97 citations

Acetylcholine compartments in mouse diaphragm. Comparison of the effects of black widow spider venom, electrical stimulation, and high concentrations of potassium.

1978 • 95 citations

The effects of prolonged repetitive stimulation in hemicholinium on the frog neuromuscular junction.

1975 • 94 citations

DIFFERENT RECOVERY RATES OF THE ELECTROPHYSIOLOGICAL, BIOCHEMICAL AND MORPHOLOGICAL PARAMETERS IN THE CHOLINERGIC SYNAPSES OF THE TORPEDO ELECTRIC ORGAN AFTER STIMULATION

1974 • 88 citations

The subcellular fractionation of the electric organ of Torpedo

1966 • 87 citations

Quantum amplitude distributions point to functional unity of the synaptic ‘active zone’

1977 • 86 citations

Postsynaptic release of adenosine triphosphate induced by single impulse transmitter action

1976 • 86 citations

Effect of Sodium Ions on Calcium Movements in Isolated Synaptic Terminals

1970 • 82 citations

INDUCED ACETYLCHOLINE RELEASE FROM ACTIVE PURELY CHOLINERGIC TORPEDO SYNAPTOSOMES

1978 • 82 citations

Preferential release of newly synthesized ³H‐acetylcholine from rat cerebral cortex slices in vitro

1973 • 82 citations

Release of ATP from stimulated nerve electroplaque junctions

1975 • 78 citations

UTILIZATION OF ACETATE AND PYRUVATE FOR THE SYNTHESIS OF‘TOTAL’,‘BOUND’AND‘FREE’ACETYLCHOLINE IN THE ELECTRIC ORGAN OF TORPEDO

1974 • 78 citations

Morphologic Alterations of Synapses in Electrically Stimulated Superior Cervical Ganglia of the Cat

1972 • 77 citations

Regulation of Neurotransmitter Release by a Complex of Actin with Relaxing Protein Isolated from Rat Brain Synaptosomes

1974 • 74 citations

Release of Acetylcholine from Sympathetic Preganglionic Nerve Terminals

1967 • 74 citations

Structural and functional changes of frog neuromuscular junctions in high calcium solutions

1971 • 72 citations

Acetylcholine as a possible sensory mediator in rabbit corneal epithelium

1971 • 69 citations

The synthesis, turnover and release of surplus acetylcholine in a sympathetic ganglion

1971 • 69 citations

Proton translocation of the bovine chromaffin-granule membrane

1978 • 69 citations

EVOLUTION DE LA DECHARGE DE L'ORGANE ELECTRIQUE DE LA TORPILLE ET VARIATIONS SIMULTANEES DE L'ACETYLCHOLINE AU COURS DE LA STIMULATION¹ CHANGES IN ACETYLCHOLINE LEVEL AND ELECTROPHYSIOLOGICAL RESPONSE DURING CONTINUOUS STIMULATION OF THE ELECTRIC ORGAN OF TORPEDO MARMORATA

1974 • 65 citations

Transmission of Impulses from Nerve to Muscle

1976 • 63 citations

EFFECTS OF CALCIUM-CONTAINING FIXATION SOLUTIONS ON CHOLINERGIC SYNAPTIC VESICLES

1974 • 63 citations

An analysis of acetylcholine in frog muscle by mass fragmentography

1977 • 62 citations

The heterogeneity of bound acetylcholine and synaptic vesicles

1972 • 61 citations

Double mode of action of black widow spider venom on frog neuromuscular junction

1978 • 60 citations

METABOLISME DU CALCIUM ET LIBERATION DE L'ACETYLCHOLINE DANS L'ORGANE ELECTRIQUE DE LA TORPILLE

1974 • 60 citations

Changes in cholinergic synaptic vesicle populations and the ultrastructure of the nerve terminal membranes of Narcine brasiliensis electron organ stimulated to fatigue in vivo.

1975 • 58 citations

ISOLATION OF [³H]ACETYLCHOLINE POOLS BY SUBCELLULAR FRACTIONATION OF CEREBRAL CORTEX SLICES INCUBATED WITH [³H]CHOLINE

1971 • 58 citations

RELATED CHANGES IN AMOUNTS OF ACh AND ATP IN RESTING AND ACTIVE TORPEDO NERVE ELECTROPLAQUE SYNAPSES

1977 • 56 citations

Identification of vesiculin as a glycosaminoglycan

1978 • 55 citations

Oscillation of acetylcholine during nerve activity in the Torpedo electric organ

1977 • 53 citations

Synaptic vesicles in freeze-etched electric tissue of Torpedo

1970 • 50 citations

Factors affecting the rate of incorporation of a false transmitter into mammalian motor nerve terminals.

1978 • 50 citations

Lack of Correspondence between the Amplitudes of Spontaneous Potentials and Unit Potentials evoked by Nerve Impulses at Regenerating Neuromuscular Junctions

1971 • 48 citations

Action of vinblastine on the spontaneous release of acetylcholine at the frog neuromuscular junction.

1976 • 47 citations

Calcium transport in a vesicular membrane preparation from rat brain synaptosomes

1978 • 47 citations

Preganglionic Stimulation Increases Calcium Uptake by Sympathetic Ganglia

1971 • 46 citations

THE EFFECT OF DEPRIVATION OF GLUCOSE ON THE ULTRASTRUCTURE AND FUNCTION OF THE SUPERIOR CERVICAL GANGLION OF THE RAT IN VITRO

1966 • 46 citations

Passive ion permeability of the chromaffin-granule membrane

1977 • 43 citations

Evaluation of the number and distribution of synaptic vesicles at cholinergic nerve-endings after sustained stimulation

1972 • 42 citations

DETERMINATION OF ACh CONCENTRATION IN TORPEDO SYNAPTOSOMES

1978 • 42 citations

Effects of stimulation and hemicholinium (HC-3) on the fine structure of nerve endings in the superior cervical ganglion of the cat

1971 • 41 citations

Synaptic vesicles and microtubules in frog motor endplates

1978 • 41 citations

Ultrastructural changes and transmitter release induced by depolarization of cholinergic synaptosomes

1980 • 39 citations

Electrogenic behavior of synaptic vesicles from Torpedo californica.

1978 • 38 citations

Variability of transmitter quanta released during incorporation of a false transmitter into cholinergic nerve terminals

1978 • 37 citations

Proteins of cholinergic synaptic vesicles from the electric organ of Torpedo: Characterization of a low molecular weight acidic protein

1974 • 37 citations

Clumping and oscillations in evoked transmitter release at the frog neuromuscular junction.

1978 • 37 citations

[Ultrastructural and cytochemical data on the mechanism of acetylcholine release in synaptic transmission]].

1973 • 36 citations

Evidence for extramitochondrial pyruvate dehydrogenase involved in acetylcholine synthesis in nerve endings

1978 • 34 citations

Neurotransmitter release from viable purely cholinergic Torpedo synaptosomes

1976 • 33 citations

Absence of adenine nucleotide release from autonomic ganglion

1974 • 33 citations

Changes of the phosphatidylcholine content and the number of synaptic vesicles in relation to the neurohumoral transmission in sympathetic ganglia

1976 • 29 citations

Is choline acetyltransferase present in synaptic vesicles?

1966 • 29 citations

Effect of stimulation on synaptic vesicles in the superior cervical ganglion of the cat

1971 • 29 citations

Chemo-Receptor Activity at the Motor End-Plate

1953 • 28 citations

The release of ATP triggered by transmitter action and its possible physiological significance: retrograde transmission.

1978 • 28 citations

Fine structural alterations of presynaptic endings in the superior cervical ganglion of the cat after exhausting preganglionic stimulation

1970 • 28 citations

ACETYLCHOLINE TRANSLOCATION IN SYNAPTIC VESICLE GHOSTS IN VITRO

1976 • 28 citations

Accumulation of calcium in cholinergic axon terminals after nerve activity. Localization by electron microscope radioautography at the nerve-electroplaque junction ofTorpedo

1977 • 27 citations

The subcellular origin of the agetylcholine released at synapses

1975 • 26 citations

Loss of vesicular acetylcholine in the Torpedo electric organ on discharge against high external resistance

1976 • 24 citations

Some effects of preganglionic nerve stimulation on synaptic vesicle populations in the rat superior cervical ganglion

1973 • 24 citations

Quick-freezing evidence in favour of the vesicular hypothesis

1978 • 20 citations

On the Mechanism of Acetylcholine Release

1979 • 19 citations

Mechanisms of synaptic transmission

1970 • 19 citations

Remarks on the organization of axon terminals in relation to secretory processes at synapses.

1974 • 19 citations

EFFECT OF CHOLINE ON THE RATES OF SYNTHESIS and OF RELEASE OF ACETYLCHOLINE IN THE ELECTRIC ORGAN OF TORPEDO

1976 • 18 citations

Incorporation of acetylcholinesterase into synaptic vesicles is associated with blockade of synaptic transmission

1975 • 18 citations

Is presynaptic acetylcholine release accompanied by the secretion of the synaptic vesicles contents?

1978 • 17 citations

Rate of fall in choline acetyltransferase activity in denervated diaphragms as dependent on the length of the degenerating nerve

1966 • 17 citations

Inhibition of creatine phosphokinase activity and synaptic transmission by black widow spider venom

1972 • 16 citations

STUDIES UPON THE MECHANISM BY WHICH ACETYLCHOLINE RELEASES SURPLUS ACETYLCHOLINE IN A SYMPATHETIC GANGLION

1975 • 15 citations

Function-dependent alterations in the distribution of synaptic vesicles.

1971 • 14 citations

Dynamics of Acetylcholine Compartments at Rest and During Nerve Activity

1975 • 14 citations

CELLULAR AND SUBCELLULAR LOCALIZATION OF ACETYLCHOLINE IN ELECTRIC ORGANS

1969 • 14 citations

The Present Status of the Vesicle Hypothesis

1978 • 13 citations

Immunochemical comparison of synaptic plasma membrane and synaptic vesicle membrane antigens

1977 • 13 citations

NMR evidence for an acetylcholine ATP complex

1975 • 13 citations

Quick-freezing evidence in favour of the vesicular hypothesis

1978 • 12 citations

Quantal acetylcholine release: Vesicles or gated channels?

1977 • 11 citations

Factors required for calcium dependent acetylcholine release from isolated torpedo synaptic vesicles

1978 • 11 citations

Acetylcholine content in physiologically fatigued frog nerve-muscle preparations and in denervated muscle

1978 • 11 citations

THE BINDING OF ACETYLCHOLINE TO SYNAPTIC VESICLES FROM TORPEDO CALIFORNICA ELECTROPLAX

1976 • 9 citations

The Origin and Some Possible Mechanisms of the Release of Acetylcholine at Synapses

1975 • 8 citations

Variations d'acétylcholine en relation avec l'évolution de la décharge, pendant la stimulation de l'organe électrique de la torpille.

1972 • 5 citations

Quantitative description of acetylcholine release and fluctuations in nerve terminals of torpedo electric organ submitted to stimulation

1978 • 3 citations

Deleted Work

1955 • 0 citations