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1998 • 4,383 citations

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Apoptosis, oncosis, and necrosis. An overview of cell death.

1995 • 3,325 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

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The Receptor for the Cytotoxic Ligand TRAIL

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BCL-2 FAMILY: Regulators of Cell Death

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Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

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1996 • 1,291 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

Pfam: A comprehensive database of protein domain families based on seed alignments

1997 • 1,211 citations

IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

1997 • 1,159 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

1998 • 1,132 citations

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL

1997 • 1,119 citations

MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex

1997 • 1,104 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

An Induced Proximity Model for Caspase-8 Activation

1998 • 1,030 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

Apoptosis signaling by death receptors

1998 • 976 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

Mitochondria and apoptosis

1998 • 892 citations

Substrate Specificities of Caspase Family Proteases

1997 • 871 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

1996 • 822 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB

1997 • 683 citations

Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

1996 • 653 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

MyD88, an Adapter Protein Involved in Interleukin-1 Signaling

1998 • 634 citations

Programmed cell death: a way of life for plants.

1996 • 580 citations

Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants

1998 • 573 citations

Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL

1997 • 566 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

The CARD domain: a new apoptotic signalling motif

1997 • 532 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

1996 • 515 citations

To Die or Not to Die

1998 • 514 citations

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

1997 • 433 citations

RIP2 Is a Novel NF-κB-activating and Cell Death-inducing Kinase

1998 • 425 citations

Transducers of life and death: TNF receptor superfamily and associated proteins.

1996 • 423 citations

NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

1996 • 379 citations

Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

1997 • 363 citations

A Novel Family of Viral Death Effector Domain-containing Molecules That Inhibit Both CD-95- and Tumor Necrosis Factor Receptor-1-induced Apoptosis

1997 • 343 citations

A death-domain-containing receptor that mediates apoptosis

1996 • 333 citations

CASH, a Novel Caspase Homologue with Death Effector Domains

1997 • 323 citations

Cell death attenuation by `Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

1998 • 318 citations

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

1997 • 316 citations

Identification of CARDIAK, a RIP-like kinase that associates with caspase-1

1998 • 316 citations

A flexible motif search technique based on generalized profiles

1996 • 306 citations

Solution Structure of the RAIDD CARD and Model for CARD/CARD Interaction in Caspase-2 and Caspase-9 Recruitment

1998 • 302 citations

NMR structure of the death domain of the p75 neurotrophin receptor

1997 • 301 citations

Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer

1997 • 300 citations

Characterization of two receptors for TRAIL¹

1997 • 293 citations

Apoptosis, cancer and cancer therapy

1997 • 286 citations

TRAMP, a Novel Apoptosis-Mediating Receptor with Sequence Homology to Tumor Necrosis Factor Receptor 1 and Fas(Apo-1/CD95)

1997 • 268 citations

MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclX _L and initiates cell death

1997 • 238 citations

Cell death induction by receptors of the TNF family: towards a molecular understanding

1997 • 237 citations

NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

1998 • 235 citations

RICK, a Novel Protein Kinase Containing a Caspase Recruitment Domain, Interacts with CLARP and Regulates CD95-mediated Apoptosis

1998 • 232 citations

Programmed Cell Death in Development

1995 • 201 citations

Early events in TNF signaling: a story of associations and dissociations

1997 • 194 citations

Sacrifice in the face of foes: Pathogen-induced programmed cell death in plants

1996 • 183 citations

The fight of viruses against apoptosis

1998 • 177 citations

Apoptosis, cancer and the p53 tumour suppressor gene

1995 • 149 citations

The importance of oxidative stress in apoptosis

1997 • 138 citations

A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other.

1996 • 134 citations

The Bcl-2 family and cell death regulation

1998 • 119 citations

Structural features and biochemical properties of TNF-α converting enzyme (TACE)

1997 • 115 citations

The death domain motif found in Fas (Apo‐1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance

1995 • 109 citations

Viral interference with apoptosis

1998 • 105 citations

Direct physical interaction between the Caenorhabditis elegans ‘death proteins’ CED‐3 and CED‐4

1997 • 83 citations

p53 and apoptosis

1997 • 82 citations

Recognition of apoptotic cells by phagocytes

1996 • 79 citations

Apoptosis: Telling cells their time is up

1996 • 74 citations

Three-dimensional structures of proteins involved in programmed cell death

1997 • 72 citations

The p53 tumour suppressor gene: a mediator of a G1 growth arrest and of apoptosis

1996 • 68 citations

The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system

1997 • 61 citations

Evasion of apoptosis by DNA viruses

1996 • 51 citations

Apoptotic Activity of REAPER Is Distinct from Signaling by the Tumor Necrosis Factor Receptor 1 Death Domain

1996 • 48 citations

Apoptosis and Cancer Chemotherapy

1999 • 46 citations

Mechanisms of action of the tumor necrosis factor and lymphotoxin ligand-receptor system.

1995 • 43 citations

Neuronal cell death: when, why and how

1997 • 40 citations

Apoptosis and Cancer Chemotherapy

1996 • 36 citations

Thymocyte and T cell apoptosis: is all death created equal?

1994 • 23 citations

The Caenorhabditis elegans death protein Ced‐4 contains a motif with similarity to the mammalian ‘death effector domain’

1997 • 12 citations