Bombesin stimulation of fibroblast mitogenesis: specific receptors, signal transduction and early events

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

The biology of platelet-derived growth factor

1986 • 2,036 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Growth factors: Mechanism of action and relation to oncogenes

1984 • 885 citations

cDNA eloping of bovine substance-K receptor through oocyte expression system

1987 • 748 citations

Fos-Associated Protein p39 Is the Product of the jun Proto-Oncogene

1988 • 643 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

The Role of Protein Kinase C in Transmembrane Signalling

1986 • 557 citations

Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

1983 • 470 citations

Allosteric regulation of the epidermal growth factor receptor kinase.

1986 • 381 citations

Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells.

1983 • 377 citations

Molecular mechanisms of transmembrane signalling

1985 • 352 citations

Phorbol esters and vasopressin stimulate DNA synthesis by a common mechanism

1980 • 334 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase.

1984 • 266 citations

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding.

1986 • 225 citations

A role for neuropeptides in the control of cell proliferation

1987 • 225 citations

Stimulation of DNA synthesis by tumour promoter and pure mitogenic factors

1978 • 207 citations

High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells.

1985 • 202 citations

v-jun encodes a nuclear protein with enhancer binding properties of AP-1

1988 • 196 citations

Platelet-derived growth factor elicits cyclic AMP accumulation in swiss 3T3 cells: Role of prostaglandin production

1983 • 189 citations

Effects of bombesin and insulin on inositol (1,4,5) trisphosphate and inositol (1,3,4) trisphosphate formation in Swiss 3T3 cells

1986 • 185 citations

Pertussis Toxin-Sensitive Pathway in the Stimulation of c- myc Expression and DNA Synthesis by Bombesin

1986 • 171 citations

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro.

1988 • 170 citations

Binding of phorbol esters to high‐affinity sites on murine fibroblastic cells elicits a mitogenic response

1982 • 167 citations

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. II. Changes in Na+ and Ca2+ fluxes, Na+/K+ pump activity, and intracellular pH.

1986 • 164 citations

Cyclic AMP: a mitogenic signal for Swiss 3T3 cells.

1981 • 150 citations

Phosphorylation of an acidic mol. wt. 80 000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity.

1986 • 147 citations

Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide.

1986 • 132 citations

Ca2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells.

1987 • 126 citations

Stimulation of Na+H+ antiport activity by epidermal growth factor and insulin occurs without activation of protein kinase C

1985 • 112 citations

Serum, like phorbol esters, rapidly activates protein kinase C in intact quiescent fibroblasts.

1985 • 110 citations

Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxin.

1987 • 100 citations

Ionic responses rapidly elicited by activation of protein kinase C in quiescent Swiss 3T3 cells.

1985 • 91 citations

Receptor for bombesin with associated tyrosine kinase activity.

1986 • 77 citations

Synergistic signals in mitogenesis: role of ion fluxes, cyclic nucleotides and protein kinase c in swiss 3t3 cells

1985 • 73 citations

Early Signals Underlying the induction of the c-fos and c-myc Genes in Quiescent Fibroblasts: Studies with Bombesin and Other Growth Factors

1988 • 72 citations

Vasopressin induces selective desensitization of its mitogenic response in Swiss 3T3 cells.

1983 • 56 citations

Internalization and degradation of peptides of the bombesin family in Swiss 3T3 cells occurs without ligand-induced receptor down-regulation.

1987 • 50 citations

Bombesin enhancement of cAMP accumulation in swiss 3T3 cells: Evidence of a dual mechanism of action

1988 • 50 citations

Two Classes of Antagonist Interact with Receptors for the Mitogenic Neuropeptides Bombesin, Bradykinin, and Vasopressin

1988 • 48 citations

Ionic responses rapidly elicited by porcine platelet-derived growth factor in Swiss 3T3 cells.

1984 • 46 citations

Rapid dephosphorylation of a Mr 80000 protein, a specific substrate of protein kinase C upon removal of phorbol esters, bombesin and vasopressin

1986 • 40 citations

Vasoactive intestinal peptide synergistically stimulates DNA synthesis in mouse 3T3 cells: Role of cAMP, Ca2+, and protein kinase C

1988 • 36 citations

Chapter 5 Early Stimulation of Na+-H+Antiport, Na+-K+Pump Activity, and Ca2+Fluxes in Fibroblast Mitogenesis

1986 • 34 citations

Bombesin and bombesin antagonists: Studies in Swiss 3T3 cells and human small cell lung cancer

1988 • 33 citations

Purification of a phosphoprotein from rat brain closely related to the 80 kDa substrate of protein kinase C identified in Swiss 3T3 fibroblasts

1988 • 32 citations

Characterization of a bombesin receptor on Swiss mouse 3T3 cells by affinity cross‐linking

1988 • 30 citations

Characterization of the high-affinity receptors on Swiss 3T3 cells which mediate the binding, internalization and degradation of the mitogenic peptide bombesin

1988 • 28 citations

Differential induction of c-fos and c-myc by cyclic AMP in Swiss 3T3 cells: significance for the mitogenic response.

1988 • 18 citations

Dissociation of c-fos induction from protein kinase C-independent mitogenesis in Swiss 3T3 cells.

1989 • 7 citations