Identification of Tyrosine Phosphorylation Sites on 3-Phosphoinositide-dependent Protein Kinase-1 and Their Role in Regulating Kinase Activity

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

1996 • 8,994 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

Analytical Properties of the Nanoelectrospray Ion Source

1996 • 1,816 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Role of Translocation in the Activation and Function of Protein Kinase B

1997 • 1,044 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 • 886 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate

1997 • 811 citations

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1997 • 740 citations

Protein kinase C isozymes and the regulation of diverse cell responses

2000 • 730 citations

The interpretation of collision‐induced dissociation tandem mass spectra of peptides

1995 • 651 citations

Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

1998 • 612 citations

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

1999 • 598 citations

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1998 • 579 citations

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

1999 • 555 citations

Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

1994 • 533 citations

Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site

2000 • 524 citations

Akt Signaling--Linking Membrane Events to Life and Death Decisions

1997 • 504 citations

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.

1996 • 490 citations

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

2000 • 487 citations

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC

1998 • 479 citations

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2

1999 • 440 citations

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1997 • 436 citations

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

1999 • 421 citations

Cellular Signaling

2000 • 415 citations

Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

1999 • 396 citations

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

1998 • 383 citations

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ

1997 • 377 citations

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

1999 • 368 citations

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1998 • 365 citations

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

1999 • 326 citations

Selective Detection and Sequencing of Phosphopeptides at the Femtomole Level by Mass Spectrometry

1996 • 309 citations

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1

2000 • 302 citations

Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes

1993 • 298 citations

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

2000 • 297 citations

The Akt kinase: Molecular determinants of oncogenicity

1998 • 294 citations

Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell–matrix and cell–cell interaction

1999 • 288 citations

The IRS-signalling system during insulin and cytokine action

1997 • 280 citations

Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B α

1998 • 275 citations

Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast

1999 • 261 citations

90-kDa Ribosomal S6 Kinase Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Protein Kinase-1

1999 • 254 citations

[2] Chemical properties and separation of phosphoamino acids by thin-layer chromatography and/or electrophoresis

1991 • 246 citations

PDK1, one of the missing links in insulin signal transduction?¹

1997 • 246 citations

p21-activated Kinase (PAK1) Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Kinase-1 (PDK1)

2000 • 235 citations

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

1998 • 230 citations

Intracellular signalling: PDK1 – a kinase at the hub of things

1999 • 221 citations

Insulin Activates Protein Kinases C-ζ and C-λ by an Autophosphorylation-dependent Mechanism and Stimulates Their Translocation to GLUT4 Vesicles and Other Membrane Fractions in Rat Adipocytes

1999 • 209 citations

Further evidence that 3‐phosphoinositide‐dependent protein kinase‐1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms

2000 • 206 citations

Cyclic AMP Inhibits Akt Activity by Blocking the Membrane Localization of PDK1

2001 • 186 citations

A 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Docking Site Is Required for the Phosphorylation of Protein Kinase Cζ (PKCζ) and PKC-related Kinase 2 by PDK1

2000 • 185 citations

p70 S6 Kinase Is Regulated by Protein Kinase Cζ and Participates in a Phosphoinositide 3-Kinase-Regulated Signalling Complex

1999 • 181 citations

The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction

1999 • 161 citations

Insulin signalling

2001 • 161 citations

Characterization of S6K2, a novel kinase homologous to S6K1

1999 • 158 citations

PDK1 Homologs Activate the Pkc1–Mitogen-Activated Protein Kinase Pathway in Yeast

1999 • 143 citations

Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK

1999 • 141 citations

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinase in Vivoat Thr-412 as well as Thr-252

1999 • 138 citations

Effect of Phosphoinositide-Dependent Kinase 1 on Protein Kinase B Translocation and Its Subsequent Activation

2000 • 137 citations

Kinase phosphorylation: Keeping it all in the family

1999 • 128 citations

Rho GTPase Control of Protein Kinase C-related Protein Kinase Activation by 3-Phosphoinositide-dependent Protein Kinase

2000 • 126 citations

Discovery of PDKI, One of the Missing Links in Insulin Signal Transduction

2001 • 125 citations

Association of the T-cell Protein Tyrosine Phosphatase with Nuclear Import Factor p97

1997 • 118 citations

Mechanism of Protein Kinase B Activation by Insulin/Insulin-Like Growth Factor-1 Revealed by Specific Inhibitors of Phosphoinositide 3-Kinase—Significance for Diabetes and Cancer

1999 • 115 citations

Domain Swapping Used To Investigate the Mechanism of Protein Kinase B Regulation by 3-Phosphoinositide-Dependent Protein Kinase 1 and Ser473 Kinase

1999 • 113 citations

The Carboxyl Terminus of Protein Kinase C Provides a Switch to Regulate Its Interaction with the Phosphoinositide-dependent Kinase, PDK-1

2001 • 111 citations

Protein Kinase C-ζ and Phosphoinositide-dependent Protein Kinase-1 Are Required for Insulin-induced Activation of ERK in Rat Adipocytes

1999 • 107 citations

Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex

1999 • 107 citations

Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway

2001 • 93 citations

Primary Structure, Tissue Distribution, and Expression of Mouse Phosphoinositide-dependent Protein Kinase-1, a Protein Kinase That Phosphorylates and Activates Protein Kinase Cζ

1999 • 92 citations

Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival

2000 • 87 citations

Dependence of Insulin-Stimulated Glucose Transporter 4 Translocation on 3-Phosphoinositide-Dependent Protein Kinase-1 and Its Target Threonine-410 in the Activation Loop of Protein Kinase C-ζ

1999 • 87 citations

Regulation of Protein Kinase B

1999 • 86 citations

Oxidative Stress and Vanadate Induce Tyrosine Phosphorylation of Phosphoinositide-Dependent Kinase 1 (PDK1)

2000 • 83 citations

Specificity in recognition of phosphopeptides by src-homology 2 domains

1994 • 66 citations

Nerve growth factor promotes activation of the α, β and γ isoforms of protein kinase B in PC12 pheochromocytoma cells

1998 • 62 citations

A Schizosaccharomyces pombe gene, ksg1, that shows structural homology to the human phosphoinositide-dependent protein kinase PDK1, is essential for growth, mating and sporulation

1999 • 57 citations

Peroxovanadate induces tyrosine phosphorylation of phosphoinositide‐dependent protein kinase‐1

2000 • 49 citations

Active-site mutations impairing the catalytic function of the catalytic subunit of human protein phosphatase 2A permit baculovirus-mediated overexpression in insect cells

2001 • 27 citations

Functional interaction between the SH2 domain of Fyn and tyrosine 324 of hamster polyomavirus middle-T antigen

1997 • 19 citations

PH Domain of Serine-Threonine Protein Kinase 6 (RAC–PKB): Expression and Binding Assay for Phosphoinositides and lnositol Phosphates

2003 • 1 citations