90-kDa Ribosomal S6 Kinase Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Protein Kinase-1

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activationofCREB

1998 • 975 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1997 • 740 citations

Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction

1999 • 722 citations

Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

1995 • 472 citations

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2

1999 • 440 citations

Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome

1996 • 398 citations

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1998 • 365 citations

Identification of Regulatory Phosphorylation Sites in Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-1a/p90 That Are Inducible by MAPK

1998 • 359 citations

pp90^rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167

1998 • 348 citations

A link between MAP kinase and p34cdc2/cyclin B during oocyte maturation: p90rsk phosphorylates and inactivates the p34cdc2 inhibitory kinase Myt1

1998 • 319 citations

Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c- fos gene

1998 • 302 citations

Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo

1999 • 281 citations

The Signal-Dependent Coactivator CBP Is a Nuclear Target for pp90RSK

1996 • 254 citations

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

1998 • 230 citations

Recombinant Proteins Can Be Isolated from E. coli Cells by Repeated Cycles of Freezing and Thawing

1994 • 225 citations

Ikappa Balpha is a target for the mitogen-activated 90kDa ribosomal S6 kinase

1997 • 225 citations

The 90-kDa Ribosomal S6 Kinase (pp90rsk) Phosphorylates the N-terminal Regulatory Domain of IκBα and Stimulates Its Degradation in Vitro

1997 • 207 citations

A protein kinase from Xenopus eggs specific for ribosomal protein S6.

1985 • 195 citations

Phosphorylation of Protein Kinase C-α on Serine 657 Controls the Accumulation of Active Enzyme and Contributes to Its Phosphatase-resistant State

1997 • 194 citations

Evidence for Two Catalytically Active Kinase Domains in pp90^rsk

1996 • 188 citations

RSK-B, a Novel Ribosomal S6 Kinase Family Member, Is a CREB Kinase under Dominant Control of p38α Mitogen-activated Protein Kinase (p38αMAPK)

1998 • 164 citations

Regulation and Interaction of pp90 Isoforms with Mitogen-activated Protein Kinases

1996 • 162 citations

A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1

1999 • 157 citations

EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2

1997 • 157 citations

Identification of insulin‐stimulated protein kinase‐1 as the rabbit equivalent of rsk^mo‐2

1993 • 141 citations

Phosphorylation Sites in the Autoinhibitory Domain Participate in p70s6k Activation Loop Phosphorylation

1998 • 135 citations

Comparison of the specificities of p70 S6 kinase and MAPKAP kinase‐1 identifies a relatively specific substrate for p70 S6 kinase: the N‐terminal kinase domain of MAPKAP kinase‐1 is essential for peptide phosphorylation

1995 • 126 citations

Human rsk isoforms: cloning and characterization of tissue-specific expression

1994 • 104 citations

Dual Requirement for a Newly Identified Phosphorylation Site in p70^s6k

1997 • 103 citations

Divergent Functional Roles for p90 Kinase Domains

1995 • 103 citations

Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase

1993 • 73 citations

Identification of Serine 380 as the Major Site of Autophosphorylation of Xenopus pp90rsk

1997 • 64 citations

Osmotic stimulation of the supraoptic nucleus: central and peripheral vasopressin release and blood pressure

1994 • 56 citations

Rapid immunoblot and kinase assay tests for a syndromal form of X linked mental retardation: Coffin-Lowry syndrome.

1998 • 36 citations