Polarized Helper-T-Cell Responses againstLeishmania majorin the Absence of B Cells

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

1995 • 699 citations

Experimental Autoimmune Encephalomyelitis Induction in Genetically B Cell–deficient Mice

1996 • 665 citations

New perspectives of C1328-137-mediated T cell costimulation

1995 • 526 citations

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

1995 • 425 citations

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo.

1995 • 410 citations

Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the J_H locus

1993 • 404 citations

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

1994 • 365 citations

Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.

1991 • 355 citations

Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation?

1995 • 347 citations

Constructing polycompetitor cDNAs for quantitative PCR

1993 • 323 citations

T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes.

1987 • 286 citations

Successful T cell priming in B cell-deficient mice.

1995 • 284 citations

Allergic Eosinophil-rich Inflammation Develops in Lungs and Airways of B Cell–deficient Mice

1997 • 257 citations

The B cell is the initiating antigen-presenting cell in peripheral lymph nodes.

1987 • 240 citations

B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes.

1993 • 210 citations

The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice.

1988 • 199 citations

CD4+ T Cell–mediated Granulomatous Pathology in Schistosomiasis Is Downregulated by a B Cell–dependent Mechanism Requiring Fc Receptor Signaling

1998 • 185 citations

A role for B cells in the development of T cell helper function in a malaria infection in mice

1998 • 173 citations

In susceptible mice, Leishmania major induce very rapid interleukin‐4 production by CD4⁺ T cells which are NK1.1⁻

1995 • 168 citations

Cutaneous leishmaniasis in anti-IgM-treated mice: enhanced resistance due to functional depletion of a B cell-dependent T cell involved in the suppressor pathway.

1984 • 153 citations

Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells.

1995 • 150 citations

Cross-linking Fc receptors stimulate splenic non-B, non-T cells to secrete interleukin 4 and other lymphokines.

1990 • 149 citations

Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice

1997 • 133 citations

Gene-targeted B-deficient mice reveal a critical role for B cells in the CD4 T cell response

1995 • 109 citations

CD4+ T cell activation and tolerance induction in B cell knockout mice.

1996 • 103 citations

Defective induction of antigen‐reactive proliferating T cells in B cell‐deprived mice

1981 • 99 citations

In infection with Schistosoma mansoni, B cells are required for T helper type 2 cell responses but not for granuloma formation.

1997 • 99 citations

Xid-associated resistance to experimental Chagas' disease is IFN-gamma dependent.

1993 • 98 citations

T cell development in B cell-deficient mice. IV. The role of B cells as antigen-presenting cells in vivo.

1986 • 88 citations

Antigen-Primed T Cells from B Cell-Deficient JHD Mice Fail to Provide B Cell Help

1998 • 83 citations

Reconstitution of C.B‐17 scid mice with BALB/c T cells initiates a T helper type‐1 response and renders them capable of healing Leishmania major infection

1993 • 78 citations

The Xid defect determines an improved clinical course of murine leishmaniasis in susceptible mice

1994 • 75 citations

Exacerbation of experimental murine cutaneous leishmaniasis with CD4⁺Leishmania major‐specific T cell lines or clones which secrete interferon‐γ and mediate parasite‐specific delayed‐type hypersensitivity

1991 • 57 citations

The B lymphocyte-deprived mouse as a tool in immunobiology

1979 • 51 citations

Interferon‐γ‐ and interleukin‐4‐producing T cells can be primed on dendritic cells in vivo and do not require the presence of B cells

1994 • 50 citations

Role of B-cell and Fc receptors in the selection of T-cell epitopes

1998 • 48 citations

Strong priming of T cells adoptively transferred into scid mice.

1991 • 42 citations

T cell development in B cell-deficient mice. II. Serological characterization of suppressor T cell factors (TsF1) produced in normal mice and in mice treated chronically with rabbit anti-mouse IgM antibodies.

1985 • 37 citations

Defective induction of antigen‐reactive proliferating T cells in B cell‐deprived mice II. Anti‐μ treatment affects the initiation and recruitment of T cells

1983 • 37 citations

Evidence for B cell participation in the in vitro and in vivo maintenance of in vivo staphylococcal enterotoxin B-induced T cell anergy

1997 • 7 citations