ERK2 but not ERK1 plays a key role in hepatocyte replication: An RNAi-mediated ERK2 knockdown approach in wild-type and ERK1 null hepatocytes

Liver Regeneration

1997 • 2,731 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Analysis of gene function in somatic mammalian cells using small interfering RNAs

2002 • 1,108 citations

Liver regeneration: molecular mechanisms of growth control

1990 • 922 citations

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

1999 • 641 citations

Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration.

1995 • 613 citations

Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory

2002 • 458 citations

Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

1997 • 402 citations

An essential function of the mitogen‐activated protein kinase Erk2 in mouse trophoblast development

2003 • 361 citations

The Extracellular Signal–Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis

2005 • 315 citations

Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation

2003 • 309 citations

Cytokine regulation of liver injury and repair

2000 • 296 citations

Essential role for ERK2 mitogen‐activated protein kinase in placental development

2003 • 286 citations

The Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Cascade Activation Is a Key Signalling Pathway Involved in the Regulation of G₁ Phase Progression in Proliferating Hepatocytes

1999 • 255 citations

Growth Factor Dependence of Progression through G1 and S Phases of Adult Rat Hepatocytes in Vitro

1996 • 225 citations

ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially

2006 • 210 citations

The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic

1998 • 191 citations

Cyclin D1 promotes mitogen-independent cell cycle progression in hepatocytes.

1999 • 167 citations

Expression and activation of cdks (1 and 2) and cyclins in the cell cycle progression during liver regeneration.

1994 • 135 citations

Mechanisms Regulating the Constitutive Activation of the Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Ovarian Cancer and the Effect of Ribonucleic Acid Interference for ERK1/2 on Cancer Cell Proliferation

2004 • 134 citations

PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival

2002 • 131 citations

MEK1 and MEK2, Different Regulators of the G1/S Transition

2004 • 111 citations

Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver

1998 • 110 citations

Impaired Hepatocyte DNA Synthetic Response Posthepatectomy in Insulin-Like Growth Factor Binding Protein 1-Deficient Mice with Defects in C/EBPβ and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Regulation

2003 • 107 citations

Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes

2002 • 104 citations

Distinct Patterns of Cyclin D1 Regulation in Models of Liver Regeneration and Human Liver

1995 • 94 citations

p44 Mitogen-Activated Protein Kinase (Extracellular Signal-Regulated Kinase 1)–Dependent Signaling Contributes to Epithelial Skin Carcinogenesis

2006 • 82 citations

Mechanism in the Sequential Control of Cell Morphology and S Phase Entry by Epidermal Growth Factor Involves Distinct MEK/ERK Activations

2001 • 77 citations

A Role for Both Ets and C/EBP Transcription Factors and mRNA Stabilization in the MAPK-dependent Increase in p21^{Cip-1/WAF1/mda6}Protein Levels in Primary Hepatocytes

2000 • 75 citations

Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice

1998 • 61 citations

The Role of Collagen Structure in Mitogen Stimulation of ERK, Cyclin D1 Expression, and G1-S Progression in Rat Hepatocytes

2003 • 50 citations

Regulation of G₁cyclin-dependent kinases in the liver: role of nuclear localization and p27 sequestration

1999 • 50 citations

Inhibition of rat hepatocyte proliferation by transforming growth factor ? and glucagon is associated with inhibition of ERK2 and p70 S6 kinase

1999 • 47 citations

Loss of cyclin D1 does not inhibit the proliferative response of mouse liver to mitogenic stimuli

2002 • 45 citations

RNA interference (RNAi) for extracellular signal-regulated kinase 1 (ERK1) alone is sufficient to suppress cell viability in ovarian cancer cells

2005 • 43 citations

An MLCK-dependent window in late G1 controls S phase entry of proliferating rodent hepatocytes via ERK-p70S6K pathway

2006 • 27 citations

Study of MAPK Signaling Using Knockout Mice

2004 • 22 citations

Skp2 induction and phosphorylation is associated with the late G1 phase of proliferating rat hepatocytes

1999 • 20 citations

Differential Role of MAP Kinases in Stimulation of Hepatocyte Growth by EGF and G-Protein-Coupled Receptor Agonists

2002 • 14 citations

Deleted Work

1955 • 0 citations