PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival

Cellular survival: a play in three Akts

1999 • 4,229 citations

Liver Regeneration

1997 • 2,731 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Liver regeneration

2000 • 987 citations

Predictors of morbidity and mortality after the first episode of upper gastrointestinal bleeding in liver cirrhosis

2000 • 892 citations

Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

1999 • 762 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Human immunodeficiency virus infection modified the natural history of chronic parenterally-acquired hepatitis C with an unusually rapid progression to cirrhosis

1997 • 719 citations

Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration.

1995 • 613 citations

Biochemical Characteristics of Caspases-3, -6, -7, and -8

1997 • 536 citations

The Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Cascade Activation Is a Key Signalling Pathway Involved in the Regulation of G₁ Phase Progression in Proliferating Hepatocytes

1999 • 255 citations

The Activation of p38 and Apoptosis by the Inhibition of Erk Is Antagonized by the Phosphoinositide 3-Kinase/Akt Pathway

1998 • 252 citations

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

1995 • 243 citations

Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus.

1996 • 231 citations

Growth Factor Dependence of Progression through G1 and S Phases of Adult Rat Hepatocytes in Vitro

1996 • 225 citations

Cyclin D1 promotes mitogen-independent cell cycle progression in hepatocytes.

1999 • 167 citations

p70 S6 Kinase-mediated Protein Synthesis Is a Critical Step for Vascular Endothelial Cell Proliferation

1999 • 160 citations

c-Raf/MEK/ERK Pathway Controls Protein Kinase C-mediated p70S6K Activation in Adult Cardiac Muscle Cells

2002 • 154 citations

Transient expression of cyclin D1 is sufficient to promote hepatocyte replication and liver growth in vivo.

2001 • 132 citations

The Ras/Rac1/Cdc42/SEK/JNK/c-Jun Cascade Is a Key Pathway by Which Agonists Stimulate DNA Synthesis in Primary Cultures of Rat Hepatocytes

1998 • 130 citations

Cross-talk between the ERK and p70 S6 Kinase (S6K) Signaling Pathways

2001 • 125 citations

Differential Regulation by Calcium Reveals Distinct Signaling Requirements for the Activation of Akt and p70S6k

1998 • 122 citations

Differential Regulation of the Mitogen-Activated Protein and Stress-Activated Protein Kinase Cascades by Adrenergic Agonists in Quiescent and Regenerating Adult Rat Hepatocytes

1997 • 110 citations

Mammalian MAP kinase modules: how to transduce specific signals.

1997 • 105 citations

Translational Homeostasis: Eukaryotic Translation Initiation Factor 4E Control of 4E-Binding Protein 1 and p70 S6 Kinase Activities

1999 • 103 citations

The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor ?-mediated rat hepatocyte survival and apoptosis

2000 • 103 citations

Liver apoptosis

1997 • 94 citations

Distinct Patterns of Cyclin D1 Regulation in Models of Liver Regeneration and Human Liver

1995 • 94 citations

Rapamycin-insensitive Regulation of 4E-BP1 in Regenerating Rat Liver

2001 • 82 citations

Epidermal Growth Factor Impairs the Cytochrome C/Caspase-3 Apoptotic Pathway Induced by Transforming Growth Factorβ in Rat Fetal Hepatocytes Via a Phosphoinositide 3-Kinase–Dependent Pathway

2000 • 80 citations

Mechanism in the Sequential Control of Cell Morphology and S Phase Entry by Epidermal Growth Factor Involves Distinct MEK/ERK Activations

2001 • 77 citations

Transient expression of c-fos and constant expression of c-myc in freshly isolated and cultured normal adult rat hepatocytes.

1988 • 75 citations

Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity

2001 • 69 citations

Ribosomal S6 Kinase 2 Inhibition by a Potent C-terminal Repressor Domain Is Relieved by Mitogen-activated Protein-Extracellular Signal-regulated Kinase Kinase-regulated Phosphorylation

2001 • 62 citations

Effects of rapamycin on cultured hepatocyte proliferation and gene expression

1992 • 56 citations

Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity

2001 • 51 citations

Inhibition of rat hepatocyte proliferation by transforming growth factor ? and glucagon is associated with inhibition of ERK2 and p70 S6 kinase

1999 • 47 citations

Epidermal Growth Factor and Insulin-Induced Deoxyribonucleic Acid Synthesis in Primary Rat Hepatocytes Is Phosphatidylinositol 3-Kinase Dependent and Dissociated from Protooncogene Induction1

1999 • 41 citations

[Ultrastructural study of monolayer hepatocytes in adult rat cultures in the presence of hydrocortisone hemisuccinate].

1975 • 34 citations

New Biocompatible Cationic Amphiphiles Derivative from Glycine Betaine: A Novel Family of Efficient Nonviral Gene Transfer Agents

1998 • 34 citations

Cationic lipids derived from glycine betaine promote efficient and non‐toxic gene transfection in cultured hepatocytes

2002 • 32 citations

Positive and negative regulation of JNK1 by protein kinase C and p42^{MAP kinase} in adult rat hepatocytes

1997 • 31 citations

Impairments in Both p70 S6 Kinase and Extracellular Signal-Regulated Kinase Signaling Pathways Contribute to the Decline in Proliferative Capacity of Aged Hepatocytes

1998 • 24 citations

Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo

1996 • 21 citations

Deleted Work

1955 • 0 citations