An MLCK-dependent window in late G1 controls S phase entry of proliferating rodent hepatocytes via ERK-p70S6K pathway

Liver Regeneration

1997 • 2,731 citations

Regulation of Cell Motility by Mitogen-activated Protein Kinase

1997 • 1,238 citations

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

2003 • 1,109 citations

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

2001 • 852 citations

Rho–Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

2001 • 743 citations

Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration.

1995 • 613 citations

Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

2001 • 387 citations

Modulation of Rho GTPase Signaling Regulates a Switch between Adipogenesis and Myogenesis

2003 • 375 citations

Cdc2–cyclin E complexes regulate the G1/S phase transition

2005 • 370 citations

Proliferation, But Not Growth, Blocked by Conditional Deletion of 40 S Ribosomal Protein S6

2000 • 366 citations

Timing of cyclin D1 expression within G1 phase is controlled by Rho

2001 • 318 citations

Myosin Light Chain Kinase Functions Downstream of Ras/ERK to Promote Migration of Urokinase-Type Plasminogen Activator-Stimulated Cells in an Integrin-Selective Manner

1999 • 306 citations

RhoA is required for cortical retraction and rigidity during mitotic cell rounding

2003 • 298 citations

Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell Cycle

2001 • 283 citations

The Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Cascade Activation Is a Key Signalling Pathway Involved in the Regulation of G₁ Phase Progression in Proliferating Hepatocytes

1999 • 255 citations

Regulation of signal transduction during liver regeneration

1996 • 228 citations

Growth Factor Dependence of Progression through G1 and S Phases of Adult Rat Hepatocytes in Vitro

1996 • 225 citations

Cyclin D1 promotes mitogen-independent cell cycle progression in hepatocytes.

1999 • 167 citations

c-Raf/MEK/ERK Pathway Controls Protein Kinase C-mediated p70S6K Activation in Adult Cardiac Muscle Cells

2002 • 154 citations

Characterization of a Rac1 Signaling Pathway to Cyclin D1 Expression in Airway Smooth Muscle Cells

1999 • 137 citations

Expression and activation of cdks (1 and 2) and cyclins in the cell cycle progression during liver regeneration.

1994 • 135 citations

Transient expression of cyclin D1 is sufficient to promote hepatocyte replication and liver growth in vivo.

2001 • 132 citations

PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival

2002 • 131 citations

Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632

2001 • 118 citations

Regulation of p70 S6 Kinase by Complex Formation between the Rac Guanine Nucleotide Exchange Factor (Rac-GEF) Tiam1 and the Scaffold Spinophilin

2003 • 118 citations

Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase

2000 • 118 citations

Effects of Rho Kinase and Actin Stress Fibers on Sustained Extracellular Signal-Regulated Kinase Activity and Activation of G₁ Phase Cyclin-Dependent Kinases

2003 • 108 citations

Cooperativity between the Ras-ERK and Rho-Rho Kinase Pathways in Urokinase-type Plasminogen Activator-stimulated Cell Migration

2002 • 97 citations

Caspase‐dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF‐α‐mediated bovine pulmonary endothelial cell apoptosis

2003 • 96 citations

Distinct Patterns of Cyclin D1 Regulation in Models of Liver Regeneration and Human Liver

1995 • 94 citations

Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability

2000 • 82 citations

Post-transcriptional Down-regulation of ROCKI/Rho-kinase through an MEK-dependent Pathway Leads to Cytoskeleton Disruption in Ras-transformed Fibroblasts

2002 • 82 citations

Comparative effects of hepatocyte growth factor and epidermal growth factor on motility, morphology, mitogenesis, and signal transduction of primary rat hepatocytes

1994 • 79 citations

Mechanism in the Sequential Control of Cell Morphology and S Phase Entry by Epidermal Growth Factor Involves Distinct MEK/ERK Activations

2001 • 77 citations

Regulation of the hepatocyte cell cycle by type I collagen matrix: role of cyclin D1

1999 • 76 citations

TNFα-mediated extracellular matrix remodeling is required for multiple division cycles in rat hepatocytes

2005 • 74 citations

Modulation of acto-myosin contractility in skeletal muscle myoblasts uncouples growth arrest from differentiation

2004 • 74 citations

Rho regulates p21CIP1, cyclin D1, and checkpoint control in mammary epithelial cells

2002 • 67 citations

Cyclin and cyclin-dependent kinase 1 mRNA expression in models of regenerating liver and human liver diseases

1993 • 62 citations

RETRACTED: Nuclear Translocation of LIM Kinase Mediates Rho-Rho Kinase Regulation of Cyclin D1 Expression

2003 • 58 citations

Cdc42 Promotes G1 Progression through p70 S6 Kinase-mediated Induction of Cyclin E Expression

2003 • 51 citations

Regulation of G₁cyclin-dependent kinases in the liver: role of nuclear localization and p27 sequestration

1999 • 50 citations

Constitutively Active Myosin Light Chain Kinase Alters Axon Guidance Decisions in Drosophila Embryos

2002 • 50 citations

Post-transcriptional Down-regulation of ROCKI/Rho-kinase through an MEK-dependent Pathway Leads to Cytoskeleton Disruption in Ras-transformed Fibroblasts

2002 • 49 citations

Inhibition of rat hepatocyte proliferation by transforming growth factor ? and glucagon is associated with inhibition of ERK2 and p70 S6 kinase

1999 • 47 citations

Upregulation of molecular motor-encoding genes during hepatocyte growth factor-and epidermal growth factor-induced cell motility

1996 • 25 citations

Impairments in Both p70 S6 Kinase and Extracellular Signal-Regulated Kinase Signaling Pathways Contribute to the Decline in Proliferative Capacity of Aged Hepatocytes

1998 • 24 citations

The catalytic domain of xPAK1 is sufficient to induce myosin II dependent in vivo cell fragmentation independently of other apoptotic events

2003 • 23 citations

Extracellular matrix-dependent myosin dynamics during G1-S phase cell cycle progression in hepatocytes

2004 • 19 citations

Deleted Work

1955 • 0 citations