Study of MAPK Signaling Using Knockout Mice

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

1999 • 641 citations

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

1999 • 602 citations

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs.

1992 • 450 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

Mitogen-activated protein (MAP) kinase pathways in plants: Versatile signaling tools

2001 • 117 citations

Mammalian MAP kinase modules: how to transduce specific signals.

1997 • 105 citations

cAMP-mediated Growth Inhibition in Fibroblasts Is Not Mediated via Mitogen-activated Protein (MAP) Kinase (ERK) Inhibition

1996 • 95 citations

The Mouse p44 Mitogen-activated Protein Kinase (Extracellular Signal-regulated Kinase 1) Gene

1995 • 81 citations

Plant mitogen-activated protein kinase cascades: Negative regulatory roles turn out positive

2001 • 40 citations

CD10 is expressed on human thymic epithelial cell lines and modulates thymopentin‐induced cell proliferation

1997 • 13 citations