Hox genes in digit development and evolution

A gene complex controlling segmentation in Drosophila

1978 • 3,668 citations

Hox genes in vertebrate development

1994 • 2,057 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

The murine and Drosophila homeobox gene complexes have common features of organization and expression

1989 • 1,021 citations

The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.

1989 • 912 citations

Fossils, genes and the evolution of animal limbs

1997 • 796 citations

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

1993 • 715 citations

Temporal colinearity and the phylotypic progression: a basis for the stability of a vertebrate Bauplan and the evolution of morphologies through heterochrony

1994 • 631 citations

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

1989 • 612 citations

Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11

1995 • 587 citations

Altered Growth and Branching Patterns in Synpolydactyly Caused by Mutations in HOXD13

1996 • 565 citations

Mutation of HOXA13 in hand-foot-genital syndrome

1997 • 492 citations

Analysis of Hox gene expression in the chick limb bud

1996 • 480 citations

Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs

1993 • 454 citations

Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod

1995 • 430 citations

Gene dosage-dependent effects of theHoxa-13andHoxd-13mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts

1997 • 360 citations

Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body.

1991 • 344 citations

Hox gene expression in teleost fins and the origin of vertebrate digits

1995 • 315 citations

Homeotic transformations and limb defects in Hox A11 mutant mice.

1993 • 260 citations

Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning

1996 • 259 citations

Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11

1994 • 253 citations

Spatially restricted domains of homeo-gene transcripts in mouse embryos: relation to a segmented body plan

1988 • 245 citations

A mutational analysis of the 5′ HoxD genes: dissection of genetic interactions during limb development in the mouse

1996 • 229 citations

Gene Transpositions in the HoxD Complex Reveal a Hierarchy of Regulatory Controls

1996 • 226 citations

Regulation of number and size of digits by posterior Hox genes: A dose-dependent mechanism with potential evolutionary implications

1997 • 219 citations

Synpolydactyly phenotypes correlate with size of expansions in HOXD13 polyalanine tract

1997 • 212 citations

Synpolydactyly in mice with a targeted deficiency in the HoxD complex

1996 • 210 citations

Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth

1997 • 208 citations

Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds.

1995 • 205 citations

The origin of vertebrate limbs

1994 • 202 citations

Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads.

1989 • 176 citations

The vertebrate limb: A model system to study the Hox/hom gene network during development and evolution

1992 • 175 citations

Function of posterior HoxD genes in the morphogenesis of the anal sphincter

1996 • 174 citations

Genomic structure of HOXD13 gene: a nine polyalanine duplication causes synpolydactyly in two unrelated families

1996 • 160 citations

Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton

1996 • 154 citations

The molecular basis of hypodactyly (Hd): a deletion in Hoxa13 leads to arrest of digital arch formation

1996 • 154 citations

Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2.

1988 • 151 citations

The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning

1997 • 139 citations

Mutations in mouseAristaless-like4causeStrong’s luxoidpolydactyly

1998 • 136 citations

The Hox-4.8 gene is localized at the 5′ extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development

1991 • 135 citations

Homoeobox gene expression in mouse embryos varies with position by the primitive streak stage

1986 • 126 citations

Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain- of-function of posterior Hoxd genes

1997 • 120 citations

Targeted Mutations inHoxa-9andHoxb-9Reveal Synergistic Interactions

1997 • 118 citations

Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice.

1995 • 107 citations

Targeted disruption of Hoxd-10 affects mouse hindlimb development

1997 • 104 citations

A new spontaneous mouse mutation of Hoxd13 with a polyalanine expansion and phenotype similar to human synpolydactyly

1998 • 101 citations

The murine Hoxc cluster contains five neighboring AbdB-related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions

1994 • 95 citations

Genetic interactions of Hox genes in limb development: learning from compound mutants

1997 • 86 citations

Hoxc-9 mutant mice show anterior transformation of the vertebrae and malformation of the sternum and ribs

1995 • 78 citations

Control of Colinearity in AbdB Genes of the Mouse HoxD Complex

1998 • 78 citations

Function of the Evx-2 gene in the morphogenesis of vertebrate limbs.

1996 • 53 citations

Developmental expression of the mouse Evx-2 gene: relationship with the evolution of the HOM/Hox complex

1994 • 51 citations

Limb Evolution: Fish fins or tetrapod limbs — a simple twist of fate?

1995 • 44 citations

Cellular analysis of limb development in the mouse mutant Hypodactyly

1996 • 15 citations

Genetic and Physical Mapping of the Mouse Ulnaless Locus

1996 • 12 citations