The growth hormone–insulin-like growth factor-I axis and colorectal cancer

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

1996 • 2,048 citations

Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans¹

2000 • 1,794 citations

The role of cyclooxygenases in inflammation, cancer, and development

1999 • 1,399 citations

The Somatomedin Hypothesis: 2001

2001 • 1,184 citations

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

1999 • 1,128 citations

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic Growth

2000 • 805 citations

Serum C-Peptide, Insulin-Like Growth Factor (IGF)-I, IGF-Binding Proteins, and Colorectal Cancer Risk in Women

2000 • 653 citations

Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans

2000 • 469 citations

The IGF-I receptor in cell growth, transformation and apoptosis

1997 • 446 citations

Growth Hormone Secretagogue Binding Sites in Peripheral Human Tissues1

2000 • 418 citations

A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women.

2000 • 407 citations

Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas.

1996 • 325 citations

Direct Functional Interactions between Insulin-like Growth Factor-binding Protein-3 and Retinoid X Receptor-α Regulate Transcriptional Signaling and Apoptosis

2000 • 320 citations

The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene.

1995 • 318 citations

Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells.

1993 • 317 citations

Selective loss of estrogen receptor beta in malignant human colon.

2000 • 313 citations

Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation

2001 • 306 citations

Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas.

1986 • 293 citations

Induction of Vascular Endothelial Growth Factor by Insulin-like Growth Factor 1 in Colorectal Carcinoma

1996 • 272 citations

Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of β-catenin

2000 • 265 citations

Regulation of Constitutive Cyclooxygenase-2 Expression in Colon Carcinoma Cells

2000 • 262 citations

The Somatomedin Hypothesis: 2001

2001 • 261 citations

Growth Hormone Secretagogue Binding Sites in Peripheral Human Tissues

2000 • 257 citations

Expression of insulin-like growth factor-1 receptor in human colorectal cancer

1999 • 238 citations

The contradictions of the insulin-like growth factor 1 receptor

2000 • 236 citations

Postmenopausal Hormone Use and Risk of Large-Bowel Cancer

1995 • 235 citations

Insulin-Like Growth Factor-1 Inhibition of Apoptosis Is Associated with Increased Expression of the bcl-xL Gene Product

1997 • 208 citations

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic Growth

2000 • 206 citations

IGF-I and IGF-II in relation to colorectal cancer

1999 • 190 citations

Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I.

1998 • 185 citations

CLINICAL PERSPECTIVE: Acromegaly and Cancer: A Problem

2001 • 181 citations

Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.

1991 • 174 citations

Effects of Gastrin, Proglumide, and Somatostatin on Growth of Human Colon Cancer

1988 • 173 citations

Insulin and Insulin-like Growth Factor I Receptors Utilize Different G Protein Signaling Components

2001 • 161 citations

Insulin-like Growth Factor-I Receptor Internalization Regulates Signaling via the Shc/Mitogen-activated Protein Kinase Pathway, but Not the Insulin Receptor Substrate-1 Pathway

1998 • 159 citations

Expression of the insulin-like growth factors and their receptors in adenocarcinoma of the colon

1999 • 148 citations

Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways.

2000 • 139 citations

Insulin-Like Growth Factor I and the Development of Colorectal Neoplasia in Acromegaly*

2000 • 128 citations

The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene

1995 • 123 citations

Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells

2001 • 120 citations

Increased epithelial cell proliferation in the colon of patients with acromegaly.

1996 • 119 citations

Alterations in serum levels of insulin‐like growth factors and insulin‐like growth‐factor‐binding proteins in patients with colorectal cancer

1994 • 108 citations

Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells.

2000 • 105 citations

IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in Caco-2 human colon carcinoma cells

2000 • 104 citations

Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.

2000 • 101 citations

A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor beta1.

1998 • 99 citations

Integrins and E-cadherin cooperate with IGF-I to induce migration of epithelial colonic cells

1999 • 87 citations

Autocrine and paracrine actions of intestinal fibroblast-derived insulin-like growth factors

1999 • 79 citations

Cell receptors and cell signalling

2000 • 79 citations

Restoration of epithelial cell polarity in a colorectal cancer cell line by suppression of beta-catenin/T-cell factor 4-mediated gene transactivation.

2001 • 77 citations

Down-regulation of TGF-β receptors in human colorectal cancer: implications for cancer development

1999 • 75 citations

Insulin-Like Growth Factor I and the Development of Colorectal Neoplasia in Acromegaly

2000 • 71 citations

Insulin-Like Growth Factor-1 Inhibition of Apoptosis Is Associated with Increased Expression of the bcl-xL Gene Product

1997 • 69 citations

True

2000 • 68 citations

The Binding of Bombesin and Somatostatin and Their Analogs to Human Colon Cancers

1992 • 61 citations

Resection-induced colonic adaptation is augmented by IGF-I and associated with upregulation of colonic IGF-I mRNA

1995 • 58 citations

Insulin-like growth factors and their binding proteins in human colonocytes: preferential degradation of insulin-like growth factor binding protein 2 in colonic cancers

1997 • 58 citations

Role of insulin-like growth factor-I (IGF-I) receptor, IGF-I, and IGF binding protein-2 in human colorectal cancers

1998 • 55 citations

Induction of transforming growth factor β1 by insulin-like growth factor-1 in dermal fibroblasts

1998 • 52 citations

Igfbp-3 mediates TGFβ1 proliferative response in colon cancer cells

2000 • 46 citations

Differential requirements of the MAP kinase and PI3 kinase signaling pathways in Src- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells

2000 • 46 citations

Growth Hormone-Like Material in Normal Human Tissues*

1981 • 41 citations

The molecular basis of growthhormone action

1998 • 35 citations

CLINICAL PERSPECTIVE: Acromegaly and Cancer: A Problem

2001 • 35 citations

Expression of IGFBP-2, -3, and -4 mRNA during differentiation of Caco-2 colon epithelial cells

1996 • 34 citations

Increased levels of insulin‐like growth factor binding protein‐2 in sera and tumours from patients with colonic neoplasia with and without acromegaly

2001 • 31 citations

Up-Regulation of Insulin/Insulin-Like Growth Factor-I Hybrid Receptors during Differentiation of HT29-D4 Human Colonic Carcinoma Cells¹

1997 • 27 citations

Growth hormone and colorectal carcinoma: localization of receptors.

2000 • 27 citations

Type I insulin-like growth factor receptors in human colorectal cancer

1995 • 26 citations

Cell polarity of the insulin-like growth factor system in human intestinal epithelial cells. Unique apical sorting of insulin-like growth factor binding protein-6 in differentiated human colon cancer cells.

1995 • 25 citations

Insulin-Like Growth Factor I Receptor Messenger RNA in the Colon Is Unchanged During Neoplasia

1997 • 22 citations

Serum Concentrations of Insulin-Like Growth Factor 1 in Colonic Neoplasia

1994 • 15 citations

[Growth hormone receptor antagonists: potential indications].

2001 • 7 citations

Up-Regulation of Insulin/Insulin-Like Growth Factor-I Hybrid Receptors during Differentiation of HT29-D4 Human Colonic Carcinoma Cells

1997 • 6 citations