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IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in Caco-2 human colon carcinoma cells

Data up to Jan 2025

Published2000
Citations104
References37

Total Citations Per Year

Abstract

References (37)

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 2,282 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

1997 • 1,411 citations

Gene Expression Profiles in Normal and Cancer Cells

1997 • 1,157 citations

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

1998 • 1,130 citations

Insulin‐like growth factors I and II

1990 • 1,006 citations

Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex

1999 • 638 citations

Cyclooxygenase-2 and carcinogenesis

2000 • 489 citations

Prostaglandin endoperoxide synthase: why two isoforms?

1996 • 464 citations

Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect.

1996 • 462 citations

Eicosanoids and the gastrointestinal tract

1995 • 426 citations

Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester.

1994 • 377 citations

Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells

1997 • 317 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Mitogenic Signaling of Insulin-like Growth Factor I in MCF-7 Human Breast Cancer Cells Requires Phosphatidylinositol 3-Kinase and Is Independent of Mitogen-activated Protein Kinase

1997 • 262 citations

Aspirin use and potential mechanisms for colorectal cancer prevention.

1997 • 252 citations

Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).

1993 • 247 citations

Arachidonic Acid in Platelet Microparticles Up-regulates Cyclooxygenase-2-dependent Prostaglandin Formation via a Protein Kinase C/Mitogen-activated Protein Kinase-dependent Pathway

1999 • 240 citations

Regulation of intestinal epithelial proliferation: a few answers, many questions

1993 • 185 citations

Helicobacter pylori Up-regulates Cyclooxygenase-2 mRNA Expression and Prostaglandin E2 Synthesis in MKN 28 Gastric Mucosal Cells in Vitro

1998 • 184 citations

Characterization of insulinlike growth factor I receptors in human colon cancer

1992 • 174 citations

Lipopolysaccharide increases cyclo-oxygenase-2 expression in a colon carcinoma cell line through nuclear factor-κB activation

2000 • 158 citations

Expression of 15-Lipoxygenase by Human Colorectal Carcinoma Caco-2 Cells during Apoptosis and Cell Differentiation

1998 • 145 citations

Insulinlike growth factors and binding proteins in colon cancer

1993 • 126 citations

Intestinal epithelial cell differentiation: new insights from mice, flies and nematodes

1995 • 89 citations

Effect of aspirin on cell proliferation and differentiation of colon adenocarcinoma Caco-2 cells

1997 • 63 citations

Activation of fetal promoters of insulinlike growth factors II gene in hepatitis C virus-related chronic hepatitis, cirrhosis, and hepatocellular carcinoma

1996 • 58 citations

Expression of insulin-like growth factor (IGF)-II and IGF-I receptor during proliferation and differentiation of CaCo-2 human colon carcinoma cells.

1994 • 50 citations

Potential autocrine role of insulin-like growth factor II during suramin-induced differentiation of HT29-D4 human colonic adenocarcinoma cell line.

1992 • 42 citations

Constitutive Insulin-like Growth Factor-II Expression Interferes with the Enterocyte-like Differentiation of CaCo-2 Cells

1996 • 41 citations

The enterocyte-like differentiation of the Caco-2 tumor cell line strongly correlates with responsiveness to cAMP and activation of kinase A pathway.

1994 • 28 citations

Up-Regulation of Insulin/Insulin-Like Growth Factor-I Hybrid Receptors during Differentiation of HT29-D4 Human Colonic Carcinoma Cells1

1997 • 27 citations

Cell cycle block at G1-S or G2-M phase correlates with differentiation of Caco-2 cells: Effect of constitutive insulin-like growth factor II expression☆, ☆☆

1999 • 16 citations

73

1995 • 6 citations

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IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in… (2000) – Oncogene | Metascience Observatory Explorer