Regulation of Constitutive Cyclooxygenase-2 Expression in Colon Carcinoma Cells

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

Cyclooxygenase in biology and disease

1998 • 2,483 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Aspirin Use and Reduced Risk of Fatal Colon Cancer

1991 • 1,695 citations

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

1997 • 1,411 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors.

2000 • 1,310 citations

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 • 1,135 citations

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

1998 • 1,130 citations

Aspirin and the Risk of Colorectal Cancer in Women

1995 • 1,116 citations

CREB Is a Regulatory Target for the Protein Kinase Akt/PKB

1998 • 939 citations

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis.

1998 • 933 citations

Aspirin use and risk of fatal cancer.

1993 • 884 citations

The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB

1999 • 882 citations

Induction of NF-κB by the Akt/PKB kinase

1999 • 847 citations

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

1995 • 837 citations

Aspirin Use and the Risk for Colorectal Cancer and Adenoma in Male Health Professionals

1994 • 804 citations

Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

1997 • 734 citations

Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells

1995 • 487 citations

Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation.

1994 • 478 citations

Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect.

1996 • 462 citations

Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells.

1996 • 426 citations

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1997 • 411 citations

Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester.

1994 • 377 citations

Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.

1999 • 363 citations

The Antiapoptotic Gene mcl-1 Is Up-Regulated by the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway through a Transcription Factor Complex Containing CREB

1999 • 358 citations

Rho family proteins and Ras transformation: the RHOad less traveled gets congested

1998 • 352 citations

Cloning and Characterization of Three Human Forkhead Genes That Comprise an FKHR-like Gene Subfamily

1998 • 350 citations

Post-transcriptional Control of Cyclooxygenase-2 Gene Expression

2000 • 342 citations

Reduced Risk of Large-Bowel Adenomas Among Aspirin Users

1993 • 301 citations

v-src Induces Prostaglandin Synthase 2 Gene Expression by Activation of the c-Jun N-terminal Kinase and the c-Jun Transcription Factor

1995 • 295 citations

Induction of Cyclooxygenase-2 by the Activated MEKK1 → SEK1/MKK4 → p38 Mitogen-activated Protein Kinase Pathway

1998 • 275 citations

Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)

1997 • 247 citations

Transcriptional Regulation of Prostaglandin Synthase 2 Gene Expression by Platelet-derived Growth Factor and Serum

1996 • 244 citations

Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation

1996 • 235 citations

Localization of Cyclooxygenase-2 in Human Sporadic Colorectal Adenomas

2000 • 222 citations

Dihydroxy Bile Acids Activate the Transcription of Cyclooxygenase-2

1998 • 210 citations

Aspirin and Nonsteroidal Anti-inflammatory Drug Use and the Risk of Subsequent Colorectal Cancer

1994 • 210 citations

Prevention of NNK-induced lung tumorigenesis in A/J mice by acetylsalicylic acid and NS-398.

1998 • 204 citations

Ceramide Regulates the Transcription of Cyclooxygenase-2

1998 • 203 citations

Transforming Growth Factor-β1 Enhances Ha-ras-induced Expression of Cyclooxygenase-2 in Intestinal Epithelial Cells via Stabilization of mRNA

2000 • 199 citations

Induction of Cyclooxygenase-2 by Activated Ha-rasOncogene in Rat-1 Fibroblasts and the Role of Mitogen-activated Protein Kinase Pathway

1998 • 193 citations

Regulation of Cyclooxygenase-2 by Interferon γ and Transforming Growth Factor α in Normal Human Epidermal Keratinocytes and Squamous Carcinoma Cells

1999 • 191 citations

The cyclic AMP response element plays an essential role in the expression of the human prostaglandin‐endoperoxide synthase 2 gene in differentiated U937 monocytic cells

1994 • 185 citations

A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells

1997 • 185 citations

Meloxicam inhibits the growth of colorectal cancer cells

1998 • 156 citations

Retinoids suppress epidermal growth factor-induced transcription of cyclooxygenase-2 in human oral squamous carcinoma cells.

1997 • 146 citations

Transcriptional Regulation of the Cyclooxygenase-2 Gene in Activated Mast Cells

2000 • 122 citations

The ubiquitin-mediated proteolytic pathway as a therapeutic area

1997 • 113 citations

A Selective Cyclooxygenase‐2 Inhibitor Suppresses Tumor Growth in Nude Mouse Xenografted with Human Head and Neck Squamous Carcinoma Cells

1999 • 104 citations

Suppression of Intestinal Polyp Development by Nimesulide, a Selective Cyclooxygenase‐2 Inhibitor, in Min Mice

1997 • 92 citations

Coordinate regulation of cyclooxygenase-2 and TGF-1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors

1999 • 82 citations

Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma

1995 • 58 citations

Introduction: Evolving roles for ubiquitin in cellular regulation

1997 • 15 citations