The molecular basis of growthhormone action

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

A Hot Spot of Binding Energy in a Hormone-Receptor Interface

1995 • 1,943 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Cytokine signal transduction

1994 • 1,358 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule

1991 • 879 citations

Rational Design of Potent Antagonists to the Human Growth Hormone Receptor

1992 • 633 citations

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

1995 • 578 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

Regulation of rat growth hormone receptor gene expression

1989 • 446 citations

Binding in the growth hormone receptor complex.

1996 • 434 citations

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.

1992 • 387 citations

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1996 • 307 citations

The Conserved Box 1 Motif of Cytokine Receptors Is Required for Association with JAK Kinases

1995 • 249 citations

Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1

1995 • 246 citations

Intermittent Plasma Growth Hormone Triggers Tyrosine Phosphorylation and Nuclear Translocation of a Liver-Expressed, Stat 5-related DNA Binding Protein.

1995 • 242 citations

Growth Hormone Activation of Stat 1, Stat 3, and Stat 5 in Rat Liver

1996 • 225 citations

Growth hormone rapidly activates insulin-like growth factor I gene transcription in vivo.

1992 • 211 citations

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH.

1996 • 198 citations

JAK2, Ras, and Raf Are Required for Activation of Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase by Growth Hormone

1995 • 194 citations

Activation of Acute Phase Response Factor (APRF)/Stat3 Transcription Factor by Growth Hormone

1995 • 180 citations

Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kDa transcription factor.

1994 • 179 citations

Regions of the JAK2 Tyrosine Kinase Required for Coupling to the Growth Hormone Receptor

1995 • 176 citations

Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase.

1994 • 171 citations

Mediation of Growth Hormone-dependent Transcriptional Activation by Mammary Gland Factor/Stat 5

1995 • 169 citations

Growth Hormone-promoted Tyrosyl Phosphorylation of SHC Proteins and SHC Association with Grb2

1995 • 168 citations

The Transcriptional Activator Hepatocyte Nuclear Factor 6 Regulates Liver Gene Expression

1996 • 144 citations

In vitro and in vivo studies of antagonistic effects of human growth hormone analogs.

1994 • 143 citations

Growth Hormone Stimulates the Tyrosine Phosphorylation of the Insulin Receptor Substrate-1 and Its Association with Phosphatidylinositol 3-Kinase in Primary Adipocytes

1995 • 134 citations

Nuclear translocation and anchorage of the growth hormone receptor.

1994 • 131 citations

Regulation of Signal Transducer and Activator of Transcription (STAT) 5b Activation by the Temporal Pattern of Growth Hormone Stimulation

1997 • 129 citations

Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor.

1996 • 126 citations

Rapid changes in nuclear protein tyrosine phosphorylation after growth hormone treatment in vivo. Identification of phosphorylated mitogen-activated protein kinase and STAT91.

1994 • 123 citations

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH

1996 • 122 citations

Growth hormone stimulates tyrosine phosphorylation of insulin receptor substrate-1.

1994 • 121 citations

Distinct cytoplasmic regions of the growth hormone receptor are required for activation of JAK2, mitogen-activated protein kinase, and transcription.

1994 • 120 citations

Mutational analysis of the intracellular domain of the human growth hormone receptor

1993 • 120 citations

Growth Hormone Induction of Hepatic Serine Protease Inhibitor 2.1 Transcription Is Mediated by a Stat5-related Factor Binding Synergistically to Two γ-Activated Sites

1995 • 118 citations

Identification of Tyrosine Residues in the Intracellular Domain of the Growth Hormone Receptor Required for Transcriptional Signaling and Stat5 Activation

1996 • 114 citations

An inducible nuclear factor binds to a growth hormone-regulated gene.

1990 • 109 citations

Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes.

1994 • 107 citations

In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3.

1995 • 106 citations

Evidence for involvement of the growth hormone receptor-associated tyrosine kinase in actions of growth hormone.

1993 • 101 citations

Identification of growth hormone receptor (GHR) tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation.

1996 • 94 citations

Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene.

1996 • 92 citations

The role of the WSXWS equivalent motif in growth hormone receptor function.

1994 • 91 citations

Growth hormone and erythropoietin differentially activate DNA-binding proteins by tyrosine phosphorylation.

1994 • 91 citations

Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase.

1996 • 90 citations

Growth Hormone (GH) and a GH Antagonist Promote GH Receptor Dimerization and Internalization

1996 • 87 citations

Early responses of trans-activating factors to growth hormone in preadipocytes: differential regulation of CCAAT enhancer-binding protein-beta (C/EBP beta) and C/EBP delta.

1995 • 86 citations

Intracellular Tyrosine Residues of the Human Growth Hormone Receptor Are Not Required for the Signaling of Proliferation or Jak-STAT Activation

1995 • 86 citations

Growth hormone receptor C-terminal domains required for growth hormone-induced intracellular free Ca2+ oscillations and gene transcription.

1995 • 85 citations

Identification of Phenylalanine 346 in the Rat Growth Hormone Receptor as Being Critical for Ligand-mediated Internalization and Down-regulation

1995 • 84 citations

Growth hormone rapidly activates insulin-like growth factor I gene transcription in vivo

1992 • 84 citations

Amino acids of the human growth hormone receptor that are required for proliferation and Jak-STAT signaling.

1995 • 83 citations

Mapping of a Cytoplasmic Domain of the Human Growth Hormone Receptor That Regulates Rates of Inactivation of Jak2 and Stat Proteins

1997 • 80 citations

Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo.

1996 • 76 citations

Differential tyrosine phosphorylation of JAK1, JAK2, and STAT1 by growth hormone and interferon-gamma in IM-9 cells.

1994 • 75 citations

The serum response element can mediate induction of c-fos by growth hormone.

1993 • 70 citations

Activation of STAT Factors by Prolactin, Interferon-γ, Growth Hormones, and a Tyrosine Phosphatase Inhibitor in Rabbit Primary Mammary Epithelial Cells

1995 • 69 citations

Growth Hormone-induced Signal Transduction Depends on an Intact Ubiquitin System

1997 • 69 citations

Conformational Changes Required in the Human Growth Hormone Receptor for Growth Hormone Signaling

1997 • 67 citations

A STAT Factor Mediates the Sexually Dimorphic Regulation of Hepatic Cytochrome P450 3A10/Lithocholic Acid 6β-Hydroxylase Gene Expression by Growth Hormone

1995 • 65 citations

Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor

1996 • 62 citations

Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene

1996 • 62 citations

Growth Hormone Promotes the Association of Transcription Factor STAT5 with the Growth Hormone Receptor

1996 • 60 citations

Identification of growth hormone receptor (GHR) tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation

1996 • 53 citations

Rapid changes in gene expression after in vivo growth hormone treatment.

1995 • 53 citations

Organization and chromosomal localization of the gene encoding the mouse acid labile subunit of the insulin-like growth factor binding complex.

1996 • 51 citations

Treatment of IM-9 cells with human growth hormone (GH) promotes rapid disulfide linkage of the GH receptor.

1994 • 50 citations

cis-Acting elements controlling transcription from rat serine protease inhibitor 2.1 gene promoter. Characterization of two growth hormone response sites and a dominant purine-rich element.

1994 • 49 citations

Mapping of the Cytoplasmic Domain of the Human Growth Hormone Receptor Required for the Activation of Jak2 and Stat Proteins

1995 • 49 citations

Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes

1994 • 48 citations

Interaction of a Novel Sex-dependent, Growth Hormone-regulated Liver Nuclear Factor with CYP2C12 Promoter

1996 • 48 citations

In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3

1995 • 47 citations

Rapid activation of rat insulin-like growth factor-I gene transcription by growth hormone reveals no alterations in deoxyribonucleic acid-protein interactions within the major promoter.

1994 • 47 citations

G120R, a Human Growth Hormone Antagonist, Shows Zinc-dependent Agonist and Antagonist Activity on Nb2 Cells

1995 • 46 citations

Growth Hormone Rapidly Activates Rat Serine Protease Inhibitor 2.1 Gene Transcription and Induces a DNA-Binding Activity Distinct from Those of Stat1, -3, and -4

1995 • 45 citations

The proline-rich region of the GH receptor is essential for JAK2 phosphorylation, activation of cell proliferation, and gene transcription.

1995 • 45 citations

Postreceptor signalling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1.

1996 • 44 citations

A Growth Hormone Agonist Produced by Targeted Mutagenesis at Binding Site 1.

1995 • 43 citations

Requirement of Tyrosine Residues 333 and 338 of the Growth Hormone (GH) Receptor for Selected GH-stimulated Function

1995 • 40 citations

Dexamethasone-induced antagonism of growth hormone (GH) action by down-regulation of GH binding in 3T3-F442A fibroblasts.

1995 • 37 citations

Distinct cytoplasmic regions of the growth hormone receptor are required for activation of JAK2, mitogen-activated protein kinase, and transcription

1994 • 35 citations

Growth Hormone Signaling Leading to CYP2C12 Gene Expression in Rat Hepatocytes Involves Phospholipase A2

1995 • 35 citations

The human growth hormone (hGH) antagonist G120RhGH does not antagonize GH in the rat, but has paradoxical agonist activity, probably via the prolactin receptor.

1996 • 35 citations

Amino acids of the human growth hormone receptor that are required for proliferation and Jak-STAT signaling

1995 • 34 citations

Regulation of Signal Transducer and Activator of Transcription (STAT) 5b Activation by the Temporal Pattern of Growth Hormone Stimulation

1997 • 31 citations

The regulation by growth hormone of lipoprotein lipase gene expression is mediated by c-fos protooncogene.

1993 • 31 citations

CCAAT/enhancer-binding protein-alpha-dependent transactivation of CYP2C12 in rat hepatocytes.

1995 • 31 citations

Distinct Cytoplasmic Domains of the Growth Hormone Receptor Are Required for Glucocorticoid- and Phorbol Ester-induced Decreases in Growth Hormone (GH) Binding

1996 • 30 citations

Early responses of trans-activating factors to growth hormone in preadipocytes: differential regulation of CCAAT enhancer-binding protein-beta (C/EBP beta) and C/EBP delta

1995 • 28 citations

Acute nuclear actions of growth hormone (GH): cycloheximide inhibits inducible activator protein-1 activity, but does not block GH-regulated signal transducer and activator of transcription activation or gene expression.

1996 • 28 citations

Transcriptional Repression, a Novel Function for 3′ Untranslated Regions

1995 • 27 citations

Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo

1996 • 27 citations

Characterization of Orphan Nuclear Receptor Binding Elements in Sex-differentiated Members of the cyp2c Gene Family Expressed in Rat Liver

1995 • 27 citations

Growth hormone synergizes with serum growth factors in inducing c-fos transcription in 3T3-F442A cells.

1992 • 26 citations

The proline-rich region of the GH receptor is essential for JAK2 phosphorylation, activation of cell proliferation, and gene transcription

1995 • 26 citations

Growth hormone modulates insulin regulation of hepatic insulin-like growth factor binding protein-1 transcription.

1996 • 24 citations

Rapid changes in gene expression after in vivo growth hormone treatment

1995 • 24 citations

A novel growth hormone response element unrelated to STAT (signal transducer and activator of transcription)-binding sites is a bifunctional enhancer.

1996 • 22 citations

Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase

1996 • 21 citations

Dexamethasone-induced antagonism of growth hormone (GH) action by down- regulation of GH binding in 3T3-F442A fibroblasts

1995 • 19 citations

Rapid activation of rat insulin-like growth factor-I gene transcription by growth hormone reveals no alterations in deoxyribonucleic acid- protein interactions within the major promoter

1994 • 18 citations

CCAAT/enhancer-binding protein-alpha-dependent transactivation of CYP2C12 in rat hepatocytes

1995 • 13 citations

The regulation by growth hormone of lipoprotein lipase gene expression is mediated by c-fos protooncogene

1993 • 12 citations

The human growth hormone (hGH) antagonist G120RhGH does not antagonize GH in the rat, but has paradoxical agonist activity, probably via the prolactin receptor

1996 • 12 citations

Acute nuclear actions of growth hormone (GH): cycloheximide inhibits inducible activator protein-1 activity, but does not block GH-regulated signal transducer and activator of transcription activation or gene expression

1996 • 12 citations

Growth hormone modulates insulin regulation of hepatic insulin-like growth factor binding protein-1 transcription

1996 • 11 citations

Treatment of IM-9 cells with human growth hormone (GH) promotes rapid disulfide linkage of the GH receptor

1994 • 10 citations

Growth hormone synergizes with serum growth factors in inducing c-fos transcription in 3T3-F442A cells

1992 • 9 citations

A novel growth hormone response element unrelated to STAT (signal transducer and activator of transcription)-binding sites is a bifunctional enhancer

1996 • 9 citations

Postreceptor signalling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1

1996 • 8 citations

Rapid activation of rat insulin-like growth factor-I gene transcription by growth hormone reveals no changes in deoxyribonucleic acid-protein interactions within the second promoter

1995 • 7 citations

Deleted Work

1955 • 0 citations