Postmortem changes in the levels and localization of microtubule‐associated proteins (tau, MAP2 and MAP1B) in the rat and human hippocampus

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

2007 • 11,720 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

The distribution of tau in the mammalian central nervous system.

1985 • 1,518 citations

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

1989 • 783 citations

Phosphorylated Tau Protein Is Integrated into Paired Helical Filaments in Alzheimer's Disease1

1986 • 504 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

1992 • 468 citations

Light and electron microscopic studies of the distribution of microtubule‐associated protein 2 in rat brain: A difference between dendritic and axonal cytoskeletons

1984 • 424 citations

Phosphorylation determines two distinct species of tau in the central nervous system

1987 • 405 citations

Calcium and the aging nervous system

1987 • 384 citations

Distribution of microtubule-associated protein 2 in the nervous system of the rat studied by immunofluorescence

1984 • 378 citations

Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease

1987 • 348 citations

Alzheimer's disease : basic mechanisms, diagnosis and therapeutic strategies

1991 • 327 citations

Differences in the cellular distributions of two microtubule-associated proteins, MAP1 and MAP2, in rat brain

1984 • 326 citations

Distribution of tau proteins in the normal human central and peripheral nervous system.

1989 • 314 citations

Microtubule-associated protein 2 as a sensitive marker for cerebral ischemic damage—Immunohistochemical investigation of dendritic damage

1989 • 303 citations

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

1990 • 283 citations

Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease

1986 • 215 citations

The role of calcium regulation in brain aging: reexamination of a hypothesis

1989 • 211 citations

MAP5: A novel brain microtubule-associated protein under strong developmental regulation

1986 • 210 citations

Microtubule-associated protein 1B: identification of a major component of the neuronal cytoskeleton.

1985 • 197 citations

Degradation of Microtubule‐Associated Protein 2 and Brain Spectrin by Calpain: A Comparative Study

1991 • 180 citations

Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease

1991 • 177 citations

Neuronal microtubule‐associated proteins in the embryonic avian spinal cord

1988 • 167 citations

Proteolysis of tau by calpain

1989 • 162 citations

Microtubular reorganization and dendritic growth response in alzheimer's disease

1989 • 159 citations

The disordered neuronal cytoskeleton in Alzheimer's disease

1992 • 124 citations

Post‐mortem stability of dopamine. glutamate decarboxylase and choline acetyltransferase in the mouse brain under conditions simulating the handling of human autopsy material

1978 • 122 citations

Differential vulnerability of microtubule components in cerebral ischemia

1990 • 107 citations

Microheterogeneity of Micro tubule‐Associated τ Proteins Is Due to Differences in Phosphorylation

1986 • 106 citations

Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease

1990 • 106 citations

Tau Epitopes are Incorporated into a Range of Lesions in Alzheimerʼs Disease

1987 • 97 citations

The sequential appearance of low- and high-molecular-weight forms of MAP2 in the developing cerebellum

1988 • 96 citations

Tau protein and Alzheimer's disease

1990 • 78 citations

Analysis of epitopes shared by Hirano bodies and neurofilament proteins in normal and Alzheimer's disease hippocampus.

1989 • 67 citations

Calpain-mediated proteolysis of microtubule associated proteins MAP1B and MAP2 in developing brain

1991 • 65 citations

Distribution of phosphate-independent MAP2 epitopes revealed with monoclonal antibodies in microwave-denatured human nervous system tissues

1989 • 54 citations

Sequestration of Tubulin in Neurons in Alzheimer's disease

1986 • 53 citations

Ca2+-calmodulin regulated effectors of microtubule stability in neuronal tissues

1992 • 38 citations

Massive accumulation of modified tau and severe depletion of normal tau characterize the cerebral cortex and white matter of Alzheimer's disease. Demonstration using the hydrated autoclaving method.

1992 • 33 citations

Microtubule-associated proteins MAP5 and MAP1x: closely related components of the neuronal cytoskeleton with different cytoplasmic distributions in the developing brain

1989 • 31 citations

Aberrant localization of MAP5 immunoreactivity in the hippocampal formation in alzheimer's disease

1991 • 21 citations

Selective Expression of Epitopes in Multiphosphorylation Repeats of the High and Middle Molecular Weight Neurofilament Proteins in Alzheimer Neurofibrillary Tangles

1989 • 12 citations