Guanosine and synthetic organoselenium compounds modulate methylmercury-induced oxidative stress in rat brain cortical slices: Involvement of oxidative stress and glutamatergic system

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Glutamate uptake

2001 • 3,867 citations

Organoselenium and Organotellurium Compounds: Toxicology and Pharmacology

2004 • 1,759 citations

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

The Toxicology of Mercury

1997 • 874 citations

Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate

1995 • 779 citations

Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123

1999 • 722 citations

Experimental and clinical neurotoxicology

1982 • 506 citations

Experimental and Clinical Neurotoxicology

1981 • 472 citations

Neurotoxicity and molecular effects of methylmercury

2001 • 350 citations

Glutamate Transporters in Neurologic Disease

2001 • 324 citations

Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration

2005 • 316 citations

The biochemistry of selenium and the glutathione system

2001 • 295 citations

Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity

2007 • 275 citations

Ebselen: A substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant

2002 • 242 citations

Methylmercury alters glutamate transport in astrocytes

2000 • 230 citations

Oxidative stress in neurotoxic effects of methylmercury poisoning.

1996 • 219 citations

Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain

2007 • 203 citations

A Novel Antioxidant Mechanism of Ebselen Involving Ebselen Diselenide, a Substrate of Mammalian Thioredoxin and Thioredoxin Reductase

2002 • 182 citations

Neurobehavioural and molecular changes induced by methylmercury exposure during development

2007 • 159 citations

S-Allylcysteine, a garlic-derived antioxidant, ameliorates quinolinic acid-induced neurotoxicity and oxidative damage in rats

2004 • 151 citations

Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes

2005 • 148 citations

Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics

2000 • 147 citations

Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists.

1996 • 147 citations

Neuroprotective effects of (−)‐epigallocatechin gallate after hypoxia‐ischemia‐induced brain damage: novel mechanisms of action

2004 • 138 citations

Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice

2008 • 125 citations

Free radical formation in cerebral cortical astrocytes in culture induced by methylmercury

2004 • 113 citations

Activation of glutamate uptake by guanosine in primary astrocyte cultures

2001 • 109 citations

Protective effects of the antioxidant selenium on quinolinic acid‐induced neurotoxicity in rats: in vitro and in vivo studies

2003 • 104 citations

Methylmercury genotoxicity: A novel effect in human cell lines of the central nervous system

2006 • 97 citations

Methylmercury-mediated inhibition of 3H-d-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase

2001 • 92 citations

Ebselen protects against methylmercury-induced inhibition of glutamate uptake by cortical slices from adult mice

2003 • 88 citations

Extracellular conversion of guanine-based purines to guanosine specifically enhances astrocyte glutamate uptake

2003 • 86 citations

The Consequences of Methylmercury Exposure on Interactive Functions between Astrocytes and Neurons

2002 • 85 citations

Involvement of enhanced sensitivity of N-methyl-d-aspartate receptors in vulnerability of developing cortical neurons to methylmercury neurotoxicity

2001 • 80 citations

Methylmercury increases glutamate extracellular levels in frontal cortex of awake rats

2002 • 80 citations

The effect of aliphatic, naphthenic, and aromatic hydrocarbons on production of reactive oxygen species and reactive nitrogen species in rat brain synaptosome fraction: the involvement of calcium, nitric oxide synthase, mitochondria, and phospholipase A11Abbreviations: BIM, bisindolylmaleimide; [Ca2+]i, concentration of intracellular calcium; ChAT, cholin acetyltransferase; CSA, cyclosporin A; DCF, 2′,7′-dichlorofluorescein; H2DCF-DA, 2′,7′-dichlorodihydrofluorescin diacetate; DEDA, …

2001 • 79 citations

Mercury pollution and childhood in Amazon riverside villages

2006 • 76 citations

The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells.

1999 • 68 citations

Additive pro-oxidative effects of methylmercury and ebselen in liver from suckling rat pups

2003 • 66 citations

Ebselen protects glutamate uptake inhibition caused by methyl mercury but does not by Hg2+

2005 • 58 citations

Acute exposure to methylmercury at two developmental windows: Focus on neurobehavioral and neurochemical effects in rat offspring

2006 • 57 citations

A general method for relieving substrate inhibition in lactate dehydrogenases

1999 • 57 citations

Studies with neuronal cells: From basic studies of mechanisms of neurotoxicity to the prediction of chemical toxicity

2008 • 55 citations

Involvement of caspase 3-like protease in methylmercury-induced apoptosis of primary cultured rat cerebral microglia

2000 • 48 citations

Effects of Hg2+ and CH3Hg+ on Ca2+ fluxes in rat brain microsomes

1996 • 43 citations

Participation of N-methyl-d-aspartate receptors on methylmercury-induced DNA damage in rat frontal cortex

2004 • 35 citations

Guanine nucleotides protect against kainate toxicity in an ex vivo chick retinal preparation

1998 • 34 citations

Methylmercury increases N-methyl-d-aspartate receptors on human SH-SY 5Y neuroblastoma cells leading to neurotoxicity

2008 • 32 citations

Mercuric chloride induces a stress response in cultured astrocytes characterized by mitochondrial uptake of iron.

1998 • 28 citations

Methylmercury Stimulates Arachidonic Acid Release and Cytosolic Phospholipase A2 Expression in Primary Neuronal Cultures

2003 • 27 citations

Studies on the antioxidant effect and interaction of diphenyl diselenide and dicholesteroyl diselenide with hepatic δ-aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase

2008 • 26 citations

The use of fluorescence for detecting MeHg-induced ROS in cell cultures

2008 • 25 citations

45Ca2+ Influx in Rat Brain: Effect of Diorganylchalcogenides Compounds

2007 • 20 citations

An excised patch membrane sensor for arachidonic acid released in mouse hippocampal slices under stimulation of l-glutamate

2004 • 9 citations

Multiple effects of chemical reagent on enzyme: o-phthalaldehyde-induced inactivation, dissociation and partial unfolding of lactate dehydrogenase from pig heart

2003 • 6 citations