Studies with neuronal cells: From basic studies of mechanisms of neurotoxicity to the prediction of chemical toxicity

GABA_A Receptor Channels

1994 • 1,948 citations

Handbook of Pesticide Toxicology

1992 • 936 citations

Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat.

1993 • 914 citations

Selective release of glutamate from cerebellar granule cells differentiating in culture

1982 • 501 citations

Homeostatic plasticity and NMDA receptor trafficking

2005 • 365 citations

A Modular Approach to the ECVAM Principles on Test Validity

2004 • 329 citations

Neurotransmitter transporters: molecular function of important drug targets

2006 • 310 citations

Apoptosis, Excitotoxicity, and Neuropathology

1998 • 290 citations

Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitro

2002 • 210 citations

ChlorinatedHydrocarbonInsecticides

1993 • 194 citations

New Insights and New Issues in Developmental Neurotoxicology

2002 • 187 citations

Maternal Stress Produces Learning Deficits Associated with Impairment of NMDA Receptor-Mediated Synaptic Plasticity

2006 • 180 citations

A Novel Membrane Potential-Sensitive Fluorescent Dye Improves Cell-Based Assays for Ion Channels

2002 • 144 citations

Allosteric positive interaction of thymol with the GABAA receptor in primary cultures of mouse cortical neurons

2005 • 123 citations

The excitatory amino acid transporters: Pharmacological insights on substrate and inhibitor specificity of the EAAT subtypes

2005 • 123 citations

The Registry of Cytotoxicity: Toxicity Testing in Cell Cultures to Predict Acute Toxicity (LD50) and to Reduce Testing in Animals

2003 • 120 citations

Overview of the Final MEIC Results: II. The In Vitro--In Vivo Evaluation, Including the Selection of a Practical Battery of Cell Tests for Prediction of Acute Lethal Blood Concentrations in Humans

1999 • 105 citations

The organochlorine pesticides γ-hexachlorocyclohexane (lindane), α-endosulfan and dieldrin differentially interact with GABAA and glycine-gated chloride channels in primary cultures of cerebellar granule cells

2003 • 99 citations

The GABA Transporter and its Inhibitors

2000 • 92 citations

Excitotoxic death induced by released glutamate in depolarized primary cultures of mouse cerebellar granule cells is dependent on GABA_A receptors and niflumic acid‐sensitive chloride channels

2005 • 78 citations

Mercury compounds disrupt neuronal glutamate transport in cultured mouse cerebellar granule cells

2005 • 75 citations

Relationship between lindane concentration in blood and brain and convulsant response in rats after oral or intraperitoneal administration

1987 • 71 citations

Identification of GABA neurons in rat cortical cultures by GABA uptake autoradiography

1980 • 67 citations

Translocation of apoptosis‐inducing factor in cerebellar granule cells exposed to neurotoxic agents inducing oxidative stress

2002 • 63 citations

Disruption of GABA-dependent chloride flux by cyclodienes and hexachlorocyclohexanes in primary cultures of cortical neurons.

1994 • 63 citations

First direct demonstration of extensive GABA synthesis in mouse cerebellar neuronal cultures

2004 • 52 citations

Cell viability and proteomic analysis in cultured neurons exposed to methylmercury

2007 • 51 citations

GABAergic modulation of lindane (γ-hexachlorocyclohexane)-induced seizures

1989 • 35 citations

Synthesis of acetylcholine and γ-aminobutyric acid by dissociated cerebral cortical cells in vitro

1985 • 34 citations

Lindane inhibition of [35S]TBPS binding to the GABAA receptor in rat brain

1990 • 34 citations

Inhibition of binding by convulsant agents in primary cultures of cerebellar neurons

1993 • 33 citations

Long‐term exposure to dieldrin reduces γ‐aminobutyric acid type A and N‐methyl‐D‐aspartate receptor function in primary cultures of mouse cerebellar granule cells

2007 • 33 citations

Allosteric interactions between γ-aminobutyric acid, benzodiazepine and picrotoxinin binding sites in primary cultures of cerebellar granule cells. Differential effects induced by γ- and δ-hexachlorocyclohexane

1997 • 31 citations

Effects of the conformationally restricted GABA analogues, Cis-and Trans-4-aminocrotonic acid, on GABA neurotransmission in primary neuronal cultures

1999 • 20 citations

Cell culture models for neurotoxicology.

2001 • 20 citations

SIRC-CVS CYTOTOXICITY TEST: AN ALTERNATIVE FOR PREDICTING RODENT ACUTE SYSTEMIC TOXICITY

2006 • 10 citations