Methylmercury alters glutamate transport in astrocytes

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

1996 • 2,470 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Cognitive Deficit in 7-Year-Old Children with Prenatal Exposure to Methylmercury

1997 • 1,723 citations

Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1

1997 • 1,715 citations

Localization of neuronal and glial glutamate transporters

1994 • 1,668 citations

Primary structure and functional characterization of a high-affinity glutamate transporter

1992 • 1,319 citations

Cloning and expression of a rat brain L-glutamate transporter

1992 • 1,230 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

Biological Methylation of Mercury in Aquatic Organisms

1969 • 940 citations

Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations

1995 • 884 citations

Oxygen radicals and the nervous system

1985 • 822 citations

Effects of Prenatal and Postnatal Methylmercury Exposure From Fish Consumption on Neurodevelopment

1998 • 668 citations

NMDA receptors activate the arachidonic acid cascade system in striatal neurons

1988 • 600 citations

Synthesis of the Antioxidant Glutathione in Neurons: Supply by Astrocytes of CysGly as Precursor for Neuronal Glutathione

1999 • 569 citations

Synthesis of Methyl-mercury Compounds by Extracts of a Methanogenic Bacterium

1968 • 541 citations

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

1994 • 527 citations

Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites

1983 • 522 citations

Exchange of cystine and glutamate across plasma membrane of human fibroblasts.

1986 • 499 citations

Rat cortical neurons in cell culture: Culture methods, cell morphology, electrophysiology, and synapse formation

1978 • 482 citations

Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?

1998 • 468 citations

The biogeochemistry of mercury in the environment

1980 • 444 citations

Glutathione deficiency leads to mitochondrial damage in brain.

1991 • 428 citations

Maintenance of Neuronal Glutathione by Glial Cells

1993 • 398 citations

High Affinity Glutamate Transporters: Regulation of Expression and Activity

1997 • 397 citations

Role of membrane transport in metabolism and function of glutathione in mammals

1986 • 376 citations

A PHYSICOCHEMICAL RATIONALE FOR THE BIOLOGICAL ACTIVITY OF MERCURY AND ITS COMPOUNDS

1957 • 326 citations

Regulation of the Glial Na⁺-Dependent Glutamate Transporters by Cyclic AMP Analogs and Neurons

1998 • 299 citations

Mechanisms of methylmercury‐induced neurotoxicity

1994 • 292 citations

METHYL MERCURY EXPOSURE IN NORTHERN QUEBEC: II. NEUROLOGIC FINDINGS IN CHILDREN

1983 • 285 citations

Volume regulation in astrocytes: A role for taurine as an osmoeffector

1988 • 260 citations

Imbalances of trace elements related to oxidative damage in Alzheimer's disease brain.

1998 • 257 citations

Physical and mental development of children with prenatal exposure to mercury from fish

1986 • 252 citations

The Role of Glia in Neurotoxicity

2004 • 196 citations

GLIAL CELLS IN NEUROTOXICITY DEVELOPMENT

1999 • 190 citations

The functional significance of brain metallothioneins

1996 • 180 citations

Uptake of Glutamate and Cystine in C‐6 Glioma Cells and in Cultured Astrocytes

1990 • 179 citations

Modification of methylmercury toxicity and metabolism by selenium and vitamin E: possible mechanisms.

1978 • 168 citations

Glutathione Turnover in Cultured Astrocytes: Studies with [¹⁵N]Glutamate

1990 • 158 citations

Biotinylation of Single Cysteine Mutants of the Glutamate Transporter GLT-1 from Rat Brain Reveals Its Unusual Topology

1998 • 154 citations

Glutathione depletion potentiates MPTP and MPP+ toxicity in nigral dopaminergic neurones

1996 • 148 citations

Reduced postischemic expression of a glial glutamate transporter, GLT1, in the rat hippocampus

1995 • 145 citations

Depletion of brain glutathione by buthionine sulfoximine enhances cerebral ischemic injury in rats

1992 • 137 citations

Family of neutral and acidic amino acid transporters: molecular biology, physiology and medical implications

1997 • 136 citations

Uptake of methylmercury in the rat brain: effects of amino acids

1988 • 131 citations

Glutamate-evoked release of arachidonic acid from mouse brain astrocytes

1994 • 129 citations

Effects of prenatal methylmercury exposure from a high fish diet on developmental milestones in the Seychelles Child Development Study.

1997 • 128 citations

Changes in the number of astrocytes and microglia in the thalamus of the monkey Macaca fascicularis following long-term subclinical methylmercury exposure.

1996 • 120 citations

A Reentrant Loop Domain in the Glutamate Carrier EAAT1 Participates in Substrate Binding and Translocation

1998 • 111 citations

Alkylmercurial encephalopathy in the monkey (Saimiri sciureus andMacaca arctoides)

1975 • 107 citations

Methylmercury-induced alterations in excitatory amino acid transport in rat primary astrocyte cultures

1993 • 107 citations

Inhibition of Amino Acid Transport and Protein Synthesis by HgCl₂ and Methylmercury in Astrocytes: Selectivity and Reversibility

1989 • 107 citations

Increases in the Number of Reactive Glia in the Visual Cortex of Macaca fascicularis Following Subclinical Long-Term Methyl Mercury Exposure

1994 • 106 citations

Methylmercury uptake in rat primary astrocyte cultures: the role of the neutral amino acid transport system

1990 • 93 citations

Constitutive Expression of Metallothionein Genes in Mouse Brain

1995 • 91 citations

In vitro evidence for the hole of glutamate in the CNS toxicity of mercury

1992 • 83 citations

Distribution of metallothionein in the human central nervous system

1993 • 80 citations

Differential modulation by sulfhydryl redox agents and glutathione of GABA- and glycine-evoked currents in rat retinal ganglion cells

1995 • 79 citations

Interactions of methylmercury with rat primary astrocyte cultures: inhibition of rubidium and glutamate uptake and induction of swelling

1990 • 78 citations

Cysteine Scanning of the Surroundings of an Alkali-Ion Binding Site of the Glutamate Transporter GLT-1 Reveals a Conformationally Sensitive Residue*

1998 • 76 citations

Neurodevelopmental outcomes of Seychellois children sixty-six months after in utero exposure to methylmercury from a maternal fish diet: pilot study.

1995 • 74 citations

On the Role of Calcium in the Regulatory Volume Decrease (RVD) Response in Ehrlich Mouse Ascites Tumor Cells

1997 • 70 citations

Cysteine and Cystine Transport at the Blood‐Brain Barrier

1982 • 69 citations

Intracellular glutathione (GSH) levels modulate mercuric chloride (MC)- and methylmercuric chloride (MeHgCl)-induced amino acid release from neonatal rat primary astrocytes cultures

1994 • 66 citations

EFFECTS OF METHYLMERCURY ON IN VIVO PROTEIN SYNTHESIS IN ISOLATED CEREBRAL AND CEREBELLAR NEURONS

1977 • 59 citations

The role of sulfhydryl groups and calcium in the mercuric chloride-induced inhibition of glutamate uptake in rat primary astrocyte cultures

1993 • 57 citations

The localization of mercury and metallothionein in the cerebellum of rats experimentally exposed to methylmercury

1994 • 51 citations

Mechanism of rapid K+-induced swelling of mouse astrocytes

1992 • 51 citations

Chapter 5: Functional consequences of astrocytic swelling

1992 • 46 citations

Induction of cystine transport via system xc− and maintenance of intracellular glutathione levels in pancreatic acinar and islet cell lines

1998 • 42 citations

Increase in rat brain glutathione following intracerebroventricular administration of γ-glutamylcysteine

1992 • 42 citations

[Neuropathological studies on organic mercury poisoning with special reference to the staining and distribution of mercury granules].

1966 • 42 citations

Transfection and overexpression of metallothionein-I in neonatal rat primary astrocyte cultures and in astrocytoma cells increases their resistance to methylmercury-induced cytotoxicity

1999 • 36 citations

Chapter 6: Swelling of C6 glioma cells and astrocytes from glutamate, high K+ concentrations or acidosis

1992 • 32 citations

Ultrastructural evidence that mercuric chloride lowers the threshold for glutamate neurotoxicity in an organotypic culture of rat cerebellum

1993 • 30 citations

Oxidative damage to nucleic acids in motor neurons containing mercury

1998 • 30 citations

Glycine site antagonists and partial agonists inhibit N-methyl-D-aspartate receptor-mediated [3H]arachidonic acid release in cerebellar granule cells.

1998 • 28 citations

Arachidonic acid inhibits uptake of amino acids and potentiates PKC effects on glutamate, but not GABA, exocytosis in isolated hippocampal nerve terminals

1997 • 23 citations

Stimulation of d-aspartate efflux by mercuric chloride from rat primary astrocyte cultures

1993 • 22 citations

Methylmercury-induced inhibition of regulatory volume decrease in astrocytes: characterization of osmoregulator efflux and its reversal by amiloride

1998 • 20 citations

Methylmercury-induced astrocytic swelling is associated with activation of the Na+/H+ antiporter, and is fully reversed by amiloride

1998 • 19 citations

Inhibition of the high-affinity uptake of d-[3H]aspartate in rat brain by l-α-aminoadipate and arachidonic acid

1996 • 9 citations