Ebselen protects glutamate uptake inhibition caused by methyl mercury but does not by Hg2+

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Biomolecule−Mercury Interactions: Modalities of DNA Base−Mercury Binding Mechanisms. Remediation Strategies

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Ebselen, a selenoorganic compound as glutathione peroxidase mimic

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1989 • 403 citations

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Neuroprotective Effect of an Antioxidant, Ebselen, in Patients with Delayed Neurological Deficits after Aneurysmal Subarachnoid Hemorrhage

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The high affinity uptake system for excitatory amino acids in the brain

1994 • 257 citations

Anti-inflammatory and antinociceptive activity of diphenyl diselenide

2003 • 243 citations

Ebselen: A substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant

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Methylmercury alters glutamate transport in astrocytes

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Mercury Induces Cell Cytotoxicity and Oxidative Stress and Increases β‐Amyloid Secretion and Tau Phosphorylation in SHSY5Y Neuroblastoma Cells

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Expedient synthesis of ebselen and related compounds

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A Novel Antioxidant Mechanism of Ebselen Involving Ebselen Diselenide, a Substrate of Mammalian Thioredoxin and Thioredoxin Reductase

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Neuronal and Glial Glutamate Transporters Possess an SH‐based Redox Regulatory Mechanism

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Neuroprotective efficacy of ebselen, an anti‐oxidant with anti‐inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion

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Hypobaric-ischemic conditions produce glutamate-like cytopathology in infant rat brain

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The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat

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Demethylation of Methyl Mercury in Different Brain Sites of Macaca-fascicularis Monkeys during Long-Term Subclinical Methyl Mercury Exposure

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Guanosine enhances glutamate uptake in brain cortical slices at normal and excitotoxic conditions.

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Diphenyl diselenide and diphenyl ditelluride affect the rat glutamatergic system in vitro and in vivo

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Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons

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Antioxidant compounds and Ca²⁺ pathway blockers differentially protect against methylmercury and mercuric chloride neurotoxicity

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Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat

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Free radical formation in cerebral cortical astrocytes in culture induced by methylmercury

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The importance of glutamate, glycine, and γ-aminobutyric acid transport and regulation in manganese, mercury and lead neurotoxicity

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Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia

2002 • 109 citations

Methylmercury-induced alterations in excitatory amino acid transport in rat primary astrocyte cultures

1993 • 107 citations

Increases in the Number of Reactive Glia in the Visual Cortex of Macaca fascicularis Following Subclinical Long-Term Methyl Mercury Exposure

1994 • 106 citations

Inhibition of superoxide and nitric oxide release and protection from reoxygenation injury by ebselen in rat kupffer cells

1992 • 98 citations

Diphenyl diselenide protects rat hippocampal slices submitted to oxygen–glucose deprivation and diminishes inducible nitric oxide synthase immunocontent

2003 • 98 citations

Acute Exposure to Methylmercury Opens the Mitochondrial Permeability Transition Pore in Rat Cerebellar Granule Cells

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Methylmercury Affects Multiple Subtypes of Calcium Channels in Rat Cerebellar Granule Cells

2000 • 95 citations

Antioxidants J811 and 17?-estradiol protect cerebellar granule cells from methylmercury-induced apoptotic cell death

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Methylmercury Increases Glutamate Release from Brain Synaptosomes and Glutamate Uptake by Cortical Slices from Suckling Rat Pups: Modulatory Effect of Ebselen

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Ebselen protects against methylmercury-induced inhibition of glutamate uptake by cortical slices from adult mice

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The Involvement of Microtubular Disruption in Methylmercury-Induced Apoptosis in Neuronal and Nonneuronal Cell Lines

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2,3-Dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase mercury- and cadmium-induced inhibition of δ-aminolevulinate dehydratase

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In vitro evidence for the hole of glutamate in the CNS toxicity of mercury

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Methylmercury increases glutamate extracellular levels in frontal cortex of awake rats

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Interactions of methylmercury with rat primary astrocyte cultures: inhibition of rubidium and glutamate uptake and induction of swelling

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The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site

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1996 • 58 citations

The role of sulfhydryl groups and calcium in the mercuric chloride-induced inhibition of glutamate uptake in rat primary astrocyte cultures

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Specificity and Reversibility of the Inhibition by HgCl₂ of Glutamate Transport in Astrocyte Cultures

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Neuroprotective effect of ebselen on rat hippocampal slices submitted to oxygen–glucose deprivation: correlation with immunocontent of inducible nitric oxide synthase

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The localization of mercury and metallothionein in the cerebellum of rats experimentally exposed to methylmercury

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Mercuric chloride, but not methylmercury, inhibits glutamine synthetase activity in primary cultures of cortical astrocytes

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Role of oxygen and nitrogen species in experimental uveitis: anti-inflammatory activity of the synthetic antioxidant ebselen

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Cellular mechanisms underlying the increase in cytosolic free calcium concentration induced by methylmercury in cerebrocortical synaptosomes from guinea pig.

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Disruption by Methylmercury of Membrane Excitability and Synaptic Transmission of CA1 Neurons in Hippocampal Slices of the Rat

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Role of nitric oxide in the cerebellar degeneration during methylmercury intoxication

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Mercury Kinetics in a Case of Severe Mercuric Chloride Poisoning Treated with Dimercapto-1-propane Sulphonate (DMPS)

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Selenium Compounds Prevent the Effects of Methylmercury on the in Vitro Phosphorylation of Cytoskeletal Proteins in Cerebral Cortex of Young Rats

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Efficacy of the antioxidant ebselen in experimental uveitis

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Pharmacological characterization of the effects of methylmercury and mercuric chloride on spontaneous noradrenaline release from rat hippocampal slices

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Facilitating infant adaptation: the nursery environment

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Inhibition of Axonal Morphogenesis by Nonlethal, Submicromolar Concentrations of Methylmercury

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Ebselen Lowers Plasma Interleukin-6 Levels and Glial Heme Oxygenase-1 Expression after Focal Photothrombotic Brain Ischemia

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Methylmercury acts at multiple sites to block hippocampal synaptic transmission.

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Selective inhibition of glutamate uptake by mercury in cultured mouse astrocytes

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Susceptibility of lipids to mercurials

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The effects of methylmercury on endogenous dopamine efflux from mouse striatal slices

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Ebselen Protects Ca²⁺Influx Blockage But Does Not Protect Glutamate Uptake Inhibition Caused By Hg²⁺

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