Pharmacological actions of melatonin in oxygen radical pathophysiology

Cellular defenses against damage from reactive oxygen species

1994 • 2,393 citations

Superoxide Dismutases

1975 • 1,673 citations

Melatonin : a potent, endogenous hydroxyl radical scavenger

1993 • 1,673 citations

Free Radicals as Mediators of Tissue Injury and Disease

1993 • 1,480 citations

The antioxidants of human extracellular fluids

1990 • 1,352 citations

Mechanisms of carbon tetrachloride toxicity

1989 • 1,250 citations

The Pineal and Its Hormones in the Control of Reproduction in Mammals*

1980 • 1,243 citations

Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences

1990 • 1,143 citations

Nuclease P1-mediated enhancement of sensitivity of ³²P-Postlabeling test for structurally diverse DNA adducts

1986 • 1,009 citations

Oxidative stress‐induced cataract: mechanism of action

1995 • 891 citations

A review of the evidence supporting melatonin's role as an antioxidant

1995 • 827 citations

Oxidative processes and antioxidative defense mechanisms in the aging brain ¹

1995 • 810 citations

Melatonin: A peroxyl radical scavenger more effective than vitamin E

1994 • 741 citations

Kainic acid seizures in the rat

1994 • 693 citations

Hepatogastroenterology

2011 • 681 citations

Melatonin stimulates brain glutathione peroxidase activity

1995 • 558 citations

Lipid peroxidation and cellular damage in toxic liver injury.

1985 • 556 citations

Melatonin, hydroxyl radical‐mediated oxidative damage, and aging: A hypothesis

1993 • 493 citations

Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes

1996 • 471 citations

The Nitric Oxide Synthase Family of Proteins

1994 • 465 citations

The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances

1993 • 434 citations

β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease

1994 • 406 citations

On the antioxidant effects of ascorbic acid and glutathione

1992 • 382 citations

Photodynamic therapy induces rapid cell death by apoptosis in L5178Y mouse lymphoma cells.

1991 • 372 citations

Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.

1992 • 362 citations

Melatonin—A Highly Potent Endogenous Radical Scavenger and Electron Donor: New Aspects of the Oxidation Chemistry of this Indole Accessed in vitroa

1994 • 356 citations

Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization

1993 • 356 citations

Melatonin As a Free Radical Scavenger: Implications for Aging and Age‐Related Diseases^a

1994 • 350 citations

Advances in Pineal Research

1991 • 344 citations

Evaluation of the antioxidant activity of melatonin in vitro

1996 • 341 citations

Nuclear localization of melatonin in different mammalian tissues: Immunocytochemical and radioimmunoassay evidence

1993 • 329 citations

Reactive oxygen and ischemia/reperfusion injury of the liver

1991 • 325 citations

The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo

1993 • 311 citations

The pineal gland and melatonin in relation to aging: A summary of the theories and of the data

1995 • 287 citations

On the primary functions of melatonin in evolution: Mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals*

1995 • 266 citations

Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats

1994 • 260 citations

Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole

1994 • 249 citations

The ageing pineal gland and its physiological consequences

1992 • 248 citations

Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum

1994 • 246 citations

N-Acetylcysteine and glutathione as inhibitors of tumor necrosis factor production

1992 • 238 citations

Melatonin protects neurons from singlet oxygen‐induced apoptosis

1995 • 223 citations

Oxidative damage in the liver induced by ischemia-reperfusion: protection by melatonin.

1996 • 219 citations

Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease

1990 • 218 citations

Melatonin reduces nitric oxide synthase activity in rat hypothalamus

1996 • 212 citations

Oxidative stress induced by glutamate receptor agonists

1993 • 210 citations

Increased brain damage after stroke or excitotoxic seizures in melatonin‐deficient rats

1996 • 208 citations

Functional Pleiotropy of the Neurohormone Melatonin: Antioxidant Protection and Neuroendocrine Regulation

1995 • 205 citations

Studies on the effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on central catecholamine neurons in C57 BL/6 mice. Comparison with three other strains of mice

1987 • 202 citations

Melatonin is protective against MPTP-induced striatal and hippocampal lesions

1996 • 200 citations

Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks

1995 • 196 citations

Paraquat

1976 • 187 citations

Melatonin protects human blood lymphocytes from radiation-induced chromosome damage

1995 • 170 citations

Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1'-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver.

1983 • 167 citations

Melatonin reduces kainate‐induced lipid peroxidation in homogenates of different brain regions

1995 • 157 citations

Oxidative damage caused by free radicals produced during catecholamine autoxidation: Protective effects of O-methylation and melatonin

1996 • 155 citations

Functional aspects of the pineal hormone melatonin in combating cell and tissue damage induced by free radicals

1996 • 155 citations

Melatonin reduces both basal and bacterial lipopolysaccharide-induced lipid peroxidation in vitro

1995 • 149 citations

Paraquat toxicity and oxidative damage

1996 • 147 citations

Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin

1995 • 142 citations

Inhibitory effect of melatonin on cataract formation in newborn rats: Evidence for an antioxidative role for melatonin

1994 • 141 citations

Melatonin and structurally-related, endogenous indoles act as potent electron donors and radical scavengers in vitro

1996 • 134 citations

Melatonin and radioprotection from genetic damage: In vivo/in vitro studies with human volunteers

1996 • 132 citations

Melatonin administration prevents lipopolysaccharide‐induced oxidative damage in phenobarbital‐treated animals

1995 • 127 citations

Oxygen free radicals, melatonin, and aging

1995 • 124 citations

Stimulation of neutrophil oxygen-dependent metabolism by human leukocytic pyrogen.

1979 • 114 citations

Melatonin is an efficient antioxidant

1995 • 113 citations

Marked Reduction of Radiation-Induced Micronuclei in Human Blood Lymphocytes Pretreated with Melatonin

1995 • 111 citations

Protective effect of melatonin against hippocampal dna damage induced by intraperitoneal administration of kainate to rats

1996 • 109 citations

Characterization of the antioxidant effects of melatonin and related indoleamines in vitro

1996 • 102 citations

Changes in the levels of endogenous antioxidants in the liver of mice with experimental endotoxemia and the protective effects of the antioxidants.

1989 • 101 citations

Melatonin counteracts lipid peroxidation induced by carbon tetrachloride but does not restore glucose‐6 phosphatase activity

1995 • 101 citations

Exploratory laser flash photolysis study of free radical reactions and magnetic field effects in melatonin chemistry

1995 • 100 citations

Melatonin as a therapeutic agent in experimental endotoxic shock

1996 • 95 citations

Melatonin in the Context of the Free Radical Theory of Aginga

1996 • 94 citations

Melatonin prevents ischemia reperfusion injury in hamster cheek pouch microcirculation

1996 • 92 citations

Preventive effect of melatonin against cyanide-induced seizures and lipid peroxidation in mice

1996 • 85 citations

Dynamics of lipid peroxidation and its inhibition by antioxidants

1993 • 82 citations

Melatonin, a mediator of electron transfer and repair reactions, acts synergistically with the chain-breaking antioxidants ascorbate, trolox and glutathione

1995 • 81 citations

Modulation of Radiation-induced Chromosome Aberrations by DMSO, an OH Radical Scavenger. 1: Dose—response Studies in Human Lymphocytes Exposed to 220 kV X-rays

1988 • 76 citations

Melatonin reduces H₂O₂‐induced lipid peroxidation in homogenates of different rat brain regions

1995 • 74 citations

Potential Radioprotective Agents. 1. Homologs of Melatonin

1994 • 68 citations

Oxygen radical detoxification processes during aging:The functional importance of melatonin

1995 • 68 citations

In vitro and in vivo protection against kainate‐induced excitotoxicity by melatonin

1996 • 61 citations

The Role of Metal Ions in Oxidative Processes and Aging

1993 • 59 citations

Melatonin and radioprotection from genetic damage : In vivo/in vitro studies with human volunteers

1996 • 58 citations

Melatonin attenuates L‐cysteine‐induced seizures and lipid peroxidation in the brain of mice

1996 • 57 citations

Lipopolysaccharide-induced DNA damage is greatly reduced in rats treated with the pineal hormone melatonin

1996 • 57 citations

Tissue Changes in Glutathione Metabolism and Lipid Peroxidation Induced by Swimming are Partially Prevented by Melatonin

1996 • 50 citations

A catalyst function for MPTP in superoxide formation

1985 • 49 citations

Reactive oxygen species induce antigenic changes in DNA

1989 • 46 citations

Melatonin affords protection against kainate-induced in vitro lipid peroxidation in brain

1996 • 40 citations

The in vivo rat micronucleus test: integration with a 14-day study

1995 • 39 citations

Antagonistic effect of melatonin against cyanide-induced seizures and acute lethality in mice

1996 • 39 citations

Free radical scavenging effects of melatonin and serotonin

1996 • 32 citations

Prevention of Carbon Tetrachloride-Induced Lipid Peroxidation in Liver Microsomes from Dehydroepiandrosterone-Pretreated Rats

1994 • 24 citations

Lens GSH depletion and electrolyte changes preceding cataracts induced by buthionine sulfoximine in suckling mice

1992 • 21 citations

The Importance of Vitamin E in Human Nutrition

1990 • 17 citations

Iron decreases the nuclear but not the cytosolic content of the neurohormone melatonin in several tissues in chicks

1996 • 4 citations

Deleted Work

1955 • 0 citations