Oxidative stress induced by glutamate receptor agonists

Free radicals in biology and medicine

1991 • 17,840 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

1983 • 1,808 citations

Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists

1988 • 1,202 citations

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1989 • 987 citations

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

1990 • 787 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Cerebral hypoxia: some new approaches and unanswered questions

1990 • 674 citations

Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage

1990 • 510 citations

Acidosis and ischemic brain damage

1988 • 378 citations

The molecular basis of brain injury and brain edema

1990 • 355 citations

Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations

1990 • 343 citations

The Molecular Basis of Brain Injury and Brain Edema: The Role of Oxygen Free Radicals

1990 • 321 citations

CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]d-AP5 binding sites on brain membranes and anticonvulsant activity

1986 • 311 citations

Sensitive and rapid quantitation of oxygen reactive species formation in rat synaptosomes

1990 • 309 citations

Receptors for the excitatory amino acids in the mammalian central nervous system

1983 • 292 citations

Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line.

1989 • 245 citations

Glutamate Receptor Agonists Stimulate Nitric Oxide Synthase in Primary Cultures of Cerebellar Granule Cells

1992 • 234 citations

Free radical generation during brief period of cerebral ischemia may trigger delayed neuronal death

1990 • 216 citations

Calcium chelator Quin 2 prevents hydrogen‐peroxide‐induced DNA breakage and cytotoxicity

1989 • 157 citations

U-78517F: a potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischemia.

1991 • 145 citations

Postischemic Cerebral Lipid Peroxidation In Vitro: Modification by Dietary Vitamin E

1985 • 129 citations

Diffusion characteristics and extracellular volume fraction during normoxia and hypoxia in slices of rat neostriatum

1991 • 123 citations

Brain lipid peroxidation and antioxidant protectant mechanisms following acute cyanide intoxication

1989 • 119 citations

The biochemical mechanisms of the excitotoxicity of Kainic acid

1992 • 95 citations

Interaction between free radicals and excitatory amino acids in the formation of ischemic brain edema in rats.

1991 • 91 citations

Time course of changes in lipid peroxidation, pre- and postsynaptic cholinergic indices, NMDA receptor binding and neuronal death in the gerbil hippocampus following transient ischemia

1991 • 90 citations

gamma-Aminobutyric acid agonists and antagonists alter chloride flux across brain membranes.

1986 • 89 citations

Calcium Enhances In Vitro Free Radical‐Induced Damage to Brain Synaptosomes, Mitochondria, and Cultured Spinal Cord Neurons

1985 • 78 citations

Domoic acid, an environmental toxin, produces hippocampal damage and severe memory impairment

1990 • 77 citations

Regulation of γ‐Aminobutyric Acid/Barbiturate Receptor‐Gated Chloride Ion Flux in Brain Vesicles by Phospholipase A₂: Possible Role of Oxygen Radicals

1988 • 75 citations

Increased excitotoxic vulnerability of cortical cultures with reduced levels of glutathione

1991 • 75 citations

Inactivation of mammalian brain glutamine synthetase by oxygen radicals

1988 • 75 citations

Release of arachidonic acid by NMDA-receptor activation in the rat hippocampus

1991 • 73 citations

Cerebral Superoxide Anion Generation during Seizures in Newborn Pigs

1989 • 71 citations

The osmotic/calcium stress theory of brain damage: Are free radicals involved?

1992 • 50 citations

Effect of extracellular Ca++ omission on isolated hepatocytes. I. Induction of oxidative stress and cell injury.

1988 • 48 citations

Effect of phenytoin and corticosteroids on seizures and lipid peroxidation in experimental posttraumatic epilepsy

1984 • 48 citations

Global elevation of brain superoxide dismutase activity following forebrain ischemia in rat

1991 • 44 citations

Accumulation of Amino Acids and Hydroxyl Free Radicals in Brain and Retina of Gerbil After Transient Ischemia

1991 • 43 citations

Protective effect of the iron chelator deferoxamine on cold-induced brain edema

1989 • 35 citations

Reduced excitatory effect of kainic acid on rat CA3 hippocampal pyramidal neurons following destruction of the mossy projection with colchicine

1987 • 30 citations

Lipid peroxidation in rat cerebral cortex during post‐ischemic reperfusion: Effect of exogenous antioxidants and Ca⁺⁺‐antagonist drugs

1992 • 24 citations

Role of early edema in the development of regional seizure-related brain damage

1987 • 20 citations

Extracellular calcium alleviates cell toxicity due to hepatotoxins that induce lipid peroxidation, but has no effect on toxins that do not cause lipid peroxidation

1989 • 11 citations

Formation of Excess Reactive Oxygen Species within the Brain

1992 • 8 citations

Excitotoxins and free radicals: accomplices in post-ischemic and other neurodegeneration

1990 • 4 citations