Adaptors as central mediators of signal transduction in immune cells

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

LAT

1998 • 1,251 citations

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

1998 • 951 citations

LAT Palmitoylation

1998 • 837 citations

Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

1998 • 759 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

1991 • 630 citations

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

2002 • 597 citations

Essential Role of LAT in T Cell Development

1999 • 537 citations

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

2000 • 527 citations

BLNK

1998 • 501 citations

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

1998 • 500 citations

LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

1998 • 486 citations

Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function

1996 • 460 citations

Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains (Pag), a Novel Ubiquitously Expressed Transmembrane Adaptor Protein, Binds the Protein Tyrosine Kinase Csk and Is Involved in Regulation of T Cell Activation

2000 • 457 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

Regulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and Syk

2003 • 417 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

1998 • 405 citations

Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues

2000 • 384 citations

p62 : A Constitutively Tyrosine-Phosphorylated, GAP-Associated Protein in Chronic Myelogenous Leukemia Progenitor Cells

1997 • 371 citations

Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76

1998 • 360 citations

An Essential Role for BLNK in Human B Cell Development

1999 • 352 citations

Staging and resetting T cell activation in SMACs

2002 • 343 citations

Vav and SLP-76 Interact and Functionally Cooperate in IL-2 Gene Activation

1996 • 335 citations

The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

1999 • 325 citations

Abnormal Development and Function of B Lymphocytes in Mice Deficient for the Signaling Adaptor Protein SLP-65

1999 • 321 citations

Coupling of the TCR to Integrin Activation by SLAP-130/Fyb

2001 • 314 citations

BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells

1999 • 313 citations

Requirement for B Cell Linker Protein (BLNK) in B Cell Development

1999 • 298 citations

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1997 • 285 citations

Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

2001 • 282 citations

A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation

2002 • 278 citations

Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade

2000 • 278 citations

SLP-65: A New Signaling Component in B Lymphocytes which Requires Expression of the Antigen Receptor for Phosphorylation

1998 • 271 citations

Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease geneSH2D1A/DSHP/SAP

2001 • 270 citations

Induction of T Helper Type 2 Immunity by a Point Mutation in the LAT Adaptor

2002 • 265 citations

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

1997 • 265 citations

Cutting Edge: Functional Requirement for SAP in 2B4-Mediated Activation of Human Natural Killer Cells as Revealed by the X-Linked Lymphoproliferative Syndrome

2000 • 263 citations

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

2001 • 258 citations

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

1999 • 252 citations

A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells.

1994 • 246 citations

Interaction of SLP adaptors with the SH2 domain of Tec family kinases

1999 • 245 citations

Negative Regulation of Immunoreceptor Signaling

2002 • 242 citations

SAP controls T cell responses to virus and terminal differentiation of TH2 cells

2001 • 242 citations

The RasGAP-Binding Protein p62dok Is a Mediator of Inhibitory FcγRIIB Signals in B Cells

2000 • 238 citations

Molecular Cloning of SLAP-130, an SLP-76-associated Substrate of the T Cell Antigen Receptor-stimulated Protein Tyrosine Kinases

1997 • 238 citations

X-Linked Lymphoproliferative Disease: A Progressive Immunodeficiency

2001 • 226 citations

Non–T Cell Activation Linker (NTAL)

2002 • 203 citations

Identification of a Phospholipase C-γ1 (PLC-γ1) SH3 Domain-Binding Site in SLP-76 Required for T-Cell Receptor-Mediated Activation of PLC-γ1 and NFAT

2001 • 194 citations

Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling

2000 • 186 citations

The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion

2002 • 184 citations

LAT Is Required for Tyrosine Phosphorylation of Phospholipase Cγ2 and Platelet Activation by the Collagen Receptor GPVI

1999 • 180 citations

Role of the rasGAP-associated docking protein p62^dokin negative regulation of B cell receptor-mediated signaling

2000 • 178 citations

Fetal hemorrhage and platelet dysfunction in SLP-76–deficient mice

1999 • 174 citations

Identification of the Minimal Tyrosine Residues Required for Linker for Activation of T Cell Function

2001 • 166 citations

LAB: A new membrane-associated adaptor molecule in B cell activation

2003 • 154 citations

B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice

2000 • 154 citations

The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R

1998 • 150 citations

Grf40, A Novel Grb2 Family Member, Is Involved in T Cell Signaling through Interaction with SLP-76 and LAT

1999 • 147 citations

Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells

2001 • 146 citations

Enhanced Hematopoiesis by Hematopoietic Progenitor Cells Lacking Intracellular Adaptor Protein, Lnk

2002 • 146 citations

Requirement for the SLP-76 Adaptor GADS in T Cell Development

2001 • 145 citations

The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells

2000 • 137 citations

The T-cell receptor signalosome: a dynamic structure with expanding complexity

2002 • 137 citations

Control of B Cell Production by the Adaptor Protein Lnk

2000 • 135 citations

Association of SLP-65 / BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-α

2001 • 129 citations

The Direct Recruitment of BLNK to Immunoglobulin α Couples the B-Cell Antigen Receptor to Distal Signaling Pathways

2002 • 125 citations

BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

2002 • 121 citations

Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells

2001 • 119 citations

Hematopoietic Progenitor Kinase 1 Associates Physically and Functionally with the Adaptor Proteins B Cell Linker Protein and SLP-76 in Lymphocytes

2001 • 115 citations

Differential Requirement for SLP-76 Domains in T Cell Development and Function

2001 • 104 citations

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

1999 • 98 citations

Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation

1999 • 96 citations

Differential Requirement for LAT and SLP-76 in GPVI versus T Cell Receptor Signaling

2002 • 90 citations

Adapters in lymphocyte signalling

2001 • 82 citations

Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through αIIbβ3 and collagen receptors

2000 • 78 citations

Differential role of SLP-76 domains in T cell development and function

2002 • 73 citations

p56dok-2 as a cytokine-inducible inhibitor of cell proliferation and signal transduction

2000 • 71 citations

Molecular Cloning of a Novel Gene Encoding a Membrane-associated Adaptor Protein (LAX) in Lymphocyte Signaling

2002 • 71 citations

SLP-76 and Vav Function in Separate, but Overlapping Pathways to Augment Interleukin-2 Promoter Activity

1999 • 70 citations

Membrane Raft-Dependent Regulation of Phospholipase Cγ-1 Activation in T Lymphocytes

2001 • 64 citations

Scaffolds, adaptors and linkers of TCR signaling: theory and practice

2002 • 47 citations

Regulation of ITAM Signaling by Specific Sequences in Ig-β B Cell Antigen Receptor Subunit

1996 • 38 citations

Cutting Edge: B Cell Linker Protein Is Dispensable for the Allelic Exclusion of Immunoglobulin Heavy Chain Locus But Required for the Persistence of CD5+ B Cells

2000 • 25 citations

SIGNALLING SCAFFOLDS AND ADAPTORS IN T‐CELL IMMUNITY

2002 • 22 citations

Stimulation of the high-affinity IgE receptor results in the tyrosine phosphorylation of a 60 kD protein which is associated with the protein-tyrosine kinase, Csk

1998 • 6 citations