LAT Is Required for Tyrosine Phosphorylation of Phospholipase Cγ2 and Platelet Activation by the Collagen Receptor GPVI

LAT

1998 • 1,251 citations

Molecular mechanisms of platelet activation.

1989 • 903 citations

LAT Palmitoylation

1998 • 837 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Activation of phospholipase Cgamma by PI 3-kinase-induced PH domain-mediated membrane targeting

1998 • 561 citations

Essential Role of LAT in T Cell Development

1999 • 537 citations

LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

1998 • 486 citations

The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

1997 • 456 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity

1999 • 399 citations

The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils

1998 • 378 citations

Integrin α2β1-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for α2β1-independent platelet reactivity

1995 • 311 citations

A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen

1998 • 242 citations

Tyrosine Phosphorylation of the Fc Receptor γ-Chain in Collagen-stimulated Platelets

1996 • 233 citations

Phospholipase C-γ1 Interacts with Conserved Phosphotyrosyl Residues in the Linker Region of Syk and Is a Substrate for Syk

1996 • 230 citations

Physical and Functional Association of the Src Family Kinases Fyn and Lyn with the Collagen Receptor Glycoprotein VI-Fc Receptor γ Chain Complex on Human Platelets

1998 • 228 citations

Phosphoinositide 3-Kinase Inhibition Spares Actin Assembly in Activating Platelets but Reverses Platelet Aggregation

1995 • 216 citations

A Collagen-Like Peptide Stimulates Tyrosine Phosphorylation of syk and Phospholipase Cγ2 in Platelets Independent of the Integrin α2β1

1997 • 198 citations

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production.

1996 • 194 citations

Collagen receptor signalling in platelets: extending the role of the ITAM

1998 • 189 citations

Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase

1997 • 178 citations

Fetal hemorrhage and platelet dysfunction in SLP-76–deficient mice

1999 • 174 citations

Phosphatidylinositol 3,4,5-Trisphosphate-dependent Stimulation of Phospholipase C-γ2 Is an Early Key Event in FcγRIIA-mediated Activation of Human Platelets

1998 • 165 citations

Dichotomous Regulation of Myosin Phosphorylation and Shape Change by Rho-Kinase and Calcium in Intact Human Platelets

1999 • 158 citations

Collagen stimulates tyrosine phosphorylation of phospholipase C‐γ2 but not phospholipase C‐γ1 in human platelets

1994 • 141 citations

The p85 Subunit of Phosphatidylinositol 3-Kinase Associates with the Fc Receptor γ-Chain and Linker for Activitor of T Cells (LAT) in Platelets Stimulated by Collagen and Convulxin

1998 • 138 citations

Phosphoinositide 3-Kinase γ and p85/Phosphoinositide 3-Kinase in Platelets

1996 • 135 citations

T Cell Receptor (TCR) Interacting Molecule (TRIM), A Novel Disulfide-linked Dimer Associated with the TCR–CD3–ζ Complex, Recruits Intracellular Signaling Proteins to the Plasma Membrane

1998 • 129 citations

A collagen-related peptide regulates phospholipase Cγ2 via phosphatidylinositol 3-kinase in human platelets

1999 • 118 citations

Synergy between Ca2+ and protein kinase C is the major factor in determining the level of secretion from human platelets

1993 • 112 citations

Tyrosine Phosphorylation of SLP-76 Is Downstream of Syk following Stimulation of the Collagen Receptor in Platelets

1999 • 110 citations

Evidence for the involvement of p59fyn and p53/56lyn in collagen receptor signalling in human platelets

1999 • 97 citations

Decreased expression of phospholipase C-beta 2 isozyme in human platelets with impaired function

1996 • 95 citations

Chromatin assembly during DNA replication in somatic cells

1999 • 81 citations

SHP2-interacting Transmembrane Adaptor Protein (SIT), A Novel Disulfide-linked Dimer Regulating Human T Cell Activation

1999 • 70 citations

Evidence that phospholipase C‐γ2 interacts with SLP‐76, Syk, Lyn, LAT and the Fc receptor γ‐chain after stimulation of the collagen receptor glycoprotein VI in human platelets

1999 • 65 citations

Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking

1996 • 50 citations

Agonist Receptors and G proteins as Mediators of Platelet Activation

1993 • 34 citations

Fcγ receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor

1994 • 33 citations

Signals elicited from human platelets by synthetic, triple helical, collagen-like peptides

1996 • 32 citations

The real LAT steps forward

1998 • 29 citations

Tyrosine phosphorylation and translocation of LAT in platelets

1998 • 15 citations