Rapid microassay for protein kinase C translocation in Swiss 3T3 cells

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease.

1983 • 601 citations

Translocation of Protein Kinase C Activity May Mediate Hippocampal Long-Term Potentiation

1986 • 532 citations

Purification and characterization of smooth muscle myosin light chain kinase.

1981 • 501 citations

Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.

1985 • 471 citations

A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters

1985 • 446 citations

Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells

1981 • 426 citations

Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.

1982 • 417 citations

Regulation of phosphatidylcholine biosynthesis

1984 • 401 citations

Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate.

1985 • 387 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways.

1985 • 351 citations

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF

1985 • 331 citations

Phospholipid degradation and signal translation for protein phosphorylation

1983 • 323 citations

Hormone-induced redistribution of calcium-activated phospholipid-dependent protein kinase in pituitary gonadotrophs.

1985 • 296 citations

Purification to homogeneity of protein kinase C from bovine brain-identity with the phorbol ester receptor.

1984 • 283 citations

Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP.

1985 • 274 citations

Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols.

1986 • 254 citations

The involvement of calpain in the activation of protein kinase C in neutrophils stimulated by phorbol myristic acid.

1986 • 228 citations

Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase.

1986 • 201 citations

Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells.

1986 • 194 citations

Binding of protein kinase C to neutrophil membranes in the presence of Ca2+ and its activation by a Ca2+-requiring proteinase.

1985 • 193 citations

Ambiquitous enzymes: Variation in intracellular distribution as a regulatory mechanism

1978 • 170 citations

Physicochemical properties of rabbit skeletal muscle phosphorylase kinase

1973 • 169 citations

Lack of association of epidermal growth factor-, insulin-, and serum-induced mitogenesis with stimulation of phosphoinositide degradation in BALB/c 3T3 fibroblasts.

1986 • 156 citations

Induction of protein kinase C activation and Ca²⁺ mobilization by fibroblast growth factor in Swiss 3T3 cells

1985 • 148 citations

A mild procedure for the rapid release of cytoplasmic enzymes from cultured animal cells

1979 • 144 citations

Activation of protein kinase C by non-phorbol tumor promoter, mezerein

1984 • 135 citations

Enzyme translocation in the regulation of phosphatidylcholine biosynthesis

1984 • 134 citations

Membrane-bound CTP: Phosphocholine cytidylyltransferase regulates the rate of phosphatidylcholine synthesis in HeLa cells treated with unsaturated fatty acids

1984 • 122 citations

Evidence that treatment of platelets with phorbol ester causes proteolytic activation of Ca²⁺‐activated, phospholipid‐dependent protein kinase

1985 • 121 citations

Protein kinase C translocates from cytosol to membrane upon hormone activation: Effects of thyrotropin-releasing hormone in GH3 cells

1985 • 119 citations

Early changes in inositol lipids and their metabolites induced by platelet-derived growth factor in quiescent Swiss mouse 3T3 cells

1985 • 114 citations

Modulation of Ca2+-activated, phospholipid-dependent protein kinase in platelets treated with a tumor-promoting phorbol ester

1984 • 109 citations

Phorbol ester induces intracellular translocation of phospholipid/Ca²⁺ ‐dependent protein kinase and stimulates amylase secretion in isolated pancreatic acini

1984 • 102 citations

Prostaglandin F_2α stimulates phosphatidylinositol turnover and increases the cellular content of 1,2‐diacylglycerol in confluent resting swiss 3T3 cells

1984 • 97 citations

Activation of V1-receptors by vasopressin stimulates inositol phospholipid hydrolysis and arachidonate metabolism in human platelets

1986 • 97 citations

Fibroblast growth factor treatment of Swiss 3T3 cells activates a subunit S6 kinase that phosphorylates a synthetic peptide substrate.

1986 • 96 citations

EGF and insulin action in fibroblasts

1986 • 93 citations

Purification of rat liver phosphorylase kinase.

1982 • 90 citations

Immunocytochemical evidence for phorbol ester-induced protein kinase C translocation in HL60 cells

1986 • 90 citations

Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin

1986 • 85 citations

Activation of myosin light chain kinase by trypsin

1980 • 84 citations

Cyclic nucleotide-independent protein kinases from rabbit reticulocytes. Purification and characterization of protease-activated kinase II.

1983 • 83 citations

Further characterization of tumor-promoter-mediated activation of protein kinase C

1984 • 83 citations

Phorbol esters stimulate phosphatidylcholine biosynthesis by translocation of CTP: Phosphocholine cytidylyltransferase from cytosol to microsomes

1984 • 77 citations

Effect of 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) on the growth inhibitory and increased phosphatidylinositol (PI) responses induced by epidermal growth factor (EGF) in A431 cells

1983 • 71 citations

A protein kinase C inhibitory activity is present in rat brain homogenate

1984 • 70 citations

Cyclic Nucleotide-independent protein kinases from rabbit reticulocytes. Identification and characterization of a protein kinase activated by proteolysis.

1981 • 69 citations

Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells

1986 • 62 citations

Subcellular distribution of phospholipid-sensitive calcium-dependent protein kinase in guinea pig heart, spleen and cerebral cortex, and inhibition of the enzyme by Triton X-100

1982 • 50 citations

Lipid requirements for the aggregation of CTP:phosphocholine cytidylyltransferase in rat liver cytosol

1979 • 48 citations

Differential mechanisms of translocation of protein kinase C to plasma membranes in activated human neutrophils

1986 • 46 citations

Inhibition of the Ca2+-and phospholipid-dependent protein kinase by a novel Mr 17,000 Ca2+-binding protein

1985 • 41 citations

Activation of calcium and phospholipid-dependent protein kinase by epidermal growth factor (EGF) in A431 cells: Attenuation by 12-0-tetradecanoylphorbol-13-acetate (TPA)

1982 • 40 citations

Rapid down‐regulation of protein kinase C and membrane association in phorbol ester‐treated leukemia cells

1985 • 34 citations

Activation of a cyclic AMP-independent protein kinase by an endogenous ATP-requiring protease from lymphosarcoma cells.

1983 • 27 citations

Proteolytic activation of protein kinase C by membrane-bound protease in rat liver plasma membrane

1985 • 25 citations

Relationship between membrane-bound protein kinase C activity and calcium-dependent proliferation of BALBc 3T3 cells

1985 • 20 citations

Possible involvement of protein kinase C in interleukin-1 production by mouse peritoneal macrophages

1986 • 14 citations

Resolution and characterization of calcium/phospholipid-dependent protein kinase and H4 protease-activated protein kinase activities in lymphoid cells

1983 • 8 citations