Nonmutagenic mechanisms in carcinogenesis: role of protein kinase C in signal transduction and growth control.

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

DNA methylation and epigenetic inheritance

1990 • 2,198 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP

1988 • 736 citations

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

1989 • 549 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment--twenty-seventh G.H.A. Clowes memorial award lecture.

1988 • 326 citations

Phorbol esters induce multidrug resistance in human breast cancer cells.

1988 • 241 citations

Immunochemical evidence that three protein kinase C isozymes increase in abundance during HL-60 differentiation induced by dimethyl sulfoxide and retinoic acid.

1988 • 239 citations

Unique substrate specificity and regulatory properties of PKC‐ε: a rationale for diversity

1989 • 226 citations

Genetic Alterations During Colorectal-Tumor Development

1989 • 187 citations

Construction and Characterization of a Retroviral Vector Demonstrating Efficient Expression of Cloned cDNA Sequences

1988 • 157 citations

Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family.

1987 • 156 citations

Production of diacylglycerol, an activator of protein kinase C, by human intestinal microflora.

1990 • 132 citations

Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas.

1987 • 126 citations

The regulation of protein kinase C by chenodeoxycholate, deoxycholate and several structurally related bile acids

1987 • 110 citations

Cells that overproduce protein kinase C are more susceptible to transformation by an activated H-ras oncogene.

1989 • 93 citations

Fecal diglycerides as selective endogenous mitogens for premalignant and malignant human colonic epithelial cells.

1989 • 89 citations

Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells

1989 • 86 citations

Disturbances in growth control and gene expression in a C3H/10T1/2 cell line that stably overproduces protein kinase C.

1989 • 64 citations

Positive and negative controls on cell growth

1989 • 46 citations

Oncogene-Induced Transformation of a Rat Embryo Fibroblast Cell Line is Enhanced by Tumor Promoters

1986 • 46 citations

Role of bile acids and neutral sterols in carcinogenesis

1988 • 45 citations

Increased levels of phorbin, c‐myc, and ornithine decarboxylase RNAs in human colon cancer

1990 • 43 citations

Studies on Protein Kinase C and Colon Carcinogenesis

1987 • 43 citations

The Protein Kinase C Family: Heterogeneity And Its Implications

1989 • 28 citations

Oncogene-induced transformation of a rat embryo fibroblast cell line is enhanced by tumor promoters.

1986 • 25 citations

Phenotypic effects of overexpression of PKC_β1 in rat liver epithelial cells

1989 • 21 citations

Characterization of a specific form of protein kinase C overproduced by a C3H 10T½ cell line

1990 • 14 citations

Cells That Overproduce Protein Kinase C Are More Susceptible to Transformation by an Activated H-ras Oncogene

1989 • 11 citations