Interindividual variation among humans in carcinogen metabolism, DNA adduct formation and DNA repair

The Molecular Genetics of Cancer

1987 • 1,729 citations

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis.

1982 • 520 citations

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

1984 • 386 citations

Molecular characterization of the human excision repair gene : cDNA cloning and amino acid homology with the yeast DNA repair gene

1986 • 330 citations

The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment--twenty-seventh G.H.A. Clowes memorial award lecture.

1988 • 326 citations

Molecular epidemiology and carcinogen-DNA adduct detection: New approaches to studies of human cancer causation

1982 • 319 citations

Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes.

1982 • 269 citations

Characterization of Human Microsomal Cytochrome P-450 Enzymes

1989 • 244 citations

Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs.

1988 • 199 citations

Role of aromatic amine acetyltransferase in human colorectal cancer

1986 • 185 citations

Human tissues and cells in carcinogenesis research.

1987 • 173 citations

Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors.

1987 • 152 citations

Metabolism of N-nitrosodialkylamines by human liver microsomes.

1988 • 149 citations

Oncogenes and human cancer: cause or consequence?

1986 • 127 citations

DNA Adducfs, Protein Adducts, and Sister Chromatid Exchange in Cigarette Smokers and Nonsmokers<xref ref-type="fn" rid="FN2">2</xref>

1987 • 126 citations

Formation and persistence of benzo(a)pyrene metabolite-DNA adducts.

1985 • 117 citations

O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells.

1985 • 113 citations

Long-lasting effects of tobacco smoking on pulmonary drug-metabolizing enzymes: A case-control study on lung cancer patients

1989 • 103 citations

Interindividual variation in the activity of O⁶-methyl guanine-DNA methyltransferase and uracil-DNA glycosylase in human organs

1983 • 102 citations

Sequence specificity of guanine alkylation and repair

1988 • 100 citations

O6-alkylguanine-DNA alkyltransferase activity in normal human tissues and cells.

1984 • 98 citations

Biochemical and molecular epidemiology of human cancer: indicators of carcinogen exposure, DNA damage, and genetic predisposition.

1987 • 80 citations

DNA repair, oncogenes and carcinogenesis

1988 • 80 citations

Some observations on the oxidation phenotype status of Nigerian patients presenting with cancer

1981 • 79 citations

Sensitivity of human placental monooxygenase activity to maternal smoking

1981 • 76 citations

GC-rich regions in genomes as targets for DNA alkylation

1988 • 66 citations

Reduced O6-methylguanine repair in fibroblast cultures from patients with lung cancer

1990 • 52 citations

Preferential DNA repair in expressed genes.

1987 • 50 citations

Individual Differences in DNA Repair Capacities in Man

1987 • 50 citations

Monoclonal antibody phenotyping of interindividual differences in cytochrome P-450-dependent reactions of single and twin human placenta.

1984 • 49 citations

DNA repair synthesis in individuals with and without a family history of cancer

1989 • 46 citations

Molecular Genetics of Cancer

1996 • 40 citations

Formation of dna adducts and water‐soluble metabolites of benzo[a]pyrene in human monocytes is genetically controlled

1988 • 40 citations

Low O6-alkylguanine DNA alkyltransferase activity in the peripheral blood lymphocytes of patients with therapy-related acute nonlymphocytic leukemia.

1988 • 39 citations

Polymorphic metabolism of the carcinogen 2-acetylaminofluorene in human liver microsomes

1985 • 37 citations

O6-methylguanine-DNA methyltransferase in human fetal tissues: fetal and maternal factors.

1987 • 34 citations

A reduced rate of bulky DNA adduct removal is coincident with differentiation of human neuroblastoma cells induced by nerve growth factor.

1988 • 32 citations

DNA binding and adduct formation of aflatoxin B₁ in cultured human and animal tracheobronchial and bladder tissues

1982 • 28 citations

Repair of chemical carcinogen-induced damage in DNA of human lymphocytes and lymphoid cell lines — Studies of the kinetics of removal of O6-methylguanine and 3-methyladenine

1986 • 24 citations

Distribution and reproducibility of aryl hydrocarbon hydroxylase inducibility in a prospective population study of middle-aged male smokers and nonsmokers

1985 • 23 citations

A genetic component of the variance of N-acetoxy-2-acetylaminofluorene-induced DNA damage in mononuclear leukocytes determined by a twin study

1983 • 15 citations

Metabolism of benzo(a)pyrene in monolayer cultures of human bronchial epithelial cells from a series of donors

1987 • 13 citations

Interindividual Differences in the Activation of Two Hepatic Carcinogens to Mutagens by Human Liver

1986 • 10 citations

Increased binding of benzo[a]pyrene metabolites to lymphocytes from patients with lung cancer

1986 • 10 citations

Interindividual Variation in the DNA Binding of Chemical Genotoxins Following Metabolism by Human Bladder and Bronchus Explants

1984 • 7 citations