The Role of Oxidative Stress in Chronic Obstructive Pulmonary Disease

Superoxide Dismutase

1969 • 12,578 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

The global burden of disease: a comprehensive assessment of mortality and disability from diseases injuries and risk factors in 1990 and projected to 2020.

1996 • 7,011 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

2001 • 6,099 citations

Reactive oxygen species in cell signaling

2000 • 2,844 citations

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordberg, 2001, Karolinska Institute, Stockholm, ISBN 91-631-1064-4.

2001 • 2,603 citations

Physiological functions of thioredoxin and thioredoxin reductase

2000 • 2,440 citations

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1995 • 1,761 citations

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

1994 • 1,348 citations

Oxidants in Cigarette Smoke Radicals, Hydrogen Peroxide, Peroxynitrate, and Peroxynitritea

1993 • 1,142 citations

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

2000 • 1,099 citations

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.

1996 • 1,020 citations

Mitochondrial Superoxide Dismutase

1973 • 965 citations

Superoxide Dismutase

1973 • 887 citations

Nitric Oxide Synthase in Human and Rat Lung: Immunocytochemical and Histochemical Localization

1993 • 825 citations

Normal alveolar epithelial lining fluid contains high levels of glutathione

1987 • 795 citations

Systemic oxidative stress in asthma, COPD, and smokers.

1996 • 781 citations

Human copper-containing superoxide dismutase of high molecular weight.

1982 • 751 citations

Oxidative stress: its role in air pollution and adverse health effects

2003 • 744 citations

Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12

2000 • 720 citations

Endothelial Cell Death and Decreased Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 in Emphysema

2001 • 687 citations

Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb

2000 • 674 citations

Analysis of proteins and respiratory cells obtained from human lungs by bronchial lavage.

1974 • 654 citations

Cytokines in chronic obstructive pulmonary disease

2001 • 607 citations

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

1991 • 599 citations

Microsatellite Polymorphism in the Heme Oxygenase-1 Gene Promoter Is Associated with Susceptibility to Emphysema

2000 • 569 citations

Severity of Airflow Limitation Is Associated with Severity of Airway Inflammation in Smokers

1998 • 564 citations

Exhaled 8-Isoprostane as an In Vivo Biomarker of Lung Oxidative Stress in Patients with COPD and Healthy Smokers

2000 • 542 citations

Differences in Airway Inflammation in Patients with Fixed Airflow Obstruction Due to Asthma or Chronic Obstructive Pulmonary Disease

2003 • 511 citations

Upregulation of Gelatinases A and B, Collagenases 1 and 2, and Increased Parenchymal Cell Death in COPD

2000 • 508 citations

Redox-dependent downregulation of Rho by Rac

2003 • 508 citations

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

1998 • 497 citations

Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease.

1996 • 497 citations

Copper,zinc superoxide dismutase is primarily a cytosolic protein in human cells.

1992 • 492 citations

In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation.

1996 • 490 citations

Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia.

1995 • 484 citations

The thioredoxin system—From science to clinic

2003 • 471 citations

Cigarette smoking and lung destruction. Accumulation of neutrophils in the lungs of cigarette smokers.

1983 • 462 citations

Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages

2001 • 455 citations

Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice

1998 • 454 citations

4-Hydroxy-2-Nonenal, a Specific Lipid Peroxidation Product, Is Elevated in Lungs of Patients with Chronic Obstructive Pulmonary Disease

2002 • 443 citations

Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema

1997 • 439 citations

pH in Expired Breath Condensate of Patients with Inflammatory Airway Diseases

2002 • 438 citations

Extracellular superoxide dismutase in human tissues and human cell lines.

1984 • 424 citations

Increased expression of nuclear factor- B in bronchial biopsies from smokers and patients with COPD

2002 • 415 citations

Skeletal muscle dysfunction in chronic obstructive pulmonary disease

2001 • 415 citations

Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans

1992 • 396 citations

Oxidative Stress and Apoptosis Interact and Cause Emphysema Due to Vascular Endothelial Growth Factor Receptor Blockade

2003 • 392 citations

Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase

2004 • 391 citations

Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema

2001 • 377 citations

Increased Expression of Transforming Growth Factor- β 1 in Small Airway Epithelium from Tobacco Smokers and Patients with Chronic Obstructive Pulmonary Disease (COPD)

2001 • 364 citations

How Do Corticosteroids Work in Asthma?

2003 • 363 citations

Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration

2004 • 355 citations

Skeletal Muscle Apoptosis and Weight Loss in Chronic Obstructive Pulmonary Disease

2002 • 337 citations

Increase in Reactive Nitrogen Species Production in Chronic Obstructive Pulmonary Disease Airways

2000 • 337 citations

Impaired Inhibition by Dexamethasone of Cytokine Release by Alveolar Macrophages from Patients with Chronic Obstructive Pulmonary Disease

2002 • 328 citations

Bronchodilator action of inhaled nitric oxide in guinea pigs.

1992 • 326 citations

Exhaled Nitric Oxide in Chronic Obstructive Pulmonary Disease

1998 • 324 citations

Neutrophils and the Pathogenesis of COPD

2002 • 323 citations

Diet and Obstructive Lung Diseases

2001 • 323 citations

Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury.

1992 • 321 citations

Inhalation of Nitric Oxide Modulates Adult Human Bronchial Tone

1993 • 296 citations

Oxidative Stress, Chromatin Remodeling and Gene Transcription in Inflammation and Chronic Lung Diseases

2003 • 292 citations

Biomarkers of some pulmonary diseases in exhaled breath

2002 • 288 citations

Exhaled Ethane, a Marker of Lipid Peroxidation, Is Elevated in Chronic Obstructive Pulmonary Disease

2000 • 287 citations

Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia

1999 • 284 citations

Increased Levels of Cell Death and Proliferation in Alveolar Wall Cells in Patients With Pulmonary Emphysema

2004 • 284 citations

The Effect of Cigarette Smoking on Neutrophil Kinetics in Human Lungs

1989 • 281 citations

Epithelial Permeability, Inflammation, and Oxidant Stress in the Air Spaces of Smokers

1999 • 278 citations

Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD

2003 • 273 citations

Diaphragm strength in chronic obstructive pulmonary disease.

1996 • 261 citations

Chronic Obstructive Pulmonary Disease Is Associated with an Increase in Urinary Levels of Isoprostane F_{2 α}-III, an Index of Oxidant Stress

1998 • 260 citations

Expression of NADH/NADPH Oxidase p22 ^phox in Human Coronary Arteries

1999 • 259 citations

Exercise-induced Quadriceps Oxidative Stress and Peripheral Muscle Dysfunction in Patients with Chronic Obstructive Pulmonary Disease

2003 • 257 citations

Oxygen and Xenobiotic Reductase Activities of Cytochrome P450

1995 • 257 citations

Superoxide dismutase: A comparison of rate constants

1973 • 242 citations

Extracellular superoxide dismutase in vessels and airways of humans and baboons

1996 • 237 citations

Regulation of antioxidant enzyme gene expression in response to oxidative stress and during differentiation of mouse skeletal muscle

1999 • 237 citations

Aldehydes in Exhaled Breath Condensate of Patients with Chronic Obstructive Pulmonary Disease

2003 • 227 citations

Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide

1993 • 222 citations

Dietary intake of antioxidant (pro)-vitamins, respiratory symptoms and pulmonary function: the MORGEN study

1998 • 218 citations

Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: report of a trial organized by the Swedish Society for Pulmonary Diseases.

1983 • 217 citations

Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations

2003 • 215 citations

Immunocytochemical localization of extracellular superoxide dismutase in human lung.

1994 • 203 citations

Urban air pollution and chronic obstructive pulmonary disease: a review

2001 • 200 citations

Reduced Muscle Redox Capacity after Endurance Training in Patients with Chronic Obstructive Pulmonary Disease

2001 • 190 citations

Airway Inflammation in Smokers with Nonobstructive and Obstructive Chronic Bronchitis

1993 • 189 citations

Genomewide Linkage Analysis of Quantitative Spirometric Phenotypes in Severe Early-Onset Chronic Obstructive Pulmonary Disease

2002 • 178 citations

Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease

2001 • 177 citations

Plasma hypoxanthine levels in ARDS: implications for oxidative stress, morbidity, and mortality.

1997 • 177 citations

Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo.

1996 • 174 citations

Exhaled Carbon Monoxide and Nitric Oxide in COPD

2001 • 173 citations

Glutathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress

1995 • 169 citations

Oxygen metabolites stimulate release of high-molecular-weight glycoconjugates by cell and organ cultures of rodent respiratory epithelium via an arachidonic acid-dependent mechanism.

1990 • 167 citations

An investigation of the role of glutathione in increased epithelial permeability induced by cigarette smoke in vivo and in vitro.

1994 • 160 citations

Role of Latent Viral Infections in Chronic Obstructive Pulmonary Disease and Asthma

2001 • 154 citations

Transcription: Gene control by targeted histone acetylation

1998 • 153 citations

Prevention of influenza-induced lung injury in mice overexpressing extracellular superoxide dismutase

2001 • 148 citations

ROS in the local and systemic pathogenesis of COPD

2003 • 145 citations

Possible effects of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease

2003 • 142 citations

Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue.

1994 • 141 citations

Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease

1997 • 141 citations

Transgenic mice with expression of elevated levels of copper-zinc superoxide dismutase in the lungs are resistant to pulmonary oxygen toxicity.

1991 • 141 citations

Role of extracellular superoxide dismutase in bleomycin-induced pulmonary fibrosis

2002 • 140 citations

Frequency of glutathione S-transferase M1 deletion in smokers with emphysema and lung cancer

1997 • 135 citations

Evidence of local exercise-induced systemic oxidative stress in chronic obstructive pulmonary disease patients

2002 • 126 citations

Markers of nitric oxide metabolism in sputum and exhaled air are not increased in chronic obstructive pulmonary disease

1999 • 126 citations

Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries

2002 • 126 citations

Is there any relationship between plasma antioxidant capacity and lung function in smokers and in patients with chronic obstructive pulmonary disease?

2000 • 123 citations

Serial measurements of exhaled nitric oxide during exacerbations of chronic obstructive pulmonary disease

1999 • 122 citations

The effect of oxidative stress on histone acetylation and IL-8 release

2003 • 121 citations

Nitrate in exhaled breath condensate of patients with different airway diseases

2003 • 115 citations

Inhibition of tobacco smoke-induced lung inflammation by a catalytic antioxidant 1 11The research described in this article has been reviewed by the National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency and approved for publication. Approval does not signify that the contents necessarily reflect the views and the policies of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use.

2002 • 114 citations

Cigarette smoke elicits leukocyte adhesion to endothelium in hamsters: Inhibition by CuZn-SOD

1993 • 114 citations

Antioxidant gene expression in rat lung after exposure to cigarette smoke.

1998 • 112 citations

Reduction in days of illness after long-term treatment with N-acetylcysteine controlled-release tablets in patients with chronic bronchitis

1988 • 112 citations

Peroxynitrous Acid Homolyzes into ^•OH and ^•NO₂ Radicals

1998 • 111 citations

Exhaled Ethane Is Elevated in Cystic Fibrosis and Correlates with Carbon Monoxide Levels and Airway Obstruction

2000 • 109 citations

Orally administered N-acetylcysteine may improve general well-being in patients with mild chronic bronchitis

1994 • 103 citations

Increased production of TGF-β and apoptosis of T lymphocytes isolated from peripheral blood in COPD

2003 • 101 citations

Oral N-acetylcysteine and exacerbation rates in patients with chronic bronchitis and severe airways obstruction. British Thoracic Society Research Committee.

1985 • 98 citations

Characterization of Human Thioredoxin-like 2

2003 • 93 citations

Sptrx‐2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP‐kinase domains is expressed in human testis germ cells

2001 • 91 citations

The cellular stress response induced by aqueous extracts of cigarette smoke is critically dependent on the intracellular glutathione concentration

1998 • 90 citations

Gene expression profiling in respiratory tissues from rats exposed to mainstream cigarette smoke

2003 • 90 citations

Regulation of macrophage function by the antioxidant N-acetylcysteine in mouse-oxidative stress by endotoxin

2003 • 89 citations

Glucocorticoids Inhibit Superoxide Anion Production and p22 Phox mRNA Expression in Human Aortic Smooth Muscle Cells

1998 • 89 citations

N-ACETYL CYSTEINE ATTENUATES ACUTE LUNG INJURY IN THE RAT

1995 • 85 citations

PROTECTIVE EFFECTS OF N-ACETYLCYSTEINE AND RUTIN ON THE LIPID PEROXIDATION OF THE LUNG EPITHELIUM DURING THE ADULT RESPIRATORY DISTRESS SYNDROME

2000 • 84 citations

Role of P-Selectin and ICAM-1 in Pancreatitis-Induced Lung Inflammation in Rats

1999 • 84 citations

Adenoviral E1A primes alveolar epithelial cells to PM₁₀-induced transcription of interleukin-8

2001 • 83 citations

Exhaled nitric oxide in chronic obstructive pulmonary disease: relationship to pulmonary function

2001 • 83 citations

Serine proteases increase oxidative stress in lung cells

2001 • 82 citations

The role of oxidative processes in emphysema.

1983 • 81 citations

Overexpression of extracellular superoxide dismutase decreases lung injury after exposure to oil fly ash

2002 • 80 citations

Susceptibility of Heterozygous MnSOD Gene-Knockout Mice to Oxygen Toxicity

1998 • 79 citations

Protein Kinase C Activation Is Required for Cigarette Smoke–Enhanced C5a-Mediated Release of Interleukin-8 in Human Bronchial Epithelial Cells

1999 • 77 citations

A controlled trial of intermittent oral acetylcysteine in the long-term treatment of chronic bronchitis

1976 • 76 citations

N-ACETYL CYSTEINE ATTENUATES ACUTE LUNG INJURY IN THE RAT

1997 • 76 citations

Role of superoxide in hemorrhagic shock-induced P-selectin expression

2000 • 75 citations

Oxidant-mediated ciliary dysfunction in human respiratory epithelium

1994 • 74 citations

Neutrophil Elastase Induces MUC5AC Messenger RNA Expression by an Oxidant-Dependent Mechanism

2000 • 74 citations

Combined inhalation of nitric oxide and oxygen in chronic obstructive pulmonary disease.

1997 • 73 citations

Fruit and fish consumption: a possible explanation for population differences in COPD mortality (The Seven Countries Study)

1998 • 69 citations

The association between diet and chronic obstructive pulmonary disease in subjects selected from general practice

2002 • 69 citations

Extracellular Superoxide Dismutase Attenuates Lung Injury after Hemorrhage

2001 • 68 citations

Enhanced resistancy of thioredoxin-transgenic mice against influenza virus-induced pneumonia

2002 • 64 citations

Glutathione in bronchoalveolar lavage fluid from smokers is related to humoral markers of inflammatory cell activity

1989 • 63 citations

The Levels of Serum Vitamin C, Malonyldialdehyde and Erythrocyte Reduced Glutathione in Chronic Obstructive Pulmonary Disease and in Healthy Smokers

2002 • 62 citations

Nitrones as Neuroprotectants and Antiaging Drugs

2002 • 62 citations

Extracellular superoxide dismutase mRNA expressions in the human lung by in situ hybridization.

1997 • 61 citations

Immunocytochemical localization of the sites of superoxide dismutase induction by hyperoxia in rat lungs.

1995 • 61 citations

N -acetylcysteine Improves In Vitro The Function of Macrophages from Mice With Endotoxin-induced Oxidative Stress

2002 • 59 citations

Variability of Exhaled Hydrogen Peroxide in Stable COPD Patients and Matched Healthy Controls

2002 • 58 citations

Amelioration of ischemia-reperfusion injury by human thioredoxin in rabbit lung

1997 • 58 citations

Mice that overexpress Cu/Zn superoxide dismutase are resistant to allergen-induced changes in airway control

2000 • 58 citations

The Bronchitis Randomized On NAC Cost-Utility Study (BRONCUS): hypothesis and design

2001 • 55 citations

Interaction of vitamin C with the relation between smoking and obstructive airways disease in EPIC Norfolk

2000 • 55 citations

Regulation of E-selectin expression in postischemic intestinal microvasculature

2000 • 55 citations

Detection of xanthine oxidase activity products by EPR and HPLC in bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease

1998 • 55 citations

Expression of the thioredoxin system in interstitial lung disease

2003 • 54 citations

Immunolocalization of antioxidant enzymes and isozymes of glutathione S-transferase in normal rat lung

1992 • 52 citations

Smoke and C5a Induce Airway Epithelial Intercellular Adhesion Molecule-1 and Cell Adhesion

2003 • 49 citations

Decreased Leukocyte Deformability after Acute Cigarette Smoking in Humans

1993 • 48 citations

Cigarette smoke-induced protein oxidation and proteolysis is exclusively caused by its tar phase: prevention by vitamin C

2001 • 47 citations

The Activity of NF-kappaB in Swiss 3T3 Cells Exposed to Aqueous Extracts of Cigarette Smoke Is Dependent on Thioredoxin

2001 • 46 citations

Crucial role of local peroxynitrite formation in neutrophil-induced endothelial cell activation

2003 • 45 citations

Correlation between change in pulmonary function and suppression of reactive nitrogen species production following steroid treatment in COPD

2003 • 45 citations

Effects of Air Pollution on Adults with Chronic Obstructive Pulmonary Disease

2002 • 45 citations

Attenuation of ischaemia reperfusion injury by human thioredoxin.

1995 • 45 citations

Dietary factors in the pathogenesis of asthma and chronic obstructive pulmonary disease

2003 • 44 citations

LUNG PRECONDITIONING WITH N-ACETYL-l-CYSTEINE PREVENTS REPERFUSION INJURY AFTER LIVER NO FLOW-REFLOW: A DOSE-RESPONSE STUDY1

2001 • 43 citations

Plasma Markers of Endothelial Dysfunction in Chronic Obstructive Pulmonary Disease

2001 • 43 citations

Imbalance between levels of nitrogen oxides and peroxynitrite inhibitory activity in chronic obstructive pulmonary disease

2003 • 42 citations

Air pollution in relation to manifestations of chronic pulmonary disease: A nested case–control study in Athens, Greece

2002 • 41 citations

Lipid Peroxidation and Changes of Glutathione Peroxidase Activity in Treatment of Chronic Obstructive Pulmonary Disease Exacerbation: Prognostic Value of Malondialdehyde

2001 • 40 citations

Neutrophil dysfunction and increased susceptibility to infection

1995 • 40 citations

Latent adenoviral infection induces production of growth factors relevant to airway remodeling in COPD

2004 • 39 citations

Histochemical Demonstration of Neuronal Nitric Oxide Synthase during Development of Mouse Respiratory Tract

1999 • 37 citations

Adenovirus E1A blocks oxidant‐dependent ferritin induction and sensitizes cells to pro‐oxidant cytotoxicity

1999 • 36 citations

Evidence of a defective thiol status of alveolar macrophages from COPD patients and smokers

2000 • 34 citations

Expression of c-fos in quiescent Swiss 3T3 cells exposed to aqueous cigarette smoke fractions.

1995 • 34 citations

Exhaled Nitric Oxide Correlated With Induced Sputum Findings in COPD

2001 • 33 citations

Nitric oxide‐related cyclic GMP‐independent relaxing effect of N‐acetylcysteine in lipopolysaccharide‐treated rat aorta

1998 • 33 citations

Effectiveness of oral N -acetylcysteine in a rat experimental model of asthma

2002 • 32 citations

Overexpression of manganese superoxide dismutase (MnSOD) in whole lung or alveolar type II cells of MnSOD transgenic mice does not provide intrinsic lung irradiation protection

2001 • 30 citations

Thioredoxin liquefies and decreases the viscoelasticity of cystic fibrosis sputum

2004 • 30 citations

Role of endogenous nitric oxide in asthma

2000 • 30 citations

Genetic Epidemiology of COPD

2002 • 30 citations

Distribution of Manganese Superoxide Dismutase mRNA in Normal and Hyperoxic Rat Lung

1993 • 26 citations

Nitric Oxide and Blood Pressure in Mice Lacking Extracellular-Superoxide Dismutase

2002 • 22 citations

SURVIVAL, LUNG INJURY, AND LUNG PROTEIN NITRATION IN HETEROZYGOUS MnSOD KNOCKOUT MICE IN HYPEROXIA

1999 • 22 citations

The diffusing capacity in pulmonary emphysema.

1974 • 21 citations

Inhaled nitric oxide does not improve cardiac or pulmonary function in patients with an exacerbation of chronic obstructive pulmonary disease

1999 • 21 citations

Effect of nitric oxide inhalation on respiratory system resistance in chronic obstructive pulmonary disease

1996 • 20 citations

Analysis of antioxidant enzyme activity and magnesium level in chronic obstructive pulmonary disease (COPD).

2001 • 19 citations

Effect of the Combination of Human Thioredoxin and L·Cysteine on Ischemia-Reperfusion Injury in Isolated Rat Lungs

1995 • 17 citations

Modulation of nitric oxide responses in asthma by extracellular antioxidants

1999 • 17 citations

Vitamins A and E in Serum in Relation to Weight and Lung Function in Patients with Advanced Pulmonary Disease

2002 • 9 citations

Superoxide production by peripheral polymorphonuclear leukocytes in patients with COPD

2003 • 6 citations