Nitrones as Neuroprotectants and Antiaging Drugs

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Oxidative DNA damage and senescence of human diploid fibroblast cells.

1995 • 697 citations

Delayed Reduction of Ischemic Brain Injury and Neurological Deficits in Mice Lacking the Inducible Nitric Oxide Synthase Gene

1997 • 655 citations

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts

2000 • 532 citations

Inducible Nitric Oxide Synthase Gene Expression in Brain following Cerebral Ischemia

1995 • 479 citations

Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage

1995 • 378 citations

Inducible Nitric Oxide Synthase Gene Expression in Vascular Cells After Transient Focal Cerebral Ischemia

1996 • 331 citations

Detection and identification of short-lived free radicals by electron spin resonance trapping techniques (spin trapping). Photolysis of organolead, -tin, and -mercury compounds

1969 • 291 citations

Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development

1999 • 248 citations

Neuroprotective Effects of a Novel Nitrone, NXY-059, after Transient Focal Cerebral Ischemia in the Rat

1999 • 242 citations

Delayed treatment with the spin trap α‐phenyl‐N‐tert‐butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats

1994 • 196 citations

NXY-059, a Free Radical–Trapping Agent, Substantially Lessens the Functional Disability Resulting From Cerebral Ischemia in a Primate Species

2001 • 180 citations

Superoxide formation in spinach chloroplasts: Electron spin resonance detection by spin trapping

1975 • 179 citations

N-t-Butyl Hydroxylamine, a Hydrolysis Product of α-Phenyl-N-t-butyl Nitrone, Is More Potent in Delaying Senescence in Human Lung Fibroblasts

2000 • 139 citations

Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-α-phenylnitrone (PBN)

1990 • 135 citations

Redox-sensitive protein phosphatase activity regulates the phosphorylation state of p38 protein kinase in primary astrocyte culture

1999 • 111 citations

The Spin-Trap N-tert-α-Phenylbutylnitrone Prolongs the Life Span of the Senescence-Accelerated Mouse

1995 • 110 citations

Antioxidant treatment with phenyl-α-tert-butyl nitrone (PBN) improves the cognitive performance and survival of aging rats

1996 • 89 citations

Excretion, Metabolism and Tissue Distribution of A Spin Trapping Agent, α-Phenyl-N-Tert-Butyl-Nitrone (Pbn) in Rats

1990 • 88 citations

Chapter 13 Nitrone-Based Free Radical Traps as Neuroprotective Agents in Cerebral Ischaemia and Other Pathologies

1996 • 85 citations

Distribution of spin-trapping compounds in rat blood and brain: In vivo microdialysis determination

1993 • 80 citations

Nitrone Inhibition of Age‐Associated Oxidative Damage

2000 • 80 citations

The Free Radical Trapping Agent N-Tert.-Butyl-α-Phenylnitrone (PBN) Attenuates Cerebral Ischaemic Injury in Gerbils

1991 • 76 citations

Nitrones, their value as therapeutics and probes to understand aging

2002 • 69 citations

Phenyl-T-Butyl-Nitrone is Active Against Traumatic Shock in Rats

1986 • 69 citations

Notes - Kinetics of the Thermal Isomerization of 2-tert-Butyl-3-Phenyloxazirane

1957 • 66 citations

A Spin Trap, N-tert-Butyl-α-phenylnitrone Extends the Life Span of Mice

1998 • 64 citations

Protective Action of Nitrone-Based Free Radical Traps against Oxidative Damage to the Central Nervous System

1996 • 55 citations

Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics

2000 • 34 citations

Basal Protein Phosphorylation Is Decreased and Phosphatase Activity Increased by an Antioxidant and a Free Radical Trap in Primary Rat Glia

1999 • 27 citations

Within-subject behavioral analysis of recent memory in aging mice

1992 • 27 citations

Cited By (0)

Loading...