Functional Analysis of Cdc42 Residues Required for Guanine Nucleotide Exchange

The structural basis of the activation of Ras by Sos

1998 • 765 citations

Rac Regulation of Transformation, Gene Expression, and Actin Organization by Multiple, PAK-Independent Pathways

1997 • 433 citations

Dbl family guanine nucleotide exchange factors

2001 • 414 citations

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

2000 • 356 citations

A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion

1998 • 349 citations

GEFs: structural basis for their activation of small GTP-binding proteins

1999 • 334 citations

Interaction of the Nuclear GTP-Binding Protein Ran with Its Regulatory Proteins RCC1 and RanGAP1

1995 • 334 citations

Dynamic properties of the Ras switch I region and its importance for binding to effectors

2001 • 310 citations

SopE and SopE2 from Salmonella typhimurium Activate Different Sets of RhoGTPases of the Host Cell

2001 • 231 citations

Structural Basis for Guanine Nucleotide Exchange on Ran by the Regulator of Chromosome Condensation (RCC1)

2001 • 231 citations

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

2002 • 221 citations

Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins

1995 • 217 citations

Crystal Structure of Human RhoA in a Dominantly Active Form Complexed with a GTP Analogue

1998 • 214 citations

A novel Cdc42Hs mutant induces cellular transformation

1997 • 213 citations

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

2002 • 209 citations

The Role of Mg2+ Cofactor in the Guanine Nucleotide Exchange and GTP Hydrolysis Reactions of Rho Family GTP-binding Proteins

2000 • 172 citations

NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio

1998 • 171 citations

Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae.

1989 • 162 citations

The Dbl-related Protein, Lfc, Localizes to Microtubules and Mediates the Activation of Rac Signaling Pathways in Cells

1999 • 153 citations

Structure and mutagenesis of the Dbl homology domain

1998 • 142 citations

Signaling to the Rho GTPases: networking with the DH domain

2002 • 136 citations

Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE

2002 • 133 citations

Structure-based Mutagenesis Reveals Distinct Functions for Ras Switch 1 and Switch 2 in Sos-catalyzed Guanine Nucleotide Exchange

2001 • 122 citations

Dependence of Dbl and Dbs Transformation on MEK and NF-κB Activation

1999 • 108 citations

Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator.

1992 • 102 citations

Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor.

1995 • 77 citations

The Ras Mutant D119N Is Both Dominant Negative and Activated

1999 • 67 citations

Functional expression in Escherichia coli of the mitotic regulator proteins p24ran and p45rcc1 and fluorescence measurements of their interaction

1993 • 64 citations

p38 MAPK-mediated activation of NF-κB by the RhoGEF domain of Bcr

2002 • 62 citations

An Open Conformation of Switch I Revealed by the Crystal Structure of a Mg2+-free Form of RHOA Complexed with GDP

2000 • 61 citations

Investigation of the GTP-Binding/GTPase Cycle of Cdc42Hs Using Fluorescence Spectroscopy

1994 • 59 citations

[41] Ras-mediated transcription activation: Analysis by transient cotransfection assays

1995 • 51 citations

A novel N-ras mutation in malignant melanoma is associated with excellent prognosis.

2001 • 49 citations