An Open Conformation of Switch I Revealed by the Crystal Structure of a Mg2+-free Form of RHOA Complexed with GDP

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Solvent content of protein crystals

1968 • 7,954 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

G PROTEIN MECHANISMS: Insights from Structural Analysis

1997 • 1,061 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

The structural basis of the activation of Ras by Sos

1998 • 765 citations

Structural determinants for activation of the α-subunit of a heterotrimeric G protein

1994 • 636 citations

Rho GTPases

1998 • 534 citations

Structural Basis for Activation of ARF GTPase

1998 • 534 citations

The Dbl family of oncogenes

1996 • 497 citations

Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI

2000 • 494 citations

GEFs: structural basis for their activation of small GTP-binding proteins

1999 • 334 citations

Tertiary and Quaternary Structural Changes in G _iα1 Induced by GTP Hydrolysis

1995 • 294 citations

Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide-binding site.

1986 • 287 citations

Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras.

1993 • 260 citations

Structure of the conserved GTPase domain of the signal recognition particle

1997 • 229 citations

Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein

1998 • 220 citations

Crystal Structure of Human RhoA in a Dominantly Active Form Complexed with a GTP Analogue

1998 • 214 citations

Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP.

1991 • 211 citations

The effect of Mg2+ on the guanine nucleotide exchange rate of p21N-ras.

1986 • 203 citations

The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.

2000 • 198 citations

Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction.

1988 • 196 citations

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

1997 • 192 citations

NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio

1998 • 171 citations

Structure and mutagenesis of the Dbl homology domain

1998 • 142 citations

Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression.

1994 • 139 citations

The structure of elongation factor G in complex with GDP: conformational flexibility and nucleotide exchange

1996 • 126 citations

Kinetics of Interaction of Rab5 and Rab7 with Nucleotides and Magnesium Ions

1996 • 116 citations

Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP.

1999 • 86 citations

Is there a rate-limiting step before GTP cleavage by H-ras p21?

1991 • 84 citations

Amino acid residues in the Ras-like GTPase Rab3A that specify sensitivity to factors that regulate the GTP/GDP cycling of Rab3A

1992 • 82 citations

Invasion of the Nucleotide Snatchers

1998 • 74 citations

Investigation of the GTP-Binding/GTPase Cycle of Cdc42Hs Using Fluorescence Spectroscopy

1994 • 59 citations

GEF-mediated GDP/GTP exchange by monomeric GTPases: A regulatory role for Mg2+?

1998 • 33 citations

Nucleotide binding to the G12V‐mutant of Cdc42 investigated by X‐ray diffraction and fluorescence spectroscopy: Two different nucleotide states in one crystal

1999 • 31 citations

Influence of Mg2+ on the Structure and Function of Rab5

1996 • 27 citations