SopE and SopE2 from Salmonella typhimurium Activate Different Sets of RhoGTPases of the Host Cell

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines

1981 • 2,042 citations

Rho GTPases and their effector proteins

2000 • 1,941 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

S. typhimurium Encodes an Activator of Rho GTPases that Induces Membrane Ruffling and Nuclear Responses in Host Cells

1998 • 804 citations

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

1998 • 667 citations

A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion

1999 • 542 citations

The Dbl family of oncogenes

1996 • 497 citations

SopB, a protein required for virulence of Salmonella dublin , is an inositol phosphate phosphatase

1998 • 436 citations

Role of the S. typhimurium Actin-Binding Protein SipA in Bacterial Internalization

1999 • 386 citations

ASalmonellainositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization

2001 • 376 citations

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

2000 • 356 citations

Requirement of CDC42 for Salmonella -Induced Cytoskeletal and Nuclear Responses

1996 • 303 citations

The invasion‐associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell

1997 • 300 citations

A secreted effector protein of Salmonella dublin is translocated into eukaryotic cells and mediates inflammation and fluid secretion in infected ileal mucosa

1997 • 290 citations

Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell

2000 • 290 citations

Salmonella typhimurium leucine‐rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systems

1999 • 274 citations

Striking a balance: Modulation of the actin cytoskeleton bySalmonella

2000 • 273 citations

Isolation of a temperate bacteriophage encoding the type III effector protein SopE from an epidemic Salmonella typhimurium strain

1999 • 246 citations

SopE, a secreted protein of Salmonelladublin, is translocated into the target eukaryotic cell via a sip‐dependent mechanism and promotes bacterial entry

1996 • 240 citations

The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton

1998 • 234 citations

A secreted Salmonella protein with homology to an avirulence determinant of plant pathogenic bacteria

1997 • 218 citations

A substrate of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage

1998 • 211 citations

Interaction of Salmonella with host cells through the centisome 63 type III secretion system

1999 • 187 citations

Identification of SopE2, a Salmonella Secreted Protein Which Is Highly Homologous to SopE and Involved in Bacterial Invasion of Epithelial Cells

2000 • 172 citations

Secreted Effector Proteins of Salmonella dublin Act in Concert To Induce Enteritis

1998 • 150 citations

The Cdc42/Rac Interactive Binding Region Motif of the Wiskott Aldrich Syndrome Protein (WASP) Is Necessary but Not Sufficient for Tight Binding to Cdc42 and Structure Formation

1998 • 143 citations

The adenovirus E4-6/7 protein transactivates the E2 promoter by inducing dimerization of a heteromeric E2F complex.

1994 • 136 citations

YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells

2001 • 134 citations

SalmonellaHost Cell Invasion Emerged by Acquisition of a Mosaic of Separate Genetic Elements, IncludingSalmonellaPathogenicity Island 1 (SPI1), SPI5, andsopE2

2001 • 132 citations

Identification of a Novel Salmonella Invasion Locus Homologous to Shigella ipgDE

1998 • 128 citations

Bacterial Toxins Block Endothelial Wound Repair

1997 • 103 citations

Biochemical Analysis of SopE from Salmonella typhimurium, a Highly Efficient Guanosine Nucleotide Exchange Factor for RhoGTPases

1999 • 88 citations

Prevalence and polymorphism of genes encoding translocated effector proteins among clinical isolates of Salmonella enterica

2000 • 78 citations

Investigation of the GTP-Binding/GTPase Cycle of Cdc42Hs Using Fluorescence Spectroscopy

1994 • 59 citations

The DH Protein Family, Exchange Factors for Rho-Like GTPases

1999 • 53 citations

Requirement of p21-activated Kinase (PAK) for Salmonella typhimurium–induced Nuclear Responses

1999 • 51 citations

Determination of GTP Loading on Rac and Cdc42 in platelets and fibroblasts

2000 • 20 citations

Purification and biochemical activity of Salmonella exchange factor SopE

2000 • 15 citations