Antagonists of the NMDA receptor-channel complex and motor coordination

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1992 • 144 citations

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1992 • 132 citations

MK-801, phencyclidine (PCP), and PCP-like drugs increase burst firing in rat A10 dopamine neurons: Comparison to competitive NMDA antagonists

1993 • 122 citations

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1992 • 122 citations

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1977 • 108 citations

Anticonvulsant effects of phencyclidine-like drugs: relation to N-methyl-d-aspartic acid antagonism

1988 • 99 citations

N-Methyl-d-aspartic acid-induced lethality in mice: selective antagonism by phencylidine-like drugs

1988 • 97 citations

Many agents that antagonize the NMDA receptor-channel complex in vivo also cause disturbances of motor coordination.

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A comparison between the non-competitive NMDA antagonist dizocilpine (MK-801) and the competitive NMDA antagonist D-CPPene with regard to dopamine turnover and locomotor-stimulatory properties in mice

1991 • 88 citations

Patterns of Excitation of Thalamic Neurones by Amino-acids and by Acetylcholine

1968 • 88 citations

MK‐801 Increases Extracellular 5‐Hydroxytryptamine in Rat Hippocampus and Striatum In Vivo

1992 • 85 citations

Sensitive and rapid behavioral differentiation ofN-methyl-d-aspartate receptor antagonists

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Comparison of competitive and uncompetitive NMDA receptor antagonists with regard to monoaminergic neuronal activity and behavioural effects in rats

1993 • 79 citations

A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats

1987 • 76 citations

Depression of synaptic excitation and of amino acid induced excitatory responses of spinal neurones by D-α-aminoadipate, α,ϵ-diaminopimelic acid and HA-966

1977 • 76 citations

Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors.

1989 • 73 citations

Selective activation of dopaminergic pathways in the mesocortex by compounds that act at the phencyclidine (pcp) binding site: tentative evidence for pcp recognition sites not coupled to n-methyl-d-aspartate (nmda) receptors

1990 • 71 citations

Serotonergic involvement in phencyclidine-induced behaviors

1984 • 67 citations

Dopamine D1 and D2 receptor antagonism differentially modulates stimulation of striatal neurotransmitter levels by acid

1994 • 65 citations

Locomotor activation induced by MK-801 in the rat: postsynaptic interactions with dopamine receptors in the ventral striatum

1994 • 65 citations

Regional effects of MK-801 on dopamine and its metabolites studied by in vivo microdialysis

1992 • 63 citations

The novel competitive N-methyl-D-aspartate (NMDA) antagonist CGP 37849 preferentially induces phencyclidine-like behavioral effects in kindled rats: attenuation by manipulation of dopamine, alpha-1 and serotonin1A receptors.

1991 • 61 citations

N-methyl-D-aspartate antagonism and phencyclidine-like activity: a drug discrimination analysis.

1990 • 61 citations

Anticonvulsant activity of the low-affinity uncompetitive N-methyl-D- aspartate antagonist (+-)-5-aminocarbonyl-10,11-dihydro-5H- dibenzo[a,d]cyclohepten-5,10-imine (ADCI): comparison with the structural analogs dizocilpine (MK-801) and carbamazepine.

1991 • 59 citations

Induction of phencyclidine-like behavior in rats by dextrorphan but not dextromethorphan

1991 • 59 citations

The contribution of the different binding sites of the N-methyl-D-aspartate (NMDA) receptor to the expression of behavior

1992 • 57 citations

MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis

1993 • 55 citations

Modulation of MK-801 response by dopaminergic agents in mice

1992 • 55 citations

Differential effects of phencyclidine (PCP) and ketamine on mesocortical and mesostriatal dopamine release

1989 • 55 citations

Inhibition of K+-evoked [3H]D-aspartate release and neuronal calcium influx by verapamil, diltiazem and dextromethorphan: evidence for non-L/non-N voltage-sensitive calcium channels

1991 • 54 citations

Phencyclidine-induced head-weaving and head-twitch through interaction with 5-HT1 and 5-HT2 receptors in reserpinized rats

1987 • 54 citations

Effects of competitive N-methyl-d-aspartate antagonists on midbrain dopamine neurons: An electrophysiological and behavioral comparison to phencyclidine

1991 • 54 citations

The non-competitive NMDA antagonists MK-801 and PCP, as well as the competitive NMDA antagonist SDZ EAA494 (D-CPPene), interact synergistically with clonidine to promote locomotion in monoamine-depleted mice

1990 • 52 citations

Dextromethorphan and phencyclidine receptor ligands: Differential effects on K+- and NMDA-evoked increases in cytosolic free Ca2+ concentration

1991 • 52 citations

Injection of the competitive NMDA receptor antagonist AP-5 into the nucleus accumbens of monoamine-depleted mice induces pronounced locomotor stimulation

1992 • 50 citations

Common and uncommon behavioural effects of antagonists for different modulatory sites in the NMDA receptor/channel complex

1993 • 45 citations

Phencyclidine increases extracellular dopamine metabolites in rat medial frontal cortex as measured by in vivo dialysis

1990 • 44 citations

A comparison of PCP-like compounds for NMDA antagonism in two models

1988 • 43 citations

Interaction between glutamatergic and dopaminergic tone in the nucleus accumbens of mice: evidence for a dual glutamatergic function with respect to psychomotor control

1992 • 42 citations

Antagonist drug selectivity for radioligand binding sites on voltage-gated and receptor-gated Ca2+ channels

1989 • 41 citations

Preferential Stimulation of Extracellular Release of Dopamine in Rat Frontal Cortex to Striatum Following Competitive Inhibition of the N‐Methyl‐<scp>d</scp>‐Aspartate Receptor

1994 • 39 citations

Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate

1986 • 38 citations

Measurement of an Explosive Behavior in the Mouse, Induced by MK-801, a PCP Analogue

1993 • 37 citations

Preclinical profile of remacemide: A novel anticonvulsant effective against maximal electroshock seizures in mice

1990 • 37 citations

DL-Quisqualic and L-aspartic acids activate separate excitatory conductances in cultured spinal cord neurons

1982 • 37 citations

Drug discrimination based on the competitive N-methyl-d-aspartate antagonist, NPC 12626

1989 • 34 citations

Analgesic, anesthetic, and respiratory effects of the competitiveN-methyl-d-aspartate (NMDA) antagonist CGS 19755 in rhesus monkeys

1990 • 33 citations

Effects of the novel 5-HT1A receptor antagonist, (+)-way 100135, on stereotyped behaviour induced by the NMDA receptor antagonist dizocilpine in rats

1993 • 32 citations

In vivo effects of local and systemic phencyclidine on the extracellular levels of catecholamines and transmitter amino acids in the dorsolateral striatum of anaesthetized rats

1994 • 32 citations

Effects of phencyclidine on extracellular levels of dopamine, dihydroxyphenylacetic acid and homovanillic acid in conscious and anesthetized rats

1990 • 30 citations

Alterations in striatal acetylcholine overflow by cocaine, morphine, and MK-801: relationship to locomotor output

1994 • 30 citations

Neurochemical Interactions of Competitive N‐Methyl‐D‐Aspartate Antagonists with Dopaminergic Neurotransmission and the Cerebellar Cyclic GMP System: Functional Evidence for a Phasic Glutamatergic Control of the Nigrostriatal Dopaminergic Pathway

1991 • 29 citations

Systemic phencyclidine administration is associated with increased dopamine, GABA, and 5-HIAA levels in the dorsolateral striatum of conscious rats: an in vivo microdialysis study

1994 • 29 citations

Behavioral pharmacology of NPC 17742, a competitive N-methyl-D-aspartate (NMDA) antagonist.

1993 • 28 citations

Centrally-administered glycine antagonists increase locomotion in monoamine-depleted mice

1994 • 27 citations

Pharmacological specificity of the discriminative stimulus properties of 2-amino-4,5-(1,2-cyclohexyl)-7-phosphono-heptanoic acid (NPC 12626), a competitive N-methyl-D-aspartate receptor antagonist.

1993 • 27 citations

A rapid method for evaluating the behavioral effects of phencyclidine-like dissociative anesthetics in mice

1991 • 26 citations

NMDA Receptor Blockade Increases In Vivo Striatal Dopamine Synthesis and Release in Rats and Mice with Incomplete, Dopamine‐Depleting, Nigrostriatal Lesions

1995 • 23 citations

Phencyclidine-induced catalepsy in pigeons: Specificity and stereoselectivity

1984 • 22 citations

Glutamate and Anoxic Neuronal Death in Vitro

1986 • 22 citations

Excitatory amino acid antagonists induce a phencyclidine-like catalepsy in pigeons: Structure-activity studies☆

1987 • 20 citations

Antagonism of phencyclidine-induced hyperactivity in mice by elevated brain GABA concentrations

1992 • 10 citations

Muscarinic antagonists attenuate dizocilpine-induced hypermotility in mice

1992 • 9 citations

Anticonvulsant 1‐Phenylcycloalkylamines: Two Analogues with Low Motor Toxicity When Orally Administered

1992 • 9 citations

9th International Conference on In Vivo Methods

2002 • 7 citations

Deleted Work

1955 • 0 citations