Antagonist drug selectivity for radioligand binding sites on voltage-gated and receptor-gated Ca2+ channels

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Quantitative analysis of drug-receptor interactions: I. Determination of kinetic and equilibrium properties

1981 • 557 citations

The glutamate antagonist MK‐801 reduces focal ischemic brain damage in the rat

1988 • 547 citations

Synaptic Activity Mediates Death of Hypoxic Neurons

1983 • 441 citations

A Controlled Trial of Nimodipine in Acute Ischemic Stroke

1988 • 423 citations

Changes in Extracellular Calcium Activity in Cerebral Ischaemia

1981 • 357 citations

Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective micropipette.

1977 • 263 citations

MK-801 protects the neonatal brain from hypoxic-ischemic damage

1987 • 261 citations

Glutamate Antagonist Therapy Reduces Neurologic Deficits Produced by Focal Central Nervous System Ischemia

1988 • 245 citations

Effect of pretreatment with the calcium antagonist nimodipine on local cerebral blood flow and histopathology after middle cerebral artery occlusion

1985 • 173 citations

Dextrorphan and dextromethorphan attenuate glutamate neurotoxicity

1987 • 163 citations

Dextrorphan and levorphanol selectively block N-methyl-D-aspartate receptor-mediated neurotoxicity on cortical neurons.

1987 • 154 citations

Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids

1985 • 153 citations

Calcium and long‐term transmission damage following anoxia in dentate gyrus and CA1 regions of the rat hippocampal slice.

1986 • 149 citations

The therapeutic value of nimodipine in experimental focal cerebral ischemia

1987 • 146 citations

Calcium channels and calcium channel antagonists

1987 • 141 citations

Dextromethorphan reduces neocortical ischemic neuronal damage in vivo

1988 • 131 citations

In vivo measurement of cytosolic free calcium during cerebral ischemia and reperfusion

1988 • 113 citations

Ketamine protects hippocampal neurons from anoxia in vitro

1987 • 113 citations

Dextromethorphan and dextrorphan as calcium channel antagonists

1988 • 111 citations

Effects of ischemia-like conditions on cultured neurons: protection by low Na+, low Ca2+ solutions

1986 • 107 citations

Diltiazem enhancement of [3H]nitrendipine binding to calcium channel associated drug receptor sites in rat brain synaptosomes

1982 • 97 citations

Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture

1987 • 91 citations

Phencyclidine receptor ligands attenuate cortical neuronal injury after N-methyl-D-aspartate exposure or hypoxia.

1988 • 76 citations

Calcium antagonist PY 108-068: demonstration of its efficacy in various types of experimental brain ischemia.

1984 • 37 citations

Striatal calcium channel antagonist receptors in huntington's disease and parkinson's disease

1988 • 23 citations

Cation interactions with putative NMDA receptor-gated channels labeled by [3H]MK-801 in rat cerebral cortex

1988 • 15 citations

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